• 대한한방내과학회지
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• 제44권4호
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• pp.635-644
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• 2023

Objectives: This study analyzed laboratory serum data results before and after patients took herbal medicine to confirm the clinical safety of herbal medicine. In addition, in the event of liver damage, the case was analyzed to confirm the characteristics of liver damage and the possibility of liver damage caused by herbal medicine. Methods: A retrospective chart review of the effects of herbal medicine on liver function in patients diagnosed with functional dyspepsia was conducted. The electronic medical records of 128 patients in a single hospital were reviewed. Results: The statistical analysis revealed a statistically significant decrease in liver function-related laboratory serum data after taking herbal medicine (p<0.05). In addition, among 128 patients, there were two cases of drug-induced liver injury (DILI) (1.56%). Conclusion: Taking herbal medicine prescribed by experts does not significantly affect liver function in patients with functional dyspepsia. Rather, the liver levels of the subjects showed a significant decrease after taking herbal medicine. To support these results, further large-scale multicenter prospective studies are necessary.

• 대한의료기공학회지
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• 제11권1호
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• pp.326-339
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• 2009

Objective : The studies on liver effect in administration of western medicine have been well-established so far, but the studies on liver effect in administration or herbal medicine haven't been made. To make things worse, people who have liver disease generally believe that taking a herbal medicine is not useful to take care or their disease and even think it can cause liver disease. But this belief is not verified at all. So we feel the need to study about how taking herbal medicine affect to liver injury patient. Methods : We chose the 4 patient who seems to have the liver injury on the index of liver function test and we administrate the herbal medicine and after several day or weeks we recheck the liver function test. Results : Through the this method, we find the positive effect of taking herbal medicine on the patients who have the liver disease. Conclusions : Our results give no evidence that herbal medicine is harmful for liver disease. We need to study more about this.

• 대한한의학회지
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• 제32권4호
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• pp.149-158
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• 2011

동일한 처방을 투여해도 환자에 따라 정상반응을 보이는 경우가 있고 과민반응을 보이는 경우가 있다. 이 경우는 한약 자체의 문제라기보다는 특정 약물이 환자에 몸속에서 과민하게 반응하는 것으로 보인다. 만약 특정 약물에 과민 반응이 있다면 이것은 한의사의 책임이라기보다는 환자의 특이한 신체 조건에 기인한다라는 것을 환자에게 충분히 인지시킨후, 과민반응을 유발하는 약물을 제거하고 처방할 필요가 있다고 본다. 또한 일부 환자에게 과민반응을 일으키는 약물이 어느 정도가 있고, 얼마 동안 복용해야 과민반응을 보이는지에 관한 부분이 좀 더 정리가 된다면 한약의 장기 복용시 간손상에 관한 부분이 크게 문제가 되지 않을 것으로 본다. 이것은 한약이 절대로 부작용이 없는 약이 아니라 특정한 사람에게는 부작용을 일으킬 수 있다는 것을 환자에게 각인시키는 계기가 될 것이며, 이는 한약을 한약의 전문가인 한의사만 다룰 수 있도록 해야 하는 근거가 되는 한 예로 작용할 것으로 보인다. 또한 한의사도 간수치 측정 기기와 같은 이화학적 의료 기기에 대한 사용권을 확보하여 수가를 받음으로서 약물의 안정성과 환자로부터 신뢰를 얻는데 노력을 경주하여야 할 것으로 보인다.

• Investigative Magnetic Resonance Imaging
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• 제20권4호
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• pp.231-240
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• 2016

Purpose: To determine whether liver stiffness (LS) measured by magnetic resonance elastography (MRE) can predict the outcome of radiofrequency ablation (RFA) in hepatocellular carcinoma (HCC) patients. Materials and Methods: A total of 107 patients with Child-Pugh class A liver function who were treated with RFA for single HCC and who had undergone a gradient-echo MRE within 6 months before RFA were included. We evaluated the relationship between the LS values and the ablation volume, local tumor progression (LTP), and intrahepatic distant recurrence (IDR). We also constructed receiver operating characteristic (ROC) curves to examine the role of LS in predicting liver function deterioration, which was defined as an increase of Child-Pugh score by one point or more at 1 year after RFA. Results: There was no significant correlation between LS and ablation volume, and neither time to LTP nor IDR was associated with LS. Among the 66 patients who did not have recurrence 1 year after RFA, 5 patients (7.6%) developed liver function deterioration. A high LS value was significantly associated with development of liver function deterioration after RFA and the area under the ROC curve was 0.764 (95% CI 0.598-0.929, P = 0.003). Conclusion: LS measured by MRE could not predict ablation volume and tumor recurrence. However, high LS values were significantly associated with development of liver function deterioration.

