• 제목/요약/키워드: library 1.0

검색결과 867건 처리시간 0.027초

No association Between Calcium Channel Blockers and Survival in Patients with Cancer: A systematic Review and Meta-analysis

  • Sun, Hong;Zhuang, Rong-Yuan;Li, Tao;Zheng, Yuan-Ting;Cai, Wei-Min
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권8호
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    • pp.3917-3921
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    • 2016
  • Background: The association between calcium channel blockers (CCBs) and survival in cancer patients remains unclear and the results of related studies are conflicting. The objective of the study was to investigate the association between calcium channel blockers (CCBs) use and survival in cancer patients. Materials and Methods: We searched PubMed, EMBASE, Web of Science and Cochrane Library for studies published before January 2016 with the terms related to CCBs and survival in cancer patients. The information was reviewed and extracted by two evaluators independently. Data of publications was extracted and calculated into hazard ratios (HRs) for overall survival (OS). Statistical analysis was performed by using Review Manager 5.3. Results: There were 11 studies included in our meta-analysis. Analysis of all studies showed that CCBs use was not associated with survival in cancer patients (HR=1.07; 95% CI: 0.91-1.25; P=0.42). No association between CCBs use and overall survival in cancer patients was existed whether in Asian (HR=1.18, 95% CI: 0.72-1.93; P=0.52) or Caucasian population (HR=1.03, 95% CI: 0.89-1.20; P=0.66). Conclusions: There is no evidence that CCBs use is associated with a better or worse outcome of survival in cancer patients.

당뇨병성 망막병증에 대한 보양환오탕(補陽還五湯)의 효과: 체계적 문헌 고찰 및 메타분석 (The Effect of Boyanghwano-tang for Diabetic Retinopathy: A Systematic Review and Meta-Analysis)

  • 오정화;김혜나;윤화정
    • 한방안이비인후피부과학회지
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    • 제36권4호
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    • pp.51-69
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    • 2023
  • Objectives : The purpose of this study is to assess the effect of using Boyanghwano-tang(BYHWT) for diabetic retinopathy. Methods : We searched randomized controlled trials(RCTs) that used BYHWT for diabetic retinopathy in 10 databases(RISS, KISS, ScienceON, KCI, OASIS, DBpia, CNKI, Wanfang Database, PubMed, Cochrane Library) on August 12, 2023. Outcome measurements included total effective rate(TER) and visual acuity as the primary outcome measurements, and the secondary outcome measurements included fasting blood glucose(FBG), 2hPG, HbA1c, ET-1, NO, etc. The indicator of stability included adverse reactions. A meta-analysis was conducted according to TER, visual acuity, FBG. Results : A total of 8 randomized control trials were selected. The treatment group which used BYHWT showed significant improvement effects in TER and visual acuity compared to the control group which used western medicine or chinese patent medicine alone. TER: (RR: 1.22, CI 1.14 to 1.31, P=<0.00001), visual acuity: (RR: 2.06, CI 1.40 to 3.03, P=0.0002). Secondary outcome measurements including FBG also showed improvement in the treatment group compared to the control group. FBG: (MD: -0.15, CI -0.43 to 0.31, P=0.28). Adverse reactions were only mentioned in one study, which showed that no adverse reactions occurred in both the treatment and control groups. Conclusions : This study suggests that BYHWT is effective for diabetic retinopathy. However these findings should be interpreted cautiously due to the insufficient number of studies and unknown or high risk of bias in the included trials.

EPC RFID 프로토콜 제너레이션 2 클래스 1 태그 디지털 코덱 설계 (Design of Digital Codec for EPC RFID Protocols Generation 2 Class 1 Codec)

