Browse > Article

A Psoriasis Case Report on Liver Damage Related to Scutellaria Radix  

Lee, Ki-Hoon (Gang-nam Dong-yak Oriental Medical Clinic)
Yang, Ji-Eun (Gang-nam Dong-yak Oriental Medical Clinic)
Chang, Gyu-Tae (Department of Pediatrics. College of Oriental Medicine, Kyung Hee University)
Publication Information
The Journal of Korean Medicine / v.32, no.4, 2011 , pp. 149-158 More about this Journal
Abstract
Object: Any medication can have the risk of liver damage. To prevent this risk, liver function tests should be monitored carefully during every course of medication. This paper is a psoriasis case report on liver damage related to Scutellaria Radix medication. Shown by this case, herbal medicine has the possibility of liver damage, too. Therefore it should be carefully used under the direction of Oriental Medical Doctors who specialize in it. The purpose of this case report is to suggest this, and that more cases of liver damage related to herbal medicine should be reported. Methods: To monitor the medication's effect on the liver, liver function was evaluated during medications. Reflotron plus was used to evaluate AST and ALT by analyzing peripheral blood. Results: By this test, a case was identified as liver damage caused by a medication including Scutellaria Radix. Conclusion: This case suggests that Scutellaria Radix medication caused liver damage in a certain patient. Therefore, to prevent liver damage related to Scutellaria Radix, doctors should monitor patient's liver function regularly.
Keywords
liver damage; Scutellaria Radix; liver function; psoriasis; hepatic toxicity;
Citations & Related Records
Times Cited By KSCI : 7  (Citation Analysis)
연도 인용수 순위
1 Kang BS, Kim IR, Kim HC, Choi HY, Lee YJ. Herbology. Seoul:Younglimsa.1999:178-179.
2 Ha KT, Jeong SS, Kim CH, Choi DY, Kim JK. Study on the Hepatoprotective Effect and Cytochrome P450 Regulation of Scutellaria Radix. Korean J. Oriental Physiology & Pathology. 2008;22(1):155-161.
3 Byun BH, Seo BI. Molecular Celll Biological Study on Rat Hepatocytes Cytotoxicity and DNA Synthesis Effects of Scutellariae Baicalensis Radix Herbal acupuncture Solution(SBRHA). Kor. J. Herbology. 2004;19(1):35-40.
4 Byun BH, Seo BI. Safety study on Acute Toxicity of Scutellariae Baicalensis Radix Herbal acupuncture Solution(SBRHA). Kor. J. Herbology. 2003;18(4):47-51.
5 Lee JS, Lee SD. Effects of Liver Function on Blood of Drug Users(Herbal and Western) in Koreans. Kor. J. Oriental Preventive Medical Society. 2004;8(1):59-74.
6 Youn JI. Etiology & Treatment of Psoriasis. Seoul:Korea Medical Book Co. 1996:15-27, 30-148, 131-3.
7 Yeom YH, Kim JE. Bokjin and Truth of Prescription. Gangwon:Euibang P.Co. 2007: 654-655, 657-659.
8 Hwong DY. Jeungmaek Bangyakhapyeon. Seoul: Namsandang. 1992:122-123.
9 Lee SD. Prescriptionology fo Oriental Medicine, Seoul:Yeogang P.Co. 1994:228.
10 Kown HO. Evaluation Method on Toxicity of Extract of Rheum palmatum through Single Blinded Study. Dongeui University. Doctoral Degree 2009.
11 Felix S., Gerlinde E., Helmut K. S. Hepatotoxicity of botanicals. Public Health nutrition. 2000;3(2): 113-124.
12 Kang SH, Kim JI, Jeong KH, Ko KH, Ko PG, Hwang SW, et al. Clinical characteristics of 159 cases of acute toxic hepatitis. The Korean Journal of Hepatology. 2008;14:483-492.   DOI   ScienceOn
13 Kim DW, Lee UJ, An IH, Ban JS, Ryu CY, Lee SM. A study on the effect of prolonged administration of different oriental medicines on the liver function. J Korean Oriental Med. 1993;14(2): 245-253.
14 Lee WY, Park BC, Kim HS, Joung KO, Yoon SI, Kwon SK, et al. A case of acute interstitial nephropathy and toxic hepatitis after short-term herbal medication. The Korean Journal of Medicine. 2007;73(1):103-106.
15 Seo JC, Jeon WJ, Park SS, Kim SH, Lee KM, Chae HB, et al. Clinical Experience of 48 Acute Toxic Hepatitis Patients. 2006;12(1):74-81.
16 Yoon YK, Han SS, Yoo JY, Chou LS, Koo BS. A Clinical Study about Effect of Long Term Herb Medication on Liver Function. J. of. Oriental Chr. Dis. 2002;8(1):30-34.
17 Yoo JW, Park SD. Effect of Whaganjeon on the hepatoxicity of carbon tetrachloride in rats. The journal of Dong Guk Oriental Medicine. 1995; 4(3):313-325.
18 Korean Dermatology Association. Dermatology (5th ed.). Seoul:Ryo Moon Gak.P.Co. 2008:241.
19 Youn JI. Psoriasis Clinic. Seoul:Designmeca. 2004:102.
20 Youn JI. Etiology & Treatment of Psoriasis Update. Seoul:Designmeca. 2006:7-8.