• Journal of Ginseng Research
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• v.46 no.1
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• pp.115-125
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• 2022

Background: Ginsenosides (GS) have potential value as cosmetic additives for prevention of skin photoaging. However, their protective mechanisms against skin barrier damage and their active monomeric constituents are unknown. Methods: GS monomer types and their relative proportions were identified. A UVB-irradiated BALB/c hairless mouse model was used to assess protective effects of GS components on skin epidermal thickness and transepidermal water loss (TEWL). Skin barrier function, reflected by filaggrin (FLG), involucrin (IVL), claudin-1 (Cldn-1), and aquaporin 3 (AQP3) levels and MAPK phosphorylation patterns, were analyzed in UVB-irradiated hairless mice or HaCaT cells. Results: Total GS monomeric content detected by UPLC was 85.45% and was largely attributed to 17 main monomers that included Re (16.73%), Rd (13.36%), and Rg1 (13.38%). In hairless mice, GS ameliorated UVB-induced epidermal barrier dysfunction manifesting as increased epidermal thickness, increased TEWL, and decreased stratum corneum water content without weight change. Furthermore, GS treatment of UVB-irradiated mice restored protein expression levels and epidermal tissue distributions of FLG, IVL, Cldn-1, and AQP3, with consistent mRNA and protein expression results obtained in UVB-irradiated HaCaT cells (except for unchanging Cldn-1 expression). Mechanistically, GS inhibited JNK, p38, and ERK phosphorylation in UVB-irradiated HaCaT cells, with a mixture of Rg2, Rg3, Rk3, F2, Rd, and Rb3 providing the same protective MAPK pathway inhibition-associated upregulation of IVL and AQP3 expression as provided by intact GS treatment. Conclusion: GS protection against UVB-irradiated skin barrier damage depends on activities of six ginsenoside monomeric constituents that inhibit the MAPK signaling pathway.

• Journal of Convergence for Information Technology
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• v.12 no.4
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• pp.1-8
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• 2022

With the development of communication infrastructure, the number of network equipment owned by one person is gradually increasing. General-purpose devices such as smartphones can implement theft/loss prevention function by implementing S/W. However, other small devices lack practicality such as long-distance communication problems due to standard communication technology specifications or H/W limitations, and lack of functions(authentication and security). This study combines the Lora communication protocol in the LPWA standard environment and the blockchain technology. Anti-theft and security functions were added to the protocol, and the PBFT consensus algorithm was applied to build a blockchain network. As a result of the test, the effectiveness of safety(authentication and trust network) and performance(blockchain processing performance) were confirmed. This study aims to contribute to the future development of portable or small device anti-theft products as a 4th industrial convergence research.

• Journal of Microbiology and Biotechnology
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• v.32 no.7
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• pp.835-843
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• 2022

Deinococcus radiodurans is an extremophilic bacterium that can thrive in harsh environments. This property can be attributed to its unique metabolites that possess strong antioxidants and other pharmacological properties. To determine the potential of D. radiodurans R1 lysate (DeinoLys) as a pharmacological candidate for inflammatory bowel disease (IBD), we investigated the antiinflammatory activity of DeinoLys in bone marrow-derived dendritic cells (BMDCs) and a colitis mice model. Lipopolysaccharide (LPS)-stimulated BMDCs treated with DeinoLys exhibited alterations in their phenotypic and functional properties by changing into tolerogenic DCs, including strongly inhibited proinflammatory cytokines (TNF-α and IL-12p70) and surface molecule expression and activated DC-induced T cell proliferation/activation with high IL-10 production. These phenotypic and functional changes in BMDCs induced by DeinoLys in the presence of LPS were abrogated by IL-10 neutralization. Furthermore, oral administration of DeinoLys significantly reduced clinical symptoms against dextran sulfate sodium-induced colitis, including body weight loss, disease activity index, histological severity in colon tissue, and lower myeloperoxidase level in mice. Our results establish DeinoLys as a potential anti-inflammatory candidate for IBD therapy.

