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Xuefuzhuyu Decoction for Essential Hypertension: Meta-Analysis and Systemic Review (혈부축어탕의 본태성 고혈압에 대한 치료 효과 관한 메타 분석 및 체계적 고찰)

  • Han, In-sik;Jang, In-soo;Sun, Seung-ho
    • The Journal of Internal Korean Medicine
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    • v.39 no.6
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    • pp.1150-1167
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    • 2018
  • Objective: The purpose of this study was to investigate the effect reducing blood pressure (BP) using Xuefuzhuyu Decoction (XFZYD) in adults with essential hypertension (EH). Method: Search engine, such as PubMed, EMBASE, Cochrane library, Web of Science, J-STAGE, CiNii, CNKI, OASIS, NDSL, KISS, RISS, and DBpia, were used. The search period was from the beginning of the search engine to June 30, 2018 and there were no limits regarding languages. The selection and extraction of literatures were performed independently by two authors. Meta-analysis was done on the total effective rate (TER), Systolic BP (SBP) and Diastolic BP (DBP). Cochrane's risk of bias (ROB) was used as the methodological quality assessment scale. Results: Twenty studies were finally selected. We observed that a combination treatment using XFZYD and an antihypertensive drug (AHD) was 5.1 times more effective in lowering BP than using AHD alone on TER. The mean differences in SBP and DBP were -10.65 mmHg (95% Confidential Interval (CI) -13.55 mmHg, -7.74 mmHg, P<0.00001), -5.92 mmHg (95% CI -7.14, -4.38, P<0.00001), respectively. Conclusion: A combination treatment using XFZYD and AHD may be more effective in reducing BP than using AHD alone. Because of the poor methodological quality of the studies conducted thus far, high-quality clinical trials will be required in the future.

Enhancing the performance of a long-life modified CANDLE fast reactor by using an enriched 208Pb as coolant

  • Widiawati, Nina;Su'ud, Zaki;Irwanto, Dwi;Permana, Sidik;Takaki, Naoyuki;Sekimoto, Hiroshi
    • Nuclear Engineering and Technology
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    • v.53 no.2
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    • pp.423-429
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    • 2021
  • The investigation of the utilization of enriched 208Pb as a coolant to enhance the performance of a long-life fast reactor with a Modified CANDLE (Constant Axial shape of Neutron flux, nuclide densities, and power shape During Life of Energy production) burnup scheme has performed. The analyzes were performed on a reactor with thermal power of 800 MegaWatt Thermal (MWTh) with a refueling process every 15 years. Uranium Nitride (enriched 15N), 208Pb, and High-Cr martensitic steel HT-9 were employed as fuel, coolant, and cladding materials, respectively. One of the Pb-nat isotopes, 208Pb, has the smallest neutron capture cross-section (0.23 mb) among other liquid metal coolants. Furthermore, the neutron-producing cross-section (n, 2n) of 208Pb is larger than sodium (Na). On the other hand, the inelastic scattering energy threshold of 208Pb is the highest among Na, natPb, and Bi. The small inelastic scattering cross-section of 208Pb can harden the neutron energy spectrum. Therefore, 208Pb is a better neutron multiplier than any other liquid metal coolant. The excess neutrons cause more production than consumption of 239Pu. Hence, it can reduce the initial fuel loading of the reactor. The selective photoreaction process was developing to obtain enriched 208Pb. The neutronic was calculated using SRAC and JENDL 4.0 as a nuclear data library. We obtained that the modified CANDLE reactor with enriched 208Pb as coolant and reflector has the highest k-eff among all reactors. Meanwhile, the natPb cooled reactor has the lowest k-eff. Thus, the utilization of the enriched 208Pb as the coolant can reduce reactor initial fuel loading. Moreover, the enriched 208Pb-cooled reactor has the smallest power peaking factor among all reactors. Therefore, the enriched 208Pb can enhance the performance of a long-life Modified CANDLE fast reactor.

