• Journal of agricultural medicine and community health
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• v.16 no.2
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• pp.172-176
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• 1991

Lyme disease, or Lyme borreliosis. is an infection caused by spirohete Borrellia burgdorferi. This disease was recognized in Lyme, Conneticut U.S.A. in 1975. The onset of the disease is usually heralded by the appearance of a pathognomic skin lesion, known as erythema chronicum migrans, and accompanied by flue like or meningitis like symptoms. Unless treatment is initiated early, the disease usually disseminated, often resulting carduac, neurologic, or joint manifestations. All stages of the disease are usually curable by appropriate antibiotic therapy, and can prevent severe late cardiac, neurologic, and joint complications. Lyme disease is typically defined by clinical evidence supported by serologic test. The diagnosis require serologic confirmantion of erythema chronicum migrans, occurring in patient in nonendemic countries. Determination of antibody titer against B. burgdorferi by enzyme linked immunosorbent assay(ELISA) currently the most practical diagnostic test. Currently Lyme disease occurs in U.S.A. Europe, and Australia. It has recently recognized in China, Japan, and Soviet Union also. In United States, Lyme disease is most common vector borne infection. There is no reported case of patients with this disease in Korea. But the vector of this disease, -Ixodes ticks- had been identified in Korea. And Korea is geographically closely related to China and Japan where Lyme disease is already reported. We expect first case of Lyme disease could he reported in near future. We review the clinical manifestations and diagnostic method of Lyme disease.

• Pediatric Infection and Vaccine
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• v.27 no.3
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• pp.184-189
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• 2020

Lyme disease is a common vector-borne disease caused by Borrelia burgdorferi. Erythema migrans represents the most common manifestation during the early phase of this disease; however, systemic manifestations involving the nervous system, joints, or heart are known to occur. We report a case of Lyme disease accompanied by cardiac complications in a 13-year-old Korean male adolescent. The patient developed annular erythematous lesions on his lower extremities after a field trip during his visit to Connecticut, USA, for a boarding school camp, and his skin lesions were consistent with erythema migrans. Indirect immunofluorescence assay and Western blot analysis for Lyme immunoglobulin M showed positive results. Electrocardiography revealed a first-degree atrioventricular block, and he was diagnosed with Lyme carditis and received a 4-week course of oral doxycycline. Follow-up electrocardiography performed a week later revealed normal findings, and the patient showed an uneventful recovery. Lyme carditis often presents as an asymptomatic heart block that can progress to an advanced heart block; however, this condition is reversible with appropriate antibiotic treatment.

• Journal of Preventive Medicine and Public Health
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• v.51 no.4
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• pp.213-214
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• 2018

Lyme borreliosis (LB) is the most common tick-borne infectious disease in North America, and it was designated as a national notifiable infectious disease in Korea in December 2010. While no cases in Jeju-do were recorded from 2012 to 2016, a recent survey reported that the seroprevalence of Borrelia burgdorferi using enzyme-linked immunosorbent assays in horses in Jeju-do was 19.0% (95% confidence interval, 12.0 to 28.3%). This fact suggests that horses may be a potential reservoir of LB in Jeju-do and that individuals in close contact with horses may be a high-risk group. Thus, a serological study in this high-risk group is urgently needed.

• Health Policy and Management
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• v.4 no.2
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• pp.126-147
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• 1994

Lyme 질환은 미국 코넷티컷주의 라임지방에서 관절염증상을 보이는 소아과환자에게서 1975년 처음 발견되었다, 사슴, 누루, 개 등에 기생하는 진드기에 의해 전염되며, 발병초기에는 감기증상을 수반한 황소의 눈과 비슷한 붉은 반점이 생긴다. 적기에 치료하지 않으면, 관절염, 심장질환, 안면신경마비 등으로 악화될 수 있다. 본 논문의 목적은 두가지로 나누어 볼 수 있다. 먼저, 진단초기의 Lyme질환과 관련된 의료 및 기타 경제적 비용을 저렴하게 계측할 수 있는 방법론을 개발하고 그 유효성을 검증하는 것이다. 둘째로 lyme질환의 비용에 대한 여러종류의 총괄적 계측치를 제공하고 발병의 위험요인을 색출하는 것이다. 본 논문에서는 차트분석이나 임상연구 등 고가의 비용이 수반되는 분석기법 대신에 Lyme질환 다발지역에 대한 설문조사를 실시하고 그 유효성을 재설문조사를 통해서 검증하는 방법을 사용하였다. 자료분석상의 난점은 조사대상자마다 응답하지 않은 항목(Missing Value)이 다르기 때문에, 총 비용을 계산할 때 모든 항목에 응답한 조사대상자만을 사용한다면 표본의 크기가 너무 작아지는 것이었다. 이에 대한 대안으로 총비용 및 부분별 비용의 합을 계산할 때 표본의 일부가 응답하지 않은 항목에 대해서는 그 항목에 응답한 나머지 조사대상자의 응답치 평균을 대체하는 방법을 사용하였다. 통계적 분석결과, 질환의 증상시작부터 설문조사시기까지 Lyme질환과 관련된 사회적 총비용은 US$ 6400으로 추정되었다. 이중에 200가량은 환자의 보호자와 관련된 비용이고 나머지는 환자와 관련되 것이다. 총의료비용의 평균은 계산방법에 따라서 US$ 3000-4200의 범위를 보였다. 응답되지 않은 항목을 해당항목에 대한 응답치평균으로 대체하였을 때 총의료비평균은 US$ 4108이었다. 시간비용을 생산성손실에 대한 사회적 가치와 실제임금 손실의 두가지 방법에 의해 계산되었다. 실제임금손실은 생산손실의 사회적 가치의 약 30%에 불과하였다. 본 논문의 결과는 의료비용 및 비용과 생산성손실에 대한 정보가 지역보건담당자에 의한 전화설문조사에 의해 경제적이고도 일관성 있게 수집될 수 있다는 근거로 해석될 수 있다.

