• Journal of Chest Surgery
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• 제35권9호
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• pp.659-663
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• 2002

이 논문은 비소세포폐암으로 새로이 진단 받은 환자에서 수술 전 병기판정에 통상적으로 골 스캔의 유용성에 대하여 연구하였다. 대상 및 방법: 서울대병원에서 2000년 1월부터 12월까지 비소세포 폐암으로 진단 받은 환자 258명을 대상으로 하였다. 수술 전 병기는 과반수에서(132명) 수술이 불가능할 정도로 진행된 상태였다. 골 원격전이의 임상 평가 항목으로 증상, alkaline phosphatase, calcium 등을 채택하였고 모든 환자의 골 스캔 결과를 검토하여, 각각의 민감도, 특이도, 음성 예측률, 양성 예측률을 산출하였다. 최종적인 골 전이의 판단은 일반 X-lay나 MRI 또는 골 생검을 기준으로 하였다. 골 전이만 없다면 수술이 가능한 (“potentially operable”)환자 126명의 임상 경과를 따로 분석하여 수술 대상 환자에서 골 전이에 대한 임상 평가의 중요성을 검토하였다. 결과: 골 전이에 대한 골 스캔의 민감도는 96%, 특이도는 75% 양성 예측률은 44%, 음성 예측률은 99%였고, 골 스캔에 대한 임상 평가의 민감도, 특이도, 양성 예측률, 음성 예측률은 각각 54%, 73%, 54%, 72%였다. 골 전이에 대한 임상 평가의 경우는 80%, 70%, 38%, 94%였다. 골 전이만 배제하면 수술이 가능하였던 “potentially operable”군 환자 126명에서 골 전이에 대한 임상 평가의 음성 예측률은 99%였다. 결론: 폐암 진단 당시 병기 결정에 있어서, 골 전이에 대한 철저한 임상 평가가 필수적이다. 특히 골 전이 외에 다른 수술 불가능 요인이 없는 환자군에서 임상 평가 결과 특이사항이 없을 경우 골 전이의 확률이 매우 낮아, 통상적인 골 스캔 없이도 근치적 수술을 고려할 수 있음을 확인하였다. 그러나 임상 평가 결과 양성인 경우에는 약 30% 이상의 환자에서 골 전이가 발견되므로 골 전이를 발견하기 위한 골 스캔은 물론 다른 여러 가지 진단법을 적극적으로 검토해야 한다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2010년도 제39회 하계학술대회 초록집
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• pp.173-173
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• 2010

$Bi_4Ti_3O_{12}$ ($B_4T_3$) is a unique ferroelectric material that has a relatively high dielectric constant, high Curie temperature, high breakdown strength, and large spontaneous polarization. As a result this material has been widely studied for many applications, including nonvolatile ferroelectric random memories, microelectronic mechanical systems, and nonlinear-optical devices. Several reports have appeared on the use of Mn dopants to improve the electrical properties of $B_4T_3$ thin films. Mn ions have frequently been used for this purpose in thin films and multilayer capacitors in situations where intrinsic oxygen vacancies are the major defects. However, no systematic study of the optical properties of $B_4T_3$ films has appeared to date. Here, we report optical data for these films, determined by spectroscopic ellipsometry (SE). We also report the effects of thermal annealing and Mn doping on the optical properties. The SE data were analyzed using a multilayer model that is consistent with the original sample structure, specifically surface roughness/$B_4T_3$ film/Pt/Ti/$SiO_2$/c-Si). The data are well described by the Tauc-Lorentz dispersion function, which can therefore be used to model the optical properties of these materials. Parameters for reconstructing the dielectric functions of these films are also reported. The SE data show that thermal annealing crystallizes $B_4T_3$ films, as confirmed by the appearance of $B_4T_3$ peaks in X-ray diffraction patterns. The bandgap of $B_4T_3$ red-shifts with increasing Mn concentration. We interpret this as evidence of the existence deep levels generated by the Mn transition-metal d states. These results will be useful in a number of contexts, including more detailed studies of the optical properties of these materials for engineering high-speed devices.

