• 제목/요약/키워드: left factor

검색결과 561건 처리시간 0.029초

급성 폐손상 소아 환자에서 조기 예후 인자로서의 antithrombin-III (Antithrombin-III as an early prognostic factor in children with acute lung injury)

  • 이영승;김성국;강은경;박준동
    • Clinical and Experimental Pediatrics
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    • 제50권5호
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    • pp.443-448
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    • 2007
  • 목 적 : 급성 폐손상이 있는 소아에서 혈액 응고 과정에서 중요한 역할을 하는 AT-III의 예후인자로서의 의미를 확인하고자 대상 환자에서 진단 초기의 AT-III 값을 측정하고 사망여부에 따라 AT-III 값을 비교 분석하고 지금까지 알려진 여러 예후인자들과 비교 분석하였다. 방 법 : 2004년 6월부터 2005년 12월까지 18개월 동안 서울대학교병원 소아중환자실에 입원한 198명의 환자 중 급성 폐손상의 정의를 만족하고 기계적 환기요법을 받은 21명의 환자를 대상으로 인구의학적인 변수와 기저질환, 초기 안정화 이후의 호흡지수들, 기계적 환기요법의 여러 설정 등을 측정하였다. 중환자실 입원 24시간 이내의 PRISM-III 점수, LIS 점수를 측정하였고 입원 3시간 내의 AT-III 값을 측정하였다. 사망여부에 따라 두 군으로 분류한 후 예후인자를 비교분석하였고, PRISM-III 값과 AT-III 값에 대해서는 상관관계와 회귀분석을 함께 시행하였다. 단변수 분석에서 사망여부에 따라 통계적으로 유의한 변수에 대해서 중회귀 분석을 시행하여 상대위험도를 측정하였다. 결 과 : 18개월 동안 198명이 입원하였고 21명의 환자가 진단기준을 만족하였다. 남자가 13명(61.9%)였고 연령은 5(1-14)세였다. 급성 폐손상이 발생한 장소가 병원이 아닌 경우가 33.3%였고 기저질환이 폐 병변인 경우가 66.7%였다. 대상 환자 중 AT-III 값이 70% 이하인 경우가 10명(42.9%)이였고 8명의 환자가 사망하여 사망률은 38.1%였다. 사망에 따른 두 군 간의 비교에서 초기 안정화 이후 동맥혈 pH와 $PaO_2/FiO_2$는 사망한 환자군에서 유의하게 더 낮았고, OI와 호기말 양압은 사망한 환자군에서 유의하게 더 높았다. 폐 유순도는 사망한 환자군에서 유의하게 더 낮았다. LIS와 PRISM-III는 사망한 환자군에서 모두 유의하게 높았고 AT-III는 사망한 환자군에서 유의하게 더 낮았다. AT-III와 PRISM-III 값은 유의한 상관관계를 보였다. 중회귀분석에서 PRISM-III, LIS, OI는 모두 다른 변수에 독립적으로 유의한 사망의 위험인자였으며 70% 미만으로 정의한 AT-III 감소는 급성 폐손상 환자에서 다른 변수에 독립적으로 사망의 유의한 위험인자였다(OR 2.725, 95% CI 1.284-4.119). 결 론 : 급성 폐손상으로 기계적 환기요법을 시행 받은 소아환자를 대상으로 한 본 연구에서 초기 AT-III 값은 PRISM-III 값과 유의한 상관관계를 보였으며, 또한 사망한 환자군에서 AT-III 값이 유의하게 더 낮았고 이것은 다른 위험인자의 영향을 보정한 상태에서도 독립적인 사망의 위험인자였다. 이로써 AT-III가 급성 폐손상의 유의한 조기 예후 예측인자라는 것을 확인하였으며 향후 급성 폐손상/급성 호흡부전증후군 환자에서 응고장애를 정상화 할 수 있는 처치들이 예후를 향상시킬 수 있을 가능성을 제시하였다.

