• BMB Reports
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• v.56 no.9
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• pp.469-481
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• 2023

The gut microbiome is widely recognized as a dynamic organ with a profound influence on human physiology and pathology. Extensive epidemiological and longitudinal cohort studies have provided compelling evidence that disruptions in the early-life microbiome can have long-lasting health implications. Various factors before, during, and after birth contribute to shaping the composition and function of the neonatal and infant microbiome. While these alterations can be partially restored over time, metabolic phenotypes may persist, necessitating research to identify the critical period for early intervention to achieve phenotypic recovery beyond microbiome composition. In this review, we provide current understanding of changes in the gut microbiota throughout life and the various factors affecting these changes. Specifically, we highlight the profound impact of early-life gut microbiota disruption on the development of diseases later in life and discuss perspectives on efforts to recover from such disruptions.

• Bulletin of the Korean Mathematical Society
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• v.33 no.2
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• pp.277-287
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• 1996

The theory of integration of functions with values in a Banach space has long been a fruitful area of study. In the eight years from 1933 to 1940, seminal papers in this area were written by Bochner, Gelfand, Pettis, Birhoff and Phillips. Out of this flourish of activity, two integrals have proved to be of lasting: the Bochner integral of strongly measurable function. Through the forty years since 1940, the Bochner integral has a thriving prosperous history. But unfortunately nearly forty years had passed until 1976 without a significant improvement after B. J. Pettis's original paper in 1938 [cf. 11].

• Proceedings of the KIEE Conference
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• 2008.07a
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• pp.1491-1492
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• 2008

This paper investigates life test of LED lighting module using accelerated life test method. Pooly designed LED lighting systems can experience a short life. By knowing the relationship between life and heat, LED system manufacturers can design and build long-lasting systems. In this study, various white LED from several other manufacturer were subjected to life tests at LED lated temperatures for prediction to life of LED lighting systems. Results show that the different LED products have various optical characteristic and different life values.

• Journal of Korean Society for Atmospheric Environment
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• v.20 no.4
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• pp.465-481
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• 2004

We determined Asian dust days by constructing the standard of Asian dust using PM$_{10}$ concentrations ($\geq$150 $\mu\textrm{g}$m$^{-3}$ , 24-hr average) and TOMS aerosol index ($\geq$0.7) for 5 years (1998-2002), and grouped Into long-lasted cases (LLCs, $\geq$4 days) and short-lasted cases (SLCs, $\leq$2 days) concerning the mean lasting time (about 3 days) of Asian dust. Further we performed the specific analyses associated with concentration variations and synoptic conditions by using PM$_{10}$ and TOMS data, weather maps during the dusty cases (LLCs and SLCs). As a result, the LLCs (9 cates) had large variations of PM$_{10}$ concentration as the mean of 131.1$\mu\textrm{g}$m$^{-3}$ and the maximum mean of 379.8$\mu\textrm{g}$m$^{-3}$ , and showed dominant features the continuous passage of deep trough caused by blocking effect and weak trough (56%, 5 cases) over Korea. The SLCs (11 cases) had relatively small variations of PM$_{10}$ concentration as the mean of 133.3$\mu\textrm{g}$m$^{-3}$ and the maximum mean of 247.2$\mu\textrm{g}$m$^{-3}$ , and showed passage of one weak trough (64%, 7 cases) over Korea. Thereafter, the case studies (April 7-13, 2002 of LLC and March 23-24, 2000 of SLC) performed by the simulation of MM5 with meteorological variables of the horizontal wind, potential temperature, isentropic potential vorticity, and helped to better understand the features of synoptic conditions in connection with the concentration variations for each case.

• Proceedings of the SCSK Conference
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• 2003.09b
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• pp.370-378
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• 2003

MFD (Make up Film Deterioration) is a gradual deterioration of applied make up and is a common problem experienced by most foundation users. Our investigation revealed that for 64% of all make up users MFD is their greatest consern is using foundations. Known that the primary cause of MFD is sebum secretion. We observed that the length of time prior to onset of MFD in people who produce high level of sebum varies significantly from person to person. This suggests that other factors besides quantity of sebum production can affect MFD. Control over this factor would, we believe, be key to developing longer-lasting makeups. We studied the relationship between MFD and skin surface conditions. Our study revealed that furrows on the skin surface affect MFD significantly. Sebum reaches the skin surface from sebaceous glands and flows along furrow on the skin. If there are many deep furrows, it takes longer for sebum to overflow. But if the furrows are few or shallow, sebum quickly overflows and spreads over the skin surface where it can degrade the make up film. Therefore even when the volume of sebum produced is the same, the rate of MFD will be different depending on the number and shape of the furrows. A longer-lasting foundation could be produced by matching personal skin condition, but this would be very difficult because individual variations in texture are very large. Therefore we approached the problem by attempting to impose sebum resistance in under make up and foundation. We have developed two new materials and make up products based on our theory. A new fluoroalkyl acrylate-methacrylates copolymer designed for incorporation in under make up is extremely sebum resistant and sweat proof. Another new acrylate polymer designed for inclusion in foundation absorbs sebum and changes to a solid. Usage tests confirm it is possible to reduce MFD by using under make up and foundation which incorporate our new materials to cover where skin furrows are few or shallow

• Parasites, Hosts and Diseases
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• v.37 no.2
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• pp.77-83
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• 1999

To ascertain residual sonographic and histopathological findings of clonorchiasis after treatment, the present study evaluated sonographic findings in rabbits which were infected with 500 metacercariae of C.sinensis every 6 months for 18 months after treatment with praziquantel. The sonographic findings were analyzed in terms of intrahepatic bile duct dilatation and periductal echogenicity, and histopathological findings were observed after the last sonographic examination. Compared with the sonographic findings before treatment, dilatation of the intrahepatic bile ducts became mild to some degree in four of the seven cases and increased periductal echogenicity resolved in four of them. The histopathological specimens after 18 months showed that periductal inflammation has almost resolved but moderate dilatation of the intrahepatic ducts and mucosal hyperplasia persisted. The periductal fibrosis minimally resolved. The log-lasting sonographic findings in cured clonorchiasis make sonography less specific.

