• Journal of Industrial Convergence
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• v.2 no.2
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• pp.127-147
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• 2004

This paper examines the time-series relations among expected return, risk, and book-to-market(B/M) at the portfolio level. The time-series analysis is a natural alternative to cross-sectional regressions. An alternative feature of the time-series regressions is that they focus on changes in expected returns, not on average returns. Using the time-series analysis, we can directly test whether the three-factor model explains time-varying expected returns better than the characteristic-based model. These results should help distinguish between the risk and mispricing stories. We find that B/M is strongly associated with changes in risk, as measured by the Fama and French(1993) three-factor model. After controlling for changes in risk, B/M contains little additional information about expected returns. The evidence suggests that the three-factor model explains time-varying expected returns better than the characteristic-based model.

• Journal of the Korean Society of Safety
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• v.12 no.2
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• pp.17-21
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• 1997

The fatigue crack propagation rate has so far been measured by the effective stress intensity factor range Δ K/sub eff/. But no research has been done to study how much the crack opening ratio influences the expectation of the fatigue crack propagation. Therefore, this paper evaluates of the crack opening ratio on the fatigue crack propagation life by using the method of parameter sensitivity study. Summarizing the result ; ( 1 ) When the crack opening ratio U' is high, the effect of U' gets larger than any other except for the material factor m. But when U' is low, the effect is also diminished. Therefore, the selection of the lowest value possible is desirable in the evaluation of life. (2) When the value of the material factor m is high, the effect of crack opening ratio U' is increased, at the same time the effect of the other parameters also increased wholly. The effect of material factor m itself on life is high, but in case the material factor m is high, that the effect of each parameter on life get higher is unique. In designing, better attention to the material selection should be drawn. (3) In case the stress ratio R gets smaller, the effect of crack opening ratio U' is unchangeable. But the effect of R itself remarkably decreases, and the effect of material factor m somewhat decreases.

• Communications of Mathematical Education
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• v.35 no.3
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• pp.233-255
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• 2021

The purpose of this study is to develop math anxiety scale for middle school students for planning and implementing math anxiety treatment programs. In this study, we describe the process of developing and validating math anxiety scale for middle school students and detailing exploratory factor analysis and confirmatory factor analysis to verify construct validity. As a result of the study, we developed the Math Anxiety Scale for Middle School Students (MASS-M) of 30 items with four factors: mathematical curriculum content, mathematical attitude, mathematical test, and environment. As a math anxiety factor for middle school students, MASS-M was developed, which includes mathematical anxiety factors such as mathematical test factor and environmental factor, especially mathematical curriculum content factor describing mathematical treatment, and mathematical attitude factor describing psychological treatment. MASS-M, derived from this study, is a standardized scale for measuring math anxiety in middle school students and is expected to serve as the basis for maintaining consistency in research on math anxiety in middle school students and developing programs to treat math anxiety in middle school students.

• Journal of Korean Neurosurgical Society
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• v.62 no.6
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• pp.626-634
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• 2019

Objective : Nerve growth factor (NGF) is a member of the neurotrophic factor family and plays a vital role in the physiological processes of organisms, especially in the nervous system. Many recent studies have reported that NGF is also involved in the regulation of tumourigenesis by either promoting or suppressing tumor growth, which depends on the location and type of tumor. However, little is known regarding the effect of NGF on interspinal schwannoma (IS). In the present study, we aimed to explored whether mouse nerve growth factor (mNGF), which is widely used in the clinic, can influence the growth of interspinal schwannoma cells (ISCs) isolated from IS in vitro. Methods : ISCs were isolated, cultured and identified by S-100 with immunofluorescence analysis. S-100-positive cells were divided into five groups, and separately cultured with various concentrations of mNGF (0 [phosphate buffered saline, PBS], 40, 80, 160, and 320 ng/mL) for 24 hours. Western blot and quantantive real time polymerase chain reaction (PCR) were applied to detect tyrosine kinase A (TrkA) receptor and p75 neurotrophin receptor ($p75^{NTR}$) in each group. Crystal violet staining was selected to assess the effect of mNGF (160 ng/mL) on ISCs growth. Results : ISCs growth was enhanced by mNGF in a dose-dependent manner. The result of crystal violet staining revealed that it was significantly strengthened the cells growth kinetics when cultured with 160 ng/mL mNGF compared to PBS group. Western blot and quantantive real time PCR discovered that TrkA receptor and mRNA expression were both up-regualated under the condition of mNGF, expecially in 160 ng/mL, while the exoression of $p75^{NTR}$ demonstrated no difference among groups. Conclusion : From these data, we conclude that exogenous mNGF can facilitate ISC growth by activating both TrkA receptor and $p75^{NTR}$. In addition, patients who are suffering from IS should not be administered mNGF in the clinic.

