• Biomaterials and Biomechanics in Bioengineering
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• 제2권1호
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• pp.1-13
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• 2015

Despite recent progresses in nanoparticle-based drug delivery systems, there are still many unsolved limitations. Most of all, a major obstacle in current nanoparticle-based drug carrier is the lack of sufficient drug delivery into target cells due to various biological barriers, such as: extracellular matrix, endolysosomal barrier, and drug-resistance associated proteins. To circumvent these limitations, several research groups have utilized photochemical internalization (PCI), an extension of photodynamic therapy (PDT), in design of innovative and efficient nano-carriers drug delivery. This review presents an overview of a recent research on utilization of PCI in various fields including: anti-cancer therapy, protein delivery, and tissue engineering.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2022년도 춘계학술대회
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• pp.357-358
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• 2022

Seafarers from 21 APEC economies, are not only an indispensable source of human capital for the global maritime industry, covering at least 56% of the world's seafaring population (BIMCO, 2015), but also pivotal in providing support to their economies as a major industrial pillar, specifically in developing economies where the development of skills and enhancement of labor mobility of human resources is essential in creating sustainable and inclusive regional growth. This paper examines challenges and barriers in seafarer mobility in relation to policies in APEC economies and investigates mutual collaborative actions that can be taken to address the issues identified in a coordinated and harmonised manner.

• Journal of Hospice and Palliative Care
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• 제23권3호
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• pp.126-138
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• 2020

Purpose: In Korea, since the Act on Hospice and Palliative Care and Decisions on Life-Sustaining Treatment for Patients at the End of Life was implemented in February 2018, advance directives (ADs) have become legally effective and should be documented after sufficient explanation by a registered counselor. However, little is known regarding the adequacy of current AD counseling. This qualitative study aimed to explore the barriers to AD counseling based on counselors' experiences. Methods: We conducted focus group interviews using purposive sampling. Seven counselors working at hospitals, community health institutions, and non-profit organizations participated in this study. They were asked about the challenges and problems they encountered during AD counseling. Results: Three themes emerged from this study; 1) issues regarding consistency in AD counseling, 2) issues regarding AD counselors' competency and work environment, and 3) issues regarding the adequacy of the service system. The interviewees stated that the lack of a manual for standardized service made AD counseling inconsistent. The limited competency and poor work environment of counselors were pointed out as major barriers. The interviewees also stated that a proper service system considering individual circumstances is absent. Conclusion: The goals of AD counseling should be clarified and guidance should be implemented for providing standardized services. Further efforts to enhance the competency of AD counselors and to improve their working conditions are needed. Establishing an integrated framework for an adequate service system is also essential to overcome systematic barriers to AD counseling.

• 한국콘텐츠학회논문지
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• 제13권11호
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• pp.404-414
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• 2013

이 연구는 경호전공 대학생의 진로장벽과 진로결정효능감 및 진로준비행동의 관계를 검증하고자 한다. 이 연구는 2012년 서울, 경기도 소재 3개 대학의 경호전공 대학생을 모집단으로 설정한 다음, 유의표집법을 활용하여 최종 130명을 활용하였다. 설문지의 타당도 및 신뢰도는 확인적 요인분석과 신뢰도 분석을 통해 검증하였으며, 설문지의 타당도는 외생변수의 경우 .664, 내생변수의 경우 .787이상으로 나탔다. 이 연구에서는 신뢰도분석을 위하여 AMOS 18.0과 SPSSWIN 18.0 프로그램을 활용하여 공변량구조분석의 기법을 활용하였다. 결론은 다음과 같다. 첫째, 경호전공 대학생의 자기명확성 부족은 진로결정 효능감에 부적 영향을 미친다. 둘째, 경호전공 대학생의 자기명확성 부족은 진로준비행동에 영향을 미치지 않는다. 셋째, 경호전공 대학생의 나이문제는 진로결정효능감에 부적 영향을 미친다. 넷째, 경호전공 대학생의 나이문재는 진로준비행동에 영향을 미치지 않는다. 다섯째, 경호전공 대학생의 신체적열등감은 진로결정효능감에 영향을 미치지 않는다. 여섯째, 경호전공 대학생의 신체적열등감은 진로준비행동에 영향을 미치지 않는다. 일곱째, 경호전공 대학생의 진로결정효능감은 진로준비행동에 영향을 미친다.

