• 한국산학기술학회논문지
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• 제16권11호
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• pp.7893-7901
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• 2015

공용중인 교량의 보다 안전하고 효율적인 유지관리를 위해서는 시간에 따른 교량 유지관리 정보의 수집과 분석이 중요하다. 교량관리시스템을 통한 안전하고 경제적인 관리를 위한 전략 수립의 기본이 되는 현장조사 정보의 신뢰도 및 획득의 편의성을 증진하기 위하여 교량 현장조사용 스마트폰 응용프로그램을 개발하고, 실 적용성을 확보하였다. 개발된 프로그램은 교량의 생애주기관리를 위한 교량관리시스템과 연계되어 유지관리 관련 정보의 조회, 수정, 전송 등이 실시간으로 가능하며, 현장조사 보고서의 자동 작성을 통해 업무를 크게 경감할 수 있을 것으로 판단된다. 본 프로그램을 이용한 점검은 편의성, 정확성 등의 향상, 정보의 지속가능성, 향후 활용성 등 직간접적으로 기대되는 가치향상 효과가 기존의 점검방법에 비해 매우 높을 것으로 기대된다.

• 한국통신학회논문지
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• 제36권6B호
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• pp.710-719
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• 2011

해운회사에서는 현재 고유가 및 물동량 감소 등의 경영환경변화에 대처하기 위해 경쟁력강화와 경영합리화를 구현하는 전략적 선박자원관리시스템 개발에 대한 관심이 고조되고 있다. 본 논문에서는 SAN(Ship Area Network) 환경에 적합한 선박자원관리시스템을 소개한다. 이 시스템은 선박관계 당사자 요구사항을 분석하여 선주사의 경영전략 실행에 맞도록 설계되었다. 이와 함께 선박의 전 생애주기에 걸쳐서 선박자원에 대한 정보와 지식을 관리할 수 있도록 선박 온톨로지와 기계장치 및 부품에 대한 국제표준인 STEP과 PLIB를 도입할 수 있게 시스템을 설계한 다음, 비즈니스 로직과 사용자 인터페이스를 분리하여 웹기반 ERP(SHERP)로 구현하였다. 본 논문에서 기술하고 있는 시스템은 선박과 선단 운영에 적용할 수 있는 정보시스템으로서 조선산업 서비스화를 지향하는 구체적인 사례가 될 것이다.

• Biomolecules & Therapeutics
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• 제28권5호
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• pp.465-472
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• 2020

Colorectal cancer (CRC) is one of the most malignant type of cancers and its incidence is steadily increasing, due to life style factors that include western diet. Abnormal activation of canonical Wnt/β-catenin signaling pathway plays an important role in colorectal carcinogenesis. Therefore, targeting Wnt/β-catenin signaling has been considered a crucial strategy in the discovery of small molecules for CRC. In the present study, we found that Nodosin, an ent-kaurene diterpenoid isolated from Isodon serra, effectively inhibits the proliferation of human colon cancer HCT116 cells. Mechanistically, Nodosin effectively inhibited the overactivated transcriptional activity of β-catenin/T-cell factor (TCF) determined by Wnt/β-catenin reporter gene assay in HEK293 and HCT116 cells. The expression of Wnt/β-catenin target genes such as Axin2, cyclin D1, and survivin were also suppressed by Nodosin in HCT116 cells. Further study revealed that a longer exposure of Nodosin induced the G₂/M phase cell cycle arrest and subsequently apoptosis in HCT116 cells. These findings suggest that the anti-proliferative activity of Nodosin in colorectal cancer cells might in part be associated with the regulation of Wnt/β-catenin signaling pathway.

• 품질경영학회지
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• 제49권3호
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• pp.269-279
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• 2021

Purpose: The purpose of this study was to suggest weapon system specifications for requirements of Condition-Based Maintenance(CBM/CBM⁺). Methods: The military documents and case studies with regard to condition-based maintenance were reviewed. Representative Korea defense specifications of weapon system such as an aircraft, a C4ISR etc. were analyzed and investigated the level of requirement for maintainability was. Results: Condition-based maintenance was defined in both U.S. instruction and Korean directive. While deparment of defense(U.S.) provide a guidebook for CBM⁺, detailed instruction was not sufficient for Korean. Ministry of national defense(ROK) define the CBM⁺ by means of IPS element which should be developed along with the system development. The maintainability was barely included in Korean defense specifications, except for BIT(Built-in test) function. As a first step for defining the condition-based maintenance requirement in defense specification, this study suggests a standard form for data needed to acquire according to types of system, fault, failure, and so on. Conclusion: The empirical researches on CMB/CBM⁺ with domestic weapon systems are not enough, and a logic which leads the maintenance strategy to CMB/CBM⁺ is not solved. Through technical researches and institutional improvements including this study, we hope that condition-based maintenance would be fully established in the Korean defense field.