• Journal of Families and Better Life
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• v.4 no.1
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• pp.1-13
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• 1986

The purpose of this study was to examine whether the Marital Satisfaction Scale(M.S.S) is properly applicable to Korean couples and further to be devoted to the designed of a marital satisfaction scale for Korea. The scale employed in this study was a Korean adaptation of the M.S.S., which originally included 73 items but was reduced to 48 through a study of its validity by Bowden. This scale was administered to 420 couples. One kindergarten, two elementary schools, one middle school, and four high schools, all of them located in Seoul or its satellite cities were selected for the present study. The results of the study were as follows. 1) Through item analysis, 85.4% of the total items showed a high index of discrimination, i.e, of more than +.40, which all was significant discrimination (P<0.001) excluding two items. 2)Factor analysis, which was oriented toward combining factors proper to theory, showed that the M.S.S. consisted of 6 factors and its total variance was 50.18%. The 6 factors were marital satisfaction (factor 1), marital social psychological companionship (factor 2), obstacles to marriage (factor 3), dissatisfaction of marital relationship (factor 4), attitude of the reasonable marital relationship (factor 5), and cognition of married life (factor 6), 3) internal consistency reliability of the M.S.S. was 0.951 and the reliability of the total items after excluding two through item analysis 0.956 and 0.949 respectively, which showed a high internal consistency 4) The marital satisfaction examined by the M.S.S showed significant differences according to sex, education , income, the duration of marriage, the number of children but no significant differences according to age, and family type. From these results, it will be concluded that the M.S.S is a reliable and valid psychological scale for examining marital satisfaction of Korean couples. The limitations of this study were as follows. 1) It can not be generalized to all Korean couples because the subjects was sampled from Seoul or satellite cities. 2)The factor analysis in this study was oriented toward combining factors proper to theory. However, it was very difficult to find out the factors because the components of the M.S.S. was more or less abstract. Thus, from these results some suggestions follow for developing the marital satisfaction scale proper to Korean couples systematically and scientifically. 1) The subjects must be sampled form urban as well as rural areas 2)Factor analysis in this study is oriented toward finding out factors of the M.S.S. Thus, it is needed to analyze the factor validity or construct validity by multitrait - multimethod of the scale with more theoretical conceptualization. 3) It is necessary to examine whether marital satisfaction shows difference according to couples and psychological variables besides objective demographic variables. 4) More research is needed before the M.S.S. con be adapted into a turely useful marital satisfaction scale for Korea.

• Korean Journal of Mathematics
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• v.5 no.2
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• pp.119-125
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• 1997

We show that there exists an isomorphism between the basic construction $(M_f)_1$ for $N_f{\subset}M_f$ and the reduction $(M_1)_f$ of the basic construction $M_1$ for $N{\subset}M$, where $f$ is a nontrivial projection in N. For a nontrivial projection $f{\in}N^{\prime}{\cap}M$ we give the basic construction $(M_f)_1$ for $N_f{\subset}M_f$ and compare it with $(M_1)_f$.

• Proceedings of the KSAR Conference
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• 2003.06a
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• pp.71-71
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• 2003

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multifunctional cytokine that has been implicated in the regulation of pre-implantation embryo development across several species. The aim of this study was to determine the effects of mouse granulocyte-macrophage colony-stimulating factor (mGM-CSF) on development of porcine parthenotes and nuclear transferred embryos, and on their expression of implantation-related genes. In the presence of bovine serum albumin, mGM-CSF did not increase the percentage of oocytes that developed to the blastocyst stage and at day 7 did not increase oocyte cell number. Addition of 10 mM GM-CSF to protein-free culture medium significantly increased the compaction and blastocoel formation of 1- to 2-cell parthenotes and cloned embryos developing in vitro. However, cell number was not increased when they were cultured in the presence of GM-CSF. Semi-quantitative reverse transcripts polymerase chain reaction (RT-PCR) revealed that mGM-CSF enhances mRNA expression of the leukemia inhibitory factor receptor, but does not influence interleukin-6 or sodium/glucose co-transporter protein gene expression in blastocyst stage parthenotes. These results suggest that mGM-CSF may enhance viability of porcine embryos developing in vitro in a defined culture medium.

