• Proceedings of the Korean Nutrition Society Conference
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• 1997.11b
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• pp.30-30
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• 1997

• Proceedings of the Korean Nutrition Society Conference
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• 1996.06b
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• pp.42-42
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• 1996

• Korean Journal of Medicinal Crop Science
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• v.22 no.3
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• pp.203-209
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• 2014

Onion (Allium cepa L.) is one of the richest sources of flavonoids in human diet. Onion peel contains over 20 times more quercetin than onion flesh. In this study, we studied the effects of onion peel water extract (OPE) on the blood lipid profiles in mice. The onion peel extracts was extracted with hot water. The experimental groups were divided with 3 groups (n = 6) of ICR male mice: normal diet + distilled water (NC), high-fat diet + distilled water (HF), high-fat diet + onion peel water extract 20 mg/kg (OPE-20). The oral administration was conducted daily. The experimental period was 7 weeks. Onion peel water extract showed higher concentration of polyphenol gallic acid and anti-oxidant trolox equivalent than the ethanol extract. The body weight gain and food efficiency ratio was significantly lower in the OPE-20 group as compared with HF group (p < 0.05). The epididymal fat and retroperitoneal fat showed significantly lower weights and sizes in the OPE-20 group as compared with HF group (p < 0.05). The serum levels of total cholesterol, LDL cholesterol and triglyceride were significantly lower in the OPE-20 group as compared with HF group (p < 0.05). The OPE-20 group showed higher HDL cholesterol concentration than HF group (p < 0.05). Atherogenic index was ignificantly lower in as compared with HF group (p < 0.05). The serum levels of glucose, GOT and GPT were significantly lower in the OPE-20 group as compared with HF group (p < 0.05). In these results, we suggests that onion peel water extracts supplementation can reduces the serum lipid components and improves the lipid metabolism in hyperlipidemic mice induced with a high-fat diet.

• The Korea Journal of Herbology
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• v.29 no.6
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• pp.141-148
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• 2014

Objectives : Onion (AlliumcepaL.) is one of the richest sources of flavonoids in human diet. In this study, we studied the effects of onion peel water extract (OPE) on the blood lipid profiles and glucose in rats. Methods : The experimental groups were divided with 5 groups (n = 6) of SD rats: normal diet + distilled water (NC), high-fat diet + Quercetin (PC), high-fat diet + onion peel water extract 4 mg/kg (OPE-4), high-fat diet + onion peel water extract 20 mg/kg (OPE-20), high-fat diet + onion peel water extract 100 mg/kg (OPE-100). Results : The liver fat showed significantly lower weights and size in the OPE-100 group as compared with NC group (p<0.05), The epididymal fat and retroperitoneal fat showed significantly lower weights and sizes in the OPE-4 and OPE-20 group as compared with NC group (p<0.05). The serum levels of total cholesterol, LDL cholesterol and triglyceride were significantly lower in the OPE-4 and OPE-20 group as compared with NC group (p<0.05). The OPE-4 and OPE-20 group showed higher HDL cholesterol concentration than NC group (p<0.05). Atherogenic index of OPE-4 and OPE-20 group was significantly lower in as compared with NC group (p<0.05). The serum levels of glucose significantly lower in the OPE-20 group as compared with NC group (p<0.05). Conclusions : In these results, we suggests that onion peel water extracts supplementation can reduces the serum lipid components and improves the lipid metabolism in hyperlipidemic SD rat induced with a high-fat diet.

• Journal of the Korean Dietetic Association
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• v.19 no.2
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• pp.124-139
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• 2013

Unlike studies of Europeans and Americans, many epidemiological studies of the Korean population have indicated that their risk for cardiovascular disease does not decrease with a vegetable-rich diet. The different dietary practices of Koreans, who consume salted vegetables instead of fresh vegetables (common in the Western diet), has been suggested as a reason for this observation. Korea is in a period of rapid epidemiologic transition, which includes dietary and disease patterns; therefore, this study investigated differences in the food consumption pattern and blood lipid profiles of Koreans compared to Europeans and Americans. The identification of dietary patterns related to blood lipid abnormalities was carried out using the 2007~2009 Korean National Health and Nutrition Survey data from 14,056 subjects. Dietary patterns were analyzed according to food group and nutrient intake. Blood lipid abnormalities were classified into three groups: hypercholesterolemia, hypertriglyceridemia, and low HDL cholesterolemia (hypo-HDL-cholesterolemia). The prevalence of hypercholesterolemia, hypertriglyceridemia, and hypo-HDL-cholesterolemia was 12.4%, 16.2%, and 27.7% respectively. In our analysis, the low consumption of all food groups was related to hypercholesterolemia. The high consumption of vegetable-containing foods, alcoholic beverages, and the low consumption of milk products were associated with hypertriglyceridemia and hypo-HDL-cholesterolemia. Thus, unlike Europeans and Americans, the low consumption of all food groups is related to hypercholesterolemia and a low consumption of milk products is related to hypertriglyceridemia and hypo-HDL-cholesterolemia. Dietary pattern might play a role in epidemiologic transition of Korean. Also, this study implies necessity of further research using longitudinal data.

