The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Safety of Herbal Medicines on Liver Function in Functional Dyspepsia Patients: A Single-Center Retrospective Study

기능성 소화불량 환자의 간 기능에 대한 한약 투여의 안전성: 단일 센터 후향적 연구

  • Aram Han (Dept. of Digestive Diseases, Kyung Hee University Korean Medicine Hospital) ;
  • Chang-Yul Keum (Dept. of Digestive Diseases, Kyung Hee University Korean Medicine Hospital) ;
  • Chae-Rim Yoon (Dept. of Digestive Diseases, Kyung Hee University Korean Medicine Hospital) ;
  • Su-Hyun Choi (Dept. of Digestive Diseases, Kyung Hee University Korean Medicine Hospital) ;
  • Dahee Jeong (Dept. of Digestive Diseases, Kyung Hee University Korean Medicine Hospital) ;
  • Nahyun Jeong (Dept. of Digestive Diseases, Kyung Hee University Korean Medicine Hospital) ;
  • Hae-in Jeong (Dept. of Digestive Diseases, Kyung Hee University Korean Medicine Hospital) ;
  • Na-Yeon Ha (Dept. of Digestive Diseases, Kyung Hee University Korean Medicine Hospital) ;
  • Jinsung Kim (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University)
  • 한아람 (경희대학교 한방병원 위장소화내과) ;
  • 금창열 (경희대학교 한방병원 위장소화내과) ;
  • 윤채림 (경희대학교 한방병원 위장소화내과) ;
  • 최수현 (경희대학교 한방병원 위장소화내과) ;
  • 정다희 (경희대학교 한방병원 위장소화내과) ;
  • 정나현 (경희대학교 한방병원 위장소화내과) ;
  • 정해인 (경희대학교 한방병원 위장소화내과) ;
  • 하나연 (경희대학교 한방병원 위장소화내과) ;
  • 김진성 (경희대학교 대학원 한의과대학 임상한의학)
  • Received : 2023.08.22
  • Accepted : 2023.09.27
  • Published : 2023.09.30
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Abstract

Objectives: This study analyzed laboratory serum data results before and after patients took herbal medicine to confirm the clinical safety of herbal medicine. In addition, in the event of liver damage, the case was analyzed to confirm the characteristics of liver damage and the possibility of liver damage caused by herbal medicine. Methods: A retrospective chart review of the effects of herbal medicine on liver function in patients diagnosed with functional dyspepsia was conducted. The electronic medical records of 128 patients in a single hospital were reviewed. Results: The statistical analysis revealed a statistically significant decrease in liver function-related laboratory serum data after taking herbal medicine (p<0.05). In addition, among 128 patients, there were two cases of drug-induced liver injury (DILI) (1.56%). Conclusion: Taking herbal medicine prescribed by experts does not significantly affect liver function in patients with functional dyspepsia. Rather, the liver levels of the subjects showed a significant decrease after taking herbal medicine. To support these results, further large-scale multicenter prospective studies are necessary.

Keywords

References

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