• Journal of Microbiology and Biotechnology
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• v.12 no.4
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• pp.702-705
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• 2002

Apicularen A (Api A) was recently isolated from Chondromyces sp. as a potent antitumor agent. Because of its unique chemical structure, a macrolide with a highly unsaturated amide side chain, and potent growth inhibitory effect in various cancer cell lines, Api A is currently in clinical trial for cancer therapy. In the present study, the effect of Api A on in vitro angiogenesis of bovine aortic endothelial cells (BAECS) was investigated. Api A potently inhibited the proliferation of BAECS in a dose-dependent manner. Treatment of the endothelial cells with up to 10 ng/ml of the compound did not show any cytotoxicity. In addition, it inhibited basic fibroblast growth factor (bFGF)-induced invasion and capillary tube formation of BAECS at concentrations of 2-5 ng/ml. These results, therefore, demonstrate that Apl A is a novel antiangiogenic agent and may suppress the growth of tumors, at least in part, by the inhibition of neovascularization.

• Journal of Ocean Engineering and Technology
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• v.32 no.3
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• pp.177-183
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• 2018

This study simulated ice load and the motion response of a moored semi-submersible rig in pack-ice conditions using a finite element method. Ice flows of random size and shape were modeled, and interactions for ice-sea, ice-structure, ice-ice were simulated using a simplified method. Parameters for the simplified method such as drag force coefficient and the pressure-penetration relation were obtained based on the result of detailed analysis using the coupled Eulerian-Lagrangian method. The mooring lines were modeled by spring elements based on their stiffness. As a result of the simulation over 1,400 seconds, the force and motion response of the rig were obtained and validated using discrete elements and compared with the results found by the Krylov State Research Centre.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.8
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• pp.3618-3622
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• 2012

In this study, the yield of the modules in LCD production lines, improving current TFT-LCD production process is essential for high-pressure silicone injection equipment, and precision control system was developed. This full-scale production of the future through the development of next-generation display production line is being prepared, being transferred to China in LCD production facilities can make the most of efficient equipment. Therefore, minimize the cost of new investment and help create the maximum effect to control the detailed behavior of the sequence H/W and S/W system was installed on the production line. In addition, Fast-evacuating the structure proposed for the Vacuum pump, Pump control circuit design and experimental results has been completed.

• Journal of the Korean Ceramic Society
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• v.49 no.1
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• pp.43-47
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• 2012

Electromigration in molten $Ge_2Sb_2Te_5$ (GST) was characterized using pulsed DC stress to an isolated line structure. When an electrical pulse was applied to the GST, GST lines were melted by Joule heating, and Ge and Sb atoms migrate to the cathode, whereas Te atoms migrate to the anode. This elemental separation in the molten GST was caused by an electrostatic force-induced electromigration. The effects of O-, N-, and Bi-doping on the electromigration were also investigated, and atomic mobility changes by the doping were investigated by quantifying $DZ^*$ values. The Bi -doping did not affect the $DZ^*$ values of the constituent atoms in the molten GST, but the D$DZ^*$ values decreased by O-doping and N-doping.

• ETRI Journal
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• v.36 no.1
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• pp.116-123
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• 2014

In this paper, a novel unequal broadband out-of-phase power divider (PD) is presented. Double-sided parallel-strip lines (DSPSLs) are employed to achieve an out-of-phase response. Also, an asymmetric dual-band matching structure with two external isolation resistors is utilized to obtain arbitrary unequal power division, in which the resistors are directly grounded for heat sinking. A through ground via (TGV), connecting the top and bottom sides of the DSPSLs, is used to short the isolation components. Additionally, this property can efficiently improve the broadband matching and isolation bandwidths. To investigate the proposed divider in detail, a set of design equations are derived based on the circuit theory and transmission line theory. The theoretical analysis shows that broadband responses can be obtained as proper frequency ratios are adopted. To verify the proposed concept, a sample divider with a power division of 2:1 is demonstrated. The measured results exhibit a broad bandwidth from 1.19 GHz to 2.19 GHz (59.2%) with a return loss better than 10 dB and port isolation of 18 dB.