• Parasites, Hosts and Diseases
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• v.56 no.6
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• pp.609-613
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• 2018

Babesiosis, caused by Babesia microti and B. divergens, is transmitted by Ixodid ticks. Symptoms of babesiosis vary from a mild flu-like illness to acute, severe, and sometimes fatal and fulminant disease. In Korea, 7 imported babesiosis cases and 1 endemic case have been reported. We report 2 cases of severe babesiosis initially mistaken as malaria. The first patient was complicated by shock and splenic infarction, the other co-infected with Lyme disease. As the population traveling abroad increases every year, physicians should be aware of babesiosis which mimics malaria, co-infection with other diseases, and its complications.

• Korean Journal of Clinical Laboratory Science
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• v.51 no.4
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• pp.436-443
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• 2019

Lyme disease is a national notifiable infectious disease as of September 2018. The number of cases of Lyme disease has recently been increasing. This study analyzed the epidemiological features and clinical symptoms of domestic and imported. From 2011 to December 31, 2018, of the 119 cases, 48 confirmed cases, 63 probable cases, and 8 suspected cases. 70 cases (58.8%) were reported in Korea and 49 cases (41.2%) of imported. In addition, 91 cases (76.5%) were reported during the summer~autumn season (June~November). In 2017, the highest number of 31 cases. The time needed to make a diagnosis was 2.8±14.7 days for domestic occurrences versus 1.4±4.5 days for those cases that infection occurred imported. Among the clinical symptoms, fever and rash were statistically significant (P<0.001). Clinical trials included early localized 31 cases (52.1%), early disseminated 43 cases (35.3%), and late disseminated 15 cases (12.6%). The estimated regions of infection in Korea were Chungnam 12 cases (17.1%), Gyeonggi 12 cases (17.1%), and Gangwon 8 cases (11.4%), Patient care is also considered to be very important as this disease occurs of all ages. Therefore, the promotion of preventive education and identification of epidemiological features are of paramount importance and should be implemented. The study's findings can be used as basic data for the prevention and management of patients with lyme disease.

• Journal of the korean veterinary medical association
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• v.28 no.8
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• pp.495-500
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• 1992

• Journal of the korean veterinary medical association
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• v.37 no.9
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• pp.846-854
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• 2001

• Parasites, Hosts and Diseases
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• v.49 no.4
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• pp.419-422
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• 2011

Severe tick infestation was found in a hare in a suburban area of Nanchang, Jiangxi Province, China. We sampled ticks and identified them based on their morphologic characteristics. Three species, Ixodes sinensis, which is commonly found in China and can experimentally transmit Borreliia burgdorferi, Rhipicephalus haemaphysaloides, and Haemaphysalis longicornis which can transmit Lyme disease were detected with an optical microscope and a stereomicroscope. Risk of spreading ticks from suburban to urban areas exists due to human transportation and travel between the infested and non-infested areas around Nanchang.

• Biomedical Science Letters
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• v.3 no.2
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• pp.95-105
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• 1997

Currently, the laboratory diagnosis for lyme disease have been performed with the detection of antibodies against Borrelia burgdorferi. However there might be some difficulties in the interpretation of obtained results due to the usage of foreign isolates as an antigen in the test. Therefore the optimization of serological tests with Korean isolates of B. burgdorferi as an antigen would be needed to establish the standardized diagnostic method for the detection of antibodies against B. burgdorferi infection. In this study, the optimization of ELISA was investigated with experimentally challenged rabbit sera and sonicated B. burgdorferi antigens of Korean isolates. Of 217 human patient's sera with unknown fever, the mean seropositivities in ELISA, done under the optimized conditions obtained in this study, were found to be about 8％ against B. burgdorferi sensu late, showing the highest seropositivity of 14.3％ against B. afzelii. In immunoblotting assay with ELISA-positive human sera, the major reactive bands were 41kDa (flagellin) which might be the indication of early infection, and 27kDa, 31kDa (OspA), 34kDa (OspB) which are the characteristics of late infection. Obtained results in this study might strongly indicate the possibility of B. burgdorferi infections in Korea.