폐금속광산 하류 논토양의 중금속 오염도 평가 (Assessment of the Heavy Metal Contamination in Paddy Soils Below Part of the Closed Metalliferous Mine)

  • 김민경;홍성창;김명현;최순군;이종식;소규호;정구복
    • 한국환경농학회지
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    • 제34권1호
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    • pp.6-13
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    • 2015
  • 폐금속광산 주변 토양의 중금속 오염특성을 평가하기 위하여 광산 하류에 위치한 논토양을 대상으로 중금속 오염지수, 부화계수 및 지화학적 농축계수를 조사한 결과는 다음과 같다. 광산 하류 논토양의 중금속 전함량 평균치는 Cd 8.88, Cu 56.7, Pb 809, Zn 754 및 As 37.9 mg/kg이었고, 중금속 중에서 Cd, Pb 및 Zn 평균함량은 우리나라 농경지의 토양오염 우려기준(Cd 4, Pb 200, Zn 300 mg/kg)을 초과하였다. 토양의 전함량에 대한 0.1M HCl 침출성의 함량비율은 Pb 35.1, Cd 27.7, Cu 21.3, Zn 13.8 및 As 10.5% (1M HCl) 순으로 나타났다. 토양 내 중금속의 오염지수 평균치는 3.21, 범위는 0.42~11.92로 나타나 심하게 오염된 상태임을 알수 있었다. 토양의 중금속별 부화계수(EFc) 평균 값은 Cd>Pb>Zn>As>Cu 순으로 높았고, 채취 지점간 편차가 큰 것을 알수 있었다. 토양 중금속별 지화학적 농축계수(Igeo) 평균치는 Cd>Pb>Zn>Cu>As 순으로 높았으며, 특히 Cd, Pb 및 Zn의 Igeo 평균 값이 각각 3.10, 2.64, 2.49로 나타나 다른 성분보다 상대적으로 높게 나타났다.

퇴원환자의 가정간호 이용의사와 관련 요인 (A Study on the Expressed Desire at Discharge of Patients to Use Home Nursing and Affecting Factors of the Desire)