• Journal of the Korea Society of Computer and Information
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• v.28 no.2
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• pp.63-68
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• 2023

In this paper, we introduce a system that tracks and shares the position of objects based on tags. After receiving the location information of objects through the tag location tracking app, the location of the tag is shared as a group, and the shared users also check the location of objects in real time. Our system offer a differentiated function that allows multiple users to manage and supervise the location of objects, compared to legacy systems. The GPS module and Bluetooth are connected to the Arduino board to obtain the location information of the tag and check it through the Android app. We used Android Studio to create app, and the tag brings up the location of the object. The location of the tag is stored in the phpMyadmin DB and the latitude/longitude is received to the Android app and displayed on the map of the app. The proposed system will be useful for loss prevention and managing public goods.

• Journal of the Korean Society of Food Culture
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• v.37 no.6
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• pp.555-563
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• 2022

The purpose of this study was to confirm the quality characteristics of distilled soju with different rice pretreatment processes. The non-steamed fermentation method is a technology that uses starch to produce saccharification and alcohol without going through the steaming of raw materials. It has advantages such as reduction of manpower and cost, prevention of nutrient loss, and minimization of waste water. In this study, rice used were non-steamed and pulverized 'Baromi2', nonsteamed and steamed 'Samgwang', and puffed rice. As the fermenting agent, koji, modified nuruk, N9 yeast, and purified enzyme were used, and lactic acid was added to prevent contamination during fermentation. The amount of water was 300% in total, and after the first watering, 5 days after fermentation, the second watering was carried out. As a result of the study, it was confirmed that the non-steamed fermentation method using 'Baromi' was superior to the existing fermentation method in terms of temperature during fermentation, final alcohol content, soluble solids, and pH. By expanding the stability of the production technology of non-steamed fermentation technology, product quality improvement can be expected.

• The Korea Journal of Herbology
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• v.34 no.2
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• pp.59-66
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• 2019

Objectives : Decrease in muscle mass and loss of muscle function due to aging are associated with various diseases. As interest in healthy aging increases, efforts to prevent and treat muscle hypoxia as an illness are increasing. Considering the physical limitations, a pharmacologic approach to the treatment of myopenia is needed. Methods : Terminalia chebula Rets has a wide range of pharmacological effects and is used as a medicinal product in traditional medicine. However, the drug effect on the treatment of muscle disorders has not been revealed. The purpose of this study was to evaluate the value of water extract of Terminalia chebula (WETC) as a therapeutic agent to relieve symptoms of muscle hypoxia. Results : WETC showed strong radical scavenging ability. In addition, WETC increased cell activity of myoblast, and we observed that WETC induces myoblast differentiation by immunoblot analysis using differentiation protein markers as well as cell morphology of myoblast. Based on these results, we examined the effect of chebulic acid, chebulagic acid, gallic acid, geraniin, and punicalagin on cell activity and differentiation of myoblasts. Gallic acid significantly increased cell activity of myoblast, and it was found to be an effective substance which not only induces myoblast differentiation but also promotes proliferation. Conclusions : We suggest that the WETC with antioxidant effect and its indicator gallic acid on cell activity, proliferation and differentiation of myoblast can be studied and developed as a food and medicine for prevention and treatment of various muscle diseases.

• International Journal of Computer Science & Network Security
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• v.22 no.3
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• pp.135-140
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• 2022

Scientific and technological progress is also fundamental to the evolving merchant shipping industry, both in terms of the size and speed of modern ships and in the level of their technical capabilities. While the freight performance of ships is growing, the number of crew on board is steadily decreasing, as more work processes are being automated through the implementation of information technologies, including ship management systems. Although there have been repeated appeals from international maritime organizations to focus on building effective maritime security defenses against cyber attacks, the problems have remained unresolved. Owners of shipping companies do not disclose information about cyberattack attempts or incidents against them due to fear of commercial losses or consequences, such as loss of image, customer and insurance claims, and investigations by independent international organizations and government agencies. Issues of cybersecurity of control systems in the world today have gained importance, due to the fact that existing threats concern not only the security of technical means and devices, but also issues of environmental safety and safety of life at sea. The article examines the implementation of cyber risk management in the shipping industry, providing recommendations for the safe ship operation and its systems in order to improve vulnerability to external threats related to cyberattacks, and to ensure the safety and security of such a technical object as a seagoing ship.

