• Title/Summary/Keyword: lower secondary

Search Result 1,300, Processing Time 0.134 seconds

Associations between Insertion/deletion Polymorphisms in Galactose Mutarotaseand Carcass Traits in the Hanwoo Population of Jeju Island (제주도 한우 집단에서 Galactose mutarotase (GALM) 유전자의 삽입/결실 다형성과 도체형질의 연관성 분석)

  • Yoo-Kyung Kim;Jongan Lee;Sang-Min Shin;Yeoung-Gyu Ko;Ji-Hyun Yoo;Miyoung Won
    • Journal of Life Science
    • /
    • v.33 no.12
    • /
    • pp.987-994
    • /
    • 2023
  • This study examined the associations between the genotypes of the galactose mutarotase (GALM) gene and carcass traits in the Hanwoo population of Jeju Island, South Korea. The GALM genotypes were determined by the 14-bp (5'-GGTCTAATGACCAG-3') insertion/deletion (InDel) polymorphisms of the 3'-untranslated region (UTR). All three genotypes (LL, LS, and SS) were found in the Hanwoo steer population. The association analysis showed significant associations between genotypes and several carcass traits, including traits related to intramuscular fat content, such as meat quality, marbling score, and backfat thickness (p<0.05). Animals harboring the SS genotype showed not only higher levels of intramuscular fat content but also lower levels of backfat thickness than animals harboring the LL and LS genotypes. On the other hand, no significant associations were found between the GALM genotypes and carcass weight, eye muscle area, meat color, or fat color (p>0.05). Deleting the 14-bp segment in the 3'-UTR resulted in the modification of the secondary structure of RNA and appeared to affect gene expression by interfering with the binding ability of GALM mRNA with RNA-binding proteins and microRNAs. These results suggest that the 14-bp InDel polymorphism in the 3'-UTR region of the GALM gene affects cattle growth traits and carcass quality through galactose metabolism-mediated fat accumulation in muscle and backfat tissues.

Measurement and Prediction of Combustion Characteristics of DEC(Diethyl Carbonate) + DMMP(Dimethyl Methylphosphonate) for Secondary Battery Solutions (2차전지 용액인 DEC(Diethyl Carbonate) + DMMP(Dimethyl Methylphosphonate)계의 연소특성치 측정 및 예측)

  • Y. S. Jang;Y. R. Jang;J. J. Choi;D. J. Jeon;Y. G. Kim;D. M. Ha
    • Journal of the Korean Society of Safety
    • /
    • v.38 no.5
    • /
    • pp.8-14
    • /
    • 2023
  • Lithium ions can induce the thermal runaway phenomenon and lead to reignition due to electrical, mechanical, and environmental factors such as high temperature, smoke generation, explosions, or flames, which is extremely likely to create safety concerns. Therefore, one of the ways to improve the flame retardancy of the electrolyte is to use a flame-retardant additive. Comparing the associated characteristic value of existing substances with the required experimental value, it was found that these values were either considerably different or were not documented. It is vital to know a substance's combustion characteristic values, flash point, explosion limit, and autoignition temperature (AIT) as well as its combustion characteristics before using it. In this research, the flash point and AIT of materials were measured by mixing a highly volatile and flammable substance, diethyl carbonate (DEC), with flame-retardant dimethyl methylphosphonate (DMMP). The flash point of DEC, which is a pure substance, was 29℃, and that for DMMP was 65℃. Further, the lower explosion limit calculated using the measured flash point of DEC was 1.79 Vol.%, while that for DMMP was 0.79 Vol.%. The AIT was 410℃ and 390℃ for DEC and DMMP, respectively. In particular, since the AIT of DMMP has not been discussed in any previous study, it is necessary to ensure safety through experimental values. In this study, the experimental and regression analysis revealed that the average absolute deviation (ADD) for the flash point of the DEC+DMMP DEC+DMMP system is 0.58 sec and that the flash point tends to increase according to changes in the composition employed. It also revealed that the AAD for the AIT of the mixture was 3.17 sec and that the AIT tended to decrease and then increase based on changes in the composition.

