• Journal of Ginseng Research
• /
• 제20권3호
• /
• pp.339-343
• /
• 1996

The effect of ginseng on the reactivity of penile corpus cavernosal smooth muscle strips of rabbits was investigated to support the clinical application of ginseng for the treatment of erectile dysfunction. New Zealand white rabbits were randomly divided into two groups, normal diet group (n=9) and ginseng saponin diet group (n=5). Then, each group was fed normal diet and Korean red ginseng saponin diet (50 mg/kg/day) for 10 weeks. We measured concentration dependent relaxation of corporal smooth muscle to acetylcholine (10-8 M to 10-4M) in organ chamber. The degree of relaxation was expressed as percentage of maximal relaxation obtained by papaverine (10-4M). Dose dependent relaxation of corpus cavernosal smooth muscle to acetylcholine, at the concentration of 10-8 M to 10-4M by half log increment, was 4.06$\pm$0.00, 4.30$\pm$1.30, 5.32$\pm$0.68, 11.64$\pm$1.74, 16.24$\pm$1.61, 23.33$\pm$ 2.29, 26.45$\pm$2.25, 30.43$\pm$2.40 and 33.41 $\pm$2.48 (%), respectively in normal diet group and 9. 83$\pm$4.15, 20.60$\pm$4.62, 24.1815.12, 35.75$\pm$5.71, 43.35$\pm$6.11, 51.30$\pm$6.22, 56.33$\pm$6.22, 54.30$\pm$4.17 and 51.98$\pm$3.92 (Vc), respectively in ginseng group. These data suggest that ginseng enhances ondothelium-dependent acetylcholine-induced relaxation of penile corpus cal.ernosal smooth muscle in rabbits.

• 조명전기설비학회논문지
• /
• 제28권2호
• /
• pp.76-83
• /
• 2014

This paper deals with the numerical method of calculating the frequency-dependent impedances of grounding electrodes. The proposed electromagnetic field approach is based on the solutions to Maxwell's equations obtained from the method of moment in the frequency domain. In order to evaluate the quality of the proposed simulation method, the frequency-dependent impedances of horizontally-buried ground electrodes were presented. The program for calculating the current distributions and impedances of grounding electrodes was implemented in MATLAB. The grounding impedances of two 10m and 50m long horizontal ground electrodes were measured and simulated in the frequency range from 100Hz to 10MHz for easy analysis and comparison. Also the simulated results were compared with those calculated from a sophisticated computer program CDEGS (HIFREQ module). As a result, the resultant results of frequency-dependent impedances obtained by using the numerical simulation method proposed in this work are in good agreement with experimental data. The validity of the approach techniques was confirmed.

• Bulletin of the Korean Chemical Society
• /
• 제18권10호
• /
• pp.1105-1108
• /
• 1997

The new amorphous intermetallic compounds, M3(AsTe3)2: M=Cr, Co, Fe, were synthesized by the precipitation reaction of the Zintl anion AsTe33- with the divalent transition metal halides in aqueous solution and analyzed by EDS equipped with SEM and PIXE. The empirical formula of the specimens was found to be Fe3.0As1.8Te5.9, Co3.0As2.1Te6.5, and Cr3.0As2.0Te6.9 by the quantitative elemental analysis. The dc specific resistivity of the materials was measured as a function of temperature in the range from 20 to 300 K, in which their resistivity of Cr3(AsTe3)2 was largely dependent on temperature, while those of Co3(AsTe3)2 and Fe3(AsTe3)2 were only slightly dependent on temperature. To characterize the spin glass state of the specimens, the ac and dc magnetic susceptibility were measured and it was found that Co3(AsTe3)2 and Fe3(AsTe3)2 undergo a transition to a spin glass state at 6 K and 38 K, respectively. Magnetization data are reported as both thermal remanent magnetization (TRM) and isothermal remanent magnetization (IRM) as a function of magnetizing field and temperature.

• 한국연초학회지
• /
• 제25권2호
• /
• pp.128-136
• /
• 2003

Although tobacco smoke has been known to have genotoxicity as well as cytotoxicity, the sensitivity of the cell lines used against cigarette smoke is poorly understood. The objective of this study was to evaluate and compare the genotoxicity of several cell lines, which are routinely used in the in vitro assays, with cigarette smoke condensate(CSC) of Kentucky Reference Cigarette 1R4F. In the micronucleus(MN) induction assays, murine(CHO-K1, V79, BALB/c 3T3) cell lines and human(MCF-7, A549) ones were used. As a result, the CSC exhibited cytotoxicity with a concentration-dependent response in all cell lines. EC$_{50}$ of CSC in CHO-K1, V79, BALB/c 3T3, MCF-7 and A549 were 140, 125, 100, 116 and 109 $\mu\textrm{g}$/mL, respectively. On the other hand, the spontaneous micronucleated cell(MNC) frequency was stable and reproducible in every cell lines tested in this study. The dose-response of various cell lines to the induction of MN by CSC was estimated using linear regression analysis. CSC(0～100 $\mu\textrm{g}$/mL) caused a dose-dependent MN induction in CHO-K1, V79, BALB/c 3T3 and MCF-7 cell lines. Putting together all the data obtained and linear regression analysis of the data, we concluded that V79 cells are more susceptible to the accurate assessment of CSC-induced MN than the others.s.