• 문화기술의 융합
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• 제5권2호
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• pp.389-395
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• 2019

본 연구는 인체에 유익한 효과가 있고 부작용 없이 장기간 안전하게 사용할 수 있으며 간보호 및 간기능 개선에 탁월한 효과가 있는지 양배추출물의 간보호 효과에 대하여 알아보았다. 약물(APAP)에 의해 유도된 간손상 동물모델에서 수행된 실험에서, 양배추 추출물은 간손상 마커인 AST 및 ALT를 효과적으로 감소시킴으로써 간 보호 및 간 기능 개선 효과를 나타냄을 알 수 있었다. 양배추 추출물은 간질환의 예방 또는 치료용 약학적 추출물로서 유효하다는 것이다. 특히, 양배추 추출물은 간손상에 수반되는 급성 염증 반응에 관여하는 염증 매개체 iNOS 및 COX-2 및 전염증성 사이토카인 $IL-1{\beta}$의 발현을 감소시킴으로써 간염 염증을 치료하는데 효과적이었다. 그 결과, $100{\sim}150^{\circ}C$에서 열처리 한 배추 추출물은 생배추 추출물에 비해 간기능 개선 효과 또는 항염증 효과가 우수 하였다.

• 대한한방내과학회지
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• 제22권3호
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• pp.291-298
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• 2001

Objectives : This study was conducted to evaluate the effects that Injinsugunomija Extract affected Liver function test of Alcoholic liver disease and Viral hepatitis patients. Methods: We adminstered eighty packets of Injinsugunomija Extract to some kinds of liver disease patients for one month. And we investigated the changes of their liver function test. Results: The results from this study were summarized as followed. In the 10 patients of Alcoholic Liver Disease (ALD), 3 cases improve prominent and 4 cases improve effective and 3 cases are ineffective. Then 70% 01 ALD patients has improved by Injinsugunomija Extract In the 9 patients of Viral hepatitis, 1 case improves prominent and 4 cases improve effective and 1 case become worse and 1 case become worst and 2 cases are ineffective. Then 55.6% of Viral hepatitis patients has improved by Injinsugunomija Extract. Conclusions: From these results, Injinsugunomija Extract showed the meaningful effects on improving liver function test of ALD patients and Viral hepatitis patients.

• Journal of Nutrition and Health
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• 제28권7호
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• pp.629-635
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• 1995

Obese children have increaed in Korean in recent years as socieconomic status have got more higher than past years. Obese children have many health problems and some kinds of complications. Obese patients who have fatty liver with abnormal liver function should be managed with weight control. This study was intended to investigate the effect of weight control on hepatic abnormalities of obese children with fatty liver. We managed 6 obese children who had fatty liver with abnormal liver finction for weight control containing behavior modification, diet and exercise during 3 months. After 3 months, we compared body weight, liver function test, dietary intake and exercise. Body mass index(BMI) showed significant decrease from 28.1$\pm$2.3kg/$m^2$ to 26.2$\pm$1.7kg/$m^2$ (p<0.01). Aspartate aminotransferase(AST) showed significant improvement from 56$\pm$15IU/l(p<0.01). Alanine aminotransferase(ALT) also showed significant improvement from 108$\pm$38IU/l to 33$\pm$9IU/l(p<0.01). Therefore if we can rule out the other causes of hepatic abnormalities in obese children with fatty liver, these patients showed benefit by weight control as it can improve both obesity and liver functions.

• 동의생리병리학회지
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• 제18권6호
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• pp.1908-1912
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• 2004

This study was designed to assess the clinical effects of Inginoryung-san on liver function. : Inginoryung-san was prescribed for the patient for 14 months. Symptoms were checked repeatedly, and liver function test(such as AST, ALT, ALP, GGT ect.) were done, as well as urinalysis, to evaluate improvement. After 14 months treatment with Inginoryung-san, most symptoms disappeared or improved. Liver function test and urinalysis showed improvement. The above results that Inginoryung-san is beneficial for patient with abnormal liver functions.

• 사상체질의학회지
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• 제19권3호
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• pp.217-226
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• 2007

1. Objectives The purpose of this study was to evaluate whether use of Yeoldahanso-tang(熱多寒少湯) may injure the liver function. We clinically studied the change of liver function rest in patients who were admitted in Dongseo Oriental Medical Hospital. 2. Methods We analyzed rhe serum alkaline phosphatase(AIP), aspartate aminotransferase(AST), alanine aminotransferase(ALT), ${\gamma}$-glutamyl transpeptidase(${\gamma}$-GT), total bilirubin of 25 patients from 1st. July. 2004 to 15th. October. 2007 admitted in Dongseo Oriental Medical Hospital. Liver function test were done on admission and before discharge. 3. Results For most patients, the values of AIP, AST, ALT, ${\gamma}$-GT and total bilirubin were within normal range or decreased. 4. Conclusions This study suggests that Yeoldahanso-tang(熱多寒少湯) does not injure liver function of human.

• 대한한방내과학회지
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• 제40권6호
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• pp.1043-1050
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• 2019

Objectives: This study aimed to investigate the effects of Gyejigabuja-tang on liver function in patients with musculoskeletal disease. Methods: This research compared and analyzed data from liver function tests on patients who were treated with Gyejigabuja-tang during 17.98±1.78 days. Results: No significant effects appeared in the liver function of patients who were treated with Gyejigabuja-tang. Conclusions: This study suggests that Gyejigabuja-tang, which includes Aconiti Radix Lateralis Preparata, known as a toxic herb, may be used without causing significant liver injury if administered correctly as in this study.