• KIEAE Journal
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• 제17권3호
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• pp.75-81
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• 2017

Purpose: The energy consumption of apartment units is affected by the lifestyle of the residents rather than system technology. In this study the numerical analysis of assumed energy consumption correlation factors with arbitrary value due to uncertainty. It is intended to be used as a simulation correction value which can be utilized as a predicted value of actual energy usage. The correction value of the simulation is set in the developed form of the existing process that derives the actual usage amount. The simulation results used in the existing evaluation system are used to maintain the useful value as the current system evaluation scale and predict the actual capacity. Method: The method of the study is to statistically analyze the data frames of all complexes capable of collecting the annual energy usage and to reconstruct the population by adding the variables that are expected to be correlated. Repeat the data frame configuration with variables that are assumed to be highly correlated with energy use levels. Determine whether there is correlation or not. The intensity of the external characteristics of the building equipment related to the energy consumption is presented as the quantitative value. Result: The correlation between electricity consumption and trading price since 2010 is analyzed as (Correlation coefficient 0.82). These results are higher than (Correlation coefficient 0.79), which is the correlation between residential area and trading price. This paper signifies the starting point of the methodology that broadens the field of view of verification of simulation feasibility limited to the prediction technique focused on the simulation tool and the element technology scope.The diversified phenomenon reproduction method develops the existing energy simulation method.It can be completed with a simulation methodology that can infer actual energy consumption.

• 수면정신생리
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• 제5권2호
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• pp.119-133
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• 1998

Attentional processes facilitate cognitive and behavioral performance in several ways. Attention serves to reduce the amount of information to receive. Attention enables humans to direct themselves to appropriate aspects of external environmental events and internal operations. Attention facilitates the selection of salient information and the allocation of cognitive processing appropriate to that information. Attention is not a unitary process that can be localized to a single neuroanatomical region. Before the cortical registration of sensory information, activation of important subcortical structures occurs, which is called as an orienting response. Once sensory information reaches the sensory cortex, a large number of perceptual processes occur, which provide various levels of perceptual resolution of the critical features of the stimuli. After this preattentional processing, information is integrated within higher cortical(heteromodal) systems in inferior parietal and temporal lobes. At this stage, the processing characteristics can be modified, and the biases of the system have a direct impact on attentional selection. Information flow has been traced through sensory analysis to a processing stage that enables the new information to be focused and modified in relation to preexisting biases. The limbic and paralimbic system play significant roles in modulating attentional response. It is labeled with affective salience and is integrated according to ongoing pressures from the motivational drive system of the hypothalamus. The salience of information greatly influences the allocation of attention. The frontal lobe operate response selection system with a reciprocal interaction with both the attention system of the parietal lobe and the limbic system. In this attentional process, the search with the spatial field is organized and a sequence of attentional responses is generated. Affective, motivational and appectitive impulses from limbic system and hypothalamus trigger response intention, preparation, planning, initiation and control of frontal lobe on this process. The reticular system, which produces ascending activation, catalyzes the overall system and increases attentional capacity. Also additional energetic pressures are created by the hypothalamus. As psychophysiological measurement, skin conductance, pupil diameter, muscle tension, heart rate, alpha wave of EEG can be used. Event related potentials also provide physiological evidence of attention during information process. NI component appears to be an electrophysiological index of selective attention. P3 response is developed during the attention related to stimulus discrimination, evaluation and response.

• 대한한방내과학회지
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• 제42권5호
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• pp.846-852
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• 2021

Objective: This study evaluated a clinical case of a patient with Rovazet-induced abnormal liver function treated with intradermal acupuncture. Method: A 59-year-old woman with abnormal liver function induced by Rovazet ceased taking the drug and instead received intradermal acupuncture treatment. After 15 days, clinical symptoms and laboratory test results were evaluated. Results: Aspartate aminotransferase and alanine aminotransferase levels decreased, and clinical symptoms such as nausea and fatigue improved after treatment with intradermal acupuncture and cessation of the Rovazet. Conclusion: This study meaningfully examined a clinical case of a patient with abnormal liver function induced by a lipid-lowering agent, which is uncommon in Korea. Unfortunately, the lack of clear evidence and the use of only one case are limitations of the study.

