Browse > Article
http://dx.doi.org/10.6114/jkood.2020.33.4.074

A Study on Effectiveness of Socheongryong-tang for Allergic Rhinitis : A Systematic Review and Meta-analysis  

Min, Kyung-Jin (Na-Num Long-term Hospital)
Shin, Seon-Ho (Na-Num Long-term Hospital)
Kang, Jeong-In (3 Dep. of Ophthalmology, Otolaryngology and Dermatology, College of Korean Medicine, Woosuk University)
Lee, Dong-Hyo (3 Dep. of Ophthalmology, Otolaryngology and Dermatology, College of Korean Medicine, Woosuk University)
Publication Information
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology / v.33, no.4, 2020 , pp. 74-99 More about this Journal
Abstract
Objectives : The purpose of this study is to assess the effectiveness and safety of Socheongryong-tang(SCRT) for allergic rhinitis(AR). Methods : We searched randomized controlled trials(RCTs) that used SCRT for AR in 8 databases(PubMed, Cochrane Library, CNKI, CiNii Articles, OASIS, NDSL, KISS, KMbase) from their inception until August 2019. The primary outcome was effective rate and scores evaluating the improvement of AR symptoms. The secondary outcome was quality of life scale, adverse events, recurrence rate, and laboratory indicators. Two researchers assessed the risk of bias in the included trials through the Cochrane Risk of Bias tool independently. The study synthesized outcomes using RevMan 5.3. Results : Eighteen RCTs involving 1686 participants were included in this review. The risk of bias was unclear for the majority of the included studies. Meta-analysis of 12 RCTs showed that there was no statistically significant difference between the SCRT group and usual care group in the effective rate(RR 1.18, 95% CI(0.98, 1.41), p=0.09, I2=46%). Meta-analysis of 5 RCTs showed that the combination treatment group of SCRT and usual care was significantly higher than the usual care group in the effective rate(RR 1.24, 95% CI(1.12, 1.38), p<0.0001, I2=0%). The SCRT group was more effective in improving nasal symptoms and quality of life than the placebo group according to one RCT. Mild adverse events such as dry mouth were identified in 5 RCTs, but no serious adverse events were reported. Conclusion : This review showed that in terms of the effective rate for AR, there was no statistically significant difference between SCRT and usual care and the combination treatment of SCRT and usual care was more effective than usual care. There were no serious adverse events. However, it is difficult to make a definite conclusion because of few included studies and heterogeneity between studies, and the quality of included studies was mostly insufficient. Further well-designed randomized controlled trials are needed.
Keywords
Allergic Rhinitis; Socheongryong-tang(Xiaoqinglong-tang); Randomized controlled trials; Systematic Review; Meta-analysis;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Zhu ZM, Geng YA, Chen H. Modified Xiaoqinglong decoction for allergic rhinitis. Hubei Journal of TCM. 2004;26(5):38-9.
2 Jin DW. Observation on therapeutic effect of Xiaoqinglong decoction combined with zinc gluconate on 15 cases of allergic rhinitis. Inner Mongolia Journal of Traditional Chinese Medicine. 2010;6:31.
3 Chen P, Yan WH. The effect of Xiaoqinglong decoction on eosinophils in nasal secretion and serum IL-4 in patients with allergic rhinitis. Journal of New Chinese Medicine. 2010;42(11):58-60.
4 Chi LP. Observation on therapeutic effect of Xiaoqinglong decoction combined with acupuncture-moxibustion therapy on 30 cases of allergic rhinitis. J Pract Tradit Chin Med. 2012;28(7): 544-5.
5 Chen P. Xiaoqinglong decoction combined with nasal fumigation for 53 cases of allergic rhinitis. Henan Traditional Chinese Medicine. 2012;32(11):1433-5.
6 Liu Z, Ruan Y. Observation on therapeutic effect of modified Xiaoqinglong decoction combined with acupoint application for allergic rhinitis. Journal of North Pharmacy. 2014;11(2):24-5.