• 한국컴퓨터정보학회논문지
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• 제26권4호
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• pp.239-245
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• 2021

4차 산업혁명과 코로나19 사태로 인하여, 키오스크와 같은 디지털기기 사용가능 여부는 디지털 격차를 가진 노인에게 생존과 직결되는 문제이다. 본 논문은 고령자 대상 기존 정보화교육의 문제점을 분석하여 고령자의 신체·인지 노화와 라이프 사이클에 맞춤화된 정보화교육 전략을 제안한다. 본 연구에서 제안하는 고령자 맞춤형 정보화교육은 시간과 장소에 구애받지 않고 반복 학습을 지원하는 교육용 애플리케이션 기반 IT교육 방법으로서, 키오스크 기능을 기능성게임 형식의 교육용 애플리케이션으로 개발하고 교육 후의 효과성을 실험하였다. 연구방법은 첫째 문헌분석과 FGI를 통하여 고령자 맞춤형 교육용 애플리케이션 UI 사용성 평가 프레임을 제안하고, 둘째 제안한 평가 프레임에 의거한 교육용 애플리케이션 개발, 셋째 키오스크 교육에 교육용 애플리케이션을 활용하여 교육 효과성을 실험하였다. 실험결과, 교육용 애플리케이션 사용한 후의 미션 성공률은 80.6%로 사용 전(25.5%)과 비교하여 55.1%P의 향상과 함께 미션성공 소요시간도 단축하였다. 본 연구는 비대면 상황에서 제안한 정보화교육이 기존 교육의 한계를 극복할 수 있음을 확인하였다.

• International Journal of Computer Science & Network Security
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• 제21권4호
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• pp.103-114
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• 2021

A conceptual model can be used to manage complexity in both the design and implementation phases of the system development life cycle. Such a model requires a firm grasp of the abstract principles on which a system is based, as well as an understanding of the high-level nature of the representation of entities and processes. In this context, models can have distinct architectural characteristics. This paper discusses model multiplicity (e.g., unified modeling language [UML]), model singularity (e.g., object-process methodology [OPM], thinging machine [TM]), and a heterogeneous model that involves multiplicity and singularity. The basic idea of model multiplicity is that it is not possible to present all views in a single representation, so a number of models are used, with each model representing a different view. The model singularity approach uses only a single unified model that assimilates its subsystems into one system. This paper is concerned with current approaches, especially in software engineering texts, where multimodal UML is introduced as the general-purpose modeling language (i.e., UML is modeling). In such a situation, we suggest raising the issue of multiplicity versus singularity in modeling. This would foster a basic appreciation of the UML advantages and difficulties that may be faced during modeling, especially in the educational setting. Furthermore, we advocate the claim that a multiplicity of views does not necessitate a multiplicity of models. The model singularity approach can represent multiple views (static, behavior) without resorting to a collection of multiple models with various notations. We present an example of such a model where the static representation is developed first. Then, the dynamic view and behavioral representations are built by incorporating a decomposition strategy interleaved with the notion of time.

• Biomolecules & Therapeutics
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• 제31권2호
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• pp.200-209
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• 2023

Patients with non-small-cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) amplification or sensitive mutations initially respond to the tyrosine kinase inhibitor gefitinib, however, the treatment becomes less effective over time by resistance mechanism including mesenchymal-epithelial transition (MET) overexpression. A therapeutic strategy targeting MET and EGFR may be a means to overcoming resistance to gefitinib. In the present study, we found that picropodophyllotoxin (PPT), derived from the roots of Podophyllum hexandrum, inhibited both EGFR and MET in NSCLC cells. The antitumor efficacy of PPT in gefitinib-resistant NSCLC cells (HCC827GR), was confirmed by suppression of cell proliferation and anchorage-independent colony growth. In the targeting of EGFR and MET, PPT bound with EGFR and MET, ex vivo, and blocked both kinases activity. The binding sites between PPT and EGFR or MET in the computational docking model were predicted at Gly772/Met769 and Arg1086/Tyr1230 of each ATP-binding pocket, respectively. PPT treatment of HCC827GR cells increased the number of annexin V-positive and subG1 cells. PPT also caused G2/M cell-cycle arrest together with related protein regulation. The inhibition of EGFR and MET by PPT treatment led to decreases in the phosphorylation of the downstream-proteins, AKT and ERK. In addition, PPT induced reactive oxygen species (ROS) production and GRP78, CHOP, DR5, and DR4 expression, mitochondrial dysfunction, and regulated involving signal-proteins. Taken together, PPT alleviated gefitinib-resistant NSCLC cell growth and induced apoptosis by reducing EGFR and MET activity. Therefore, our results suggest that PPT can be a promising therapeutic agent for gefitinib-resistant NSCLC.

