• Science of Emotion and Sensibility
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• v.22 no.3
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• pp.21-34
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• 2019

This study was an examination of the relevance and clinical significance of electroencephalographic (EEG) indexes (e.g., mental/physical stress and attention) and indexes of heart rate variability (HRV) with regard to cognitive function and physiological health conditions in elderly people. A device was used to record two-channel EEGs of the frontal lobe and a one-channel ECG simultaneously. Subjects were 76 people average aged 73. The significant findings are as follows: First, subjects whose intrinsic alpha rhythm had high amplitude, regardless of peak, showed higher resistance to mental stress and lower physical stress than did subjects with low-amplitutde intrinsic alpha rhythm. Second, HRV, SDNN, and RMSSD indexes showed strong positive correlations between the two groups of subjects regardless of the division of groups. Third, the alpha asymmetry of the left and right sides of the brain in subjects with low-amplitude intrinsic alpha rhythm was larger, and the delta/alpha ratio (reflecting physical stress) and theta/sensorimotor rhythm (SMR) ratio (showing the decline in attention) were bigger. Fourth, the subjects in whom intrinsic alpha rhythm peak occurred during slow rhythm had a higher theta/SMR ratio than did subjects whose peak occurred during fast rhythm, which was related to a steeper decline in attention. Therefore, the presence or absence of intrinsic alpha rhythm peak and amplitude on quantitative EEG may be an index reflecting the cognitive function and physiological health of elderly people.

• The Korean Journal of Nuclear Medicine
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• v.30 no.1
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• pp.35-46
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• 1996

Dopamine transporter concentrations have been known to decrease in Parkinson's disease (PD) or increase in Tourette's disorder. The purpose of this study was to evaluate the effectiveness of [I-123]N-(3-iodopropene-2-yl)-$2{\beta}$-carbomethoxy-$3{\beta}$-(4-chlorophenyl) tropane (IPT) as an imaging agent for measuring changes in transporter concentrations with PD. IPT labelled with 6.69+/-0.64 mCi(247.53+/-23.68 MBq) of I-123 was intravenously injected into ten patients(age: 55+/-11) with PD, and six normal controls(NC)(age: 46+/-14) as a bolus. Dynamic SPECT scans of the brain were then performed for 5 minutes each over 120 minutes on a triple headed camera. Time activity curves were generated for the left basal ganglia(LBG), right basal ganglia(RBC), and occipital cortex(OCC). The statistical parameters included the time to peak activity, the contrast ratio of LBG and RBG to OCC at several time points, and the accumulated specific binding counts/mCi/pixel(ASBC) from 0 to 115 minutes. The uptake of IPT in the brains of PD and NC peaked within 10 minutes of injection in all subjects. The maximum target to background ratio in the basal ganglia of PD and NC occurred at 85+/-20 min and 110+/-6 min of injection, respectively. The BG/OCC ratios at 115 minutes for PD and NC were 2.15+/-0.54 and 4.26+/-0.73, respectively. The ASBC at 115 minutes for PD and NC were 152.91+/-50.09 and 289.51+/-49.00, respectively. The ratio of BG/OCC for the NC was significantly higher than the ratio for PD. SPECT data matched with clinical diagnosis for PDs. The ratio between BG and OCC and the ASBC for PD were clearly separated from NC and may be useful outcome measures for clinical diagnosis. The findings suggest that IPT may be a very useful tracer for early diagnosis of PD and study of dopamine reuptake site.

• Korean Journal of Radiology
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• v.22 no.10
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• pp.1680-1689
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• 2021

Objective: To investigate the diagnostic yield of diffusion-weighted imaging (DWI) in patients with transient global amnesia (TGA) and identify significant parameters affecting diagnostic yield. Materials and Methods: A systematic literature search of the MEDLINE and EMBASE databases was conducted to identify studies that assessed the diagnostic yield of DWI in patients with TGA. The pooled diagnostic yield of DWI in patients with TGA was calculated using the DerSimonian-Laird random-effects model. Subgroup analyses were also performed of slice thickness, magnetic field strength, and interval between symptom onset and DWI. Results: Twenty-two original articles (1732 patients) were included. The pooled incidence of right, left, and bilateral hippocampal lesions was 37% (95% confidence interval [CI], 30-44%), 42% (95% CI, 39-46%), and 25% (95% CI, 20-30%) of all lesions, respectively. The pooled diagnostic yield of DWI in patients with TGA was 39% (95% CI, 27-52%). The Higgins I² statistic showed significant heterogeneity (I² = 95%). DWI with a slice thickness ≤ 3 mm showed a higher diagnostic yield than DWI with a slice thickness > 3 mm (pooled diagnostic yield: 63% [95% CI, 53-72%] vs. 26% [95% CI, 16-40%], p < 0.01). DWI performed at an interval between 24 and 96 hours after symptom onset showed a higher diagnostic yield (68% [95% CI, 57-78%], p < 0.01) than DWI performed within 24 hours (16% [95% CI, 7-34%]) or later than 96 hours (15% [95% CI, 8-26%]). There was no difference in the diagnostic yield between DWI performed using 3T vs. 1.5T (pooled diagnostic yield, 31% [95% CI, 25-38%] vs. 24% [95% CI, 14-37%], p = 0.31). Conclusion: The pooled diagnostic yield of DWI in TGA patients was 39%. DWI obtained with a slice thickness ≤ 3 mm or an interval between symptom onset and DWI of > 24 to 96 hours could increase the diagnostic yield.