  • 이용주;조정현;김형규;김상훈;이용석
    • 한국통신학회논문지
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    • 제31권3A호
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    • pp.360-367
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    • 2006
  • 본 논문에서는 RFID 표준 중의 하나인 EPC 글로벌 제너레이션 2 클래스 1(EPC global generation 2 class 1) 태그의 설계에 대하여 논하였다. RFID 표준에 관한 연구나 충돌 방지(anti-collision) 알고리즘에 관한 연구는 많이 진행이 되었지만 태그디지털 코덱 아키텍처 하드웨어의 구체적인 설계에 관한 논문은 아직 없는 실정이기 때문에 본 논문에서 연구하게 되었다. 본 논문의 목적은 RFID 태그 블록의 구성 및 기능설계에 관한 연구를 함으로써 대략적인 전력소모, 하드웨어 크기 등에 대한 방향을 제시하고있다. 스탠더드 셀 라이브러리 합성방식을 사용하여 합성한 결과 설계된 디지털 코덱의 크기는 111640.328125개(인버터 개수)였고 소모 전력은 동적 소모 전력을 기준으로 10.3575uW로 추정되었다. 풀커스텀(full-custom)방식을 사용할 경우, 더욱 개선된 효과를 발휘할 것으로 보인다.

A Plausible Method for the Diagnosis of Genetic Disorders Using Full Length cDNA

  • Hur, Hyang-Suk;Lee, Young-Won;Park, Hyoung-Woo;Kim, Myoung-Hee
    • 대한의생명과학회지
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    • 제7권1호
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    • pp.1-5
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    • 2001
  • A cDNA of coagulation Factor IX gene has been screened from the $\lambda$gt11 human fetal liver cDNA library, and used to construct a 2.8-kb full length cDNA after recombining with the N-terminal fragment from pTZ-FIX. Human genomic DNA was isolated, digested with the restriction endonucleases, TaqI, EcoRI, and HindIII, and Southern hybridization was performed using the full length factor IX cDNA as a probe. The hybridized bands generated by the restriction endonucleases were the followings: TaqI, 0.3, 1.0, 1.6, 1.8, 2.7, 3.7, and 5.3 kb bands; EcoRI, 1.8, 4.8, 4.9, 5.5, 6.8, and 12.6 kb bands; HindIII, 4.1, 4.4, 5.2, 5.8, 7.6, and 12.5 kb bands. When the Southern bands were physically mapped along the genome, about 50-kb continuous region harboring almost all of the genomic region of Factor Ⅸ gene was covered. These results suggest a possibility of using an exonal cDNA probe to diagnose abnormalities including large deletions, insertions, and rearrangements along the genome, if there is any.

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수술 환아의 불안에 적용한 비약물적 중재의 효과: 체계적 문헌고찰 및 메타분석 (The Effectiveness of Non-pharmacological Interventions on Anxiety in Children Undergoing Surgery: A Systematic Review and Meta-analysis)

  • 김현영;신선화
    • 동서간호학연구지
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    • 제27권1호
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    • pp.1-13
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    • 2021
  • Purpose: The purpose of this study was to examine the effectiveness of non-pharmacological interventions for reducing perioperative anxiety in children undergoing surgery. Methods: A systematic review of randomized controlled trials (RCTs) with the primary outcome of children's perioperative anxiety was conducted. The literature search was performed using various databases, including Cochrane Library, CINAHL, EMBASE, PubMed, and Korean electronic databases with confined to RCTs between 2000 and 2020. A total of sixteen studies were suitable the inclusion criteria and were systematically reviewed. The bias risk of randomized studies was evaluated using Cochrane's risk of bias tool. For the meta-analysis, RevMan 5.4 was used to analyze effect sizes of interventional factors. Results: Finally, twelve RCTs studies were used for meta-analysis. The non-pharmacological interventions implemented to reduce perioperative anxiety in children were therapeutic play, clown therapy and information provision. First, therapeutic play had a significant effect on reducing preoperative anxiety, with an effect size of -1.46 (95% CI=-1.78~-1.14). Second, clown therapy had a significant effect on reducing preoperative anxiety, with an effect size of -0.97 (95% CI=-1.45~-0.49). Finally, the provision of information had a significant effect on reducing preoperative anxiety, with an effect size of -0.75 (95% CI=-0.99~-0.51). Conclusion: This meta-analysis suggests that non-pharmaceutical interventions provide effective methods of reducing perioperative anxiety in children. Therefore, the findings verify evidence that various non-pharmacological interventions are effective means for reducing children's preoperative anxiety.