  • 이지현;이영은;이명화;손수경
    • 재활간호학회지
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    • 제2권2호
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    • pp.257-270
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    • 1999
  • The purpose of this study is to investigate factors related to the intent of using home nursing of chronic disease patients who got out of a university hospital. For the purpose, the study selected 153 patients who were hospitalized and left K university hospital with diagnoses of cancer, hypertension, diabetes and cerebral vascular accident and ordered to be discharged and performed interviews with them and surveys on their medical records to obtain the following results. For this study a direct-interview survey and medical record review was conducted from June 28 to Aug. 30, 1998. The frequency and mean values were computed to find the characteristics of the study subjects, and $X^2$-test, t-test, factor analysis and multiple logistic regession analysis were applied for the analysis of the data. The following results were obtained. 1) When characteristics of the subjects were examined, men and women occupied for 58.8% and 41.2%, respectively. The subjects were 41.3 years old in aver age and had the monthly aver age earning of 0.99 million won or below, which was the most out of the total subjects at 34.6%. Among the total, 87.6% resided in cities and 12.4 in counties. The most left the hospital with diagnosis of cancer at 51.6%, followed by hyper tension at 24.2%, diabetes at 13.7% and cerebral vascular accident at 7.2%. 2) 93.5% of the selected patients had the intent of using home nursing and 6.5%, didn't. Among those patients having the intent, 85.6% had the intent of paying for home nursing and 14.4%, didn't. The subjects expected that the nursing would be paid 9,143 won in aver age and 47.7% of them preferred national authorities as the main servers. 86.3% of the subjects thought that home nursing business had the main advantage of making it possible to learn nursing methods at home and thereby contributing to improving the ability of patients and their facilities to solve health problems. 3) Relations between the intent of use and characteristics of the subjects such as demography-related social, home environment, disease and physical function characteristics did not show statistically significant differences among one another. Compared to those who had no intent of using home nursing, the group having the intent had more cases of male patients, the age of 39 or below, residence in cities, 5 family member s or more, no existence of home nursing servers, leaving the hospital from a non-hospitalized building, disease development for five months or below, hospitalization for ten days or more, non-hospitalization with in the recent one month, two times or over of hospitalization, leaving the hospital with no demand of special treatment, operation underwent, poor results of treatment, leaving the hospital with demand of rehabilitation services, physical disablement and high evaluation point of daily life. 4) Among those patients having the intent of using home nursing, 47.6% demanded technical nursing and 55.9%, supportive nursing. As technical nursing,' inject into a blood vessel ' and 'treat pustule and teach basic prevention methods occupied for 57.4%, respectively, topping the list. Among demands of supportive nursing, 'observe patients 'status and refer them to hospitals or community resources as available, if necessary' was the most with percent age point of 59.5. Regarding the intent of paying for home nursing, 39.2% of those patients wishing to use the nursing responded paying for technical services and 20.2, supportive services. In detail, 70.0% wanted to pay for a service stated as 'inject into a blood vessel', highest among the former services and 30.7%, a service referred to as 'teaching exercises needed to make the body of patients move', highest among the latter. When this was analyzed in terms of a relation between the need(the need for home nursing) and the demand(the intent of paying for home nursing), The rate of the need to the demand was found two or three times higher in technical nursing(0.82) than in supportive nursing(0.35). In aspects of tech ical nursing, muscle injection(1.26, the 1st rank) was highest in the rate while among aspects of supportive nursing, a service referred to as 'teach exercises needed for making patients move their bodies normally'(0.58, the 1st rank). 5) factors I(satisfaction with hospital services), II(recognition of disease state), III(economy) and IV(period of disease) occupied for 34.4, 13.8, 11.9 and 9.2 percents, respectively among factors related to the intent by the subjects of using home nursing, totaled 59.3%. In conclusion, most of chronic disease patients have the intent of using hospital-based home nursing and satisfaction with hospital services is a factor affecting the intent most. Thus a post-management system is needed to continue providing health management to those patients after they leave the hospital. Further, supportive services should be provided in order that those who are satisfied with hospital services return to their community and live their in dependent lives. Based on these results, the researcher would make the following recommendation. 1) Because home nursing becomes more and more needed due to a sharp increase in chronic disease patients and elderly people, related rules and regulations should be made and implemented. 2) Hospital nurses specializing in home nursing should be cultivated.

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구안와사(口眼喎斜)에 대한 한의(韓醫) 및 한(韓)·서의(西醫) 협진(協診) 치료(治療)의 임상(臨床) 관찰(觀察) (Comparative Clinical Study between Oriental Medicine and Oriental-western Medicine Treatment on Facial Nerve Paralysis)