• Microbiology and Biotechnology Letters
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• v.31 no.4
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• pp.395-399
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• 2003

Nebramycin is a complex of aminocyclitol compounds that is produced by aerobic culture in fermentation process. The major antibiotic factors produced by Streptoalloteichus hindustanus are nebramycin factor 2, 4, 5'and kanamycin A. A mutant was selected, producing nebramycin factor 5' activity 16.4 times higher than parent strain by microbiological assay using Pseudomonas aeruginosa CH-U34AF. The component ratio of nebramycin factor 5' was dramatically increased from 34% to 70% by the optimization of fermentation condition. It was found that the component ratio of nebramycin factor 5' in fermentation was especially affected by the oxygen transfer rate. Optimum oxygen transfer rate for maximal nebramycin factor 5' productivity and ratio during S. hindustanus fermentation was elucidated to $0.50 mMO_2$/min.

• Magazine of the Korean Society of Agricultural Engineers
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• v.33 no.4
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• pp.105-120
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• 1991

This study was performed to investigate the minimum safety factor of embankment in consideration of seismic coefficient by the psuedo-static analysis The variables were cohesion, the internal friction angle, angle of slope, height of seepage, height of embankment, depth of replacement The results obtained were compared with those by Fellenius method, simplified Bishop method and Janbu method. The results were summarized as follows: 1.The increasing rate of the minimum safety factor with the increasing of cohesion appeared larger in Fellenius method and Bishop method than in Janbu method. And that with the increasing of the internal friction angle appeared the lowest value in Janbu method. The minimum safety factor was influenced larger on the internal friction angle than on cohesion. 2.The variation of the minimum safety factor with the height of seepage at 0m and 5 m was nearly similar to Fellenius method, Bishop method and Janbu method. On the other hand, it was decreased suddenly at 25 m. 3.The minimum safety factor with the height of embankment was decreased remarkably under 10 m with the increasing of seismic coefficient. But, it was decreased slowly more than 10 m. As the height of embankment was low, the influence of cohesion appeared larger. 4.In heigher case of the depth of replacement, the phenomenon of reduction of the minimum safety factor appeared remarkably with seismic coefficient increased. And in lower case of the depth of replacement, the minimum safety factor was similar in Fellenius method and Bishop mehtod. But it appeared larger in Bishop method and Janbu method than in Fellenius method with the depth of replacement increased. 5.As the cohesion and the internal friction angle were large, the phenomenon of reduction of the minimum safety factor with the increasing of seismic coefficient appeared remarkably. Also, the influence of seismic coefficient in minimum safety factor appeared larger with the soil parameter increased. 6.When the seismic coefficient was considerated, investigation of the structural body on the slope stability appeared profitably in Fellenius method and Janbu method than in Bishop method.

• Journal of Life Science
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• v.18 no.10
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• pp.1348-1354
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• 2008

mi transcription factor (MITF) is important in regulating the differentiation of mast cells. In particular, MITF regulates the transcription of the mouse mast cell-specific serine protease (mMCP)-6 gene, which is generally expressed by the connective tissue-type of mast cells. In this study, we investigated alternative isoforms of MITF that regulate transcription of the mMCP-6 gene in bone marrow-derived cultured mast cells in mice. The expression of MITF isoforms was examined by RT-PCR. We observed that MITF-A, -E, -H and -Mc were expressed by mucosal-type mast cells cultured in the presence of IL-3, whereas the connective tissue-type mast cells cultured in the presence of stem cell factor (SCF) expressed MITF-A. Overexpression of MITF isoforms increased luciferase activity through the mMCP-6 promoter in NIH-3T3 cells and elevated the level of mMCP-6 expression in the MC/9 mast cell line. Moreover, mMCP-6 expression in mast cells was significantly inhibited by the depletion of MITF. The transcriptional activity and DNA binding of MITF-A was comparable to that of MITF isoforms, including MITF-E, -H, and -Mc. Our results therefore suggest that MITF-A may be an important isoform of MITF in regulating the transcription of mMCP-6 in mouse connective tissue mast cells.