• The Korean Journal of Nuclear Medicine
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• v.32 no.1
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• pp.10-19
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• 1998

The SPECT radiopharmaceuticals labeled with I-123 for dopamine transporter imaging have been used to measure dopamine transporters in patients with movement disorders. However, a cyclotron produced I-123 limits its availiability and ease of use as a radioisotope to be labeled with pharmaceuticals in routine clinical diagnostic procedures. Recently, new radiophannaceuticals for Tc-99m which has optimal characteristic for SPECT imaging have been developed to overcome the limits of using I-123. The purpose of this study was to compare the quality of [Tc-99m]TRODAT-1 with [I-123]IPT SPECT data and then to evaluate the usefulness of [Tc-99m]TRODAT-1 SPECT by using three noninvasive simplified quantitative methods. TRODAT-1 labeled with Tc-99m($15.93{\pm}0.82mCi$) and IPT labeled with I-123($6.60{\pm}0.11mCi$) were injected into five normal controls. Dynamic [Tc-99m]TRODAT-1 SPECT scans of brain were performed for 10 minutes each over 180 minnutes, and for 20 minutes at 4 hrs and 5 hrs. [I-123]IPT SPECT scans were performed for 5 minutes each over 120 minutes. Time activity curves were generated for the left basal ganglia(LBG), right basal ganglia(RBG), and occipital cortex(OCC). Dopamine transporter parameters were ohtained using (BG-OCC)/OCC, graphical method($R_V$), and area ratio method($R_A$). TRODAT-1 and IPT SPECT imaging showed high uptake at the level of the basal ganglia. (BG-OCC)/OCC ratios for TRODAT-1 and IPT were $0.80{\pm}0.14$, and $3.22{\pm}0.81$, $R_Vs$ were $0.62{\pm}0.12$, and $2.30{\pm}0.35$, and $R_As$ were $0.37{\pm}0.08$ and $1.73{\pm}0.31$, respectively. In conclusion, further improvement of [Tc-99m]TRODAT-1 imaging characteristics may be required to estimate the dopamine transporter concentrations in human brains although it shows clear BG localization.

• The Journal of the Korea Contents Association
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• v.13 no.11
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• pp.106-118
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• 2013

I discussed how the Zen training could be used to previous acting training methods focused on the way draw efficiently subconsciousness in the process of the training of actors. It is believed that the practice of the Zen would contribute to the development of training subconsciousness of actors. I examined the validities of the Zen practices which could be helpful to young students and existing actors' training processes and started from the existing proven analyses of mental and psychological effects of it. It is certain that the practices of Zen is a new continent which has infinite possibilities of analyzing and studying in terms of thinking highly of the Zen and brain science together. If we would utilize the Zen efficiently in the course of training actors, we could achieve four elements: the first, a trigger to operate actors' subconsciousness, the second, establishing the presence of actors through the reinforcement of concentration, the third, overcoming any mental and psychological obstacles, and the fourth, the establishment of transformation skills through the combined use of left and right brains. Additionally, actors could have mental and psychological stability through the Zen practice in their daily lives. I believe that we could also find a unique Eastern actor training way through vigorous and practical following analyses and practices which are based on the Zen tradition for training actors' subconsciousness and unconsciousness.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.46 no.6
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• pp.44-49
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• 2009

EAS (electronic article surveillance) systems have increased rapidly for article surveillance. In this paper, the strength of the EMF (electromagnetic fields) of EAS systems were measured. Pacemaker and ICD were investigated for inappropriate response resulting from EM (electromagnetic) EAS systems. The strength of EMF and the response of pacemaker and ICD were measured in the inner left side, outer right sides and the center of gates of the 6.3 kHz and 14.25 kHz EAS systems at a height of 130cm. As the result, EMF of the EAS system using 14.25 kHz was stronger than that of 6.3 kHz. AU interferences were observed only for 14.25 kHz, and the noisy ECG was found in three static positions on the pacemaker. The ICD resulted in noise reversion and VF (ventricular fibrillation) both static and moving positions by the EMP of 14.25 kHz EAS system. Therefore, it is necessary to post a message warning radiation of EMF from every EAS systems and possible risk of pacemakers and ICDs.

