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Homograft Aortic Root Replacement  

Kim Jae Hyun (Department of Thoracic and Cardiovascular Surgery, Sejong General Hospital, Sejong Heart Institute)
Oh Sam Sae (Department of Thoracic and Cardiovascular Surgery, Sejong General Hospital, Sejong Heart Institute)
Lee Chang-Ha (Department of Thoracic and Cardiovascular Surgery, Sejong General Hospital, Sejong Heart Institute)
Baek Man Jong (Department of Thoracic and Cardiovascular Surgery, Sejong General Hospital, Sejong Heart Institute)
Kim Chong Whan (Department of Thoracic and Cardiovascular Surgery, Sejong General Hospital, Sejong Heart Institute)
Na Chan-Young (Department of Thoracic and Cardiovascular Surgery, Sejong General Hospital, Sejong Heart Institute)
Publication Information
Journal of Chest Surgery / v.38, no.3, 2005 , pp. 197-203 More about this Journal
Abstract
Homograft aortic valve replacement (AVR) has many advantages such as excellent hemodynamic performance, faster left ventricular hypertrophy regression, resistance to infection and excellent freedom of thromboembolism. To find out the results of homograft AVR, we reviewed our surgical experiences. Material and Method: Eighteen patients (male female=16 : 2, mean age=39.3$\pm$16.2 years, range: 14$\~$68 years) who underwent homo-graft aortic valve replacement between May 1995 and May 2004 were reviewed. The number of homografts was 20 (17 aortic and 3 pulmonic homografts) including two re-operations. Ten patients had a history of previous aortic valve surgery. Indications for the use of a homograft were native valve endocarditis (n=7), prosthetic valve endocarditis (n=5), or Behcet's disease (n=8). The homograft had been implanted predominantly as a full root except in one patient in the subcoronary position. Result: Mean follow-up was 41.3 $\pm$ 26.2 months. There was one operative mortality. Postoperative complications included postoperative bleeding in 3 patients, and wound infection in 1. There was no late death. Three patients underwent redo-AVR. The etiology of the three reoperated patients was Behcet's disease (p=0.025). Freedom from reoperation was $87.5\pm8.3\%$, $78.8\pm11.2\%$ at 1, 5 years respectively, In patients with infective endocarditis, there was no recurrence of endocarditis. There was no thromboembolic complication. Conclusion: Although longer term follow-up with larger numbers of patients is necessary, the operative and mid-term results for homograft AVR was good when we took into account the operative risks of Behcet's disease or infective endocarditis. Behest's disease was a risk factor for reoperation after the homograft AVR. We think homograft AVR is the procedure of choice, particularly in patients with infective endocarditis.
Keywords
Homograft; Aortic valve; surgery; Aortic root;
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1 Eriksson MJ, Kallner G, Rosfors S, Ivert T, Brodin L. Hemodynamic performance of cryopreserved aortic homograft vlaves during midterm follow-up. J Am Coll Cardiol 1998;32:1002-8   DOI   ScienceOn
2 O'Brien MF, Harrocks S, Stafford EG, et al. The homograft aortic valve: a 29-year, 99.3% follow up of 1,022 valve replacement. J Heart Valve Dis 2001;10:334-44
3 Kirklin JK, Smith D, Novick W, et al. Long-term function of cryopreserved aortic homografts. a ten-year study. J Thorac Cardiovasc Surg 1993;106:154-65
4 Yankah AC, Klose H, Petzina R, et al. Surgical management of acute aortic root endocarditis with viable homograft; 13-year experience. Eur J Cardiothorac Surg 2002; 21:260-7   DOI   ScienceOn
5 Hampton CR, Chong AJ, Verrier ED. Stentless aortic valve replacement: homograft/autograft. In: Cohn LH, Edmunds LH. Cardiac surgery in the adult. 2nd ed. USA: McGraw-Hill Co. 2003;867-88
6 Lund O, Chandrasekaran V, Grocott-Mason R, et al. Primary aortic valve replacement with allografts over twenty- five years: valve related and procedure related determinants of outcome. J Thorac Cardiovasc Surg 1999;117:77-91   DOI   ScienceOn
7 Maselli D, Pizio R, Bruno LP, Bella ID, Gasperis CD. Left ventricular mass reduction after aortic valve replacement: homografts, stentless and stented valves. Ann Thorac Surg 1999;67:966-71   DOI   ScienceOn
8 Fischlein T, Schutz A, Haushofer M, et al. Immunologic reaction and viability of cryopreserved homografts. Ann Thorac Surg 1995;60:122-6   DOI
9 Dearani JA, Orszulak TA, Schaff HV, et al. Results of allograft aortic valve replacement for complex endocarditis. J Thorac Cardiovasc Surg 1997;113:285-91   DOI   ScienceOn
10 Niwaya K, Knott-Craig CJ, Santangelo K, et al. Advantages of autograft and homograft valve replacement for complex aortic valve endocarditis. Ann Thorac Surg 1999;67:1603-8   DOI   ScienceOn
11 Barratt-Boyes BG. Homograft aortic valve replacement in aortic incompetence and stenosis. Thorax 1964;19:131-50   DOI   PUBMED   ScienceOn
12 Ross DN. Homograft replacement of the aortic valve. Lancet 1962;2:487   PUBMED
13 Xu YJ, Zhong-Ming Z, Gibson DG, Yacoub MH, Pepper JR. Effects of valve substitute on changes in left ventricular function and hypertrophy after aortic valve replacement. Ann Thorac Surg 1996;62:683-90   DOI   PUBMED   ScienceOn
14 Hasegawa J, Kitamura S, Taniguchi S, et al. Comparative rest and exercise hemodynamics of allograft and prosthetic valves in the aortic position. Ann Thorac Surg 1997;64: 1753-6   DOI   ScienceOn
15 Lim CY, Lee HJ, Kim JE. Aortic root replacement using aortic homograft in acute bacterial endocarditis -one case report-. Korean J Thorac Cardiovasc Surg 1997;30:819-22
16 O'Brien MF, Stafford EG, Gardner MAH, Pohlner PG, McGiffin DC. A comparison of aortic valve replacement with viable cryopreserved and fresh allograft valves, with a note on chromosomal studies. J Thorac Cardiovasc Surg 1987;94:812-23
17 Langley SM, McGuirk SP, Chaudhry MA, et al. Twenty- year follow-up of aortic valve replacement with antibiotic sterilized homografts in 200 patients. Semin Thorac Cardiovasc Surg 1999;11:28-34