  • 강미정;김기현;황현서
    • Journal of Acupuncture Research
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    • 제17권1호
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    • pp.55-66
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    • 2000
  • The following results have been obtaind after examing 72patients with facial paralysis who were hospitalzed and treated through the time period of December 1st, 1996 to November 30th, 1999 at the Department of Acupuncture and Moxibustion of Seoul Oriental Medicine, Kyungwon University. During the examination, those 72 patients were divided into two groups, and One group was treated by oriental-western treatment, the other group was treated by oriental treatment. Oriental treatments were acupuncture and moxibustion, herb medicine, physical treatment and hygienic treatment. The one of main western treatments is steroid therapy. The results were obtained as follows : 1. In regard to signs at the first medical examination, lacrimation was showed highest number and facial paralysis, dysgeusia, hyperacusis were showed in numerical order. 2. In regard to prescription of oriental herb medicine, Kamissangbotang(加味雙補湯) was prescribed in greatest numbers and Boyangwhanotang(補陽還五湯), Kamiboiktang(加味補益湯), Ligigepungtang(理氣祛風湯) were prescribed in numerical order. 3. In regard to treatment number, 10~19 times for treatment was showed highest number and 1~9 times, 20~29 times, 40~49 times were showed in numerical order . 4. In regard to mean treatment times about injury region and main sign, the effect of oriental-western treatment was showed as follows: lacrimal gland disorder, hyperacusis, dysgeusia, facial paralysis were treated for 15.1, 27, 13.2 and 21.4 times, repectively. The effect of oriental treatment was showed as follows: lacrimal gland disorder, hyperacusis, dysgeusia, facial paralysis were treated for 34.8, 22.1, 33.8 and 16.3 times, respectively. 5. In regard ta the effect of treatment about injury region and main sign, oriental-western treatment was showed as follows: cases of lacrimal gland disorder were showed 1 of excellent case, 1 of fair case, 5 of good cases. In hyperacusis patients, there was showed 1 of fair case. In dysgeusia patients, there was showed 1 of excellent case, 3 of fair cases, 1 of good case. In facial paralysis, there were showed 5 of fair cases. Oriental treatment was showed as follows: In lacrimal gland disorder, the excellent were 4 cases, the fair were 10 cases, the good were 3 cases and the poor were 4 cases, In hyperacusis, the fair were 5 cases, the poor 2 cases. In dysgeusia, the excellent were 4 cases, the fair were 1 case, the good were 1 case and the poor was 1 case, In facial paralysis, the excellent were 9 cases, the fair were 4 cases, the good 3 cases and the poor were 3 cases. 6. The effect of total treatment was as follows: 30 cases were showed fair effect, 19 cases were showed excellent effect, 13 cases were showed good effect and 10 cases were showed poor effect. 7. In regard to attack factor, overlabour was showed highest number and wind-cold, mental stress, trauma, ear disease, common cold, dental diseae, reason unknwon were showed in numerical order. 8. In regard to premonitory symptoms, non significant symptoms were in 38 cases, the pain of peri-stylomastoid region were in 38 cases and headache, dysaesthesia of periorbit, dysgeusia, stomatitis, eyelid tic were showed in numerical order. 9. In regard to sex, male were 33 cases and female were 39 cases. The distribution of age was disclosed that thirty, forty, fifty, seventy, sixty, twenty and below twenty years were revealed in turn. Sex and paralytic side were showed as follows: male-left were 15 cases, male-right were 18 cases, female-left were 19 cases and female-right were 19 cases. In regard to attack frequence in month, March was showed highest number and January, April, May, August, October, etc were showed in numerical order. In regard to attack frequence in season, spring was showed highest number and winter, summer, fall were showed in numerical order, but attack frequence between four seasons wasn't showed significant difference.

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치과 파노라마 촬영에서 환자의 피폭선량에 관한 연구 (A Study on the Patient Exposure Doses from the Panoramic Radiography using Dentistry)