• Asian-Australasian Journal of Animal Sciences
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• v.21 no.6
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• pp.883-889
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• 2008

Lipid peroxidation (LPO) has been identified as an important component of atherosclerosis. In this study, the effects of supplementation with cholesterol (0.5%), olive oil (5%) and vitamin E (0.05%) on erythrocyte glutathione (GSH), plasma malondialdehyde (MDA), total cholesterol, HDL-LDL cholesterol and triacylglycerol, brain and liver MDA and GSH concentrations of rats were investigated. A total of 50 Sprague-Dawley male rats aged 6 months, and of equal body weight were used and fed a standard ration ad libitum. Animals were housed in the University of Selcuk, Veterinary Faculty Experimental Animals Unit. The experiment lasted 60 days and there were five experimental groups as follows: 1. Control, 2. Cholesterol (0.5%), 3. Olive oil (5%), 4. Cholesterol plus vitamin E (0.05%), 5. Olive oil plus vitamin E (0.05%). At the end of the experiment, blood samples were taken by cardiac puncture and erythrocyte GSH, plasma MDA, cholesterol, HDL-LDL cholesterol, triacylglycerol and also GSH and MDA concentrations in brain and liver tissue of rats were spectrophotometrically determined. Supplementation of olive oil and cholesterol into rat diets (groups 2 and 3) caused significant differences in lipid parameters; HDL cholesterol concentrations were increased in the olive oil group and LDL cholesterol was lower than in the cholesterol fed group. Moreover, these decreases in LDL and triacylglycerol concentrations were more significant with vitamin E supplementation. The high plasma MDA concentrations showed that lipid peroxidation occurred in the olive oil group and the highest brain MDA concentrations were determined also in the olive oil group. These findings suggest that vitamin E addition may decrease the sensitivities of several oils to oxidation and that monounsaturated fatty acids in olive oil may decrease the incidence of atherosclerosis by regulating blood lipid profiles.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.49 no.3
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• pp.317-322
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• 2016

This study was carried out to investigate the effects of various dietary lipid sources on the growth performance, body composition, and fatty acid profiles of juvenile fancy carp (Cyprinus carpio var. koi). Three replicate groups of fish (initial mean body weight, 15.1±0.18 g) were fed one of five experimental diets containing fish oil (SLO), soybean oil (SO), linseed oil (LO), lard (LA), or a mixture of SLO, SO, and LO (Mix) for 8 weeks. Fish fed the LA diet gained less weight than did fish fed the LO diet. The feed efficiency and protein efficiency ratio of fish fed the LA and Mix diets were lower than those of fish fed the SO and LO diets. The body lipid content of fish fed the SO diet was lower than those of the other groups. Whole-body fatty acid compositions reflected the fatty acid compositions of dietary lipid sources. Fish fed the SO diet had high concentrations of linoleic acid and arachidonic acid, whereas fish fed the LO diet were rich in linolenic acid. Fish fed the SLO diet had significantly higher levels of eicosapentaenoic acid and docosahexaenoic acid compared with fish fed the SO, LO, and LA diets. The results of this study suggest that SO or LO could be used as a replacement for SLO in the diets of juvenile fancy carp without any negative effects on growth and feed utilization when the dietary essential fatty acid requirements are satisfied for juvenile fancy carp.