• Journal of Veterinary Science
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• 제23권1호
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• pp.16.1-16.13
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• 2022

Background: Xylazole (Xyl) is a veterinary anesthetic that is structurally and functionally similar to xylazine. However, the effects of Xyl in vitro remain unknown. Objectives: This study aimed to investigate the anesthetic mechanism of Xyl using fetal rat nerve cells treated with Xyl. Methods: Fetal rat nerve cells cultured for seven days were treated with 10, 20, 30, and 40 ㎍/ mL Xyl for 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, and 120 min. Variations of amino acid neurotransmitters (AANTs), Nitric oxide-Cyclic GMP (NO-cGMP) signaling pathway, and ATPase were evaluated. Results: Xyl decreased the levels of cGMP and NO in nerve cells. Furthermore, Xyl affected the AANT content and Na⁺-K⁺-ATPase and Ca²⁺-Mg²⁺-ATPase activity in nerve cells. These findings suggested that Xyl inhibited the NO-cGMP signaling pathway in nerve cells in vitro. Conclusions: This study provided new evidence that the anesthetic and analgesic effects of Xyl are related to the inhibition of the NO-cGMP signaling pathway.

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2159-2165
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• 2013

Cancer registries help to establish and maintain cancer incidence reporting system, serve as a resource for investigation of cancer and its causes, and provide information for planning and evaluation of preventive and control programs. However, their wider role in directly enhancing oncology drug access has not been fully explored. We examined the value of cancer registries in oncology drug access in the Asia-Pacific region on three levels: (1) specific registry variable types; (2) macroscopic strategies on the national level; and (3) a regional cancer registry network. Using literature search and proceedings from an expert forum, this paper covers recent cancer registry developments in eight economies in the Asia-Pacific region - Australia, China, Hong Kong, Malaysia, Singapore, South Korea, Taiwan, and Thailand - and the ways they can contribute to oncology drug access. Specific registry variables relating to demographics, tumor characteristics, initial treatment plans, prognostic markers, risk factors, and mortality help to anticipate drug needs, identify high-priority research area and design access programs. On a national level, linking registry data with clinical, drug safety, financial, or drug utilization databases allows analyses of associations between utilization and outcomes. Concurrent efforts should also be channeled into developing and implementing data integrity and stewardship policies, and providing clear avenues to make data available. Less mature registry systems can employ modeling techniques and ad-hoc surveys while increasing coverage. Beyond local settings, a cancer registry network for the Asia-Pacific region would offer cross-learning and research opportunities that can exert leverage through the experiences and capabilities of a highly diverse region.

• 대한공업교육학회지
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• 제39권2호
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• pp.122-143
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• 2014

이 연구는 기술사를 활용한 기술교육 프로그램의 개발과 그 적용 효과를 알아보기 위하여 수행되었다. 연구의 목적을 달성하기 위하여 문헌고찰을 통해 기술사 프로그램을 개발하였고, 프로그램 적용 효과를 알아보기 위해 설문지, 사진 및 활동자료 등을 통한 양적 질적 실험 연구를 하였다. 연구의 설계는 Likert 척도에 의한 양적 자료 수집과 개방형 질문을 함께 포함하여 질적 자료를 수집하여 혼합모형설계(mixed-model design)를 하였다. 연구 결과는 다음과 같다. 연구결과 첫째, 기술사를 활용한 기술교육 프로그램은 12 주제로 이루어진 총 12차시의 학생용 교사용 프로그램을 개발하였다. 둘째, 초등학생을 대상으로 기술사를 활용한 기술교육 프로그램을 적용한 결과, 기술사 프로그램의 만족도에 대하여 '다음에 또 이러한 체험활동을 계속하고 싶습니까?(4.95)'라는 의견이 가장 높았으며, '실과 교과에 대한 인식이 좋아졌습니까?'라는 의견이 가장 낮았다. 전체적으로는 학생들의 체험활동 과제로 적절하고 다음에 이러한 활동을 하고 싶으나, 실과 교과의 인식의 개선은 상대적으로 낮았다. 이를 통하여 기술사를 활용한 기술교육 프로그램의 구성과 난이도, 만족도 등 전반적인 만족도가 높았다고 볼 수 있다. 또한 개방형 질문지를 통해 얻은 결과, 흥미로웠던 점은 카메라 옵스큐라로 그림 그리기가 13명으로 가장 많았으며, 재미있었던 점은 카메라를 직접 만들고 감광지를 이용하여 직접 사진을 찍어 인화하기가 16명으로 가장 많았으며, 더 알고 싶은 점은 현재의 DSLR 카메라의 제작원리를 알고 싶은 학생이 5명으로 가장 많았으며, 부족한 점은 현재 카메라의 기능과 사용방법을 알고 싶은 학생이 1명 있었다.

