• The Korean Journal of Health Service Management
• /
• v.7 no.3
• /
• pp.261-273
• /
• 2013

The purpose of this study is a chronic liver disease that affects the drinking behavior is to identify the factors. The subjects of the study was diagnosed with chronic liver disease outpatient visit were studied in 120 patients. The collected data were analyzed by using SPSS WIN 18.0. Drinking behavior of chronic liver disease to determine the factors influencing the results of the multiple regression analysis, the regression model was found to be significant(F=8.58, p<.001), drinking behavior of chronic liver disease a major contributor to the drinking habits(${\beta}$ = -.29, p = .004)was found in, followed by drinking motives(${\beta}$ = .20, p = .044), drinking refusal self-efficacy(${\beta}$ = -.17, p = .037), after which the diagnosis of the disease(${\beta}$ = .15, p = .041), respectively. These variables showed explanatory power of 44.1%. Drinking behavior is a serious health problem in patients with chronic liver disease. The factors that influence drinking behavior by considering the management of chronic liver disease drinking continued to provide information and education is needed abstinence.

• BMB Reports
• /
• v.31 no.2
• /
• pp.189-195
• /
• 1998

Methylmercury (MeHg), which is widely distributed in the environment, is well known for both its acute and chronic poisoning effects on the human health; however, the precise biochemical mechanisms by which this compound elicits its toxicity in a cellular level are still poorly understood. To examine whether MeHg-induced liver injury involves activation of Phospholipase $A_2$ ($PLA_2$), the $PLA_2$ activity of control and MeHg-administrated livers was measured. MeHg stably enhanced a liver form of cytosolic $PLA_2$ activity, which exhibited several biochemical properties similar to those of the 100 kDa $cPLA_2$, except in its elution profile of a DEAE-5PW HPLC, and it migrated as a molecular weight of 80 kDa in Western blot analysis. This blotting analysis also indicated that the MeHg-induced enhancement of the activity could be due to the increase in the amount of the enzyme protein rather than a stable modification of the enzyme such as phosphorylation. Our data also showed the higher myeloperoxidase activity in MeHg-administrated liver than in the control, suggesting that this increase in the amounts of the 80 kDa $PLA_2$ and its activity may be resulted from infiltration of neutrophils into the liver during a hepatic injury process such as MeHg-induced inflammation. Taken together, these data suggest that MeHg-induced liver injury may be mediated by activation of the 80 kDa form of liver cytosolic $PLA_2$.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• v.25 no.1
• /
• pp.70-78
• /
• 2022

Purpose: Cholestasis resulting from cytomegalovirus (CMV)-induced hepatitis manifests in 40% of patients with a CMV infection. Ganciclovir treatment in children with CMV infections has proven to be highly effective. Until now, there are very few studies have identified predictive factors for liver biochemistry improvement after ganciclovir therapy. This study aimed to identify the predictors of liver biochemistry improvement in patients with CMV cholestasis after ganciclovir treatment. Methods: A retrospective cohort study was conducted using medical records from Dr. Sardjito General Hospital Yogyakarta, Indonesia from 2013 to 2018. CMV cholestasis was confirmed based on serum CMV IgG and IgM positivity and/or blood and urine CMV antigenemia positivity. Incomplete medical records and other etiologies for cholestasis, such as biliary atresia, choledochal cyst, metabolic diseases, and Alagille syndrome, were excluded. Patient age at cholestasis diagnosis and ganciclovir treatment, duration of CMV cholestasis, history of prematurity, central nervous system involvement, and nutritional status were analyzed and presented as an odds ratio (OR) with a 95% confidence interval (95% CI). Results: CMV cholestasis with ganciclovir therapy was found in 41 of 54 patients. Multivariate analysis showed that a shorter duration of CMV cholestasis (OR: 4.6, 95% CI: 1.00-21.07, p=0.04) was statistically significant for liver biochemistry improvement after 1 month of ganciclovir treatment. The remaining factors that were analyzed were not significant predictors of liver biochemistry improvement in patients with CMV cholestasis after ganciclovir treatment. Conclusion: A shorter duration of CMV cholestasis is the predictor of liver biochemistry improvement after 1 month gancyclovir treatment.

• Korean Journal of Occupational Health Nursing
• /
• v.22 no.4
• /
• pp.334-342
• /
• 2013

Purpose: This study attempted to compare the metabolic syndrome components, liver function and heathy living habits according to abdominal obesity in male and female workers. Methods: The subjects of this study are 1,078 adult workers who visited N hospital in Incheon for health examination. The data were analyzed using t-test or $x^2$-test with the SPSS/WIN 20.0 program. Results: Prevalence of metabolic syndrome are 22.2% in male workers, and 5.2% in female workers. There were significant differences in 4 metabolic syndrome components (high blood pressure, elevated blood sugar, hypertriglyceridemia, low HDL cholesterolemia), abnormal liver function, and living habits (alcohol drinking) according to abdominal obesity in male workers. There were significant differences in 1 metabolic syndrome component (low HDL cholesterolemia), and abnormal liver function in female workers. Conclusion: It is important to manage all metabolic syndrome components and alcohol drinking in the case of male workers with abdominal obesity, and low HDL cholesterolemia in the case of female workers. Also, occupational nurses should include the relevance between abdominal obesity and liver function index when training health for workers in workplace.

