• 한국환경보건학회:학술대회논문집
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• 한국환경보건학회 2005년도 국제학술대회
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• pp.315-318
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• 2005

$PM_{10}$ and 16 PAHs were measured in indoor and outdoor air of 5 different old houses, new and sick houses, respectively. $PM_{10}$ concentrations measured in indoor of three different kinds of houses ranged from 23 to 43 ${\mu}g/m^3$ and in outdoor ranged in 40-64 ${\mu}g/m^3$. Sum of average concentrations of PAHs in old, new and sick houses indoor air were 3.7 $ng/m^3$, 6.6 $ng/m^3$ and 16.1 $ng/m^3$, respectively, which were lower than those of outdoors. Most of the indoor/outdoor ratio for PAHs in each house were less than 1.0 and significant correlation(p<0.05) between indoor and outdoor samples was observed.

• 한국치위생학회지
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• 제7권4호
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• pp.569-582
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• 2007

The author aims at first securing basic material required for developing and operating proper oral health care education programs though making an investigation into the undergraduates of S College of Education on the actual status of oral health care and perceptions of oral health care education. The obtained results were as follows 1. In the actual status of oral care based on whether or not they have experiences in taking oral health care education, undergraduates with teeth brushing for more than three minutes a time were found to be 25.9% and 15.7% respectively according to the existence and nonexistence of experiences in the education(pM0.020), and undergraduates with teeth brushing in a circular motion was found to be 64.7% and 51.7% respectively, showing statistically significant differences(pM0.015). 2. In the actual status of preventative oral care according to whether or not they have experiences in taking oral care education, degrees of awareness of the usefulness of dental cleansers among the undergraduates were found to be 37.6% and 21.5% respectively according to the existence and nonexistence of experiences in the education(pM0.001), undergraduates with experiences in scaling were found to be 51.8% and 34.9% respectively(pM0.002) and undergraduates with experiences in having dental sealants were found to be 26.5% and 16.9%(pM0.031), showing statistically significant differences. 3. In the survey on perceptions of oral health care according to the existence and nonexistence of experiences in oral health care education, it was revealed that the case that they indicated 'the necessity of oral health care education' was 87.1% and 64.0% respectively according to the existence and nonexistence of the experience(pM0.000), and undergraduates intended to 'participate in oral care education for students(at mid and high schools and so on) after being teachers' were 77.6% and 65.7% respectively, showing statistically significant differences(pM0.011). 4. In general characteristics according to awareness of the necessity of cultivating oral health professionals, groups with awareness of the necessity consisted of 31.8% of freshmen and juniors(pM0.001), 55.69b of female undergraduates(pM0.001), 80.8% of non-smokers(pM0.012), 38.9% of large city residents(pM0.002) and 32.3% of undergraduates living in their own houses (pM0.028), showing statistically significant differences.

• Journal of Microbiology and Biotechnology
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• 제24권3호
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• pp.421-426
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• 2014

To characterize the extended-spectrum beta-lactamases (ESBLs) in diarrheagenic Escherichia coli from Korea in 2008-2011, we screened seven enterotoxigenic E. coli (ETEC) and one enteroaggregative E. coli (EAEC) that produce ESBLs from a nationwide survey. All eight isolates produced CTX-M-type ESBLs, including CTX-M-12 (n = 4), CTX-M-14 (n = 2), and CTX-M-15 (n = 2). PCR-based replicon typing indicated that the $bla_{CTX-M-12}$ genes of four ETEC isolates were carried on a conjugative IncF plasmid, whereas the $bla_{CTX-M-14}$ of one EAEC was located on an IncK plasmid. This is the first report of the occurrence of $bla_{CTX-M}$ genes in clinical isolates of EAEC in Korea. The ESBL-producing isolates were shown to be different based on pulsed-field gel electrophoresis and multilocus sequence typing, whereas the four isolates with CTX-M-12 were clonally related. These observations raise an alarm for the spread of plasmid-mediated resistance to ESBL among diarrheagenic E. coli.