  • 박일우;정원교;황형석;임성환;이대남;임인철;이재승;박형후;곽병준;유윤식
    • 한국방사선학회논문지
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    • 제7권1호
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    • pp.17-24
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    • 2013
  • 본 연구는 파노라마 표준 촬영에서 환자의 피폭 선량을 측정하여 방사선 생물학적 위험인자를 평가하고 환자의 피폭 선량 저감화 방안을 제시하고자 하였다. 피폭 선량의 측정 오차를 최소화하기 위하여 각 OSL 선량계의 교정상수를 구하였으며 파노라마 표준 촬영에서 간접적으로 포함되는 좌 우측 수정체와 갑상선, 직접적으로 포함되는 상 하 입술, 하악골 첨부, 촬영 중심점을 대상으로 ICRP에서 권고하는 인체 모형 표준 팬텀을 이용하여 측정하였다. 측정 결과, 촬영 중심점의 선량이 $413.67{\pm}6.53{\mu}Gy$로 최대였으며 상 하 입술의 경우 각각 $217.80{\pm}2.98{\mu}Gy$, $215.33{\pm}2.61{\mu}Gy$이었다. 또한 파노라마 표준 촬영에서 간접적으로 포함되는 좌 우측 수정체의 등가선량은 각각 $30.73{\pm}2.34{\mu}Gy$, $31.87{\pm}2.50{\mu}Gy$이었으며 하악골 첨부 및 갑상선의 등가선량은 $276.73{\pm}14.43{\mu}Gy$, $162.07{\pm}4.13{\mu}Gy$이었다. 결론적으로 측정된 피폭 선량은 방사선 생물학적 효과를 유발할 수 있었으며 치과 의료기관의 파노라마 표준 촬영에서 환자의 피폭 선량에 대한 저감화 방안으로 국제기구에서 권고하고 있는 방사선 방어 원칙에 대한 정당한 해석과 제도적 뒷받침(regulation)이 필요하다. 이에 파노라마 검사에 의한 피폭 선량은 기술적 경제적 측면뿐 만 아니라 사회적 인자를 고려하여 합리적으로 용인 가능한 수준까지 최소화하기 위한 체계화된 프로토콜의 제정과 주변 결정 장기를 방어하기 위한 방사선 보호 기구에 대한 추가적 연구가 필요할 것으로 판단되었다.

인라인 스케이트(Inline Skate) 힐 브레이크(Heel-Brake) 정지에 관한 운동학적 분석 (Kinematical Analysis of Heel-Brake Stop in Inline Skate)

  • 한제희;임용규
    • 한국운동역학회지
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    • 제15권2호
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    • pp.11-20
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    • 2005
  • This study has a purpose on contributing to apprehend safe and right way to stop to the inline skate beginners and to the instructors who teaches line skating on the basis for the result of the kinematical analysis on Heel brake stop movement of the inline skate, focusing on the displacement on COG, angle displacement of ankle joint, angle displacement of knee joint, angle displacement of hip joint, using a 3D image method by DLT. To achieve this goal, we analysed the kinematical factor of the 3 well-trained inline skating instructors and obtained the following results. 1. During the movement of heel-brake stop, when strong power was given to a stable and balanced stop and the lower limbs, if the physical centroid is lowered the stability increases, and if it is placed high from the base surface, as the stability decreases compared to the case of low physical centroid, we should make a stop by placing a physical centroid in the base surface and lowering the hight of physical centroid. 2. To make a stable and balanced stop and to provide a strong power to the lower limbs, it is advisable to make a stop by decreasing an angle displacement of ankle joint during a "down" movement. In case of the left ankle joint, in all events and phases the dorsiflexion angle showed a decrease. Nevertheless, in the case of the right ankle joint, the dorsiflexion angle shows an increase after a slight decrease. The dorsiflexion angle displacement of ankle joint can be diminished because of the brake pad of the rear axis frame of the right side inline skate by raising a toe, but cannot be more decreased if certain degree of an angle is made by a brake pad touching a ground surface. To provide a power to a brake pad, it is recommended to place a power by lowering a posture making the dorsiflexion angle of the left ankle joint relatively smaller than that of the right ankle. 3. To make a stable and balanced stop and to add a power to a brake pad, the power must be given to the lower limbs in lowering the hight of physical centroid. For this, it is recommended to make a down movement by decreasing the flexion angle of a knee joint and it is necessary to make a down movement by a regular decrease of the angle displacement of knee joint rather than a swift down movement in every event and phase. 4. The right angle displacement of hip joint is made by lowering vertically the hight of physical centroid as leaning slightly forward. If too narrow angle displacement of hip joint is made by leaning forward too much, the balance is lost during the stop by placing the center in front. To make a stable and balance stop and to place a strong power to the lower limbs, it is recommendable to make a narrow angle by lower the hip joint angle. However, excessive leaning of the upper body to make the angle too narrow, can cause an instable stop and loss of physical centroid. After this study, it is considered to assist the kinematical understanding during the heel brake stop movement of the inline skate, and, to present basic data in learning a method of stable and balanced stop for the inline skating beginners or for the inline skate instructors in the present situation of the complete absence of the study in inline skating.