• Journal of Power System Engineering
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• v.11 no.1
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• pp.98-106
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• 2007

This paper presents a statistical prediction procedure for the propeller racing of ships with twin screw propellers sailing in ocean waves. The propeller racing is one of the most important factors of seakeeping qualities in relation to the safety of main engine and shafting system. It is especially significant key word for designing the twin-screw-propeller-type ship in view of allowable maximum propeller diameter etc.. In former studies, the propeller racing generally means the situation (propeller exposed) in which the relative motion amplitude between ship hull and wave surface would exceed a depth of point in rotary disk propeller. Therefore, it seems that the magnitude of the amplitude and its exceeding frequency have been examined as a principal subject of study as usual. However, the time during which the amplitude exceeds a depth of point must be also one of most important factor affecting the trend of propeller racing. This paper proposes a simply practical method for estimating the time lasting of exposed propeller related to twin screw propeller racing in rough confused seas on the basis of the statistics. Then, it is confirmed that the practical method is useful and convenience for considering the propeller racing in the stage of the basic design.

• Biomolecules & Therapeutics
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• v.15 no.1
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• pp.40-45
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• 2007

The vascular relaxant effects on isolated rat aorta of amlodipine camsylates (S-, R-enantiomer, and R/S-racemate), were evaluated and compared with that of S-amlodipine besylate. Furthermore, antihypertensive effects were measured in spontaneously hypertensive rat (SHR). The S-amlodipine camsylate concentration-dependently inhibited $Ca^{2+}$-induced contraction of rat aorta with a very slow onset of action (reached its maximum at 3.5h; $ED_{50}:\;1.50\;{\pm}\;0.24$ nM), having a potency 2-fold higher than those of R/S-amlodipine camsylate $(ED_{50}:\;3.36\;{\pm}\;0.91\;nM)$ and similar to those of S-amlodipine besylate $(ED_{50}:\;1.44\;{\pm}\;0.14\;nM)$, whereas the R-amlodipine camsylate has 590-fold lower vasorelaxant activity $(ED_{50}:\;886.4\;{\pm}\;49.7\;nM)$. In SHR, orally administered S-amlodipine camsylate produced a dose-dependent and long-lasting (>>10 h) antihypertensive effect $(ED_{20}:\;0.89\;mg/kg)$, with a potency 2-fold higher than those of R/S-amlodipine camsylate $(ED_{20}:\;1.82\;mg/kg)$ and similar to those of S-amlodipine besylate $(ED_{20}:\;0.71\;mg/kg)$. In contrast, the R-amlodipine camsylate has no effect even-though administrated high concentration 10 mg/kg. These results suggest that S-amlodipine camsylate has the potency and long-lasting antihypertensive activity as single enantiomer drug, and its antihypertensive effect is not significantly different to that of S-amlodipine besylate.

• Journal of Astronomy and Space Sciences
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• v.22 no.3
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• pp.293-310
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• 2005

We made a revised catalogue for reliable records of meteor outbursts that were recorded in Korean, Japanese, and Chinese chronicles. In order to avoid the effects of both Earth's precession and perihelion shift, we introduced a new time-coordinate of records, or the number of days elapsed within the sidereal year of the record for a given origin of time or the perihelion passage time of the you 2000. We added nineteen new records of meteor showers that are wrongly classified i, individual meteors in a Chinese archive. We found that the ${\eta}-Aquarids,$ the Perseids, the Orionids, and the Leonids have been active during the last two millennia. Due to the change of time-coordinate, the oldest record of each long-lasting meteor shower has been slightly corrected. We discuss that these long-lasting meteor showers belong to the Halley-type comets.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.11
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• pp.3473-3479
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• 2009

The pharmacological profile of KR-31081, a newly synthesized AT1 receptor antagonist, was evaluated in pithed rats, conscious renal hypertensive rats (RHRs) and conscious furosemide-treated beagle dogs. In pithed rats, KR-31081 (i.v.) induced a non-parallel right shift in the dose-pressor response curve to angiotensin II (ID50: 0.05 mg/kg) with a dose-dependent reduction in the maximum responses; this antagonistic effect was about 40 times more potent than losartan (ID50: 1.74 mg/kg) which showed competitive antagonism. KR-31081 did not alter the responses induced by other agonists such as norepinephrine and vasopressin. In RHRs, orally given KR-31081 produced a dose-dependent and long-lasting (>24 h) antihypertensive effect with a higher potency to losartan (ED20: 0.30 and 3.36 mg/kg, respectively). In furosemide-treated dogs, orally given KR-31081 produced a dose-dependent and long-lasting (>8h) antihypertensive effect with a rapid onset of action (time to Emax: 1-1.5 h) and 20-fold greater potency than losartan (ED20: 0.41 and 8.13 mg/kg, respectively). These results suggest that KR-31081 is a potent, orally active AT1 receptor antagonist useful for the research and diagnostic tools as an added exploratory potential.