• Journal of Preventive Medicine and Public Health
• /
• v.25 no.4 s.40
• /
• pp.343-356
• /
• 1992

Authors studied the workers' knowledge about the health problems detected through the previous workers' periodic health examination, content of follow-up management ana actions taken for their health problem detected on previous health examination. From June to September 1992, workers' periodic health examination was peformed on workers employed in 10 companies located in 2 middle-sized Korean cities. A questionnaire survey was done far 150 workers who reported to have $D_2$ result of either hypertension or liver disorder at the previous workers' periodic health examination done in 1991. The results are as follows; 1. Of 160 workers who had $D_2$ result of either hypertension or liver disorder in previous examination one year before, only 85 workers(51.3%, 43 workers with hypertension, 38 workers with live disorder) responded that they have such disorders. The other 65 workers responded to questionnaire were all those with C results. Respondents' knowledge about their diagnoses was relatively precise (95.2% in hypertension group, 94.6% in liver disorder group) but knowledge about classification of diseases was poor. 2. The main efforts to solve the health problem nab self management (20 spells, 55.3%), visiting clinic or hospital(6 spells, 12.8%), use of herb medicine (2 spells, 4.3%) and use of drug store(2 spells, 4.3%) in hypertension group. In liver disorder group, 30 spells (71.4%) relied on self management,6 spells (14.3%) on hospital or clinic and 9 spells (21.4%) had no effort to improve the health problem. Content of self management was low salt diet, quit smoking, regular exercise and quit alcohol drinking in order. Avoidance of salt in diet was high in hypertension group and quitting alcohol drinking was high in liver disorder group. In those with self management, 80.7% of hypertension group and 83.3% of liver disorder group continued previous effort. Those, however, who utilized clinic or hospital, only 16.7% and 50.0% were still visiting hospital or clinic. 3. Fifty seven percent of hypertension group and 64.3% of liver disorder group was presently smoking,8.5% and 11.9% reduced smoking and 21.3% and 14.3% stopped smoking. Forty nine percent of hypertension group and 28.6% of liver disorder group was presently drinking. Reduced alcohol intake was reported in 29.8% and 40.5%, 12.8ole and 23.8% stopped alcohol drinking. Sixty six percent of hypertension group and 73.8% of liver disorder group did no regular exercise, but 12.8% and 11.9% of each group increased their physical exercise far last one year. Forty three percent of hypertension group and 38.l% of liver disorder group was overweight (defined by bodymass index greater or equal than 25). Reduced body Weight was reported in 17.2% and 16.7% of each group. Reduced dietary salt intake was high in hypertension group (51.5%). The study results suggest that follow-up management after workers' periodic health examination is not satisfactory. In order to improve this situation, adequate information on the result of the workers' periodic health examination should be distributed to each worker group with health education and counselling.

• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.4
• /
• pp.1713-1716
• /
• 2016

Background: Liver fluke infection is associated with cholangiocarcinoma; the bile duct cancer found frequently in the northeast and north of Thailand. Prevention and control particularly requires health education and behavior change. Objective: This study aimed to improve health behavior among village health volunteers (VHV) regarding liver fluke exposure in an epidemic area. Materials and Methods: A quasi-experimental study was performed during July 2015 to January 2016 in Sang Kha district of Surin province, Thailand. A total of 67 VHVs underwent a health education program (HEP) and data were collected on knowledge, attitude, and practice (KAP) before and after participation for HEP 3 months with a pre-designed questionnaire. The Students paired T-test was used for comparisons of mean KAP levels before/after the intervention. Results: The results revealed that knowledge (P-value=0.004), attitude (P-value=0.004), and practice level (P-value=0.000) were significantly improved after participation in the HBP. Attitude was significantly associated with knowledge (r=0.266, p<0.05), and practice (r=0.348, p<0.01). Conclusions: The implementation of health education among VHVs is feasible and increases their KAP. This improvement should have potential in liver fluke prevention and control in local communities in rural Thailand.

