• 가정∙방문간호학회지
• /
• 제23권1호
• /
• pp.90-99
• /
• 2016

Purpose: The purpose of this study was to examine the influences of emotional intelligence and attitudes about death on hospice volunteers' perception of life as meaningful. Methods: In this study, 232 hospice volunteers who were serving at 3 university hospitals and 7 general hospitals for 6 months or longer. Data were collected using self-report questionnaires from January 20 to February 15, 2016. Data were analyzed using descriptive statistics, independent-tests, one way ANOVAs, Pearson's correlation coefficients, and multiple regression analyses with SPSS 21.0. Results: Hospice volunteers' perception of life as meaningful was positively correlated with their attitudes toward death and emotional intelligence. The significant predictors of perception of meaning were emotional intelligence, attitudes toward death, religion and perceived health status. These variables explained 41.0% of the variance in hospice volunteers' perception of life as meaningful. Conclusion: These results suggest that hospice volunteers perceptions of life as meaningful can be changed positively by increasing emotional intelligence and positive attitudes about death.

• Food Science and Biotechnology
• /
• 제15권4호
• /
• pp.534-542
• /
• 2006

The effects of ethanol fractions of three different rice grain extracts, Jakwangchalbyeo, Hwasunchalbyeo, and Ilpumbyeo, on apoptotic cell death in the rat hepatoma H4IIE cell line were investigated using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] cell viability assay. One hundred mg/mL Jakwangchalbyeo extract significantly reduced cell viability to 69.5, 57.2, and 46.1% within 24, 48, and 72 hr, respectively. Fluorescence-activated cell sorting (FACS) analyses were also performed to characterize the cell death pattern caused by treatment with the rice grain extracts. Apoptotic cell death was clearly observed with time after treatment with the Jakwangchalbyeo extract. In Western blotting analysis, degradation of the 116 kDa poly-ADP-ribose polymerase (PARP) molecule was observed with concomitant formation of an 89 kDa product 24, 48, and 72 hr after treating cells with the Jakwangchalbyeo extract. This indicates that an apoptotic process caused cell death in these cells. In conclusion, red-pericarp Jakwangchalbyeo extract induced apoptotic cell death in H4IIE cells to a larger extent than the other rice extracts.

• Molecules and Cells
• /
• 제46권7호
• /
• pp.430-440
• /
• 2023

Linear ubiquitin chain assembly complex (LUBAC) is a ubiquitin E3 ligase complex composed of HOIP, HOIL-1L, and SHARPIN that catalyzes the formation of linear/M1-linked ubiquitin chain. It has been shown to play a pivotal role in the nuclear factor (NF)-κB signaling induced by proinflammatory stimuli. Here, we found that tumor susceptibility gene (TSG101) physically interacts with HOIP, a catalytic component of LUBAC, and potentiates LUBAC activity. Depletion of TSG101 expression by RNA interference decreased TNFα-induced linear ubiquitination and the formation of TNFα receptor 1 signaling complex (TNF-RSC). Furthermore, TSG101 facilitated the TNFα-induced stimulation of the NF-κB pathway. Thus, we suggest that TSG101 functions as a positive modulator of HOIP that mediates TNFα-induced NF-κB signaling pathway.

• 디지털융복합연구
• /
• 제17권11호
• /
• pp.427-434
• /
• 2019

이 연구의 목적은 간호대학생의 생명존중의지에 영향을 미치는 요인을 조사하고 간호대학생을 위한 효과적인 생명윤리 교육프로그램을 개발하는 데 도움이 되는 기초 자료로 활용하고자 하는 것이다. 442 명의 간호대학생을 대상으로 조사연구를 시행하였으며, 분석방법은 t-test, ANOVA, Pearson correlation coefficients, and Multiple regression을 이용하였다. 결과는 생명존중의지에 영향을 미치는 요소들이 죽음의 의미, 죽음의 불안, 죽음의 관여도라는 것을 보여 주었고, 이 세 요인의 생명존중의지에 대한 설명은 43.6%였다. 따라서 간호대학생들은 죽음의 의미에 대한 이해를 향상시켜 죽음의 의미를 이해하고, 죽음의 불안을 줄여야한다. 또한 긍정적 죽음의미 형성을 통해 간호학생의 생명존중의지 향상을 기대할 수 있을 것이며, 궁극적으로 죽음을 맞이하는 환자에게 진정한 도움을 줄 수 있는 간호사로 성장할 것이라고 사료된다.

• 아동학회지
• /
• 제30권4호
• /
• pp.241-256
• /
• 2009

This survey of children's perceptions and experiences of death was conducted with 118 6th-grade elementary school children in Seoul. Data consisted of responses to questionnaires in three categories : (1) perceptions of death, (2) views of afterlife, and (3) death-related experiences (life, education, and media). Results showed that children had negative emotions (61.8%) such as fear and anxiety about death. Children's attitudes about suicide were sympathetic (34.5%) as well as critical (53.7%). There was no relation between religion and view of afterlife. Finally, children experienced death more through mass media (TV, internet, etc.) than through life experience or death education. This study suggests the necessity for death education and warns of negative effects of media and games.