• Journal of the Korea Furniture Society
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• v.19 no.5
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• pp.319-327
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• 2008

As art of lamination by plywood got to be generally used, it became a suitable material for expressing live curves that were not able to be expressed on wood furniture made of plank and timber, as well as, openwork deep in curved space, heavy quality of material, and changing contour line-looking wave lines with different process angles. As an alternative, it would be good to build a full scale model, since it would provide practice in form-building and it would also provide a chance to correct the form. Less material can be used and reduce the cutting process by Properly trimming models made of soft formal structure such as Styrofoam Iso-pink and adhesive Styrofoam, and separating the layers and using them on shape cutting of plywood with the same thickness. And by attaching the model veneer that was used in shape cutting of the model and using it as a cutting guide, we can reduce the error of work and successively build the planned form. Since this study is about the need of a full scale model for a laminated wood model and an efficient process, this study concentrates more on process.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.46 no.2
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• pp.147-151
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• 2009

A wideband correlator, with 45% relative bandwidth is proposed at the frequency range of 3.1-5.1GHz. The structures of the correlator components such as the delay line and the Wilkinson power divider are designed to be realized in transmission line form using the Agilent's Advanced Design System (ADS). The correlator made by using three unique wideband 3-dB couplers, rat-race coupler and one 3-dB wilkinson power divider to reach the required bandwidth. The insertion loss, amplitude imbalance and phase imbalance between ports are presented. The proposed correlator makes compact size better than correlator of conventional structure.

• Archives of Pharmacal Research
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• v.22 no.2
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• pp.179-183
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• 1999

3-Arylisoquinolin-1(2H)-ones (2) are possible bioisosteres of the $5-[4^{l}-(piperidinomethyl)phenyl]-2<$,3-dihydroimidazo[2,1-$\alpha$]isoquinoline (1) which is in clinical evaluation for the treatment of cancer. Structure-activity relationship studies of 3-arylisoquinolin-1(2H)-ones. (2) led to the synthesis of 3-arylquinolin-2(1H)-ones (3). A number of 3-phenyl substituted quinolin-2(1H)-ones were synthesized and tested for their in vitro antitumor activity against four different human tumor cell lines and 3-phenyl-N-benzyl-3,4-dihydroquinolin-2(1H)-one (12) showed the most potent activity.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.21 no.4
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• pp.354-361
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• 2008

The dielectric characteristics of low-k interlayer dielectric materials was fabricated by plasma enhanced chemical vapor deposition (PECVD). BTMSM precursor was evaporated and introduced with the flow rates from 16 sccm to 25 sccm by 1sccm step in the constant flow rate of 60 sccm $O_2$ in process chamber. Manufactured samples are analyzed components by measuring FT/IR absorption lines. Decomposition each Microscopic structures through two-dimensional correlation analysis about mechanisms for the formation of SiOCH in $SiOCH_3$, Si-O-Si and Si-$CH_3$ bonding group and analyzed correlation between the micro-structure of each group. It is a tendency that seems to be growing of Si-O-Ci(C) bonding group and narrowing of Si-O-$CH_3$ bonding group relative to the increasing flow-rate BTMSM. The order of changing sensitivity about changes of flow-rate in Si-O-Si(C) bonding group is cross link mode$(1050cm^{-1})$ $\rightarrow$ open link mode$(1100cm^{-1})\rightarrow$ cage link mode $(1140cm^{-1})$.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.19 no.3
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• pp.582-590
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• 1994

This paper introduce a highly verstile and simple data transmission system designed for commercial power distribution lines. The system operates on the DSSS principle but utilizes two independent carrier frequencies each represents polarity of DS MODEM outiputs. At the receiving terminal, outputs of two envelope detectors are directly applied to separate DS correlators before the two components are compared. The recovered signals which represents data and line noise are then compared at comparator. With the noise power greatly rudused at the correlator, the error rate of the data observed at comparator desplays great improvement comparing to the conventional FSK-DS system in which the detector output are compared before the correlator stage. Despite its simplest structure, the prototype MODEM transmitts 2400 bps with the error rate 10 , about 10dB improved compared to conventional FSK system.