• Toxicological Research
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• v.19 no.4
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• pp.285-291
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• 2003

The use of skin whitening agents has been recently increased in various kinds of cosmetic products, although there were some reports that whitening agents might cause allergic contact dermatitis. A murine local lymph node assay (LLNA) has been developed as an alternative to guinea pigs for contact sensitization potential. This study was carried out to investigate the skin sensitization potential of three whitening agents, arbutin, azelaic acid, and kojic acid, by LLNA using a non-radiois-topic endpoint. Female Balb/c mice were exposed topically to a weak allergen, $\alpha$-hexylcinnamalde-hyde (HCA), and three whitening agents following LLNA protocol. Lymph node (LN) weight and cell proliferation in ears and auricular lymph node using bromodeoxyuridine (BrdU) immunohistochemistry were evaluated. LN weights were significantly increased at the HCA group compared to the vehicle control. A weak allergen, HCA elicited 3-fold or greater increase in cell proliferation of lymph nodes as well as increase in cell proliferation of ear as measured by BrdU immunohistochemistry. However, in the case of skin whitening agent groups, there were no significant changes in LN weight and cell proliferation in the ear and lymph node of mice treated with 5, 10 and 20% of three whitening agents compared to the vehicle control. These results show that these three skin whitening agents may not have contact sensitization potentials at tested concentrations in Balb/c mice by LLNA.

• Journal of the Korea Society of Computer and Information
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• v.13 no.1
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• pp.37-44
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• 2008

Data stream has the tendency to change in Patterns over time. Also known as concept drift, such problem can reduce the predictive performance of a classification model CVFDT and IOLIN tried to solve the problem of a concept drift through incremental classification model updates. The local changes in patterns. however was revealed to be unable to resolve the problems of local concept drift that occurs by influencing on total classification results. In this paper, we propose adapted IOLIN system that improves system's predictive performance by detecting the local concept drift. The experimental result shows that adaptive IOLIN, the Proposed method, is about 2.8% in accuracy better than IOLIN and about 11.2% in accuracy better than CVFDT.

• Journal of Agricultural Extension & Community Development
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• v.18 no.3
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• pp.665-691
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• 2011

The implementation of an place-based rural policy requires changes in the intra-governmental relations and between the public and private sectors and civil society. Over the past decades, Japan has been increasingly devolving and decentralizing public responsibilities and resources to sub-national government levels. There is assumption that such transfers produce more efficiency in terms of public management and create better conditions for economic development. At the same time, these transfer respond to new expectations of citizens and civil society to participate more closely in the democratic decision-making process. Coordination is also needed at the local level to integrate sectoral approaches, to involve private partners and to achieve the appropriate geographic scale. Local public and private actors join a partnership and pool knowledge and resources. This type of local partnership is characterized by the participation of different actors, including municipalities, sub-regional government institution and development agencies. The participation of private actors(private firms, cooperatives, associations, non-profit organizations, farm organizations, other categories organizations, etc,) is also important.

• Journal of the Korean Institute of Educational Facilities
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• v.18 no.4
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• pp.13-24
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• 2011

The purpose of this research is to investigate the characteristics of layout of Jinhae's educational facilities from the perspective of space syntactic changes since the era of Japanese Imperialism. The observations that we made in this research are summarized as the following three points. First, most of the educational facilities are located near the integrated space. Axes of roads near educational facilities display similar spatial patterns as those of entire Jinhae. Second, the level of local integration has been rising near the site of elementary schools for the past decades, and the level of local integration near middle and high schools recently began to rise around the new town. Third, the level of integration is strongly related with the levels of local integration, and the locations of educational facilities are also related with the level of local integration. It implies that the locations of educational facilities are determined not by Jinhae's overall street composition but by nearby road composition.

• Journal of Fisheries and Marine Sciences Education
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• v.26 no.6
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• pp.1245-1260
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• 2014

This paper is to analyze the size of Busan Metropolitan City Office of Education Special Account and Educational finance Changes based on the welfare types from 2009 to 2013. It also identifies the impact on welfare finance education programs that target low-income students. The size of Education welfare finance was increased to 355.3 billions (2013) from 90.9 billions (2009), with the last 5 years average annual growth rate as high as 41.9%. But there has been relative decrease in the size of selective welfare budget for low income students such as tuition assistance & IT support to low-income and vulnerable groups, rural schools support to improve facilities, education welfare priority program. The finding suggests that the size of selective welfare budget should not be decreased due to universal education welfare policy. If it is to expand the universal education welfare, then there should be redesigning of local educational finance and further revenue for local education finance to keep the budget for the education welfare target groups.

• International journal of advanced smart convergence
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• v.11 no.3
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• pp.142-149
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• 2022

This study aims to develop the education for college students who should perform the social role of the fut ure by conducting trekking activities including the characteristics, history, and culture of Cheonan area and then investigating the sociality and history of 36 college students. Taejosan, Seonggeosan, and Heukseongsan, which are part of the independent ring of Cheonan city, were selected as courses. The training was conducted by six instructors majoring in humanities, history, physical education and medicine. Teachers of humanities and history majors conducted theoretical lectures to raise the historical awareness of Cheonan area related to trekking course. In trekking practice, instructors of physical education and medicine majored in trekking safety education and course progress. Among the social development factors, responsibility, autonomy, and sociality were high. After the education, students recognized that the interest and necessity of history were high in order to understand the present society, thought that they made a lot of development compared to the previous one, and answered that the main development factors of history were the people and that there was a change in perception through this education. This study was composed of the survey after the education, so the psychological characteristics of the individual were not reflected, and it is difficult to generalize it because the number of subjects is small. In the future, more subjects need to be investigated and local residents need to investigate changes in local awareness.