Psychosocial support interventions for women with gestational diabetes mellitus: a systematic review

  • Jung, Seulgi;Kim, Yoojin;Park, Jeongok;Choi, Miyoung;Kim, Sue
    • Women's Health Nursing
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    • v.27 no.2
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    • pp.75-92
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    • 2021
  • Purpose: This study aimed to analyze the content and effectiveness of psychosocial support interventions for women with gestational diabetes mellitus (GDM). Methods: The following databases were searched with no limitation of the time period: Ovid-MEDLINE, Cochrane Library, Ovid-Embase, CINAHL, PsycINFO, NDSL, KoreaMed, RISS, and KISS. Two investigators independently reviewed and selected articles according to the predefined inclusion/exclusion criteria. ROB 2.0 and the RoBANS 2.0 checklist were used to evaluate study quality. Results: Based on the 14 selected studies, psychosocial support interventions were provided for the purpose of (1) informational support (including GDM and diabetes mellitus information; how to manage diet, exercise, stress, blood glucose, and weight; postpartum management; and prevention of type 2 diabetes mellitus); (2) self-management motivation (setting goals for diet and exercise management, glucose monitoring, and enhancing positive health behaviors); (3) relaxation (practicing breathing and/or meditation); and (4) emotional support (sharing opinions and support). Psychosocial supportive interventions to women with GDM lead to behavioral change, mostly in the form of self-care behavior; they also reduce depression, anxiety and stress, and have an impact on improving self-efficacy. These interventions contribute to lowering physiological parameters such as fasting plasma glucose, glycated hemoglobin, and 2-hour postprandial glucose levels. Conclusion: Psychosocial supportive interventions can indeed positively affect self-care behaviors, lifestyle changes, and physiological parameters in women with GDM. Nurses can play a pivotal role in integrative management and can streamline the care for women with GDM during pregnancy and following birth, especially through psychosocial support interventions.

The effects of diagnostic hysteroscopy on the reproductive outcomes of infertile women without intrauterine pathologies: a systematic review and meta-analysis

  • Yang, Soo Yeon;Chon, Seung-Joo;Lee, Seon Heui
    • Women's Health Nursing
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    • v.26 no.4
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    • pp.300-317
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    • 2020
  • Purpose: Hysteroscopy can be used both to diagnose and to treat intrauterine pathologies. It is well known that hysteroscopy helps to improve reproductive outcomes by treating intrauterine pathologies. However, it is uncertain whether hysteroscopy is helpful in the absence of intrauterine pathologies. This study aimed to confirm whether hysteroscopy improves the reproductive outcomes of infertile women without intrauterine pathologies. Methods: We conducted a systematic review of 11 studies retrieved from Ovid-MEDLINE, Ovid-Embase, and the Cochrane Library. Two independent investigators extracted the data and used risk-of-bias tools (RoB 2.0 and ROBINS-I) to assess their quality. Results: Diagnostic hysteroscopy prior to in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) was associated with a higher clinical pregnancy rate (CPR) and live birth rate (LBR) than non-hysteroscopy in patients with recurrent implantation failure (RIF) (odds ratio, 1.79 and 1.46; 95% confidence interval, 1.40-2.30 and 1.08-1.97 for CPR and LBR, respectively) while hysteroscopy prior to first IVF was ineffective. The overall meta-analysis of LBR showed statistically significant findings for RIF, but a subgroup analysis showed effects only in prospective cohorts (odds ratio, 1.40 and 1.47; 95% confidence interval, 0.62-3.16 and 1.04-2.07 for randomized controlled trials and prospective cohorts, respectively). Therefore, the LBR should be interpreted carefully and further research is needed. Conclusion: Although further research is warranted, hysteroscopy may be considered as a diagnostic and treatment option for infertile women who have experienced RIF regardless of intrauterine pathologies. This finding enables nurses to educate and support infertile women with RIF prior to IVF/ICSI.

Chuna Manual Therapy for Carpal Tunnel Syndrome: A Systematic Review (손목 터널 증후군에 대한 추나요법의 효과: 체계적 문헌 고찰)

  • Park, Sun-Young;Lee, Sang-Hyun;Heo, In;Hwang, Eui-Hyoung
    • The Journal of Churna Manual Medicine for Spine and Nerves
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    • v.16 no.2
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    • pp.9-19
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    • 2021
  • Objectives This systematic review aimed to provide evidence for the effectiveness and safety of Chuna manual therapy (CMT) for carpal tunnel syndrome (CTS). Methods We searched 12 electronic databases (PubMed, Ovid-MEDLINE, EMBASE, The Cochrane Library, CNKI, CiNii, ScienceON, KMbase, KISS, OASIS, KMTANK, and RISS) up to the end of October 2021. We only included randomized controlled trials (RCTs) investigating CMT for the treatment of CTS. The methodological quality of the included RCTs was evaluated using the Cochrane Risk of Bias Tool 1.0. Results Six RCTs were eligible for inclusion in our study. A meta-analysis of four studies demonstrated positive results for the use of CMT when used in conjunction with Korean medicine treatment compared to those for Western conservative treatment for CTS. Conjunction treatment significantly improved the total efficacy rate compared to conservative treatment alone (P=0.0007, n=4). Conclusions There is reliable evidence for the use of CMT in treating CTS based on a published meta-analysis. To measure only the effect of Chuna, an experimental group should be designed with Chuna alone to evaluate its effectiveness. However, it should be noted that the studies included in this systematic review were heterogeneous and of low quality, thus warranting further investigation using well-designed RCTs.

