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Apicularen A, a Macrolide from Chondromyces sp., Inhibits Growth Factor Induced In Vitro Angiogenesis  

Kwon, Ho-Jeong (Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University)
Kim, Dong-Hoon (Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University)
Shim, Joong-Sub (Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University)
Ahn, Jong-Woong (Korea Research Institute of Chemical Technology)
Publication Information
Journal of Microbiology and Biotechnology / v.12, no.4, 2002 , pp. 702-705 More about this Journal
Abstract
Apicularen A (Api A) was recently isolated from Chondromyces sp. as a potent antitumor agent. Because of its unique chemical structure, a macrolide with a highly unsaturated amide side chain, and potent growth inhibitory effect in various cancer cell lines, Api A is currently in clinical trial for cancer therapy. In the present study, the effect of Api A on in vitro angiogenesis of bovine aortic endothelial cells (BAECS) was investigated. Api A potently inhibited the proliferation of BAECS in a dose-dependent manner. Treatment of the endothelial cells with up to 10 ng/ml of the compound did not show any cytotoxicity. In addition, it inhibited basic fibroblast growth factor (bFGF)-induced invasion and capillary tube formation of BAECS at concentrations of 2-5 ng/ml. These results, therefore, demonstrate that Apl A is a novel antiangiogenic agent and may suppress the growth of tumors, at least in part, by the inhibition of neovascularization.
Keywords
Apicularen A; angiogenesis; macrolide; Chondromyces sp.; Myxobacteria;
Citations & Related Records
Times Cited By KSCI : 6  (Citation Analysis)
Times Cited By Web Of Science : 14  (Related Records In Web of Science)
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