도서관경영(圖書館經營)에 있어서의 시스팀 분석기법응용(分析技法應用)에 관한 연구(硏究) (A Study on Systems Analysis Applied to Library Management)

  • 권기원
    • 한국비블리아학회지
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    • 제2권1호
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    • pp.178-210
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    • 1974
  • It needs to put into practice the systems analysis in the analysis of some operations and status of library for the purpose of systematizing the work of reforming in the new easier form to process, to storage, to retrieve and to make use of the increasing informations and data of library. In this study, some of systems which are generally using in every library was caught in the case study of K university library. Having analyzed them with the two methods of the flowcharting and mathematical analysis, we found the obstructive factors in operation. As the result of this research, it was gained the new system as the alternative one. A. Alternative System B. Advantages of alternative systems 1. In the reference room When it converts the present system into the new system, it can profit 6.771 won/user (13.815won-7.044won=6.771 won). Therefore, a half the average required cost of the present system can be saved. If this saving would be alloted for the cost 33,000won required to make the cataloging cards, it would be taken for 94 days (33,000 won ${\div}$ 6,771 won/user=4,874users. 4,874users ${\div}$ 52users/day=94days) to get it. The saving cost/year by the new system will be 95,417 won, and in the first year the initial cost (33,000won) reduces the saving cost to 62,417won. 2. In the periodical room The average required time for using the materials of the present system is 17 minutes/user and the average required cost/user is 23.775won, while the average required time of the new system is 4 minutes and the average required cost/user is 5.33won. Therefore, the new system has profit 4 times of the present system. Accordingly, it occurs when the dispersed periodical materials get together. 3. In the classification and cataloging When one processes - the oriental books - by the Linear Programming Technique, the maximum of the process can be increased from 11.6 volumes per librarian of the present system to 12 volumes per librarian of the new system increased 0.4 volume in a day, and cataloging by the manual printer can be shorten from 3 minutes per card of the present system to 1.5 minutes per card of the new system. Consequently, we can complete the other operations (books equipment, updating of cataloging cards, etc.) with 141 minutes which are saved in the course of the afore-mentioned works. 4. In the status of collections The average growth rate of 4 years from 1968 to 1971 is 9.825 %, and that of the purchased materials is 6.2% similar to the advanced nations, but it has the different position from 215,000 volumes by the Standard Degree for Establishment of College and University, and the difference between the total collections 151,671 volumes and Dunns' growth model ($N_t=N_oe^{-at}$) claimed by Leimkuhler 155,297 volumes in 1971 is 3,626 volumes, and for the purpose of compensation the difference, we found the fact that it needs to have the increased budget of 24~30% per year, Thus, if the budget of 24~30 % per year. Thus, if the budget would be increased per year as the rate of the afore-mentioned figure, it would be reached at the Standard Degree for Establishment of College and University in 1975, and thereafter, it can be decreased to the lebel which is able to maintain the growth rate of 5~6% per year.

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홍화(Carthamus tinctorius L.)씨의 sterol 및 Phytoestrogen 분석 (Sterol Composition and Phytoestrogen Activity of Safflower(Carthamus tinctorius L.) Seed)

  • 최영주;최상욱
    • 생명과학회지
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    • 제13권4호
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    • pp.529-534
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    • 2003
  • 홍화씨가 골절, 골다공증 및 골형성부전증 등의 골 질환 치료에 효과가 있다는 것이 알려져 민간요법으로 사용되고 있으나 홍화씨의 어떤 성분이 이러한 작용을 하는지에 관해서는 거의 밝혀져 있지 않다. 본 연구에서는 흥화씨의 sterol 조성을 분석하고 폐경기 여성들의 골다공증 치료에 사용되고 있는 합성 estrogen 대체물질로써 그 기능이 확인된 phytoestrogen 활성을 측정하였다. Cholesterol에서 성호르몬인 estrogen이 합성되는 것처럼 식물 sterol 도 phytoestrogen 합성을 위한 전구체 작용을 하는 것으로 알려져 있다. 홍화씨에 존재하는 식물성 sterol은 stigmast-5-en-3-ol (3$\beta$, 24S)-form인 ${\gamma}$-sitosterol (clionasterol)로 확인되었으며 홍화에 존재하는 식물성 sterol의 함량은 총지질의 약 4%를 함유하였다. 홍화씨의 sterol 분석은 GC-MS와 Wiley MS spectrum library를 사용하여 분석하였으며 홍화씨에 존재하는 중요한 4-desmethyl sterols 에는 sitosterol 만이 확인되었다. 홍화씨의 식물성 estrogen 효과는 $\beta$-estradiol ($10^{-8}$ M)의 활성을 1로 했을 때 홍화씨의 에탄을 층(5 mg/ml) 및 메탄올 층(5 mg/ml)에서 각각 0.37과 0.43으로 estrogen 유사효과를 나타내었다(ANOVA p<0.001). 홍화씨에 포함된 estrogen에 의한 전사활성 촉진은 MCF7/pDS-CAT-ERE119-Ad2MLP system을 사용하여 estrogen수용체와 reporter gene 발현을 이용하는 방법으로 세포에 직접 처리함으로써 phytoestrogen 활성을 측정할 수 있었다.