Analysis of Soil and Leaf Characteristics of Pear Orchards with Lime-Induced Chlorosis Leaves (배나무 엽 황화증상 발생 과원의 토양 및 엽 특성 분석)

  • In Bog Lee;Dae Ho Jung;Pyoung Ho Yi;Seung Tak Jeong;Yoon Kyeong Kim
    • Korean Journal of Environmental Agriculture
    • /
    • v.42 no.4
    • /
    • pp.331-337
    • /
    • 2023
  • Physiological disorders in pear fruit are mainly caused by problems during the growing season, such as lack of calcium in the soil, poor drainage, low porosity, vigorous pruning, and excessive fruiting. In this study, soil physicochemical properties and leaf characteristics were analyzed in pear orchards in four regions of Korea where chlorosis symptoms occurred to determine the causes of chlorosis. The color of chlorotic leaves was diagnosed using the naked eye or SPAD and Hunter values. The soil of the chlorotic orchard had a significantly higher soil pH than that of the regular orchard. Although adequate soil depth was not significantly associated with chlorosis, combined with over-fertilization of the soil with lime, it could potentially impair plant iron uptake. Chlorotic leaves had significantly lower iron and calcium contents and significantly higher magnesium contents than those of regular leaves. Therefore, the intensive occurrence of chlorosis during secondary shoot development around June and July when it is hot and humid may be due to impaired iron and calcium absorption, leading to physiological disorders. To solve this problem, avoiding the over-application of lime and applying foliar fertilizers containing chelated iron is recommended.

No-Touch vs. Conventional Radiofrequency Ablation Using Twin Internally Cooled Wet Electrodes for Small Hepatocellular Carcinomas: A Randomized Prospective Comparative Study

  • Yun Seok Suh;Jae Won Choi;Jeong Hee Yoon;Dong Ho Lee;Yoon Jun Kim;Jeong Hoon Lee;Su Jong Yu;Eun Ju Cho;Jung Hwan Yoon;Jeong Min Lee
    • Korean Journal of Radiology
    • /
    • v.22 no.12
    • /
    • pp.1974-1984
    • /
    • 2021
  • Objective: This study aimed to compare the efficacy between no-touch (NT) radiofrequency ablation (RFA) and conventional RFA using twin internally cooled wet (TICW) electrodes in the bipolar mode for the treatment of small hepatocellular carcinomas (HCC). Materials and Methods: In this single-center, two-arm, parallel-group, prospective randomized controlled study, we performed a 1:1 random allocation of eligible patients with HCCs to receive NT-RFA or conventional RFA between October 2016 and September 2018. The primary endpoint was the cumulative local tumor progression (LTP) rate after RFA. Secondary endpoints included technical conversion rates of NT-RFA, intrahepatic distance recurrence, extrahepatic metastasis, technical parameters, technical efficacy, and rates of complications. Cumulative LTP rates were analyzed using Kaplan-Meier analysis and the Cox proportional hazard regression model. Considering conversion cases from NT-RFA to conventional RFA, intention-to-treat and as-treated analyses were performed. Results: Enrolled patients were randomly assigned to the NT-RFA group (37 patients with 38 HCCs) or the conventional RFA group (36 patients with 38 HCCs). Among the NT-RFA group patients, conversion to conventional RFA occurred in four patients (10.8%, 4/37). According to intention-to-treat analysis, both 1- and 3-year cumulative LTP rates were 5.6%, in the NT-RFA group, and they were 11.8% and 21.3%, respectively, in the conventional RFA group (p = 0.073, log-rank). In the as-treated analysis, LTP rates at 1 year and 3 years were 0% and 0%, respectively, in the NT-RFA group sand 15.6% and 24.5%, respectively, in the conventional RFA group (p = 0.004, log-rank). In as-treated analysis using multivariable Cox regression analysis, RFA type was the only significant predictive factor for LTP (hazard ratio = 0.061 with conventional RFA as the reference, 95% confidence interval = 0.000-0.497; p = 0.004). There were no significant differences in the procedure characteristics between the two groups. No procedure-related deaths or major complications were observed. Conclusion: NT-RFA using TICW electrodes in bipolar mode demonstrated significantly lower cumulative LTP rates than conventional RFA for small HCCs, which warrants a larger study for further confirmation.

Salivary Gland Uptake on 18F-FP-CIT PET as a New Biomarker in Patients With Parkinsonism