• Biomedical Science Letters
• /
• v.7 no.3
• /
• pp.111-116
• /
• 2001

To investigate an effect of aging on the xylene metabolism in liver damaged animals, a study was conducted. 50% carbon tetrachloride ($CCl_4$) in olive oil (0.1 ml/100 g body weight) was intraperitoneally given to 5-week and 12-week rats 12 times every other day and then one dose of 50% xylene in olive oil (0.25 ml/100 g body weight) was intraperitoneally given to the rats, and after 24 hr, the animals were sacrificed. On the basis of the functional findings in rat liver, ie, serum levels of alanine aminotransferase activity, liver protein and malonedialdehyde contents, 5-week rats showed less liver damage than 12-week rats. The increasing rate of urinary methylhippuric acid concentration to the control was significantly higher in 5-week rats than 12-week rats in case of xylene treatment after induction of liver damage. On the other hand, liver damaged 5-week rats showed significant rise of hepatic cytochrome P45O content compared with the liver damaged 12-week rats by the xylene treatment. And increasing rate of hepatic alcohol or aldehyde dehydrogenase activities to each liver damaged animals was higher tendency in 5-week rats than 12-week rats by the xylene treatment. In conclusion, 5-week rat showed greater metabolic rate of xylene than 10-week rats in case of liver injury because 5-week rats led to a slight liver damaged compared with 12-week rats.

• The KIPS Transactions:PartB
• /
• v.18B no.6
• /
• pp.389-396
• /
• 2011

There is getting worse to various liver diseases due to change in eating habits, stress, alcohol etc in modern society. Therefore, we proposed methodology to diagnose early for liver disease to study the influence on voice in liver diseases. To this end, we carried out experiment to apply parameter of voice analysis to collect each voice inpatients and patients by treatment of liver diseases patients. Particularly, we carried out experiment to apply element value of pronunciation and the third formant frequency bandwidths about velar sounds associated liver in oriental medicine, then to produce objective index resonance cavity and influence vocalization in liver diseases. In addition, we carried out to study about design of system to monitoring a liver function in u-Health environment based on result by experiment.

• Journal of radiological science and technology
• /
• v.24 no.1
• /
• pp.33-41
• /
• 2001

This study is to get preliminary data for an effectiveness evaluation of abdominal examination and improvement of it. Abnormal cases of abdominal ultrasonography are classified by sex, frequency, diagnosis and age. 4,924 examinees were included at a university hospital of health promotion center from January to December in 1999. The results are as follows. 1. According to the distribution of sex, there are more male patients(55.0%) than females patients(48.0%). For men, 40's showed the highest percentage among examinees. For women, 50's were the highest. 2. The reason that they visited the health promotion center was that 'they wanted to check their health status'. This answers were reported the highest(59.3%). 3. Patients that had abnormal cases of abdominal ultrasonography were 48.3%. Liver, kidney, gallbladder showed the highest percentage of abnormal cases in order of organs. Additionally, abnormal cases were discovered in liver cases. 4. According to the frequency of abnormal cases among examinees, the slight fatty liver were the highest regardless of sex. Men had the slight fatty liver, kidney simple cyst, liver calcification and liver simple cyst in order of abnormal cases. Women showed the slight fatty liver kidney simple cyst, kidney calcification, liver simple cyst, and blood vessel tumor in order of abnormal cases. 5. For the abnormal cases of liver by sex and age, the 50's reported the highest number of abnormal cases in men(299 patients). In addition, 60's had the highest of disease rata 47.8%. For women, 50's reported the highest number of abnormal cases(361 patients). Over 70's patients had the highest of disease rata 52.6%. For kidney, men and women showed the highest number of abnormal cases -62 vs 44 respectively. Over 70's patients had the highest percentage of disease rata-23.2% vs 14.0% respectively. For gallbladder, the number of abnormal cases were the most in men's 60's (31 patients) and in women's in the same age group (32patients). Disease showed the highest percentage in men's 60's(7.6%) and in women's 70's (14.0%). 6. According to malignant tumor, 17patients were liver cancer, 2patients stomach ca and 1pt kidney cancer. 7. The relationship between the malignant tumor and the examination motive was that 'they wanted to check their health status(41.0%)' and 'regular checkup (24.0%)'.

• Journal of the Korea Safety Management & Science
• /
• v.16 no.3
• /
• pp.289-294
• /
• 2014

The purpose of this report is to discuss the obtained findings gathered from ultrasound screenings of the liver. After running diagnostic tests health, screens were then conducted to analyze and compare the gained results. This data was then charted and used to strengthen our theorized hypothesis. From January 2013 to June 2013 a recorded 2906 people over the age of 20 visited Health Promotion Centers in various areas throughout Daejeon. Of those 2906 participants 1789 underwent screenings for abdominal ultrasonography; these participants as well as their ultrasound results were used as the bases of our study. For the establishment of our baseline and the comparison of our results, we gathered case-controlled studies from various reputable sources. Both the control and the experimental groups were tested to measure the following liver enzymes (AST, ALT, r-GTP, ALP, and etc.). Kidney functions were measured as well enzymes such as BUN, Creatinine, and Uric Acids levels were analyzed and recorded to see if any relationships existed between the levels documented in the liver and those in the kidneys. It was shown that the two primary causes of fat build up within the liver were significantly connected to obesity BMI(OR=4.14) and waist circumference(OR=3.88).