• Asian Pacific Journal of Cancer Prevention
• /
• 제16권12호
• /
• pp.4927-4935
• /
• 2015

Northeastern India is a major nasopharyngeal carcinoma (NPC) high risk-area although the rest of the country has very low incidence. A case-control study of 105 NPC cases and 115 controls was conducted to identify the potential risk factors for NPC development in this region. Information was collected by interviewer about socio-demographic characteristics, cigarette smoking, alcohol consumption, dietary history, occupational history, and a family history of cancer. Epstein-Barr viral load was assayed from the blood DNA by real time PCR. Associations between GSTs genotypes, cytochrome P450 family including CYP1A1, CYP2E1 and CYP2A6 polymorphisms and susceptibility to relationship between the diseases were studied using PCR-RFLP assay. Results indicate that Epstein-Barr virus load was significantly higher in patients compared to controls (p<0.0001). Furthermore, concentration of blood EBV-DNA was significantly higher in advanced stage disease (Stage III and IV) than in early stage disease (Stage I and II) (p<0.05). Presence of CYP2A6 variants that reduced the enzyme activity was significantly less frequent in cases than controls. Smoked meat consumption, exposure to smoke, living in poorly ventilated house and alcohol consumption were associated with NPC development among the population of Northeastern India. Thus, overall our study revealed that EBV viral load and genetic polymorphism of CYP2A6 along with living practices which include smoked meat consumption, exposure to smoke, living in poorly ventilated houses and alcohol consumption are the potential risk factors of NPC in north eastern region of India. Understanding of the risk factors and their role in the etiology of NPC are helpful forpreventive measures and screening.

• 한국전산구조공학회논문집
• /
• 제20권5호
• /
• pp.623-628
• /
• 2007

마찰형 감쇠를 갖는 구조물은 구조물의 고유주기, 하중의 특성, 그리고 외부하중에 대한 마찰력의 상대적인 크기에 따라 강한 비선형성을 나타내므로, 구조물의 최대응답을 예측하기 매우 어렵다. 기존의 연구에서는 비선형 시스템을 등가의 선형 시스템으로 치환하거나, 구조물의 비선형 시간이력해석을 통한 응답스펙트럼 분석에 의한 간단한 확률해석에 의해 수행되었다. 지진 하중은 불확실성과 불규칙성을 갖고 있기 때문에 확률적으로 정의된다면, 지진하중을 받는 마찰형 감쇠를 갖는 구조물의 응답 역시 확률분포를 나타낼 것이다. 본 논문에서는 Kanai-Tajimi 필터를 이용해 생성된 인공지진하중에 대해 마찰형 감쇠를 갖는 구조물의 비선형 시간이력 해석이 수행되었다. 그리고 정규분포 확률밀도 함수에 선형 회귀분석을 통해 얻어진 구조물의 주기와 마찰력의 크기에 의한 변수를 업데이트 시킨 마찰형 감쇠를 갖는 구조물의 변위 응답 확률밀도함수식이 제시된다.

• 대한토목학회논문집
• /
• 제14권1호
• /
• pp.49-62
• /
• 1994

본 논문에서는 평면 PC 사장교의 시장교의 각 단계를 고려할 뿐 아니라 재료의 비선형성은 물론 기하학적 비선형도 고려하는 해석방법을 제시했다. 재료의 시간의존적 특성들로는 콘크리트의 크리프, 건조수축, 강도증가와 PC 강재 및 케이블의 이완을 고려했다. 시공중의 각 단계를 표현하기 위해 시공명령어를 정의하여 임의의 해석단계마다 하중과 경계조건의 변화, 구조계의 변화와 가설장비의 이동을 고려했다. 본 해석방법을 실제적인 PC 사장교의 해석에 적용하여 시공의 진행에 따른 PC 사장교의 비선형거동 및 응력과 변형의 변화를 검토했고 또한 시공단계를 고려한 해석에 있어서 재료의 시간의존적 특성이 끼치는 영향을 검토했다.

• Structural Engineering and Mechanics
• /
• 제54권1호
• /
• pp.19-33
• /
• 2015

Open ground storey (OGS) buildings are characterized by the sudden reduction of stiffness in the ground storey with respect to the upper infilled storeys. During earthquakes, this vertical irregularity may result in accumulated damage in the ground storey members of OGS buildings without much damage in the upper storeys. Hence, the structural design of OGS buildings needs special attention. The present study suggests a modification of existing displacement-based design (DBD) procedure by proposing a new lateral load distribution. The increased demands of ground storey members of OGS buildings are estimated based on non-linear time history analysis results of four sets of bare and OGS frames having four to ten storey heights. The relationship between the increased demand and the relative stiffness of ground storey (with respect to upper storeys) is taken as the criterion for developing the expression for the design lateral load. It is also observed that under far-field earthquakes, there is a decrease in the ground storey drift of OGS frames as the height of the frame increases, whereas there is no such reduction when these frames are subjected to near-field earthquakes.

• Wind and Structures
• /
• 제36권2호
• /
• pp.133-147
• /
• 2023

The random vibration of saddle membrane structures under wind load is studied theoretically and experimentally. First, the nonlinear random vibration differential equations of saddle membrane structures under wind loads are established based on von Karman's large deflection theory, thin shell theory and potential flow theory. The probabilistic density function (PDF) and its corresponding statistical parameters of the displacement response of membrane structure are obtained by using the diffusion process theory and the Fokker Planck Kolmogorov equation method (FPK) to solve the equation. Furthermore, a wind tunnel test is carried out to obtain the displacement time history data of the test model under wind load, and the statistical characteristics of the displacement time history of the prototype model are obtained by similarity theory and probability statistics method. Finally, the rationality of the theoretical model is verified by comparing the experimental model with the theoretical model. The results show that the theoretical model agrees with the experimental model, and the random vibration response can be effectively reduced by increasing the initial pretension force and the rise-span ratio within a certain range. The research methods can provide a theoretical reference for the random vibration of the membrane structure, and also be the foundation of structural reliability of membrane structure based on wind-induced response.