• Biomolecules & Therapeutics
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• 제31권5호
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• pp.550-558
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• 2023

Hair loss is a common condition that can have a negative impact on an individual's quality of life. The severe side effects and the low efficacy of current hair loss medications create unmet needs in the field of hair loss treatment. Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1), one of the components of the extracellular matrix, has been shown to play a role in maintaining its integrity. HAPLN1 was examined for its ability to impact hair growth with less side effects than existing hair loss treatments. HAPLN1 was predominantly expressed in the anagen phase in three stages of the hair growth cycle in mice and promotes the proliferation of human hair matrix cells. Also, recombinant human HAPLN1 (rhHAPLN1) was shown to selectively increase the levels of transforming growth factor-β receptor II in human hair matrix cells. Furthermore, we observed concomitant activation of the ERK1/2 signaling pathway following treatment with rhHAPLN1. Our results indicate that rhHAPLN1 elicits its cell proliferation effect via the TGF-β2-induced ERK1/2 pathway. The prompt entering of the hair follicles into the anagen phase was observed in the rhHAPLN1-treated group, compared to the vehicle-treated group. Insights into the mechanism underlying such hair growth effects of HAPLN1 will provide a novel potential strategy for treating hair loss with much lower side effects than the current treatments.

• 식물병연구
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• 제29권2호
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• pp.101-107
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• 2023

배 검은별무늬병을 일으키는 원인 병원균은 Venturia nashicola는 국내를 포함한 일본, 중국, 대만에서 가장 문제가 되는 대표적인 병이다. 이 병을 관리하기 위해서는 주로 화학적 방제에 의존하는 방식으로 관리가 되고 있었다. 하지만 지속인 화학적방제는 환경오염뿐만 아니라 병원균의 저항성 출현을 야기하여 보다 지속 가능한 관리방안이 필요한 시점이다. 이에 V. nashicola의 생환 및 감염 특성을 이해하고 과거부터 이어져온 달력형 방제나 특정 계통의 살균제 연용에서보다 기상환경조건에 따라 능동적인 방제시기 설정이 필요한 상황이다. 이 논문에서는 배 검은별무늬병인 V. nashicola의 병환, 감염특성 그리고 방제체계에 대한 내용을 정리하고 보다 효과적인 방제관리체계에 대한 방안을 논의하고자 다양한 연구결과들을 리뷰하였다.

• 한국환경과학회지
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• 제32권11호
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• pp.745-756
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• 2023

Growing stringent global regulations in Korea poses a threat to corporate sustainability. Companies must respond strategically to navigate these regulations and avoid greenwashing. Objective of this research was to analyze how Korean companies are responding to the global trend of reducing plastic use and propose improved management strategies. Seven indicators were developed to assess companies' post-plastic strategies and applied to analyze the sustainability reports of Amore Pacific and LG Household & HealthCare. These indicators included, 1) disclosure of plastic raw materials used by weight or volume, 2) disclosure of recycled plastic raw materials used by weight or volume, 3) disclosure of waste recycling, reuse amounts, and disposal using waste treatment method 4) strategies to reduce environmental impact of plastics, 5) plastic packaging, reduce, recycle, reuse, and composting (in the real environment), 6) plastic management roadmap for the circular economy, and 7) education for sustainable plastic management. Based on the review of considered companies, we propose in-listed sustainable plastics management strategies: disclosing the ratio of plastic raw materials and recycled raw materials for all products, considering recycling rate throughout the product value chain, and not only for the production phase, reviewing carbon dioxide emissions based on life cycle assessment rather than reducing plastic consumption, studying the biodegradability of biodegradable plastics in natural environment such as soil, considering the consumer's perspective.