• BMB Reports
• /
• 제42권8호
• /
• pp.493-499
• /
• 2009

MicroRNAs (miRs) are a family of small noncoding RNAs that regulate gene expression by targeting mRNAs in a sequence specific manner, inducing translational repression or mRNA degradation. In this paper we have first analyzed by microarray the miR-profile in erythroid precursor cells from one normal and two thalassemic patients expressing different levels of fetal hemoglobin (one of them displaying HPFH phenotype). The microarray data were confirmed by RT-PCR analysis, and allowed us to identify miR-210 as an highly expressed miR in the erythroid precursor cells from the HPFH patient. When RT-PCR was performed on mithramycin-induced K562 cells and erythroid precursor cells, miR-210 was found to be induced in time-dependent and dose-dependent fashion, together with increased expression of the fetal $\gamma$-globin genes. Altogether, the data suggest that miR-210 might be involved in increased expression of $\gamma$-globin genes in differentiating erythroid cells.

• Communications for Statistical Applications and Methods
• /
• 제3권3호
• /
• pp.113-123
• /
• 1996

Data-dependent (adaptive) choice of asymptotically efficient score functions for rank estimators and M-estimators of regression parameters in a linear regression model with left-truncated and right-censored data are developed herein. The locally adaptive smoothing techniques of Muller and Wang (1990) and Uzunogullari and Wang (1992) provide good estimates of the hazard function h and its derivative h' from left-truncated and right-censored data. However, since we need to estimate h'/h for the asymptotically optimal choice of score functions, the naive estimator, which is just a ratio of estimated h' and h, turns out to have a few drawbacks. An altermative method to overcome these shortcomings and also to speed up the algorithms is developed. In particular, we use a subroutine of the PPR (Projection Pursuit Regression) method coded by Friedman and Stuetzle (1981) to find the nonparametric derivative of log(h) for the problem of estimating h'/h.

• 대한의용생체공학회:학술대회논문집
• /
• 대한의용생체공학회 1995년도 춘계학술대회
• /
• pp.27-33
• /
• 1995

A time-dependent large deformation fracture theory is developed for application to soft biological tissues. The theory uses the quasilinear viscoelastic theory of Fung, and particularizes it to constitutive assumptions on polyvinyl-chloride (PVC) (Part I) and cartilage (Part II). This constitutive theory is used in a general viscoelastic theory by Christensen and Naghdi and an energy balance to develop an expression for the fracture toughness of the materials. Experimental methods are developed for measuring the required constitutive parameters and fracture data for the materials. Elastic stress and reduced relaxation functions were determined using tensile and shear tests at high loading rates with rise times of 25-30 msec, and test times of 150 sec. The developed method was validated, using an engineering material, PVC to separate the error in the testing method from the inherent variation of the biological tissues. It was found that the the proposed constitutive modeling can predict the nonlinear stress-strain and the time-dependent behavior of the material. As an approximation method, a pseudo-elastic theory using the J-integral concept, assuming that the material is a time-independent large deformation elastic material, was also developed and compared with the time-dependent fracture theory. For PVC. the predicted fracture toughness is $1.2{\pm}0.41$ and $1.5{\pm}0.23\;kN/m$ for the time-dependent theory and the pseudo-elastic theory, respectively. The methods should be of value in quantifying fracture properties of soft biological tissues. In Part II, an application of the developed method to a biological soft tissue was made by using bovine humeral articular cartilage.

• Computers and Concrete
• /
• 제19권1호
• /
• pp.51-58
• /
• 2017

The paper presents the experimental investigations for studying the effect of ground granulated blast furnace slag (GGBFS) on the time-dependent deflection of reinforced concrete (RC) beams due to creep and shrinkage. The RC beams were reinforced with 2-10 mm bars at tension side and subjected to constant sustained two-point loading for the period of 150 days. The amount of cement replacement by GGBFS was varied from 0 to 60% with an increment of 20%. The total deflection was measured at different ages of up to 150 days under sustained loads. The experiments revealed that the time-dependent deflection of the reinforced concrete RC beams containing GGBFS was higher than that of plain concrete RC beams. At 150 days, the average creep and shrinkage deflection of RC beams containing 20%, 40% and 60% GGBFS was 1.25, 1.45 and 1.75 times higher than the plain concrete beams. A new model, which is an extension of authors' earlier model, is proposed to incorporate the effect of GGBFS content in predicting the long-term deflection of RC beams. Besides validating the new model with the current data with higher percentage of tension reinforcement, it was also used to predict the authors' earlier data containing lesser percentage of tension reinforcement with reasonable accuracy.

• International Journal of Reliability and Applications
• /
• 제6권2호
• /
• pp.117-133
• /
• 2005

Estimations of the parameters included in a two-component system are derived based on masked system life test data, when the probability of masking depends upon the exact cause of system failure. Also estimations of reliability for the individual components at a specified mission time are derived. Maximum likelihood and Bayes methods are used to derive these estimators. The problem is explained on a series system consisting of two independent components each of which has a Pareto distributed lifetime. Further we present numerical studies using simulation.

• 동력기계공학회지
• /
• 제16권4호
• /
• pp.37-43
• /
• 2012

This paper performed experimental research in order to measure boiling heat transfer coefficient of water in microchannel with hydraulic diameter of $500{\mu}m$. Tests were conducted within the ranges of heat fluxes from 100 to 400 kW/$m^2$, vapor qualities from 0 to 0.2, and mass fluxes of 200, 400, and 600 kg/$m^2s$. From the experimental results, it was found that flow boiling heat transfer coefficient is not dependent on mass flux or vapor quality, but instead on heat flux to a certain degree. The measured data of heat transfer are compared to a few available correlations proposed for mini-channels. Among them, Sun and Mishima's correlation is found to predict the present data well, within the mean absolute error of 17.84%.