• 한국지반공학회지:지반
• /
• 제12권2호
• /
• pp.19-32
• /
• 1996

시간영역의 지진 가속도-시간 이력을 주파수 영역의 courier 진폭-주파수 이력으로 변화시키는 Trifunac의 경험적 모델을 기초로 하여 지진 관측소에서 측정된 임의 규모의 실제 지진기록들을 필요한 규모의 지진기록으로 유사화시키는 지진 확대 (scaling) 기법을 제안하였다. 또한, 지진 규모(M) 5.6의 지진기록을 이용하여 지진 규모(M) 8.0의 유사지진을 작성하여 동적 재하 시험 장치에 적용가능하도록 하였다. 지진 확대 (scaling) 기법은 MMI(modified mercalli intensity), 지진기록 부지의 조건,진앙거리,지진 가속도 성분의 방향, 해석의 신뢰도 등을 고려할 수 있으며, 다양한 지진 기록들에 적용가능하였다.유사지진은 수평방향의 성분들만을 고려하여 작성되었다. 압력토조내에 설치된 모형인장말뚝과 개단압출말뚝에 대한 유사지진 진동에 의한 동적 말뚝재하시험이 가능하였다. 정적 말뚝재하시험시 인장말뚝과 압축말뚝의 거동은 매우 상이하였는데, 인장말뚝은 2~3회의 급작스런 미끄러짐 변위를 수반하였다. 또한, 유사 지진 진동중 인장말뚝과 개단압축말뚝의 거동특성은 매우 상이하였으며, 지지력 감소특성도 크게 달랐다.

• Computers and Concrete
• /
• 제13권1호
• /
• pp.1-16
• /
• 2014

To evaluate the behavior of the advanced unbonded pre-stressed concrete containment vessel (UPCCV) for one typical China nuclear power plant under Japan's March 11 earthquake, five nonlinear time history analysis and a nonlinear static analysis of a 1:10 scale UPCCV structure have been carried out with MSC.MARC finite element program. Comparisons between the analytical and experimental results demonstrated that the developed finite element model can predict the earthquake behavior of the UPCCV with fair accuracy. The responses of the 1:10 scale UPCCV subjected to the 11 March 2011 Japan earthquakes recorded at the MYG003 station with the peak ground acceleration (PGA) of 781 gal and at the MYG013 station with the PGA of 982 gal were predicted by the dynamic analysis. Finally, a static analysis was performed to seek the ultimate load carrying capacity for the 1:10 scale UPCCV.

• Smart Structures and Systems
• /
• 제6권4호
• /
• pp.363-372
• /
• 2010

Accurate peak response estimation of a seismically excited structure with frictional damping system (FDS) is very difficult since the structure with FDS shows nonlinear behavior dependent on the structural period, loading characteristics, and relative magnitude between the frictional force and the excitation load. Previous studies have estimated the peak response of the structure with FDS by replacing a nonlinear system with an equivalent linear one or by employing the response spectrum obtained based on nonlinear time history and statistical analysis. In case that earthquake excitation is defined probabilistically, corresponding response of the structure with FDS becomes to have probabilistic distribution. In this study, nonlinear time history analyses were performed for the structure with FDS subjected to artificial earthquake excitation generated using Kanai-Tajimi filter. An equation for the probability density function (PDF) of the displacement response is proposed by adapting the PDF of the normal distribution. Coefficients of the proposed PDF are obtained by regression of the statistical distribution of the time history responses. Finally, the correlation between the resulting PDFs and statistical response distribution is investigated.

• Nuclear Engineering and Technology
• /
• 제43권4호
• /
• pp.361-374
• /
• 2011

Two types of numerical modeling techniques were considered for the dynamic response of a structure subjected to a ground acceleration. One technique is based on the equation of motion relative to ground motion, and the other is based on the equation of absolute motion of the structure and the ground. The analytic background of the former is well established while the latter has not yet been extensively verified. The latter is called a large mass method, which allocates an appropriate large mass to the ground so that it causes the ground to move according to a given acceleration time history. In this paper, through the use of a single degree-of-freedom spring-mass system, the equations of motion of the two techniques were analyzed and useful theorems are provided on the large mass method. Using simple examples, the numerical results of the two modeling techniques were compared with analytic solutions. It is shown that the theorems provide a clear insight on the large mass method.

• 한국방재학회 논문집
• /
• 제6권3호
• /
• pp.29-35
• /
• 2006

교량의 지진응답해석시 단면의 비선형 거동특성에 따른 휨변형을 정밀하게 구현하기 위해 섬유요소를 이용한 해석이 수행되었다. 2주형 다주교각을 섬유요소로 모델링하여 지진하중에 대한 비선형 정적해석을 수행하였으며 소성힌지 영역에서의 파괴 메카니즘을 분석하였다. 비선형 정적해석으로 얻어진 하중-변위 곡선을 이용하여 역량스펙트럼 방법에 의한 지진응답해석을 수행되었다. 또한 교량 전체 시스템을 섬유요소를 이용하여 모델링하고 동일한 응답스펙트럼을 가지는 지진파를 입력하여 비선형 시간이력 해석을 수행되었으며 이는 역량스펙트럼 방법과 유사한 결과를 보인다.