동종이식편을 이용한 대동맥 근부 치환술 (Homograft Aortic Root Replacement)

  • 김재현;오삼세;이창하;백만종;김종환;나찬영
    • Journal of Chest Surgery
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    • 제38권3호
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    • pp.197-203
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    • 2005
  • 대동맥판막 치환술 시 사용되는 동종이식편은 훌륭한 혈역학적 기능과 우수한 좌심실 근육량 감소(enhanced left ventricular mass regression), 감염에 대한 내성, 혈색전증 발생 위험이 적다는 등의 많은 장점들이 있다. 저자들은 본원에서 시행한 동종이식편을 이용한 대동맥판막 치환술의 결과를 알아보고자 한다. 방법 및 대상: 1995년 5월부터 2004년 5월까지 18명의 환자(남 : 여=16 : 2, 평균 연령=39.3$\pm$16.2세, 연령 범위 14$\~$68세)에서 동종이식편을 이용한 대동맥판막 치환술은 20예가 시행되었다. 2예의 재수술을 포함하여 대동맥 동종이식편이 17개 사용되었고 폐동맥 동종이식편이 3개 사용되었다. 대동맥 판막에 대한 수술 과거력이 있는 환자는 10명이었다. 동종이식편 사용의 적응증으로는 자가판막 심내막염(n=7), 인공심장판막 심내막염(n=5), 혹은 Behcet 병에 동반된 대동맥판막 질환(n=8) 이었다. 수술방법은 관상동맥하 삽입술(subcoronary implantation)을 시행한 1명을 제외한 모든 환자에서 완전 근부 치환술(full root replacement)을 이용하였다. 결과 : 평균 관찰기간은 41.3$\pm$26.2 개월이었다. 수술사망이 1예 있었으며 합병증으로는 수술 후 출혈이 3예, 총격동염이 1예 발생하였다. 만기 사망 예는 없었으며 3예에서 대동맥판막 재치환술을 시행하였고 3명이 모두 Behcet 병 환자였다(p=0.025). 재수술에 대한 자유도는 1년과 5년에 각각 $87.5\pm8.3\%$, $78.8\pm11.2\%$였다. 심내막염 환자들에서 수술 후 심내막염의 재발은 없었다. 관찰 기간 중 항응고 요법은 사용하지 않았고 판막에 의한 혈색전증은 관찰되지 않았다. 결론: Behcet병과 감염성 심내막염의 수술 위험도를 고려할 때 동종이식편 대동맥판막 치환술의 수술결과 및 술 후 관찰 결과는 양호하였다. Behcet 병은 동종이식편을 이용한 대동맥판막 치환술 후 재수술의 위험요인이었다. 심내막염 환자들에서 동종이식편 대동맥판막 치환술은 최선의 수술방법이라고 생각하며 더 많은 수의 환자들을 대상으로 장기 관찰이 필요할 것이다.

허혈양상화와 KATP 통로가 허혈후 재관류된 흰쥐의 골격근육에서 SOD 활성 및 apoptosis에 미치는 영향 (Effects of ischemic preconditioning, KATP channel on the SOD activation and apoptosis in ischemic reperfused skeletal muscle of rat)

