• Title/Summary/Keyword: long-term prescription

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Researches on the Phase Institution of the Folk Remedies in Dongyibogam (동의보감(東醫寶鑑)에서 단방(單方) 민간요법이 주는 의미)

  • Oh Se-Chang;Kim Kwang-Joong
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.20 no.1
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    • pp.1-9
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    • 2006
  • To accept folk remedies in view of oriental medicine and to use as one of social health materials, 1 have looked for the phase institution of folk remedies in the oriental medicine and their adopting method to the oriental medicine, on the basis of the present social-communicating situation, the degree of interest in folk remedies among people and oriental medicine doctors and the content of folk remedies in Dongyibogam(東醫寶鑑). The results are following; The researches of relative importance in the folk remedy's meaning of Dongyibogam show that the proper use can help disease cured, not by unconditional choice but by symptoms. The use of folk remedies are different from the prescription in the oriental medicine, as showing the type and ratio of folk remedies and prescriptions in Dongyibogam. When considering used materials, forms and time in the meaningful content of folk remedies in Dongyibogam, they established two categories. One is radical treatment on acute disease by short-term use. The other is slow treatment on chronic disease by long-term use. For wide application to people, they also had the prudent attitude to accept symptom-oriented treatment and tried to connect with syndrome which needed diagnosis as precisely as possible.

Long Term Management of Congenital Ventricular Tachyarrhythmia in a Dog

  • Lee, Geonyoung;Kang, Jooyeon;Ko, Minho;Cho, Hyunkee;Choi, Sooyoung;Park, In-Chul;Chung, Jin-Young
    • Journal of Veterinary Clinics
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    • v.34 no.5
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    • pp.353-355
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    • 2017
  • A four month old, intact female Jindo dog presented to the Veterinary Teaching Hospital of Kangwon National University with collapse. Physical examination revealed a heart rate of more than 200 beats per minute. Blood tests showed mild anemia and mild neutrophilia, while thoracic radiography and ultrasonography revealed no remarkable findings. Electrocardiography showed ventricular premature complexes (VPCs). The dog was diagnosed with congenital ventricular tachyarrhythmia. The condition was improved by lidocaine infusion. After 10 days, the dog was discharged from the hospital with a prescription of atenolol, pimobendan, diltiazem, furosemide, spironolactone, and L-carnitine. This dog is still alive after 31 months. However, progressive cardiac remodeling was confirmed on radiography and ultrasonography. Congenital ventricular tachyarrhythmia is rare in dogs, and the prognosis of reported cases is poor. This report describes the long-term successful management of a dog with congenital ventricular tachyarrhythmia.

Study of the Drugs Prescribed on Alzheimer's Disease: from the Insurance Claims Data of Korea National Health Insurance Service (우리나라 건강보험 청구자료를 이용한 알츠하이머성 치매 치료제의 사용현황 분석)

  • Kim, Jungeun;Lee, Jonghyuk;Jeong, Ji Hoon;Kang, Minku;Bang, Joon Seok
    • Korean Journal of Clinical Pharmacy
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    • v.24 no.4
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    • pp.255-264
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    • 2014
  • Objective: The aims of this study are to investigate the total volume of prescribed medicines against Alzheimer's disease (AD) and the trends of usage by analyzing the claims-data from the Korea National Health Insurance Service. Method: The demographic and claims-data were included the major AD treating medicines such as donepezil, galantamine, rivastigmine and memantine, and analyzed during the period of 2010~2012. The assessing criteria were gender, age, habitation, types of medical institution, code of ingredients, outcomes of treatment, volume and amount of claims, and the numbers of patients with dementias. After trimming the data, it were analyzed by the market size, demographic traits, characteristics of medical service, characteristics of each anti-AD medicine, etc. Results: Among the chosen 4 medicines, donepezil had the top prescription volumes. Most prevalent prescribing preparations of donepezil were conventional types. However, among the non-conventional types, oro-dispersible formulation is the fast increasing one in both volume and growth rate. This specialized preparations to improve both toleration and adherence, tend to being prescribed generally at the tertiary medical institutions. While the younger patients with mild-to-moderate AD mostly treated by expensive medicines in resident at the tertiary hospitals, the rest older patients with severe AD have been treated non-expensive one at long-term care facilities. Conclusion: AD is a chronic illness therefore, long-term use of therapeutic medications are highly important. If an anti-AD treatment was applied steadily in the earlier stages, it would be achieved not only improving the quality of life of patient but also reducing the expenses in the medical and nursing cares. As the socioeconomical impacts of AD is expanding, healthcare professionals need to aware the importance of pharmacotherapy and to improve sociopolitical fundamentals.