7 Li XR, Liu Y, Wang P, Kang HR, Zeng B, Xie C, et al. Efficacy of Xiao-qing-long-tang in Treatment of Allergic Rhinitis with Lung-qi Deficiency and Cold Syndrome. Journal of Chengdu Medical College. 2015;6:696-9.
8 Zhang AP. Clinical study on the TCM syndrome differentiation law of allergic rhinitis and modified Xiaoqinglong decoction. Chinese and Foreign Medical Research. 2016;14(34):106-8.
9 Du EG. Clinical effect of the Xiaoqinglong decoction on allergic rhinitis of the Feiqi Xuhan type. Clinical Journal of Chinese Medicine. 2017;9(36):42-4.
10 Chen DF, Zhang ZL, Xiao HB, Xiao LH. Analysis of clinical effect of "five steps of differentiating Yang Deficiency" and "Xiaoqinglong decoction with Pulvis Aconiti Tuberis" in treating allergic rhinitis. China Prac Med. 2017;12(14):128-9.
11 Wang CQ, Chai MS. Therapeutic effect of Xiao Qing Long decoction on allergic rhinitis. Medical Information. 2018;31(4):141-2.
12 Zhu M, Fei B. Observation on the effect of Xiaoqinglong mixture in adjuvant treatment of allergic rhinitis in children. Journal of Pediatric Pharmacy. 2011;17(6):60.
13 Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008. Allergy. 2008;63(Suppl. 86):8-160.   DOI
14 Bousquet J, Van Cauwenberge P, Khaltaev N. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol. 2001;108(Suppl. 5):S147-S334.   DOI
15 Brozek JL, Bousquet J, Baena-Cagnani CE, et al. Allergic Rhinitis and its Impact on Asthma(ARIA) guidelines: 2010 revision. J Allergy Clin Immunol. 2010;126:466-76.   DOI
16 Xu L. The effect of Xiaoqinglong decoction for allergic rhinitis. Chin Med J Metall Indus. 2018;35(3):332-3.
17 Li YJ, Hui P, Fan FC. The clinical obsevation on 42 cases of allergic rhinitis and asthma treated with modified Xiaoqinglong decoction. Hebei Medicine. 2005;11(6):560-2.   DOI
18 Chai BX. Modified Xiaoqinglong decoction for the treatment of 18 cases of allergic rhinitis. Shandong Journal of Traditional Chinese Medicine. 2013;32(9):636-7.
19 Zhang ZM, Li GY, Chen XJ, Fu YQ. The clinical research into allergic rhinitis treated with Xiao Qinglong decoction. Henan Traditional Chinese Medicine. 2015;35(8):1743-5.
20 Wu ZM, Li RF. Observation on therapeutic effect of combination of Traditional Chinese Medicine with Western Medicine on allergic rhinitis. Journal of New Chinese Medicine. 2015;47(12):173-4.
21 Healthcare Bigdata Hub[Internet]. 2019.05.04.[cited 2019 May 04]. Available from: URL:http://opendata.hira.or.kr/op/opc/olapHifrqSickInfo.do
22 Canonica GW, Holgate S, Karlsson G, Lobaton P, Mosges R, O'Hanlon J, et al. The impact of allergic rhinitis on quality of life and other airway diseases. Allergy. 1998;53(Suppl. 41):7-30.
23 Leonard B. Complementary and alternative therapies for allergic rhinitis and conjunctivitis. UpToDate(last updated: Jun 20, 2018).[cited 2019 Nov 24]. Available from: URL :http://www.uptodate.com/contents/complementary-and-alternative-therapies-for-allergic-rhinitis-and-conjunctivitis
24 Co-authored by Herbal Formula Science Professors, College of Korean Medicine. Herbal Formula Science. Seoul:Younglim Books. 2003.