• 디지털융복합연구
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• 제14권8호
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• pp.69-80
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• 2016

본 연구의 목적은 대학생의 성별, 학년별, 전공계열별 등 배경변인별 특성에 따른 진로태도성숙, 진로장벽, 진로직업역량의 차이를 분석하는 것이다. 이에 2015학년 2학기에 A대학에 개설된 '자기개발과 진로탐색'과 '취업성공전략'등 진로관련 교양수업에 참가한 대학생 320명을 대상으로 실시한 설문을 다변량분산분석을 통해 분석하였다. 그 결과 성별에 따라 진로장벽과 진로태도성숙에 차이가 나타났는데, 여학생들이 남학생들에 비해 자기명확성 부족과 대인관계 어려움을 겪고 있으며, 진로태도성숙의 하위요인 중 독립성에서 남학생들이 여학생들보다 높았다. 또한 성별, 학년별, 전공계열별로 진로직업역량에 차이가 나타났다. 여학생들이 남학생들보다 진로탐색 역량이 높았으며 진로 직업탐색과 직업 수행에서는 공통적으로 2학년이 가장 낮았으며, 학년이 높아질수록 높아졌다. 진로 직업탐색과 진로설계에서 전공계열별로 차이가 나타났는데, 공통적으로 사회계열 전공이 제일 높았으며, 인문과 공학계열이 낮게 나타났다. 이에 제도적 차원에서 대학은 이러한 집단 간 차이를 고려하여 진로지도의 방향 설정 및 취업지원서비스를 기획 운영해야 할 것이다.

• Archives of Plastic Surgery
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• 제48권6호
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• pp.703-713
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• 2021

The field of vascularized composite allografts (VCAs) has undergone significant advancement in recent decades, and VCAs are increasingly common and accepted in the clinical setting, bringing hope of functional recovery to patients with debilitating injuries. A major obstacle facing the widespread application of VCAs is the side effect profile associated with the current immunosuppressive regimen, which can cause a wide array of complications such as infection, malignancy, and even death. Significant concerns remain regarding whether the treatment outweighs the risk. The potential solution to this dilemma would be achieving VCA tolerance, which would allow recipients to receive allografts without significant immunosuppression and its sequelae. Promising tolerance protocols are being studied in kidney transplantation; four major trials have attempted to withdraw immunosuppressive treatment with various successes. The common theme in all four trials is the use of radiation treatment and donor cell transplantation. The knowledge gained from these trials can provide valuable insight into the development of a VCA tolerance protocol. Despite similarities, VCAs present additional barriers compared to kidney allografts regarding tolerance induction. VCA donors are likely to be deceased, which limits the time for significant pre-conditioning. VCA donors are also more likely to be human leukocyte antigen-mismatched, which means that tolerance must be induced across major immunological barriers. This review also explores adjunct therapies studied in large animal models that could be the missing element in establishing a safe and stable tolerance induction method.

• Asian Pacific Journal of Cancer Prevention
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• 제17권5호
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• pp.2549-2554
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• 2016

Background: Early detection remains the cornerstone of breast cancer control in terms of outcome and survival. Thus far the only breast cancer screening method proven effective is mammography. The awareness of female health care workers (HCW) about breast cancer prevention is of vital importance, as their beliefs and behavior may have a major impact on other women. This study was designed to assess mammography screening uptake among female healthcare workers at primary healthcare centers, and to identify the primary motivators and barriers that affect uptake results. Materials and Methods: A cross sectional study design was used to assess mammography screening by 299 female healthcare workers who completed a self-administered questionnaire that assessed demographics, screening uptake, motivators and barriers. Results: The mean age was 46 years (within age of risk). The majority (95.1%) demonstrated adequate knowledge about breast cancer and mammography screening and 50% of the participants reported having at least one mammogram; however only 21% of them had regularly scheduled mammograms. The most frequent reported motivator was the perceived benefit that early detection of breast cancer is important for its management (89.6%), followed by the belief that mammography can detect breast cancer before its symptoms appear (84.4%). On the other hand, the most frequent barrier reported was being busy (46.7%), followed by the lack of perceived susceptibility (41.5%). Conclusions: Mammography screening was found to be sub-optimal in a population of HCW's with 50 % stating that they received a mammogram at least once, and a minority reported regular screening. There is a pressing need for educational programs aimed at removing the barriers that limit compliance with recommendations for mammography screening, and to emphasize the importance of early detection in breast cancer treatment. Ensuring the availability and accessibility of screening services, particularly for healthcare workers within their work settings are other important factors that would improve the acceptance and compliance for mammography screening programs.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2901-2904
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• 2014

