• Journal of Korean Library and Information Science Society
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• v.45 no.3
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• pp.415-440
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• 2014

This study intends to make a comprehensive inquiry into the meaning and limitations of Discovery, and to explore how to make full use of Discovery in library cataloging. To this end, first discussed is the meaning of Discovery, which has a variety definitions. For the quality evaluation, 5 criteria were developed on the basis of literature review. Then this study conducted the quality evaluation on the basis of previously developed 5 criteria and usefulness of Discovery in library catalogs is thoroughly discussed. Based on these, the final discussion includes strategies for Korean LIS scholars and library practitioners to consider when applying Discovery as an integrated search tool.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.27 no.4
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• pp.5-20
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• 2016

Discovery service has as its object to cope with the user to take advantage of the collection of the library as possible to index and search, one step further, the interface by more efficiently to the user's information needs. Discovery service has features such as providing a ranking and navigation services to subdivide the search results by facet results along the suitability and visually rich display, suggestions, recommendations associated resources. In this study introduces the status of discovery services such as discovery service products, usage status, and features, and compares and analyzes the use agencies, content status, main functions, and features of the three discovery services used in Korea library.

• Journal of Information Science Theory and Practice
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• v.10 no.4
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• pp.3-22
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• 2022

This paper provides an overview of the emergence of resource discovery systems and services, along with their advantages, best practices, and current landscapes. It outlines some of the key services and functionalities of a comprehensive discovery model suitable for academic libraries in developing countries. The proposed model (VuFind as a discovery tool) performs like other existing web-scale resource discovery systems, both commercial and open-source, and is capable of providing information resources from different sources in a single-window search interface. The objective of the paper is to provide seamless access to globally distributed subscribed as well as open access resources through its discovery interface, based on a unified index. This model uses Koha, DSpace, and Greenstone as back-ends and VuFind as a discovery layer in the front-end and has also integrated many enhanced search features like Bento-box search, Geodetic search, and full-text search (using Apache Tika). The goal of this paper is to provide the academic community with a one-stop shop for better utilising and integrating heterogeneous bibliographic data sources with VuFind (https://vufind.org/vufind).

• Journal of the Korean Society for Library and Information Science
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• v.50 no.1
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• pp.493-511
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• 2016

Discovery is an emerging concept to enhance the search capabilities of library resources with the Next Generation Library Catalog. This paper defined the Discovery feature based on the information search behavior, and then derived the elements that make up its function. After that, the 11 regional representatives libraries' OPACs and 3 Internet bookstores are evaluated and compared against Search & Discovery capabilities. As a result, the Internet bookstores were superior to the libraries' OPACs for all the elements that make up the Discovery functions. This study verified that the public libraries OPACs are still concentrating on known item search, and it is hard for the users to meet a serendipity which is gained through the Discovery functions.

• Journal of the Korean Society for Library and Information Science
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• v.48 no.4
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• pp.5-23
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• 2014

This study reports the first step in the Classification-based Search and Knowledge Discovery (CSKD) project, which aims to combine information organization and retrieval approaches for building digital library applications. In this study, we explored the generation and application of a faceted vocabulary as a potential mechanism to enhance knowledge discovery. The faceted vocabulary construction process revealed some heuristics that can be refined in follow-up studies to further automate the creation of faceted classification structure, while our concept search application demonstrated the utility and potential of integrating classification-based approach with retrieval-based approach. Integration of text- and classification-based methods as outlined in this paper combines the strengths of two vastly different approaches to information discovery by constructing and utilizing a flexible information organization scheme from an existing classification structure.

• BMB Reports
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• v.48 no.9
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• pp.489-494
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• 2015

The in vitro antibody discovery technologies revolutionized the generation of target-specific antibodies that traditionally relied on the humoral response of immunized animals. An antibody library, a large collection of diverse, pre-constructed antibodies, can be rapidly screened using in vitro display technologies such as phage display. One of the keys to successful in vitro antibody discovery is the quality of the library diversity. Antibody diversity can be obtained either from natural B-cell sources or by the synthetic methods that combinatorially generate random nucleotide sequences. While the functionality of a natural antibody library depends largely upon the library size, various other factors can affect the quality of a synthetic antibody library, making the design and construction of synthetic antibody libraries complicated and challenging. In this review, we present various library designs and diversification methods for synthetic antibody library. From simple degenerate oligonucleotide synthesis to trinucleotide synthesis to physicochemically optimized library design, the synthetic approach is evolving beyond the simple emulation of natural antibodies, into a highly sophisticated method that is capable of producing high quality antibodies suitable for therapeutic, diagnostic, and other demanding applications. [BMB Reports 2015; 48(9): 489-494]

• Bulletin of the Korean Chemical Society
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• v.35 no.8
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• pp.2385-2390
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• 2014

Novel 2,6-difuctionalized 2H-benzopyrans were synthesized and evaluated for a sphingosylphosphorylcholine(SPC) inhibitor. The synthetic 2H-benzopyrans 1c and 3a showed high potency in SPC-induced cell proliferation assay ($IC_{50}$ < 20 nM). Neither hERG $K^+$ channel binding (> $10{\mu}M$) nor CYP inhibitions (> $10{\mu}M$) were observed. Also, the simple structure-activity relationship (SAR) results were obtained from analysis of 2H-benzopyran derivatives 1-3 and the anti-SPC effect of 2H-benzopyran 1c was confirmed by a HUVEC tube formation assay.

• Journal of the Korean Magnetic Resonance Society
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• v.19 no.3
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• pp.132-136
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• 2015

Nuclear magnetic resonance (NMR) spectroscopy, owing to its ability to provide atomic level information on molecular structure, dynamics and interaction, has become one of the most powerful methods in early drug discovery where hit finding and hit-to-lead generation are mainly pursued. In recent years, drug discovery programs originating from the fragment-based drug discovery (FBDD) strategies have been widely incorporated into academia and industry in which a wide variety of NMR methods become an indispensable arsenal to elucidate the binding of small molecules onto bimolecular targets. In this review, I briefly describe FBDD and introduce NMR methods mainly used in FBDD campaigns of my company. In addition, quality control of fragment library and practical NMR methods in industrial aspect are discussed shortly.

• Journal of the Korean Society for Library and Information Science
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• v.54 no.2
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• pp.399-417
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• 2020

In this study, we tried to analyze the relative importance of features for various functions provided by Discovery. We identified a total of 36 assessment items in five categories including contents, search function, serendipity, interactivity, and ease of use based on literature review. In order to objectively evaluate the relative importance of each evaluation element, an AHP technique was adopted. As a result, 'Easy of use' received the highest weighted value among the five categories, followed by 'contents', 'search function', 'interactivity', and 'serendipity'. In addition, among all the 36 assessment items, 'Quality of data for central index' had higher weighted value. These findings can be used as basic data to adopt a discovery tool for libraries.

• Proceedings of the PSK Conference
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• 2003.10a
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• pp.92-92
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• 2003

The drug discovery landscape is changing rapidly in the post-genomic era. Mapping of the human genome has led to an abundance of potential drug targets. Drug discovery times and costs can be significantly reduced by developing methods for high throughput target identification/ validation, multiplexed assay development and high efficient combinatorial chemistry. (omitted)