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http://dx.doi.org/10.15324/kjcls.2019.51.4.436

Study on the Epidemiological Features of Lyme Disease in Korea between 2011 and 2018  

Seo, Choong Won (Division of Control for Zoonotic and Vector Borne Disease, Korea Centers for Disease Control and Prevention)
Publication Information
Korean Journal of Clinical Laboratory Science / v.51, no.4, 2019 , pp. 436-443 More about this Journal
Abstract
Lyme disease is a national notifiable infectious disease as of September 2018. The number of cases of Lyme disease has recently been increasing. This study analyzed the epidemiological features and clinical symptoms of domestic and imported. From 2011 to December 31, 2018, of the 119 cases, 48 confirmed cases, 63 probable cases, and 8 suspected cases. 70 cases (58.8%) were reported in Korea and 49 cases (41.2%) of imported. In addition, 91 cases (76.5%) were reported during the summer~autumn season (June~November). In 2017, the highest number of 31 cases. The time needed to make a diagnosis was 2.8±14.7 days for domestic occurrences versus 1.4±4.5 days for those cases that infection occurred imported. Among the clinical symptoms, fever and rash were statistically significant (P<0.001). Clinical trials included early localized 31 cases (52.1%), early disseminated 43 cases (35.3%), and late disseminated 15 cases (12.6%). The estimated regions of infection in Korea were Chungnam 12 cases (17.1%), Gyeonggi 12 cases (17.1%), and Gangwon 8 cases (11.4%), Patient care is also considered to be very important as this disease occurs of all ages. Therefore, the promotion of preventive education and identification of epidemiological features are of paramount importance and should be implemented. The study's findings can be used as basic data for the prevention and management of patients with lyme disease.
Keywords
Clinical features; Epidemiological features; Erythema migrans; Lyme disease;
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1 Lee D, Kim SH, Hong SK, Seo JK, Sung HS, Hwang SW, et al. A case of Lyme disease with various general symptoms. Korean J Dermatol. 2008;46:1112-1116.
2 Park KH, Lee SH, Won WJ, Park MY. Isolation of Borrelia burgdorferi, the causative agent of Lyme disease, from Ixodes ticks in Korea. J Korean Soc Microbiol. 1992;27:307-312.
3 Kee SH, Hwang KJ, Oh HB, Kim MB, Shim JC, Ree HI, et al. Isolation and identification of Borrelia burgdorferi in Korea. J Korean Soc Microbiol. 1994;29:301-309.
4 Lee MG, Chung KY, Choi YS, Cho SN. Lyme disease. Korean J Dermatol. 1993;31:601-605.
5 Moon S, Gwack J, Hwang KJ, Kwon DH, Kim SY, Noh YT, et al. Autochthonous Lyme borreliosis in humans and ticks in Korea. Osong Public Health Res Perspect. 2013;4:52-56.   DOI
6 Jung EK. 2017 Case definitions for national notifiable infectious diseases [Internet]. Cheongju: Korea Centers for Disease Control and Prevention; 2017 [cited by 2019 Nov 10]. Available from: http://cdc.go.kr.
7 Jung EK. 2017 Guideline for vector borne disease prevention and control [Internet]. Cheongju: Korea Centers for Disease Control and Prevention; 2017 [cited by 2019 Nov 10]. Available from: http://cdc.go.kr.
8 Allen CS. Lyme disease. N Engl J Med. 2001;345:115-125.   DOI
9 Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, et al. The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the infectious disease society of America. Clin Infect Dis. 2006;43:1089-134.   DOI
10 Allen CS. Lyme disease. N Engl J Med. 1989;321:586-596.   DOI
11 Masuzawa T. Terrestrial distribution of the Lyme borreliosis agent Borrelia burgdorferi sensu lato in East Asia. Jpn J Infect Dis. 2004;57:229-235.
12 Lee MG, Cho YH. Lyme disease. J Korean Med Assoc. 2004;47:1063-1069.   DOI
13 Ai CX, Wen YX, Zhang YG, Wang SS, Qiu QC, Shi ZX, et al. Clinical manifestations and epidemiological characteristics of Lyme disease in Hailin county, Heilongjiang Province, China. Ann N Y Acad Sci. 1988;539:302-313.   DOI
14 Hao Q, Hou X, Geng Z, Wan K. Distribution of Borrelia burgdorferi sensu lato in China. J Clin Microbiol. 2011;49:647-650.   DOI
15 Murase Y, Konnai S, Githaka N, Hidano A, Taylor K, Ito T, et al. Prevalence of Lyme borrelia in Ixodes persulcatus ticks from an area with a confirmed case of Lyme disease. J Vet Med Sci. 2013;75:215-218.   DOI
16 Kim TH, Choi EH, Lee MG, Ahn SK. Serologically diagnosed Lyme disease manifesting erythema migrans in Korea. J Korean Med Sci. 1999;14:85-88.   DOI
17 Aguero-Rosenfeld ME, Wang G, Schwarts I, Wormser GP. Diagnosis of Lyme borreliosis. Clin Micobiol Rev. 2005;18:484-509.   DOI
18 Wang G, van Dam A, Schwarts I Dankert J. Molecular typing of Borrelia burgdorferi sensu lato: toxomic, epidemiological, and clinical implications. Clin Micobiol Rev. 1999:12:633-653.
19 Burgdorfer W, Barbour AG, Hayes SF, Benach JL, Grunwaldt E, Davis JP. Lyme disease-a tick-borne spirochetosis? Science. 1982;216:1317-1319.   DOI
20 Schwartz AM, Hinckley AF, Mead PS, Hook SA, Kugeler KJ. Surveillance of Lyme disease-United States, 2008-2015. MMWR Morb Mortal Wkly Rep. 2017;66:1-12.   DOI
21 Lee CN, Mo HJ, Kim JE, Park HJ, Lee JY, Jo BG, et al. A case of Lyme disease presenting with erythema migrans. Korean J Dermatol. 2003;41:1202-1205.
22 Kim JW, Kim JS. A case of Lyme disease with unusual cutaneous manifestations. Korean J Dermatol. 2005;43:501-506.