오픈 피어 리뷰 환경에서 학술 논문 심사 결과와 영향력 지표 간의 관련성에 관한 연구 (A Study on the Relationship between the Review Results of Articles and Impact Metrics in an Open Peer Review Platform)

  • 조재인;박종도
    • 한국문헌정보학회지
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    • 제57권2호
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    • pp.79-96
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    • 2023
  • 본 연구는 대표적인 OPR(Open Peer Review) 플랫폼인 F1000Research에서 사회과학분야의 논문 585건을 대상으로 개방형 동료 심사 결과를 분석하고 피인용, 알트메트릭스와 어떠한 관련성을 보이는지 확인하였다. 더불어 논문의 활용이 피인용에 미치는 영향 관계 내에서 심사 점수가 조절효과(Moderating effect)를 나타내는지 검증함으로써, OPR 환경에서 고품질로 평가된 논문이 피인용을 촉진할 수 있는지 확인하였다. 분석 결과 첫 번째, 승인과 조건부 승인된 논문 그룹 간에 피인용 횟수에 유의미한 차이가 나타나지 않았지만, 환산된 심사 점수와 피인용 횟수는 유의한 정(+)의 상관성(r= 0.40 ~ 0.60)을 나타냈다. 두번째, 심사 점수는 알트메트릭스와도 약한 상관성을 나타내 심사자의 품질 평가 결과는 피인용과 사회적 영향을 약하게 예측할 수 있는 것으로 분석되었다. 마지막으로 심사 점수는 논문의 활용을 피인용으로 이어지게 하는데 유의한 양의 방향의 조절효과 (B=1.69, P < 0.01)를 수행하며, 조건부 효과 검사 결과 가장 고품질로 평가된 논문 집단에서 가장 큰 효과(B=11.32, 95% CI [10.57, 12.08])를 나타내는 것으로 검증되었다. 따라서 공개된 심사 결과는 연구자들의 우수 논문 선별을 도와 인용을 유도하는데 도움을 줄 수 있는 것으로 파악되었다.