Tissue Expanders in Staged Calvarial Reconstruction: A Systematic Review

  • Andrea Y. Lo;Roy P. Yu;Anjali C. Raghuram;Michael N. Cooper;Holly J. Thompson;Charles Y. Liu;Alex K. Wong
    • Archives of Plastic Surgery
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    • v.49 no.6
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    • pp.729-739
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    • 2022
  • Cranioplasties are common procedures in plastic surgery. The use of tissue expansion (TE) in staged cranioplasties is less common. We present two cases of cranioplasties with TE and systematically review literature describing the use of TE in staged cranioplasties and postoperative outcomes. A systematic review was performed by querying multiple databases. Eligible articles include published case series, retrospective reviews, and systematic reviews that described use of TE for staged bony cranioplasty. Data regarding study size, patient demographics, preoperative characteristics, staged procedure characteristics, and postoperative outcomes were collected. Of 755 identified publications, 26 met inclusion criteria. 85 patients underwent a staged cranioplasty with TE. Average defect size was 122 cm2, and 30.9% of patients received a previous reconstruction. Average expansion period was 14.2 weeks. The most common soft tissue closures were performed with skin expansion only (75.3%), free/pedicled flap (20.1%), and skin graft (4.7%). The mean postoperative follow-up time was 23.9 months. Overall infection and local complication rates were 3.53 and 9.41%, respectively. The most common complications were cerebrospinal fluid leak (7.1%), hematoma (7.1%), implant exposure (3.5%), and infection (3.5%). Factors associated with higher complication rates include the following: use of alloplastic calvarial implants and defects of congenital etiology (p = 0.023 and 0.035, respectively). This is the first comprehensive review to describe current practices and outcomes in staged cranioplasty with TE. Adequate soft tissue coverage contributes to successful cranioplasties and TE can play a safe and effective role in selected cases.

An Experimental Study on the Effectiveness of Storyboard Surrogates in the Meanings Extraction of Digital Videos (비디오자료의 의미추출을 위한 영상초록의 효용성에 관한 실험적 연구)

  • Kim, Hyun-Hee
    • Journal of the Korean Society for information Management
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    • v.24 no.4
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    • pp.53-72
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    • 2007
  • This study is designed to assess whether storyboard surrogates are useful enough to be utilized for indexing sources as well as for metadata elements using 12 sample videos and 14 participants. Study shows that first, the match rates of index terms and summaries are significantly different according to video types, which means storyboard surrogates are especially useful for the type of videos of conveying their meanings mainly through images. Second, participants could assign subject keywords and summaries to digital video, sacrificing a little loss of full video clips' match rates. Moreover, the match rate of index terms (0.45) is higher than that of summaries (0.40). This means storyboard surrogates could be more useful for indexing videos rather than summarizing them. The study suggests that 1)storyboard surrogates can be used as sources for indexing and abstracting digital videos; 2) using storyboard surrogates along with other metadata elements (e.g., text-based abstracts) can be more useful for users' relevance judgement; and 3)storyboard surrogates can be utilized as match sources of image-based queries. Finally, in order to improve storyboard surrogates quality, this study proposes future studies: constructing key frame extraction algorithms and designing key frame arrangement models.