• Fashion & Textile Research Journal
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• v.24 no.1
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• pp.156-163
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• 2022

Loss of leg muscle and muscle weakness, which are caused by aging, affect muscle function and sense of balance. As a way of preventing seniors from falling, we developed the idea of wearing functional supporters based on graduated compression technique and in the form of a taping supporter. Their impact on power, sense of balance, overcoming fatigue, and subjective wearing sensation was investigated. The following results were obtained. After wearing functional compression supporters, body temperature increased from 24.5 ± 0.5℃ to 26.3 ± 0.6℃. Calf size, which assesses the level of edema, decreased from 26.1 ± 1.8cm to 25.7 ± 1.8cm. The result of dynamic balance test, which helps estimate the fall prevention effect, increased from 6.4 ± 0.9sec to 7.1 ± 0.6sec. Lactate level, which indicates the level of fatigue, decreased from 8.1 ± 0.6mmol/L to 7.3 ± 0.8mmol/L. Standing long jump record, which assesses power, increased from 110.1 ± 3.1cm to 112.0 ± 2.8cm. Standing on one leg with eyes closed, which assesses sense of balance, increased from 4.2 ± 1.1sec to 6.5 ± 0.8sec. Ankle angle, which assesses joint stability, increased from 75.3 ± 4.0° to 80.1 ± 1.7°. In metabolism and physical performance testing, which assesses keep, the score increased from 26.3 ± 1.7 to 28.8 ± 1.2. Muscle supporting score, which assesses joint stability, increased from 7.3 ± 0.6 to 7.8 ± 0.4. In the category of body type, which assesses wearing sensation and body shaping function, the score increased from 5.7 ± 1.4 to 6.4 ± 1.2

• The Journal of Engineering Geology
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• v.32 no.4
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• pp.547-558
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• 2022

In August 2020, a debris flow occurred in Gokseon, Jeollanam-do, that resulted in the death of five residents. In this study area, high-resolution 0.03 m topographic information was generated through photogrammetry, and the amount of soil movement/loss was measured. In addition, sensitivity analysis was performed for flow depth, flow velocity, and debris flow area with the program Flo-2D using the difference in simulation parameter that discharge and topographic information. Wth increasing debris flow input discharge, increases were seen in flow depth, flow velocity, and debris flow area, as ell as in the gap in results from high-resolution topographic information and low-resolution topographic information. Also, when high-resolution topographic information was used, the results were similar to the actual (measured) flow direction of the debris flow. Therefore, the application of high-resolution topographic information increases the accuracy of the debris flow analysis results compared with low-resolution information. Results could be further imporved in the future by considering geological information such as yield stress and viscosity.

• Journal of Ecology and Environment
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• v.46 no.3
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• pp.204-217
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• 2022

Background: Increasing land demands for food production have led to biodiversity loss and land degradation in the Madhupur Sal forest. Reforestation activities such as agroforestry and woodlot plantation support the conservation of diversity, restoration of forest and prevention of soil erosion in degraded natural Sal forest. Knowing about these reforestation activities, this study is needed to compare the species composition, richness, and soil nutrients of these two plantation activities to the natural Sal forest in the degraded Madhupur Sal forest in Bangladesh. Results: The analysis showed that in between the reforestation activities, the highest Shannon-Wiener index (1.79), evenness (0.60) and Simpson's index (0.79) were found in the agroforestry site compared to the woodlot plantation site. On the contrary, the highest species richness (n = 14), tree basal area (19.56 m² ha^-1), Margalef's index (1.96) were recorded in woodlot plantation than in the agroforestry site. We observed that at 0-15 cm depth, soil organic matter (2.39%), total nitrogen (0.14%), available phosphorous (62.67 ㎍ g^-1) and exchangeable potassium (0.36 meq/100 g) in agroforestry plots were significantly higher compared to other forest sites. At topsoil (15-30 cm depth), soil organic matter (1.67%) and available phosphorous (21.09 ㎍ g^-1) were found to be higher in agroforestry site. Conclusions: Both reforestation approaches improved soil function, although woodlot plantation had the higher species richness. Therefore, plantation activities by the sustainable implementation of these two practices are the best alternative to restore the biodiversity, richness and conserve soil fertility in the Madhupur Sal forest of Bangladesh.