• Journal of Cadastre & Land InformatiX
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• v.52 no.1
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• pp.17-36
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• 2022

The purpose of this study is to diagnose problems in the regulation and management of Restricted Development Zone and to prepare a construction plan to convert it to a data-based monitoring system. Unlike other land-use zones, the Restricted Development Zone is a exceptional zone that prohibits all development activities other than the minimum maintenance and must be strictly controlled and managed by the local government. However, the current Restricted Development Zone management is distributed according to the conditions of each local government, and it is not possible to monitor changes in the entire Restricted Development Zone as shown in the survey results. In particular, in this study, by introducing an AI-based monitoring system, MOLIT sends the results of detecting changes across the country at regular time points(monthly and quarterly) to the local governments based on the same regulation standards, and the local governments can be trusted while inputting the regulation results into the system. To propose this methodology, first, a survey and interview were conducted with local government officials and experts. Second, we analyzed cases in which AI analysis was applied to local governments and proposed a plan to improve the efficiency of regulation work according to the introduction of the monitoring system. Third, a plan was prepared to establish a monitoring system based on the advancement of the management information system. This monitoring system can be expanded and applied to land that needs periodic regulation and management in the future, and this study tried to propose a methodology and policy for this.

• The Journal of the Korea Contents Association
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• v.19 no.6
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• pp.379-386
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• 2019

It is a study of the changing times of cooking programs that were broadcast and aired on TV. The media has shown a lot of changes in appearance, and it's also showing a lot We want to look at various changes and changes in the times through programs on cuisine and food that many people now prefer. In the preceding study, we looked at changes in media formats and changes in social changes and programs until the 2000s. Based on this analysis, the changes of the cooking program were analyzed according to the changes of the times. For the purpose of this study, changes were divided into cooking and historical changes, which were divided and examined by the period. Through this study, we were able to see the change in the cooking program in an era where changes in diet are mixed with changes in culture. It was possible to see the change through programs that consumers could feel, not unilateral delivery of information, and to see the change from the era of experts to culture. Further, through the introduction and challenge of local culture through food, subsequent research aims to see changes and social phenomena caused by the division of programs.

• Journal of Dental Anesthesia and Pain Medicine
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• v.15 no.3
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• pp.121-128
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• 2015

Background: The authors studied the hemodynamic effect influent by using the novel high concentration of lidocaine HCl for surgical removal impacted lower third molar. The objective of this study was to evaluate the hemodynamic change when using different concentrations of lidocaine in impacted lower third molar surgery. Methods: Split mouth single blind study comprising 31 healthy patients with a mean age of 23 years (range 19-33 years). Subjects had symmetrically impacted lower third molars as observed on panoramic radiograph. Each participant required 2 surgical interventions by the same surgeon with a 3-week washout period washout period. The participants were alternately assigned one of two types of local anesthetic (left or right) for the first surgery, then the other type of anesthetic for the second surgery. One solution was 4% lidocaine with 1:100,000 epinephrine and the other was 2% lidocaine with 1:100,000 epinephrine. A standard IANB with 1.8 ml volume was used. Any requirement for additional anesthetic and patient pain intra-operation was recorded. Post-operatively, patient was instructed to fill in the patient report form for any adverse effect and local anesthetic preference in terms of intra-operative pain. This form was collected at the seven day follow up appointment. Results: In the 4% lidocaine group, the heart rate increased during the first minute post-injection (P < 0.05). However, there was no significant change in arterial blood pressure during the operation. In the 2% lidocaine group, there was a significant increase in arterial blood pressure and heart rate in the first minute following injection for every procedure. When the hemodynamic changes in each group were compared, the 4% lidocaine group had significantly lower arterial blood pressure compared to the 2% lidocaine group following injection. Post-operatively, no adverse effects were observed by the operator and patient in either local anesthetic group. Patients reported less pain intra-operation in the 4% lidocaine group compared with the 2% lidocaine group (P < .05). Conclusions: Our results suggest that a 4% concentration of lidocaine HCl with 1:100,000 epinephrine has better clinical efficacy than 2% lidocaine HCl with 1:100,000 epinephrine when used for surgical extraction of lower third molars. Neither drug had any clinical adverse effects.

• Journal of Korean Ophthalmic Optics Society
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• v.16 no.1
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• pp.31-40
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• 2011

Purpose: This study was performed to investigate the actual state about ultrasonic cleaning of soft contact lenses in local optical shops and evaluate the removal effect of protein deposit on soft contact lenses with different lens containers by ultrasonic cleaner for eyeglasses. Methods: The actual state about ultrasonic cleaning of soft contact lenses was surveyed in total 75 local optical shops in Seoul, Korea. The cleaning efficacy of different lens containers was compared by measuring the protein remained on ocufilcon D contact lenses after washing by an ultrasonic cleaner for eyeglasses. The changes on surfaces and wetting angles of ocufilcon D contact lenses by repeat ultrasonication were further investigated. Results: The main purpose to use ultrasonic cleaners in local optical shops was rapid cleaning. The ultrasonic cleaning efficacy of ocufilcon D contact lenses with glass containers was little higher than it with plastic containers, but was not significantly different. The changes on surfaces and wetting angles of ocufilcon D contact lenses in a plastic lens container by repeat ultrasonication such as 30 and/or 60 times were shown. Conclusions: There was not significant difference in cleaning efficacy between glass and plastic lens containers. However, repeat cleaning with ultrasonic cleaner for eyeglasses would be carefully considered since some significant changes in the parameters of lens surface and wetting angles were detected by repeat ultrasonification even when lens containers were used for ocufilcon D contact lens during ultrasonictions.