  • Seo Young Kang;Ji Young Yun;Yeon-Koo Kang;Byung Seok Moon;Hai-Jeon Yoon;Min Young Yoo;Bom Sahn Kim
    • Korean Journal of Radiology
    • /
    • v.24 no.7
    • /
    • pp.690-697
    • /
    • 2023
  • Objective: 18F-FP-CIT positron emission tomography (PET) is known for its high sensitivity and specificity for evaluating striatal dopamine transporter (DAT) binding. Recently, for the early diagnose of Parkinson's disease, many researchers focused on the diagnosis of synucleinopathy in organs involved in non-motor symptoms of Parkinson's disease. We investigated the feasibility of salivary gland uptake on 18F-FP-CIT PET as a new biomarker in patients with parkinsonism. Materials and Methods: A total of 219 participants with confirmed or presumed parkinsonism, including 54 clinically diagnosed idiopathic Parkinson's disease (IPD), 59 suspected and yet undiagnosed, and 106 with secondary parkinsonism, were enrolled. The standardized uptake value ratio (SUVR) of the salivary glands was measured on both early and delayed 18F-FP-CIT PET scans using the cerebellum as the reference region. Additionally, the delayed-to-early ratio (DE_ratio) of salivary gland was obtained. The results were compared between patients with different PET patterns. Results: The SUVR in early 18F-FP-CIT PET scan was significantly higher in patients with IPD pattern compared that in the non-dopaminergic degradation group (0.5 ± 0.19 vs. 0.6 ± 0.21, P < 0.001). Compared with the non-dopaminergic degradation group, the DE_ratio was significantly lower in patients with IPD (5.05 ± 1.7 vs. 4.0 ± 1.31, P < 0.001) or atypical parkinsonism patterns (5.05 ± 1.7 vs. 3.76 ± 0.96, P < 0.05). The DE_ratio was moderately and positively correlated with striatal DAT availability in both the whole striatum (r = 0.37, P < 0.001) and posterior putamen (r = 0.36, P < 0.001). Conclusion: Parkinsonism patients with an IPD pattern exhibited a significant increase in uptake on early 18F-FP-CIT PET and a decrease in the DE_ratio in the salivary gland. Our findings suggest that salivary gland uptake of dual-phase 18F-FP-CIT PET can provide diagnostic information on DAT availability in patients with Parkinson's disease.

Method to Derive the Optimal Vent Position when Flammable Liquid Leaks Based on CFD (CFD 기반 인화성 액체 누출 시 최적의 환기구 배치 도출 방안)

  • Eun-Hee Kim;Seung-Hyo An;Jun-Seo Lee;Byung-Chol Ma
    • Journal of the Korean Institute of Gas
    • /
    • v.28 no.1
    • /
    • pp.11-18
    • /
    • 2024
  • If flammable liquid leaks, vapor evaporated from the pool can cause poisoning or suffocation to workers, leading to secondary accidents such as fires and explosions. To prevent such damage, ventilation facilities shall be installed when designing indoor workplaces. At this time, the behavior varies depending on the characteristics of the leaked chemical, so it is necessary to select a suitable vent location according to the material. Therefore, 3D CFD simulations were introduced to derive optimal vent position and ventilation efficiency was quantitatively evaluated by vent position. At this time, assuming a situation in which flammable liquids leak at indoor workplaces to form pools, the concentration of vapor evaporated from pools was compared to derive the optimal vent position. As a result of research on toluene with high vapor density, ventilation efficiency was confirmed to be the highest at the upper supply-lower exhaust, and it is judged that introducing it can achieve about 3.7 times ventilation effect at the same maintenance cost. Through this study, it is expected that the workplace will be able to secure workers' safety by applying simulation results and installing ventilation ports.

Mental Health in Adolescents with Allergic Disease : Using Data from the 2021 Korean Youth's Health Behavior Online Survey (알레르기질환 청소년의 정신건강: 2021 청소년건강행태 온라인조사 활용)

  • Young-Seon Seo;Sumi Cho;Eunju Seo
    • Journal of Industrial Convergence
    • /
    • v.22 no.7
    • /
    • pp.81-91
    • /
    • 2024
  • This study was conducted to determine the status of allergic diseases and mental health in adolescents, confirm the relationship between allergic diseases and mental health, and provide basic data for developing effective disease management measures for adolescents at the developmental stage. Secondary analysis was performed on the data from the 17th Youth Health Behavior Online Survey, and complex sample descriptive statistics, cross-tabulation, and logistic regression analysis were performed using the SPSS 26.0 program. As a result of the study, those with one or more allergic diseases were 1.286 times more likely to have stress (B=1.286, p<.000), 1.289 times more likely to be depressed (B=1.289, p<.000), and 1.399 times more likely to have generalized anxiety disorder (B=1.399, p<.000) was highly likely to experience it. Additionally, factors affecting the mental health of adolescents with allergic diseases were gender, economic level, academic performance, drinking experience, and smoking experience. Stress and generalized anxiety disorder were more likely to be experienced by female students, if they had a lower economic level and academic performance, and if they drank alcohol or smoked. Male students were more likely to experience depression if their economic level and academic performance were higher, and if they did not drink alcohol or smoke. Based on these results, we hope to establish a practical approach by establishing effective strategies to manage allergic diseases in adolescents and the mental health conditions that may arise from them.