• 보건교육건강증진학회지
• /
• 제24권1호
• /
• pp.109-125
• /
• 2007

How an elderly people meets death is the matter of how he has lived his life. It is very important for an elderly people at the last step of his life to re-light up life and to meet death with dignity. The purpose of this study is to investigate where fear or anxiety of death come from among the four dimensins of death anxiety and to compare the differenced between the elderly group and non-elderly group, For this research, the 473 of the subjects from 20 to 80 years old attending social welfare center and community areas in Seoul have been questionned. The summary for the study mentioned the following: First, the overall scores of death anxiety, in the non-aged group, gender and religiosity are important factors affecting the decrease of death anxiety, On the other hand, in the aged group, self-respect, death readiness and number of friends are significant factors. Secondly, for death anxiety of self, age and spouse are significant relationships among non-aged group and gender, death readiness and number of friends for aged-group. In the dying of self, the following each three significant variables: gender, self-respect and spouse among non-aged group and gender, self-respect and number of friends among aged group. In death anxiety of others, age, view on next world and spouse are best predictor for non-aged group. Finally, family-relationship, self-respect and spouse are significant factors for aged group. In dying of others, only one factors are influenced for non-aged group, on the other hand, gender, self-respect and death readiness are important factors for aged group. There remains the need for more detailed examination into the nature of this relationship and the extent to which core components strongly affecting the above subscales.

• 한국보건간호학회지
• /
• 제27권3호
• /
• pp.539-550
• /
• 2013

Purpose: The objectives of this study were to investigate the level of meaning in life(MIL) among university students as well as identify the effects of death perception, including good death and concerns about dying, and self-esteem on MIL. Methods: A questionnaire survey was developed and carried out using a convenient sampling method (N=301). Data were analyzed by applying descriptive statistics, t-test, ANOVA, Duncan test, Pearson's correlation coefficient, and stepwise multiple regression. Results: The average score for MIL was 4.70 on a 7-point scale. The factor of purpose of life received highest score among all factors in MIL. MIL was positively correlated with age, good death, and self-esteem. However, concerns about dying were negatively correlated with MIL. MIL showed a strong association with self-esteem(r=.72). Specifically, self-esteem(${\beta}$=.608), satisfaction of school life(${\beta}$=.190), relationship with parents(${\beta}$=.180), good death(${\beta}$=.080), school grades(${\beta}$=.078), and age(${\beta}$=.074) all significantly influenced MIL. These variables accounted for 61.0% of the total variance. Conclusion: The results show that self-esteem is an important factor for MIL among university students. Therefore, self-esteem should be carefully considered to increase their MIL. These research findings can be utilized to support programs such as counseling and education of university students.

• Molecules and Cells
• /
• 제22권2호
• /
• pp.198-202
• /
• 2006

The $P2X_7$ receptor, an ATP-gated cation channel, induces cell death in immune cells and is involved in neurodegenerative diseases. Although the receptor plays various roles in these diseases, the cellular mechanisms involved are poorly understood and antagonists are limited. Here, the development of a cell-based assay for human $P2X_7$ receptor is reported. We established permanent lines of HEK 293 cells expressing a high level of $hP2X_7$ receptor. Functional activity of the $hP2X_7$ receptor was confirmed by whole-cell patch recording of ATP-induced ion currents. Prolonged exposure to ATP resulted in death of the $hP2X_7$-expressing HEK 293 cells and this cell death could be quantified. Two known $P2X_7$ antagonists, PPADS and KN-62, blocked ATP-induced death in a concentration-dependent manner. Thus, this assay can be used to screen for new antagonists of $hP2X_7$ receptors.

• 영어영문학
• /
• 제55권6호
• /
• pp.1221-1244
• /
• 2009

The death scenes are the culmination of both Doris Lessing's "To Room Nineteen" and Toni Morrison's Sula. Lessing's Susan, an intelligent white English woman, gradually loses the meaning of life as awealthy housewife in the patriarchal society and commits suicide as her solution in Room Nineteen of Fred's Hotel. Morrison's Sula, an African-American woman, grows up without having the normal ego under Eva's matriarchy in a black community named the Bottom. Sula, after Nel's marriage, becomes a symbol of evil to her community and drifts down to death in Eva's bed. Reading these two death stories from the perspective of Jung's archetypal psychology, Susan is not able to continue to live a meaningful life because her life energy is cut off from its source which is in the unconscious. According to Jung, the symbol is the medium of the psychic energy from the unconscious to consciousness. In modern society which is represented by intelligence, the religious and mythical symbols are removed by rationalism, which means disconnection of the flow of life energy from the unconscious. Susan's death can be read as a kind of creating symbol to connect the modern people to the source of life energy. Sula's case is the opposite of Susan's. She remains in the unconscious world without having the proper ego in the absurd reality of racial and sexual problems. Sula finally rises again in Nel's awareness, becoming a symbol of the feminine goddess like goddess Inanna.

• Journal of Hospice and Palliative Care
• /
• 제16권3호
• /
• pp.155-165
• /
• 2013

한국인의 전통적 죽음관은 유교, 불교, 도교, 그리고 샤머니즘의 깊은 영향을 받았다. 유교에서는 죽음이 모든 생명이 겪는 자연스러운 운명이며, 죽음을 고민하기보다는 현세의 삶에 충실할 것을, 도교에서는 삶과 죽음이 크게 다르지 않으니 자연에 순응하여 살아갈 것을, 그리고 불교에서는 삶과 죽음이 모두 허상임을 깨달으면 궁극적인 진리에 도달하여 죽음을 극복할 수 있다는 가르침을 배웠다. 이러한 사상들은 한민족 고유의 샤머니즘과 결합하여 현세를 중시하지만 사후세계와 윤회전생을 믿는 태도를 낳기도 하였다. 이러한 모습들은 역사를 통해서 매우 다양한 내러티브들로 나타나며 현대 한국인들이 죽음을 맞는 모습에도 여전히 큰 영향을 미치고 있다.