Mini-transposon을 사용한 단백질의 세포내 분포 결정

  • 최의열
    • 한국응용약물학회:학술대회논문집
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    • 한국응용약물학회 1993년도 제2회 신약개발 연구발표회 초록집
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    • pp.134-134
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    • 1993
  • Tn3 Transposon을 이용한 Shuttle Mutagenesis방법으로 효모의 Genome 상에 무작위적으로 $\beta$-gal 표지 유전자를 삽입하고 효모생활사의 각 세포시기 마다 특이하게 발현되는 유전자를 X-Gal plate상에서 찾아내고 이들 효모 유전자의 단백질이 세포내에 어떤 위치에 분포하는가를 간접 면역현미경법으로 추적해보았다. 먼저 효모의 genomic library를 38bp의 Tn3 Termial repeat를 가지고 있지 않은 pHSS6 Vector에 patial fill-in 방법으로 조성하였으며 최종적으로 20 Genome equivalent에 해당하는 18개 Pool의 genomic library를 만들었다. 이들 library를 조사하여 본 결과 모든 클론이 평균 3kb 크기의 insert를 가지고 있었으며 이는 99.99%의 효묘 genome을 대표하였다. 특정한 유전자의 발현을 알아보기 위해 먼저 mini-Tn3로 shuttle mutagenesis를 실시하고 vegetative growth동안 발현되는 유전자를 X-gal을 사용하여 골라내었다. 지금까지 16823개의 클론을 조사하였는데 이중 13%에 해당하는 2187개가 X-gal plate상에서 양성반응을 보여주었다. 양성반응을 보여주는 융합단백질의 세포내 분포틀 anti-$\beta$-galactosidase 항체를 사용하여 추적해보았다. 항체론 이용한 형광염색결과 약 70%의 세포가 background이상의 염색을 보여주었으며 이중 novel한 염색 pattern을 나타내는 클론도 다수 탐지되었다. 이상의 결과를 종합하면 Tn3틀 이용한 Shuttle Mutagenesis 방법으로 지금까지 전통적인 유전학적인 접근 방식으로 탐지되지 않았던 다수의 새로운 효모 유전자를 찾아낼 수 있을 것으로 사료된다.tamine제중 triprolidine이 $K_{M}$ /K$_{H}$ 비가 가장 높았고 diphenidol이 가장 낮았다. 이상의 결과로 보아 항 histamine제의 muscarinic receptor 차단작용은 이들 약물의 항 alleragy 효과에 필요한 작용이 아니며 본 실험에서 추정된 항 histamine제의 H$_1$-receptor와 muscarinic receptor에 대한 상대적 역가는 이들 약물의 선택과 평가에 중요한 지표가 될수 있을 것으로 생각된다.ing ischemic insults. The nature of the receptor is being explored by molecular genetic techniques, and we have recently cloned two of the major subunits; some of the data will be presented.LIFO, 우선 순위 방식등을 선택할 수 있도록 확장하였다. SIMPLE는 자료구조 및 프로그램이 공개되어 있으므로 프로그래머가 원하는 기능을 쉽게 추가할 수 있는 장점도 있다. 아울러 SMPLE에서 새로이 추가된 자료구조와 함수 및 설비제어 방식등을 활용하여 실제 중형급 시스템에 대한 시뮬레이션 구현과 시스템 분석의 예를 보인다._3$", chain segment, with the activation energy of carriers from the shallow trap with 0.4[eV], in he amorphous regions.의 증발산율은 우기의 기상자료를 이용하여 구한 결과 0.05 - 0.10 mm/hr 의 범위로서 이로 인한 강우손실량은 큰 의미가 없음을 알았다.재발이 나타난 3례의 환자를 제외한 9례 (75%)에서는 현재까지 재발소견을 보이지 않고 있다.

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새로운 알츠하이머 치료제의 안전성 유효성에 관한 체계적 문헌고찰 (Systemic Literature Review Study on the Efficacy and Safety of Novel Alzheimer's Disease Treatments)

  • 박신웅;장하린;손현순;심미경
    • 한국임상약학회지
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    • 제33권4호
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    • pp.290-304
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    • 2023
  • Background: Innovative Alzheimer's disease drugs received approval in the United States in 2021 and 2023. This study aims to assess the safety and efficacy of these novel treatments, elucidate their mechanisms of action, and compare their impact on cognitive function improvement with approved drugs. Methods: We conducted a comprehensive search of pivotal clinical studies related to Alzheimer's disease treatments in PubMed/Medline, Embase, and the Cochrane Library databases from January 1st, 2020 to December 31st, 2022. Meta-analysis was performed using RevMan 5.4 software. Results: A total of 14 studies were included in this systematic review. When compared to the placebo, the new drugs did not exhibit a statistically significant effect on MMSE (Mini-Mental State Examination) (mean difference= -0.04, 95% confidence intervals [CIs]: -0.31, 0.23, N=3662, I2=0%). However, they demonstrated a significant impact on ADAS-cog (Alzheimer's Disease Assessment Scale-Cognitive Subscale) (standardized mean difference= -0.15, 95% CIs: -0.2, -0.1, N=6710, I2=17%). When compared to the approved drugs, the new drugs showed a statistically significantly lower effect on MMSE (test for subgroup difference Chi2=23.13, N = 5870, p<0.00001) but showed only a trend of decreased efficacy on ADAS-cog (Chi2=1.16, N = 8670, p=0.28). Conclusion: New drugs yielded diverse clinical endpoint results compared to the placebo, and in comparison to existing approved drugs, they exhibited lower efficacy in improving cognitive function. The safety profile of these new drugs, as reported in clinical trials, was generally well-tolerated.