Lithologic and Structural Controls and Geochemistry of Uranium Deposition in the Ogcheon Black-Slate Formation (옥천대(沃川帶) 우라늄광층(鑛層)의 구조규제(構造規制) 및 지구화학적(地球化學的) 특성연구(特性硏究))

  • Lee, Dai Sung;Yun, Suckew;Lee, Jong Hyeog;Kim, Jeong Taeg
    • Economic and Environmental Geology
    • /
    • v.19 no.spc
    • /
    • pp.19-41
    • /
    • 1986
  • Structural, radioactive, petrological, petrochemical, mineralogical and stable isotopic study as well as the review of previous studies of the uranium-bearing slates in the Ogcheon sequence were carried out to examine the lithological and structural controls, and geochemical environment in the uranium deposition in the sequence. And the study was extended to the coal-bearing formation (Jangseong Series-Permian) to compare the geochemical and sedimentologic aspects of uranium chemistry between Ogcheon and Hambaegsan areas. The results obtained are as follows: 1. The uranium mineralization occurs in the carbonaceous black slates of the middle to lower Guryongsan formation and its equivalents in the Ogcheon sequence. In general, two or three uranium-bearing carbonaceous beds are found with about 1 to 1.5km stratigraphic interval and they extend from Chungju to Jinsan for 90km in distance, with intermittent igneous intrusions and structural Jisturbances. Average thickness of the beds ranges from 20 to 1,500m. 2. These carbonaceous slate beds were folded by a strong $F_1$-fold and were refolded by subsequent $F_1$-fold, nearly co-axial with the $F_1$, resulting in a repeated occurrence of similar slate. The carbonaceous beds were swelled in hing zones and were shrinked or thined out in limb by the these foldings. Minor faulting and brecciation of the carbonaceous beds were followed causing metamorphism of these beds and secondary migration and alteration of uranium minerals and their close associations. 3. Uranium-rich zones with high radioactive anomalies are found in Chungju, Deogpyong-Yongyuri, MiwonBoun, Daejeon-Geumsan areas in the range of 500~3,700 cps (corresponds to 0.017~0.087%U). These zones continue along strike of the beds for several tens to a few hundred meters but also discontinue with swelling and pinches at places that should be analogously developed toward underground in their vertical extentions. The drilling surveyings in those area, more than 120 holes, indicate that the depth-frequency to uranium rich bed ranging 40~160 meter is greater. 4. The features that higher radioactive anomalies occur particularly from the carbonaceous beds among the argillaceous lithologic units, are well demonstrated on the cross sections of the lithology and radioactive values of the major uranium deposits in the Ogcheon zone. However, one anomalous radioactive zone is found in a l:ornfels bed in Samgoe, near Daejeon city. This is interpreted as a thermal metamorphic effect by which original uranium contents in the underlying black slate were migrated into the hornfels bed. 5. Principal minerals of the uranium-bearing black slates are quartz, sericite, biotite and chlorite, and as to chemical composition of the black slates, $Al_2O_3$ contents appear to be much lower than the average values by its clarke suggesting that the Changri basin has rather proximal to its source area. 6. The uranium-bearing carbonaceous beds contain minor amounts of phosphorite minerals, pyrite, pyrrhotite and other sulfides but not contain iron oxides. Vanadium. Molybdenum, Barium, Nickel, Zirconium, Lead, Cromium and fixed Carbon, and some other heavy metals appear to be positive by correlative with uranium in their concentrations, suggesting a possibility of their genetic relationships. The estimated pH and Eh of the slate suggests an euxenic marine to organic-rich saline water environment during uranium was deposited in the middle part of Ogcheon zone. 7. The Carboniferous shale of Jangseong Series(Sadong Series) of Permian in Hambaegsan area having low radioactivity and in fluvial to beach deposits is entirely different in geochemical property and depositional environment from the middle part of Ogcheon zone, so-called "Pibanryong-Type Ogcheon Zone". 8. Synthesizing various data obtained by several aspects of research on uranium mineralization in the studied sequence, it is concluded that the processes of uranium deposition were incorporated with rich organic precipitation by which soluble uranyl ions, $U{_2}^{+{+}}$ were organochemically complexed and carried down to the pre-Ogcheon sea bottoms formed in transitional environment, from Red Sea type basin to Black Sea type basin. Decomposition of the organic matter under reducing conditions to hydrogen sulfide, which reduced the $UO{_2}^{+2}$ ions to the insoluble uranium dioxide($UO_2$), on the other side the heavy metals are precipitated as sulfides. 9. The EPMA study on the identification of uraninite and others and the genetic interpretation of uranium bearing slates by isotopic values of this work are given separately by Yun, S. in 1984.