• 한국동물위생학회지
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• 제36권2호
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• pp.79-86
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• 2013

Mycobacterium (M.) bovis, a member of the M. tuberculosis complex (MTC), is a re-emerging, zoonotic agent of bovine tuberculosis whose prevalence probably depends on variations in direct exposure to cattle and ingestion of raw milk. Accurate species differentiation of M. bovis and M. tuberculosis is needed to distinguish between human and zoonotic tuberculosis. This study successfully developed a loop-mediated isothermal amplification (LAMP) assay for rapid detection and differentiation of M. bovis and M. tuberculosis, however showed negative reactions in eight non-tuberculous mycobacteria (NTM) samples and ten other bacterial species. Sensitivity of this assay for detection of genomic M. bovis DNA was 10 $fg/{\mu}l$. And this assay successfully detected M. bovis in bovine clinical specimens. In conclusion, the LAMP assay is a simple and powerful tool for rapid detection of M. bovis in both pure bacterial culture and in clinical samples.

• 한국HCI학회논문지
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• 제10권1호
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• pp.19-27
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• 2015

모바일 헬스(m-health) 시장은 특히 젊은 연령층 사이에서 스마트폰과 같은 모바일 기기를 통해 건강 컨텐츠를 활용하는 양상으로 발전하면서 확장하고 있는 추세이다. 이 연구는 서울대학교 대학(원)생을 대상으로, 젊은 층의 건강 어플리케이션 사용 현황 및 지속적 사용요인을 살펴봄으로써 건강 어플리케이션의 기전을 보다 파악하여 앞으로 등장할 가능성이 높은 모바일 헬스를 활용한 건강증진 프로그램에 기초 자료를 제공할 것으로 본다. 연구 방법으로는 연구 대상자의 인구학적 특성 및 지속적 사용여부에 따른 앱 이용 성향의 차이를 분석하고, 건강 어플리케이션에 대한 지식(Knowledge), 태도(Attitude), 믿음(Belief), 실천(Practice) 수준을 비교하였다. 지속적으로 건강 어플리케이션을 사용하는 집단은 전체의 28%로, 이들의 건강 어플리케이션에 대한 지식, 태도, 믿음, 실천(KABP)에 대한 정도가 건강 어플리케이션 사용중단자에 비하여 높았다. 본 연구는 기존 선행연구들의 마케팅 차원의 서비스 만족도 및 수용도 분석에서 더 나아가, 보건학적 관점에서 건강 어플리케이션 이용 욕구를 폭넓게 분석했다는 데 그 의의가 있다

• Environmental Analysis Health and Toxicology
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• 제24권1호
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• pp.43-52
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• 2009

Fullerene의 유전독성을 평가하기 위하여 Chinese hamster유래의 난소유아세포(CHO-K1 cell)를 이용하여 직접법(-S9)과 대사활성화법(+S9 mix)의 염색체이상시험을 실시하였다. 시험물질은 1% CMC 나트륨염의 현탁액(1% CMC 용액)에 희석하여 조제하였다. 대사활성화를 시키지 않은 직접법의 염색체이상시험에서 24시간 투여군은 8단계의 농도(0.078, 0.156, 0.313, 0.625, 1.25, 2.5, 5, 10 mM)로 투여하여 실시하였다. 투여 농도 증가에 따른 염색체이상의 빈도가 증가하는 양상이 나타나지 않았다. 48시간의 투여군에서는 8단계의 농도(0.078, 0.156, 0.313, 0.625, 1.25, 2.5, 5, 10 mM)로 투여하여 실시하였는데 투여 농도 증가에 따른 염색체이상의 빈도가 증가하는 양상이 나타나지 않았다. 배수체의 염색체이상은 직접법에서 관찰되지 않았다. 대사활성화법을 이용하여 6시간 시험물질을 투여한 시험에 있어서는 8단계의 용량단계(0.078, 0.156, 0.313, 0.625, 1.25, 2.5, 5, 10mM)를 설정하였는데 투여 농도가 증가함에 따른 염색체이상빈도의 증가양상이 관찰되지 않았다. 이상의 결과를 종합할 때 본 시험물질은 본 시험 조건하에서 CHO-K1세포에서 대사활성화를 시켰을 때 염색체이상을 유발하지 않는 것으로 판단된다.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2009년도 추계학술대회
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• pp.866-870
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• 2009