  • 안동춘;백두진;양홍현
    • 대한수의학회지
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    • 제39권5호
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    • pp.878-895
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    • 1999
  • Ischemic preconditioing (IPC), i.e., a preliminary brief episode of ischemia and reperfusion, has been shown to reduce the cell damage induced by long ischemia and reperfusion. Superoxide radical which is produced during reperfusion after ischemia was recognized as a factor of the ischemic injury and it is dismutated into $H_2O_2$ and $O_2$ by two types of intracellular superoxide dismutase (SOD), Cu,Zn-SOD in cytoplasm and Mn-SOD in mitochondria. Recently oxygen free radicals are suggested to induce the apoptosis, however mechanism of the reduced apoptosis by ischemic preconditioing was unknown, while many studies performed in mammalian heart indicated that ATP-sensitive $K^+$ ($K_{APT}$) channel activation related with the protective effects. The aim of present study is to investigate 1) whether IP upregulate the Cu,Zn-SOD and Mn-SOD activities, and 2) whether ischemic preconditioning decreases apoptosis via $K_{APT}$ channel activation in timely reperfused skeletal muscle after long ishemia. The experimental animals, Sprague-Dawley rats weighing 250~300g, were divided into 8 groups; 1) control group, 2) ischemic preconditioning only groups, 3) pinacidil, a $K_{APT}$ channel opener, treatment only groups, 4) glibenclamide, a $K_{APT}$ channel blocker, treatment only groups, 5) ischemia groups, 6) ischemia after IPC groups, 7) ischemia and pinacidil treatment groups, and 8) IP and ischemia after glibenclamide pretreatment groups. Animals of the control group were administered with the vehicle (DMSO) alone. Pinacidil (1mg/kg) was administered intravenously 5 minutes after initiation of ischemia, and glibenclamide (0.5mg/kg) was injected intravenously 20 minutes before IPC. In rats that were ischemic preconditioned, the left common iliac artery was occluded for 5 minutes followed by 5 minutes of reperfusion by three times using vascular clamp. Ischemia was done by occlusion of the same artery for 4 hours. The specimens of left rectus femoris muscle were obtained immediately (0 hour), 12 hours, 24 hours after drug administrations, IP or ischemia and reperfusion. The immunoreactivities of SOD and its alterations were observed by use of sheep antihuman Cu,Zn-SOD and Mn-SOD antibodies on the $10{\mu}m$ cryosections. The incidencies of apoptosis were observed by TUNEL methods with in situ apoptosis detection kit on $6{\mu}m$ paraffine section. The results obtained were as follows : 1. After IPC, immunoreactivities of Cu,Zn-SOD mainly in the small-sized fibers were increased by 24 hours, that of Mn-SOD at 0 hour and 24 hours. 2. No significant changes in immunoreactivities of SOD was observed in the pinacidil and in the glibenclamide treatment only groups, and in the ischemia only groups. 3. The immunoreactivities of the Cu,Zn-SOD were increased in the ischemia after IPC groups and the ischemia and pinacidil treatment groups. 4. The immunoreactivities of the Cu,Zn-SOD in the IPC and ischemia after glibenclamide pretreatment groups were not increased except for the 12 hours reperfusion group. But, Mn-SOD immunoreactivities were increased in the 0 hours, 12 hours and 24 hours after reperfusion. 5. In the control group, the IPC only groups, and the pinacidil treatment only groups, negative or trace apoptotic reactions were observed, but the positive apoptotic reaction occured in the glibenclamide treatment groups. 6. Moderate or many number of apoptosis were revealed in the ischemia groups, and also the IPC and ischemia after glibenclamide pretreatment group except for 12 hours and 24 hours after reperfusion. However, the incidence of apoptosis was decreased in the ischemia after IPC groups and in the ischemia and pinacidil treatment groups. 7. There is a coincidence between the increase of Cu,Zn-SOD immunoreactivities and the decrease of apoptosis in the presence of ischemia and reperfusion. These results suggest that the protective effects of ishemic preconditioing may related to the SOD activation, and the ischemic preconditioning decreases the apoptosis partially via $K_{APT}$ channel activation in timely reperfused rat skeletal muscle. It is also suggested that inhibition of apoptosis by IPC may related with the SOD activation.