Drug Use Evaluation of the Elderly Patient with Major Depressive Disorder (Major Depressive Disorder 질환성 노인 환자들의 치료제 평가)

  • Lim, Ok-Jeong;Lee, Ok Sang;Yun, Hye-Sul;Choe, Kevin Kyungsik;Lim, Sung Cil
    • YAKHAK HOEJI
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    • v.57 no.2
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    • pp.101-109
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    • 2013
  • Depressive disorders are the most common psychiatric problem in the elderly. Most depression treatment guidelines emphasize treatment with antidepressant medication and recommend that benzodiazepine use be minimized for limited period, particularly to elderly patients. In order to evaluate appropriate use of antidepressants and benzodiazepine, retrospective review of prescriptions was performed. The study population are older than 65 years who had been newly diagnosed with major depressive disorder in specialty mental health at a community general hospital from January $1^{st}$, 2007 to October $31^{th}$, 2012 (N=373). Initial antidepressant accounted for 89.5% with SSRI, and escitalopram accounted for 60.9% of SSRI group. 79% or more of the patients were prescribed the recommended dosage. The maintenance rate for 4 weeks of initial antidepressant was 48% and 6 weeks was 39%. Treatment-discontinuation rate was 68% at 3 month. Alprazolam (short acting benzodiazepine) was prescribed the most, followed by clonazepam (long acting benzodiazepine) and then diazepam. 55% of patients received a duplicated prescription for short acting plus long acting benzodiazepine. 61% of patients used long acting benzodiazepines. Prescribed dosages of benzodiazepines were commonly within a recommended range, while no one was prescribed a appropriate period (up to 2 weeks) except for the early discontinued patients. Appropriate use of zolpidem was only 16.2%. The depressed elderly treated in specialty mental health mostly received long-term treatment with benzodiazepines in combination with antidepressants, guideline recommendations was not followed. Multidisciplinary interventions like audit and feedback of benzodiazepine use are needed and education for the elderly is needed to properly maintain antidepressant treatment.

Compilation of 104 Experimental Theses on the Antitumor and Immuno-activating therapies of Oriental Medicine (한의학의 항종양 면역치료에 관한 연구 -1990년 이후 발표된 실험논문을 중심으로-)