  • PDF

Effects of Accelerated Curing on the Strength of Mortar Using Briquette Ash. (촉진양생(促進養生)이 연탄재를 사용(使用)한 Mortar의 강도(强度)에 미치는 영향(影響))

  • Kim, Seong Wan;Kang, Sin Up;Sung, Chan Yong
    • Korean Journal of Agricultural Science
    • /
    • v.8 no.2
    • /
    • pp.185-194
    • /
    • 1981
  • This study was carried out to determine the effect of accelerated curing on the strength of standard sand mortar and briquette ash mortar. The standard sand mortars and the briquette ash mortars made by mixture of the standard sand:cement and the briquette ash:cement at the ratio of 2 : 1, 3: 1 and 4 : 1, respectively, were cured at 4 different temperature of $20^{\circ}C$, $60^{\circ}C$, $80^{\circ}C$ and $100^{\circ}C$. The compression and tensil strength of mortars were measured at ${\sigma}_3$, ${\sigma}_7$, ${\sigma}_28$. The results obtained are summarized as follows; 1. At each age of curing and each curing temperature, the compression and tensile strength of the mortars made by the mixture of cement and standard sand was significantly higher than that of the mortars made by the mixture of cement and briquette ash. But the increasing rate of strength in compression and tension was significantly higher at the mortars of cement and briquette ash than those of cement and standard sand. 2. The strength of mortars which showed lower strength than Korean Standard at ordinary curing temperature was significantly increased and showed higher value than Korean Standard by the accelerated curing at high temperature. The increasing rate of strength by the accelerated curing was higher at the mortars containing less amount of cement than those containing more cement. The hardening of the mortars containing less amount of cement was significantly promoted by the accelerated curing in high temperature. 3. When the briquette ash was substituted for the materials of cement mortar, decline of the mortar strength is. unavoidable. But the enhancement of the mortar strength is still expected by the experimental results that the strength of cement-briquette ash mortar showed an increase of 137.6% by the accelerated curing at $60^{\circ}C$, 164.1% at $80^{\circ}C$ C and 183.8% at $100^{\circ}C$, respectively, compared with the strength of mortar cured at $20^{\circ}C$ for 28 days. 4. As the strength of cement briquette mortar is lower than that of cement standard sand mortar, the cement briquette ash mortar is expected to be increased in strength by the accelerated curing at high temperature. The cement briquette mortar is expected to be utilized to the production of secondary mortar goods or the constructions which need low strength of mortar.

  • PDF

Detection of Dopamine and Serotonin by Competitive Enzyme-Linked Immunosorbent Assay (경쟁적 ELISA를 이용한 도파민과 세로토닌의 검출)

  • Namkung, Su Min;Choi, Jeong Su;Park, Ji Hyang;Yang, Man Gil;Lee, Min Woo;Kim, Suhng Wook
    • Korean Journal of Clinical Laboratory Science
    • /
    • v.49 no.3
    • /
    • pp.220-226
    • /
    • 2017
  • Dopamine (DA) and serotonin (5-Hydroxytryptamine, 5-HT) are neurotransmitters and hormones that exist in small amounts but have important role in the body. Serum and 24-hour urine are used as specimens, and are usually examined by HPLC-MS. In this study, we tried to detect DA and 5-HT by competitive ELISA using antigen-antibody (Ab) reaction. After immobilizing $5{\mu}g/mL$ BSA conjugate on a 96-well surface, hormone and primary Ab, which are respectively diluted to different concentrations, were treated. Then, HRP-conjugated secondary Ab and TMB were added to measure absorbance. The regression equation and $R^2$ value were calculated based on absorbance, and sensitivity of Ab to hormone as well as the correlation between hormone concentration and absorbance were determined. In DA ELISA, $R^2$, the correlation between the concentration of hormone and absorbance, was the highest by 0.91 when anti-dopamine Ab was diluted 6,000 times and 7,000 times. In 5-HT ELISA, $R^2$ was bigger than 0.90 in every concentration except 3,000 times and 6,000 times. Both DA and 5-HT were not effectively detected at low concentrations (less than $1.0{\times}10^{-7}M$); and because reference value of serum DA is lower than this, HPLC-MS was required to detect serum DA. However, competitive ELISA may be effective in detecting 24-hour urine DA, serum, and 24-hour 5-HT. Further studies are needed to detect hormones more accurately at lower concentrations.