The incidence of colorectal cancer has been increasing in many Asian countries including Malaysia during the past few decades. A physician recommendation has been shown to be a major factor that motivates patients to undergo screening. The present study objectives were to describe the practice of colorectal cancer screening by primary care providers in Malaysia and to determine the barriers for not following recommendations. In this cross sectional study involving 132 primary care providers from 44 Primary Care clinics in West Malaysia, self-administered questionnaires which consisted of demographic data, qualification, background on the primary care clinic, practices on colorectal cancer screening and barriers to colorectal cancer screening were distributed. A total of 116 primary care providers responded making a response rate of 87.9%. About 21% recommended faecal occult blood test (FOBT) in more than 50% of their patients who were eligible. The most common barrier was "unavailability of the test". The two most common patient factors are "patient in a hurry" and "poor patient awareness". This study indicates that colorectal cancer preventive activities among primary care providers are still poor in Malaysia. This may be related to the low availability of the test in the primary care setting and poor awareness and understanding of the importance of colorectal cancer screening among patients. More awareness programmes are required for the public. In addition, primary care providers should be kept abreast with the latest recommendations and policy makers need to improve colorectal cancer screening services in health clinics.

• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.667-674
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• 2015

Background: Colorectal cancer (CRC) is the third most common malignancy in Malaysia, where data are limited regarding knowledge and barriers in regard to CRC and screening tests. The aim of the study was to assess these parameters among Malaysians. Materials and Methods: The questionnaires were distributed in the Umra Private Hospital in Selangor. The questionnaire had four parts and covered social-demographic questions, respondent knowledge about CRC and colorectal tests, attitude towards CRC and respondentaction regarding CRC. More than half of Malay participants (total n=187) were female (57.2%) and 36.9% of them were working as professionals. Results: The majority of the participants (93.6%) never had a CRC screening test. The study found that only 10.2% of the study participants did not consider that their chances of getting CRC were high. A high percentage of the participants (43.3%) believed that they would have good chance of survival if the cancer would be found early. About one third of the respondents did not want to do screening because of fear of cancer, and concerns of embarrassment during the procedure adversely affected attitude to CRC screening as well. Age, gender, income, family history of CRC, vegetable intake and physical activity were found to be significant determinants of knowledge on CRC. Conclusions: The major barriers identified towards CRC screening identified in our study were fear of pain and embarrassment. The findings have implications for understanding of similarities and differences in attitude to CRC amongst elderly patients in other cultural/geographic regions.

• 한국직업건강간호학회지
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• 제11권1호
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• pp.52-62
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• 2002

Purpose: This study was to analyze changes of motivation and health-promoting lifestyle in 3 months after medical examination, and to identify the influencing factors on the change of health-promoting lifestyle. Methods: The subjects of this study were 81 adults who took medical examination at a general hospital health clinic in Cheonan city. The instruments used in this study were the motivation scale and modified HPLP. For data collection, the first survey was conducted from March 16 to April 19, 2001, and the second survey was carried out by mail three months after the medical examination from June 16 to July 19, 2001. Results: 1. The age of the subjects ranged from 26 to 66 years, 71.6% were male, and the major group was office workers(43.2%). 2. The average score of motivation scale was significantly improved in three months to 520.7(SD=82.7). All sub-scales of motivation scale, self-efficacy(t=-4.204, p=.000), perceived benefits(t=-4.263, p=.000), perceived barriers (t=4.305, p=.000), and emotional salience (t=-6.169, p=.000) showed significant improvements in 3 months. 3. The average score of health-promoting lifestyle was significantly increased to 62.5 (SD=9.8) (t=-5.111, p=.000) after 3 months. Health responsibility(t=-6.098, p=.000), eating habit(t=-3.625, p=.001), exercise(t=-2.557, p=.012), and smoking habit(t=-2.157, p=.034) showed significant improvement. But stress management was not changed at the significant level in 3 months(t=-1.832, p=.071). 4. As the result of multiple regression analysis, it was found that perceived barriers, self-efficacy and monthly mean income had a significant influence on health-promoting lifestyle in 3 months after the medical examination. These variables explained 42.4% of variance in health-promoting lifestyle in 3 months after the medical examination. Conclusion: Periodic medical examination and guidance for healthy lifestyle was effective to change the motivation and to improve health promoting lifestyle.