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도시고속도로 연속류의 교통특성을 고려한 가변속도제어 활성화 방안 - 부산광역시를 중심으로 - (The Activation Plan of Variable Speed Control of Considering Urban Freeway Continuos Traffic Characteristics (In Busan Metropolitan City))

  • 정용화;최양원;임창식
    • 대한토목학회논문집
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    • 제34권2호
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    • pp.627-635
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    • 2014
  • 현재 도로상에서의 최고속도제한은 교통 혼잡이나 기상변화에 대처하기 힘들기 때문에 교통사고를 유발하는 요인이 될 수 있다. 물론 도로교통법에 따르면 악천후 시 20~50% 속도를 감속시켜야 하지만 운전자들의 판단에 맡겨야 하는 어려움이 있고, 감속하는 차량과 하지 않는 차량들간의 상대속도가 달라져서 주행환경과 안전에 큰 영향을 끼친다. 따라서 가변속도제어는 도로상의 운전자들에게 적절한 최고속도제한을 지정해 줌으로서 운전자들이 악천후 시에 감속된 속도로 달리게 하여 사고를 미연에 방지하거나 사고피해 심각도를 낮출 수 있을 거라 예상된다. 본 연구의 목적은 교통사고가 잦은 부산광역시의 연속류(도시고속도로)를 중심으로 적절한 구간에서 가변속도제어가 실시될 수 있도록 교통사고의 특성을 분석하여 사고 심각도를 조사하였다. 그리고 도시고속도로의 기하구조상 많은 곡선부 환경을 가지고 있으므로 평면 곡선부 지점을 건조한 노면과 젖은 노면을 비교 시뮬레이션 해봄으로써 비에 젖은 노면일수록 속도에 따른 사고위험이 크다는 결과를 얻었다. 이러한 결과를 토대로 먼저 도시고속도로에서 기본구간, 터널부근, 램프부근, 요금소 부근, 진 출입부 등 다양한 요인을 고려한 뒤 속도감소가 필요한 구간에서 우선 실시하여 운전자들의 참여의식과 필요성을 인식시키고 향후 도시고속도로 전 구간에 설치 및 운영이 확대되어야 할 것으로 판단된다.

GIS기반 분묘관리시스템의 구축 및 적용 (Construction and Applicability of GIS-Based Grave Management System)

  • 이진덕;이승환
    • 한국지리정보학회지
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    • 제14권4호
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    • pp.208-220
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    • 2011
  • 국토 공간이 한정되어 있는데다 분묘의 이용 및 설치에 관한 국가적, 사회적 관리 기반이 미비된 현실에서 우리나라의 전통적인 매장 위주의 묘지설치 관행은 체계적인 국토관리와 도시개발을 저해할 뿐 아니라 자연환경 및 주민생활 공간에 영향을 미쳐 심각한 갈등 요인이 되곤 한다. 정부 및 지방자치단체에서는 "장사등에관한법률" 등을 제정하여 대응을 하고 있으나, 통일된 지리 공간의 기반 위에서 축적된 개별 분묘들에 대한 정보 부재와 관리시스템의 미비로 인해 많은 문제점을 시사하고 있다. 이에 본 연구에서는 관할 행정관청에서 개별묘지 관리를 위주로 하는 GIS 기반 분묘관리시스템을 개발하고 대상지역에 적용하여 타당성을 분석하고자 하였다. 행정체계 또는 조사에 의해 수집되는 분묘에 관한 정보를 데이터베이스로 구축하고, 이를 본 시스템을 통해 시한부 매장제도, 무연분묘 관리 등에 활용될 수 있음을 제시할 수 있었다. 또한 문중 중심의 장묘문화의 전통 하에서 현세 및 후대의 자손들에게 전승할 수 있는 체계적인 선산분묘관리 방법이 될 수 있을 것이다.