Mobile Health (M-Health) system is a recent term for medical and public health practice supported by mobile devices, such as mobile phones, PDAs, and other wireless devices. Mobile Health system has been successfully establishing at few general hospital in Korea. However, to use diverse devices manufactured by various company cause inoperability, and lack of security disappoints customers often. Although the outstanding health environment, most of hospitals are unavailable to share electronic patient records due to lack of standard protocol to handle the interoperability each other. Health Level 7 (HL7) is the best solution for the problem. In this paper, we will analyse a current M-Health service in terms of security and mobile device, and suggest iPhone for the best device against hospital environment. Also, for keep confidentiality of health information and patient privacy, enhanced security mechanism is introduced. As a consequence, interoperable standard, and most appropriate device for supporting staffs and M-Health performance, and enhanced securirty mechanism will be integrated in order to propose improved M-health model.

• 한국환경보건학회지
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• 제26권4호
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• pp.65-74
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• 2000

The sensitivity of a mehtanogen and sulfate-reducing bacterium isolated from a sea-based landfill site Cd$^{2+}$ and CU$^{2+}$ was studied. Methanogens and sulfate-reducing bacteria in leachates of the waste disposal site were enumerated using the MPN method. Methanobacterium thermoautotrophicum KHT, isolated from the leachate, could not grow at 0.5 mM Cd$^{2+}$ or 1.0 mM CU$^{2+}$. Desulfotomaculum sp. RHT, isolated from the same leachate, was able to insolubilization 3.0 mM Cd$^{2+}$ or 2.0 mM CU$^{2+}$ by production of hydrogen sulfide. When strains KHT and RHT were cultured together in the presence of the heavy metals, strain KHT could grow at high heavy metal concentrations after insolubilization of the metals by strain RHT. strain RHT.

• 대한의생명과학회지
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• 제22권4호
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• pp.220-226
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• 2016

Hypertriglyceridemia induces atherosclerosis and accordingly is a major causative factor in cardiovascular diseases. Macrophages that develop into foam cells are a crucial component in the development of atherosclerosis. Monocytes can be differentiated into M1 or M2 macrophages. M1 macrophages promote inflammatory responses, whereas M2 macrophages exhibit anti-inflammatory activity. Recently, we found that triglyceride (TG)-treated THP-1 monocytes express a variety of macrophage-specific surface markers, indicating that TG treatment could trigger the differentiation of monocytes into macrophages. In this study, we investigated whether TG-induced macrophages express the M1 or the M2 macrophage phenotype. THP-1 cells were treated with various concentrations of TG for different times and the expression of M1- and M2-specific markers was evaluated by RT-PCR. We found increased expression of M1 markers (CD40, CD80, and CD86) in TG-treated THP-1 cells in a TG dose- and time-dependent manner. The expression of M2 markers (CD163, CD200R, and CD206) showed variable responses to TG treatment. Taken together, our results indicate that TG treatment triggers the differentiation of monocytes into M1 macrophages, rather than into M2 macrophages, suggesting that TG contributes to pro-inflammatory responses.

• 중환자간호학회지
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• 제13권1호
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• pp.63-75
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• 2020

Purpose : The purpose of this study was to review mobile health (mHealth) interventions based on studies from online databases for community-dwelling patients with heart diseases. Methods : Six databases (RISS, KISS, PubMed, CINAHL, EMBASE, and SCOPUS) were searched to select studies conducted from January 1 to September 30, 2010. After this, quality appraisals were carried out using the Scottish Intercollegiate Guidelines Network checklist and a total of 11 studies were selected. Results : The selected 11 studies included 7 randomized controlled studies, 1 quasi-experimental study and 3 pilot studies. The main components of mHealth interventions included symptom monitoring at home, provisions for individualized messages for health management using text messaging, telephone or smart phone applications, and running websites for symptom monitoring or health education. Intervention periods varied from 6 weeks to 12 months. The findings of the studies suggested that the mHealth interventions were effective in improving self-management of heart diseases, quality of life, and decreasing symptoms. Conclusions : The results of the review suggested that mHealth interventions had positive effects on community-dwelling patients with heart diseases. More mHealth intervention studies need to be conducted in Korea to aid community-dwelling patients with heart diseases.