A Study on Effectiveness of Socheongryong-tang for Allergic Rhinitis : A Systematic Review and Meta-analysis (알레르기 비염에 대한 소청용탕(小靑龍湯)의 효과 평가 연구 : 체계적 문헌고찰과 메타분석)

  • Min, Kyung-Jin;Shin, Seon-Ho;Kang, Jeong-In;Lee, Dong-Hyo
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.33 no.4
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    • pp.74-99
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    • 2020
  • Objectives : The purpose of this study is to assess the effectiveness and safety of Socheongryong-tang(SCRT) for allergic rhinitis(AR). Methods : We searched randomized controlled trials(RCTs) that used SCRT for AR in 8 databases(PubMed, Cochrane Library, CNKI, CiNii Articles, OASIS, NDSL, KISS, KMbase) from their inception until August 2019. The primary outcome was effective rate and scores evaluating the improvement of AR symptoms. The secondary outcome was quality of life scale, adverse events, recurrence rate, and laboratory indicators. Two researchers assessed the risk of bias in the included trials through the Cochrane Risk of Bias tool independently. The study synthesized outcomes using RevMan 5.3. Results : Eighteen RCTs involving 1686 participants were included in this review. The risk of bias was unclear for the majority of the included studies. Meta-analysis of 12 RCTs showed that there was no statistically significant difference between the SCRT group and usual care group in the effective rate(RR 1.18, 95% CI(0.98, 1.41), p=0.09, I2=46%). Meta-analysis of 5 RCTs showed that the combination treatment group of SCRT and usual care was significantly higher than the usual care group in the effective rate(RR 1.24, 95% CI(1.12, 1.38), p<0.0001, I2=0%). The SCRT group was more effective in improving nasal symptoms and quality of life than the placebo group according to one RCT. Mild adverse events such as dry mouth were identified in 5 RCTs, but no serious adverse events were reported. Conclusion : This review showed that in terms of the effective rate for AR, there was no statistically significant difference between SCRT and usual care and the combination treatment of SCRT and usual care was more effective than usual care. There were no serious adverse events. However, it is difficult to make a definite conclusion because of few included studies and heterogeneity between studies, and the quality of included studies was mostly insufficient. Further well-designed randomized controlled trials are needed.

Fast Image Pre-processing Algorithms Using SSE Instructions (SSE 명령어를 이용한 영상의 고속 전처리 알고리즘)

  • Park, Eun-Soo;Cui, Xuenan;Kim, Jun-Chul;Im, Yu-Cheong;Kim, Hak-Il
    • Journal of the Institute of Electronics Engineers of Korea SP
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    • v.46 no.2
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    • pp.65-77
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    • 2009
  • This paper proposes fast image processing algorithms using SSE (Streaming SIMD Extensions) instructions. The CPU's supporting SSE instructions have 128bit XMM registers; data included in these registers are processed at the same time with the SIMD (Single Instruction Multiple Data) mode. This paper develops new SIMD image processing algorithms for Mean filter, Sobel horizontal edge detector, and Morphological erosion operation which are most widely used in automated optical inspection systems and compares their processing times. In order to objectively evaluate the processing time, the developed algorithms are compared with OpenCV 1.0 operated in SISD (Single Instruction Single Data) mode, Intel's IPP 5.2 and MIL 8.0 which are fast image processing libraries supporting SIMD mode. The experimental result shows that the proposed algorithms on average are 8 times faster than the SISD mode image processing library and 1.4 times faster than the SIMD fast image processing libraries. The proposed algorithms demonstrate their applicability to practical image processing systems at high speed without commercial image processing libraries or additional hardwares.

A single-memory based FFT/IFFT core generator for OFDM modulation/demodulation (OFDM 변복조를 위한 단일 메모리 구조의 FFT/IFFT 코어 생성기)

  • Yeem, Chang-Wan;Jeon, Heung-Woo;Shin, Kyung-Wook
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2009.05a
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    • pp.253-256
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    • 2009
  • This paper describes a core generator (FFT_Core_Gen) which generates Verilog HDL models of 8 different FFT/IFFT cores with $N=64{\times}2^k$($0{\leq}k{\leq}7$ for OFDM-based communication systems. The generated FFT/IFFT cores are based on in-place single memory architecture, and use a hybrid structure of radix-4 and radix-2 DIF algorithm to accommodate various FFT lengths. To achieve both memory reduction and the improved SQNR, a conditional scaling technique is adopted, which conditionally scales the intermediate results of each computational stage, and the internal data and twiddle factor has 14 bits. The generated FFT/IFFT cores have the SQNR of 58-dB for N=8,192 and 63-dB for N=64. The cores synthesized with a $0.35-{\mu}m$ CMOS standard cell library can operate with 75-MHz@3.3-V, and a 8,192-point FFT can be computed in $762.7-{\mu}s$, thus the cores satisfy the specifications of wireless LAN, DMB, and DVB systems.

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