  • Kang Yeon Yee;Kim Tai Im;Park Jong Ho;Kim Sung Hoon;Park Jong Dai;Kim Dong Hee
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.17 no.1
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    • pp.1-24
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    • 2003
  • This study was done to compile 104 experimental theses which are related to the antitumor and immuno-activating therapies between February 1990 through February 2002. Master's and doctoral theses were dassified by schools, degrees, materials, effects, experimental methods of antitumor and immunoactivity, and results. The following results were obtained from this study : 1. Classifying the theses by the school, 34.6% were presented by Daejeon University, 29.8% by Kyung-hee University and 11.5% by Won-kwang University. Of all theses, 51.0% were aimed for the doctoral degree and 43.3% were for the master's degree. All of three universities have their own cancer centers. 2. Classifying the theses by herb materials, complex prescription accounted for 60.3%, single herb accounted for 24.8% and herbal acupuncture accounted for 14.2%. Considering the key principles of the traditional medicine, complex prescription was much more thoroughly studied than single herb prescription. The results showed that the complex prescription had both antitumor activity and immuno-activating activity, which might reflects on multi-activation mechanisms by complex components. 3. Classifying the theses by the efficacy of herbs examined, in single herb, invigorating spleen and supplementing was 35.5%, expelling toxin and cooling was 29.0%, activating blood flow and removing blood stasis was 12.9%. In herbal acupuncture, invigorating spleen and supplementing was 52.9%, expelling toxin and cooling was 29.4%. In complex prescription, pathogen-free status was 41.9%, strengthening healthy qi to eliminate pathogen was 35.5%, strengthening healthy qi was 22.6%. It is presumed that the antitumor and immunoactivating therapy based on syndrome differentiation is the best way to develop oriental oncology. 4. Classifying the theses by antitumor experiments, cytotoxic effect was 48.1 %, survival time was 48.1 % and change of tumor size was 42.3%. Survival rate was not necessarily correlated with cytotoxicity. These data reflect the characteristic, wholistic nature of the oriental medicine which is based on BRM (biological response modifier). 5. Classifying the theses by immunoactivating experiments, hemolysin titer was 51.0%, hemagglutinin titer was 46.2% and NK cell's activity was 44.2%. In the future studies, an effort to elucidate specific molecular and cellular mechanisms of cytokine production in the body would be crucial. 6. Classifying the theses according to the data in terms of antitumor activity, 50% was evaluated good, 24.0% was excellent, and 15.5% have no effect. In an evaluation of immuno-activating activity, 35.9% was excellent and 18.0% showed a little effect. The index point, as described here, may helps to use experimental data for clinical trials. Changes in index points by varying dosage implicate the importance of oriental medical theory for prescription. 7. In 167 materials, IIP (immunoactivating index point, mean : 3.12±0.07) was significantly higher than AIP(antitumor index point, mean : 2.83±0.07). These data demonstrate that the effect of herb medicine on tumor activity depends more on immunoactivating activity than antitumor activity. This further implies that the development of herbal antitumor drugs must be preceded by the mechanistic understanding of immunoactivating effect. 8. After medline-searching tumor and herb-related articles from NCBI web site, we conclude that most of the studies are primarily focused on biomolecular mechanisms and/or pathways. Henceforth, we need to define the biomolecular mechanisms and/or pathways affected by herbs or complicated prescriptions. 9. Therefore, the most important point of oriental medical oncology is to conned between experimental results and clinical trials. For the public application of herbal therapy to cancer, it is critical to present the data to mass media. 10. To develop the relationship of experimental results and clinical trials, university's cancer clinic must have a long-range plan related to the university laboratories and, at the same time, a regular consortium for this relationship is imperative. 11. After all these efforts, a new type herbal medicine for cancer therapy which is to take care of the long-term administering and safety problem must be developed. Then, it would be expected that anti-tumor herbal acupuncture can improve clinical symptoms and quality of life (QOL) for cancer patients. 12. Finally, oriental medical cancer center must be constructed in NCC (National Cancer Center) or government agency for the development of oriental medical oncology which has international competitive power.

Skin Irriation Effect of Glycolic Acid and UVB in Guinea Pig (Guinea pid를 이용한 Glycolic acid 및 UVB의 피부 자극성 평가)

  • 조대현;홍진태
    • Toxicological Research
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    • v.16 no.1
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    • pp.89-94
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    • 2000
  • Alpha-hydroxy acid(AHA) are used in cosmetic products as a pH adjuster, mild exfoliant and humectant-skin conditioner. Cosmetics containing higher concentration (30%) and lower pH (3.0) of AHA can cause side effects if it is applied without the prescription. For providing information on the safety of AHA and on human risk assessments we studied skin irritation effect of glycolic acid, one of the most commonly used AHA in guinea pigs. The skin irritation by glycolic acid was increased in a dose(10% to 70%), acidity (pH 2.5 to 5.5.) and length of exposure dependent manner (for up to 14 days), respectively. The combination treatment with UVB (0.4 or 3.0 J/$cm^2$) increased glycolic acid-induced skin irritation. Histological examination showed that hyperplasia of non-inflammatory cells in the epidermis of skin treated with high dose of glycolic acid (pH 3.0). There results show that glycolic acid increased skin irritation in a dose, length of exposure and pH dependent manner, respectively, in guinea pig, and the combination with UVB increased glycolic acid-induced skin irritation. The cell proliferation of non-inflammatory cell may be involved in high doses of glycolic acid-induced skin irritation. Long-term application of more than 30% of glycolic acid (pH 3.0) may cause skin irritation.