• Nutrition Research and Practice
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• v.7 no.6
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• pp.481-487
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• 2013

High-fat diet up-regulates either insulin resistance or triglycerides, which is assumed to be related to the expression of peroxisome proliferator-activated receptor (PPAR)-${\alpha}$ and PPAR-${\gamma}$. The beneficial effects of vitamin E on insulin resistance are well known; however, it is not clear if vitamin E with a high-fat diet alters the expression of PPAR-${\alpha}$ and PPAR-${\gamma}$. We investigated the effects of d-${\alpha}$-tocopherol supplementation on insulin sensitivity, blood lipid profiles, lipid peroxidation, and the expression of PPAR-${\alpha}$ and PPAR-${\gamma}$ in a high-fat (HF) diet-fed male C57BL/6J model of insulin resistance. The animals were given a regular diet (CON; 10% fat), a HF diet containing 45% fat, or a HF diet plus d-${\alpha}$-tocopherol (HF-E) for a period of 20 weeks. The results showed that the HF diet induced insulin resistance and altered the lipid profile, specifically the triglyceride (TG) and total cholesterol (TC) levels (P < 0.05). In this animal model, supplementation with d-${\alpha}$-tocopherol improved insulin resistance as well as the serum levels of TG and very-low-density lipoprotein-cholesterol (VLDL-C) (P < 0.05). Moreover, the treatment decreased the levels of malondialdehyde (MDA) in the serum and liver while increasing hepatic PPAR-${\alpha}$ expression and decreasing PPAR-${\gamma}$ expression. In conclusion, the oral administration of d-${\alpha}$-tocopherol with a high-fat diet had positive effects on insulin resistance, lipid profiles, and oxidative stress through the expression of PPAR-${\alpha}$ and PPAR-${\gamma}$ in a high-fat diet-fed male mice.

• Journal of the Korean Dietetic Association
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• v.12 no.2
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• pp.118-126
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• 2006

The purpose of this study was to estimate sugar intake and relation between it and blood lipid profiles in Korean adult according to age. The 346 subjects were measured anthropometric assessment, dietary intake using 24-hour recall method, and serum lipid profiles. The average age of the subjects of 20-49, 50-64, over 65 years were 40.8, 57.0, 70.2 years, respectively. The mean height and weight were significantly decreased with increment of age(p<0.001, p<0.01). The mean energy, food, and sugar intakes of the age groups were decreased with increment of age(p<0.05, p<0.001, p<0.001), that is, 1649.8 ㎉/1253.6 g/36.1 g for 20~49 years, 1555.4 ㎉/1157.0 g/31.4 g for 50~64 years, 1404.4 ㎉/893.5 g/17.1 g for over 65 years. The major foods consumed sugar of the age groups were watermelon, sugar, ice cream for 20-49 years, watermelon, sugar, peach for 50-64 years, watermelon, sugar, kimchi for over 65 years. Carbohydrate intake of the subject adjusted age provided significantly negative correlation with serum HDL-cholesterol(p<0.05). However, there was not significant correlation between sugar intake and serum lipid profile. Based on these results, further studies on effects on blood lipid of sugar and carbohydrate intakes were needed for proper carbohydrate intake.

• Journal of Community Nutrition
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• v.3 no.1
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• pp.14-20
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• 2001

A cross-sectional study to determine dietary intake and plasma triglyceride total cholesterol LDL-cholesterol and HDL-cholesterol of 185K Korean men was conducted across three different age groups The younger group (age 21 to 34) was significantly (p<0.001) taller but showed lower (p<0.05) percent body fat than the older group (age 45 to 60) Weight and body mass index was not different among age groups. Older men showed significantly(p<0.01) lower energy and total fat intake than younger men Besides macronutrients, most participants consumed an adequate amount of micronutrients but calcium consumption of the middle age group (age 35 to 44) was less than 75% of RDA In older men plasma triglyceride(207.8$\pm$155.5 mg/dl) total cholesterol (201.4$\pm$40.0 mg/dl) and LDL-cholesterol(106.0$\pm$32.7 mg/dl) concentrations were significantly hight(p<0.001) than in younger men wereas no significant difference was observed in HDL-cholesterol concentration Subjects with a higher BMI(bMI$\geq$25.0) showed significantly higher (p<0.001) triglyceride(200.2$\pm$107.6 mg/dl) total cholesterol(211.0$\pm$40.1 mg/dl) LDC-cholesterol(118.16$\pm$35.5 mg/dl) concentrations and lower(p=0.001) HCL-cholesterol concentration (52.8$\pm$15.9 mg/dl) than subjects with lower BMI(BMI<23.0) Dietary intake of fat cholesterol did not show significant associations with any of the plasma lipid profiles. However, anima fat intake was significantly (p<0.05) correlated with plasma total cholesterol and triglyceride concentrations in the older age group. On the hand percent body fat was correlated (p<0.05) with all of the plasma lipid and lipoprotin concentrations examined for all age groups Results indicate both dietary intake and percent body fat are important determinants of the plasma lipid concentrations is the elderly but only percent body fat or body mass could be valid predictors for the plasma lipid concentrations of the younger age group.