25 Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in metaanalyses. BMJ. 2003;327(7414):557-60.   DOI
26 Korean Statistical Information Service [Internet]. 2019.12.03.[cited 2019 Dec 3]. Available from:URL:http://kosis.kr/statHtml/statHtml.do?orgId=117&tblId=DT_11702_N118&conn_path=I2
27 Juniper EF. Quality of life in adults and children with asthma and rhinitis. Allergy. 1997;52(10):971-7.   DOI
28 David AD, Catherine MB, R Van Harrison, Christine LH, Lauren MR, Tami LR, et al. University of Michigan Health System(UMHS) Allergic Rhinitis Guideline. Michigan: University of Michigan. 2013:1-17.
29 Rapiejko P, Jurkiewicz D, Pietruszewska W, Zielnik-Jurkiewicz B, Woron J, Lipiec A. Treatment strategy of allergic rhinitis in the face of modern world threats. Otolaryngol Pol. 2018;72(2):1-12.   DOI
30 Seidman MD, Gurgel RK, Lin SY, Schwartz SR, Baroody FM, Bonner JR, et al. Clinical practice guideline: Allergic rhinitis. OTO Open. 2015;152(1_Suppl):S1-S43.
31 Yonekura S, Okamoto Y, Sakurai D, Sakurai T, Iinuma T, Yamamoto H, et al. Complementary and alternative medicine for allergic rhinitis in Japan. Allergol Int. 2017;66(3):425-31.   DOI
32 Xue CC, Thien FC, Zhang JJ, Da Costa C, Li CG. Treatment for seasonal allergic rhinitis by Chinese herbal medicine: a randomized placebo controlled trial. Altern Ther Health Med. 2003;9:80-7.
33 Hu G, Walls RS, Bass D, Ramon B, Grayson D, Jones M, et al. The Chinese herbal formulation biminne in management of perennial allergic rhinitis: a randomized, double-blind, placebo-controlled, 12-week clinical trial. Ann Allergy Asthma Immunol. 2002;88:478-87.   DOI
34 Korean Medicine Encyclopedia Compilation Committee. Korean Medicine Encyclopedia. Seoul:Jeongdam Books. 2001.
35 Kim MH, Hong SU, Kim HT, Seo HS, Kim K, Ko SG, et al. A multicenter study on the efficacy and safety of So-Cheong-Ryong-Tang for perennial allergic rhinitis. Complement Ther Med. 2019;45:50-6.   DOI
36 Ng DK, Chow PY, Ming SP, Hong SH, Lau S, Tse D, et al. A double-blind, randomized, placebo-controlled trial of acupuncture for the treatment of childhood persistent allergic rhinitis. Pediatrics. 2004;114:1242-7.   DOI
37 Kim YE, Jeong UM, Lee DH. A Survey on Treatment Trend for Allergic Rhinitis in Korean Medicine Clinic. J Korean Med Ophthalmol Otolaryngol Dermatol. 2017;30(4):75-96.   DOI
38 Kim MH, Ko Y, Ahn JH, Yun Y, Yun MN, Ko SG, et al. Efficacy and safety of So-Cheong-Ryong-tang in treatment of perennial allergic rhinitis: study protocol for a double-blind, randomised, parallel-group, multicentre trial. BMJ Open. 2017;7(9):e016556.   DOI
39 Kim IH, Ku JM, Hur HS, Na CH, Jang BH, Shin YC, et al. Anti-allergic effects of So-Cheong-Ryong-Tang in ovalbumin-induced allergic rhinitis model. Journal of Society of Preventive Korean Medicine. 2014;18(3):69-80.
40 Wang B, Shen Q. Meta-analysis of Xiaoqinglong Decoction in Treating Allergic Rhinitis. China Journal of Chinese Medicine. 2015;30:665-7.
41 Kang H. Statistical Considerations in Meta-Analysis. Hanyang Medical Reviews. 2015;35(1):23-32.   DOI
42 Otolaryngology Branch of Chinese Medical Association, Chinese Journal of Otorhinolaryngology Editorial Committee. Attachment: Diagnostic criteria and efficacy evaluation criteria for allergic rhinitis (revised in 1997, Haikou). Chin J Otorhinolaryngol. 1998;33(3):134-5.