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A Study on the Reliability Improvement of Guided Missile (유도탄의 신뢰성 향상 방안 고찰)

  • Kim, Bohyeon;Hwang, Kyeonghwan;Hur, Jangwook
    • Journal of Applied Reliability
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    • v.16 no.3
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    • pp.208-215
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    • 2016
  • Purpose: ASRP for the domestic development guided missiles requires not only for the reliability evaluation of the products in storage but also for the life cycle management of the products including development prototypes and initial production items. Methods: For this purpose, it should be performed to build a performance database before and after the accelerated aging test with shelf life items including development prototypes and initial production items, based on which the lifetime prediction should also be carried out. In addition, HILS must be applied for the acceptance test with the initial and follow-up production items, and also for ASRP for the long-term storage products in order to secure systematic quality assurance. Results: The results for the life cycle reliability Improving of domestic development of guided missiles are DB building of prescription Item performance, active application of HILS, Management associated with guided missiles life cycle and to Secure technology data about the introduction of foreign guided missiles. Conclusion: Furthermore, it is demanded that DTaQ, the managing agency of ASRP, actively take part in the process to maintain reliability engagement consistency over the life cycle of guided missiles.

Studies on the Application of Food Ingredients to Danbang prescription of "Dong-uibogam(東醫寶鑑)" ("동의보감(東醫寶鑑)" 단방처방(單方處方) 중 식재료활용(食材料活用)에 관한 연구 - 양념류를 중심으로 -)

  • Ji, Myoung-Soon;Yoon, Chang-Yeol
    • Journal of Korean Medical classics
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    • v.23 no.1
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    • pp.279-302
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    • 2010
  • Spices are used to enhance the taste of Korean food. The term "Yangnyeom" contains a wishful meaning that it would be as good for health as medicine when eaten. It is prescribed as a medicine to heal disease according to the ancient medical books. Fifteen spices in Korean food such as vinegar, liquor, honey, water, wheat-gluten, sesame, sesame oil, garlic, green onion, ginger, mustard, pepper, cinnamon, soy sauce, salt, cheoncho, and others are prescribed as medicine for internal and external uses for almost every disease. To examine these spices, the subjects were treated with either the spice-boiled water or spice-mixed water, or applied externally. It is suggested that spices that are produced through peculiar traditional cooking method, fermenting, and those that have long-growth period, grew in the natural environment, and the like have efficacy as medicine. Spices can be sufficiently applied as emergency medicine, disease-treatment, subsidiary supplement, and preventive medicine.

Follow-up Study on Chronic Idiopathic Urticaria Patients Treated with Pyungweesangamibang (평위산가미방으로 치료한 만성 특발성 두드러기 환자의 추적조사)

  • Lee, Jin-Huk;Kim, Se-Yon;Kim, Jeong-Hun
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.29 no.1
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    • pp.168-173
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    • 2016
  • Objective : The purpose of this study is to investigate the recurrence rate of Chronic Idiopathic Urticaria patients treated with Pyungweesangamibang through long-term follow-up survey.Methods : This tracing study was conducted for sixty-seven Chronic Idiopathic Urticaria patients who received and have finished treatment with Pyungweesangamibang at Woobo Korean Medicine Clinic in 2013 and 2014.Result : 81.4% of the patients, who had spent over 1 year since the finish of treatment with Pyungweesangamibang, did not relapse. In case of more than 2 years elapse, 66.7% of the patients did not suffer relapse.Conclusion : The result of tracing recurrence of the Chronic Idiopathic Urticaria patients treated with Pyungweesangamibang describes that the Korean medical treatment (Pyungweesangamibang prescription) shows lower recurrence rate than other general treatment shows.

Development of a smart pillbox and improvement of the medication adherence for the efficient management of medicine administration (효율적인 복약 관리를 위한 스마트 약상자의 개발과 약물순응도의 향상)

  • Kim, Beom-Joon
    • The Journal of the Korea institute of electronic communication sciences
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    • v.8 no.9
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    • pp.1391-1397
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    • 2013
  • As Korea is expected to enter an aging society in near future, the number of patients who need a long-term prescription is expected to increase as well. In particular, Korea shows the highest in both the incident rate and the death rate among OECD member nations. The current situation requires more strict monitoring and management for patients' taking medicine, there are a few practical problems such as personnel expenses. In order to realize the efficient management of medicine administration, this paper proposes a smart pillbox that is developed based on IT technologies. Through the experiments in which actual patients participate, it is proved that the smart pillbox is beneficial to the patients taking medicine.