• 지질공학
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• 제21권4호
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• pp.281-293
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• 2011

이 연구에서는 과거 산사태의 이력이 있을 뿐만 아니라 추가적인 산사태가 예상되는 부산 황령산의 한 산사면에 대하여 산사태의 발달원인 및 특성에 대해 알아보기 위하여, 연구지역에 대한 (연도별)항공사진, 강우특성, 단열의 발달특성, GIS를 기반으로 한 지형분석, 그리고 수목들의 손상 및 기울어짐에 대한 통계학적 분석을 시도하였다. 그 결과, 북서-남동 방향의 사면파괴가 관찰되는 이 산사면은 1975년까지 비교적 안정한 상태를 유지하였으나, 1975년과 1985년 사이에 취약한 지질구조, 사면절개 및 집중호우와 같은 외적요인이 복합적으로 영향을 미쳐 비교적 큰 규모의 산사태가 발생하였음이 확인된다. 이는 도시형 산사태의 주요 원인 중 하나인 용지 및 택지개발을 위한 사변의 절취 시, 지질구조, 절취사면의 안식각 및 강우특성 동을 면밀히 검토하는 것이 중요함을 보여준다. 또한 기울어진 수목의 기울어진 방향과 각도에 대한 분석결과는 1985년 이후 낙석 및 포행의 형태로 추가적으로 진행되는 산사태가 주로 서쪽방향으로 진행되고 있으며, 산사면의 북서쪽 지점에 이들이 집중되고 있음을 지시한다. 이는 산사태 연구에 있어 손상되거나 변형된 수목을 이용한 분석방법이 매우 유용할 수 있음을 지시하고, 산사태의 예측 및 방재에도 적절히 활용될 수 있을 것으로 사료된다.

• Preventive Nutrition and Food Science
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• 제8권1호
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• pp.24-28
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• 2003

There is evidence to suggest that cranberry juice supplements improve the health of the urinary tract by inhibiting the binding of fimbriated uropathogenic E. coli to the bladder mucosa. In patients with neurogenic bladders, urinary tract infections (UTI) are particularly common and often poorly managed by antibiotic treatment. A double-blind, randomized, placebo-controlled trial was undertaken on 29 geriatric and spinal cord injured patients with dysfunctional bladders. They received three times daily at mealtimes a 4 oz bottle of cranberry juice (Ocean Spray Cranberries, USA) or a specially prepared synthetic placebo drink. Two episodes of UTI arose in week one of cranberry intake and none thereafter, compared to four episodes of UTI in 4 placebo patients in weeks four, six and 10. Mean bacterial adhesion counts on bladder cells of the patients rose during the first month of treatment in 71 % of the placebo patients compared to only 31 % of cranberry patients (p < 0.001). The difference persisted to some extent for the second and third months. Bacterial adhesion levels correlated with culture findings (higher adhesion and higher viable counts in urine) (p < 0.001), positive leukocyte nitrite tests (136$\pm$131 bacteria per cell versus 52$\pm$86 in negative tests) (p < 0.001), and higher white blood cell counts (> 10) per high power field (126$\pm$125 versus 48$\pm$85 bacteria per cell) (p<0.001). E. coli was the most frequently isolated organism (40% samples) followed by K. pneumoniae (17%) and a number of other uropathogens. Group B Streptococci, and coagulase negative Staphylococcus were recovered from urine in 4 samples but were not associated with any red blood cell presence. The daily intake of cranberry juice, in amounts which are not detrimental to long term compliance, appeared to have a role in reducing the risk of bladder colonization and infection in a highly susceptible patient population.