• Science of Emotion and Sensibility
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• v.12 no.4
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• pp.425-432
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• 2009

The purposes of the study were to examine cerebellar areas and lateralization responsible for visuospatial and verbal tasks using functional Magnetic Resonance Imaging(fMRI). Eight healthy male college students($21.5\;{\pm}\;2.3$ years) and eight male college students($23.3\;{\pm}\;0.5$ years) participated in this fMRI study of visuospatial and verbal tasks, respectively. Functional brain images were taken from 3T MRI using the single-shot EPI method. All functional images were aligned with anatomical images using affine transformation routines built into SPM99. The experiment consisted of four blocks. Each block included a control task(1 minute) and a cognitive task(1 minute). A run was 8 minutes long. Using the subtraction procedure, activated areas in the cerebellum during the visuospatial and verbal tasks were color-coded by t-score. A cerebellar lateralization index was calculated for both cognition tasks using number of activated voxels. The activated cerebellar regions during the both cognition tasks of this study agree with previous results. Since the number of activated voxels of the left and right cerebellar hemisphere was almost same, there was no cerebellar lateralization for both cognition tasks.

• Journal of Korean Neurosurgical Society
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• v.44 no.3
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• pp.131-135
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• 2008

Objective : Hemifacial spasm (HFS) is considered as a reversible pathophysiological condition mainly induced by continuous vascular compression of the facial nerve root exit zone (REZ) at the cerebellopontine angle. As an offending vessel, vertebrobasilar artery tends to compress much more heavily than others. The authors analyzed HFS caused by vertebrobasilar artery and described the relationships between microsurgical findings and clinical courses. Methods : Out of 1,798 cases treated with microvascular decompression (MVD) from Jan. 1980 to Dec. 2004. the causative vessels were either vertebral artery or basilar artery in 87 patients. Seventy-nine patients were enrolled in this study. Preoperatively, computed tomography (CT) or brain magnetic resonance (MR) imaging with 3-dimentional short range MR technique was performed and CT was checked immediately or 2-3 days after anesthetic recovery. The authors retrospectively analyzed the clinical features. the compression patterns of the vessels at the time of surgery and treatment outcomes. Results : There were 47 were male and 32 female patients. HFS developed on the left side in 52 cases and on the right side in 27. The mean age of onset was 52.3 years (range 19-60) and the mean duration of symptoms was 10.7 years. Many patients (39 cases; 49.1%) had past history of hypertension. HFS caused only by the vertebral artery was 8 cases although most of the other cases were caused by vertebral artery (VA) in combination with its branching arteries. Most frequently, the VA and the posterior inferior cerebellar artery (PICA) were the simultaneous causative blood vessels comprising 32 cases (40.5%). and in 27 cases (34.2 %) the VA and the anterior inferior cerebellar artery (AICA) were the offenders. Facial symptoms disappeared in 61 cases (77.2%) immediately after the operation and 68 cases (86.1%) showed good outcome after 6 months. Surgical outcome just after the operation was poor in whom the perforators arose from the offending vessels concurrently (p<0.05). Conclusion : In case where the vertebral artery is a cause of HFS, commonly branching arteries associated with main arterial compression on facial REZ requires more definite treatment for proper decompression because of its relatively poor results compared to the condition caused by other vascular compressive origins.

• Korean Journal of Cognitive Science
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• v.22 no.3
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• pp.255-270
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• 2011

The purpose of this study was to examine the effects of nonspecific and specific cue on decision making during situation awareness. Participants were 36 male college students who were randomly assigned to one of three groups: (1) nonspecific situation awareness, (2) specific situation awareness, and (3) a control group. Every participant was in the level 3-4.5 according to American National Tennis Level Program. Participants were asked to watch tennis single defence, single offence, double defence rally and when the screen stops, they were required to push the button(left, middle, or right) appropriate for the ball's direction to return as soon as possible. The experiment was designed to be analyzed for group(3)${\times}$condition(3)${\times}$area(7) using three-way ANOVA. The dependent variables were reaction time, accuracy rate, and amplitude and latency of P300. The result showed that the latency of the nonspecific situation awareness group and the specific situation awareness group was shorter and their amplitudes were higher than the control group. Fz, Cz, Pz were prominent among areas, and the single defence condition was more prominent than the single offence and the double defence condition. As a result of the study, it can be suggested that the information about situation awareness provided beforehand directly affects the brain's information processing. In addition, it shows that ERP can be a useful index for studying situation awareness.

• The Journal of Internal Korean Medicine
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• v.25 no.3
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• pp.529-538
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• 2004

This clinical study on 93 cases of Dyslogia after stroke confirmed through brain CT, MRI scan and clinical observation. They were hospitalized in the oriental medical hospital of Dong-Eui University from january to September 2003. The following results were found: I. The ratio between males and females was 1.6:1. Of Dyslogia p who had suffered stroke, most were in their sixties. 2. Categorized by attack site, right hemiplegia patients comprised 15 cases(l6.1%), and left hemiplegia patients, 71 cases(54.8%), so the ratio between Rt. and Lt. was 1:4.7. 3. Categorized by preceeding disease, hypertension was seen 51 cases(54.8%), and diabetes mellitus was seen 21 cases(22.6%). 4. Categorized by repeat attack, it was the first attack for 71 cases(76.3%), and the second attack for 13 cases(l4.0%), and for 9 cases(9.7%) it was the third or nth attack. 5. According to the classification of Zhang Zhongjing, apoplexy involving Bu-organs comprised 42 cases(45.2%), apoplexy involving meridians 39 cases(41.9%), apoplexy involving Jang-organs 11 cases(11.8%), and for apoplexy involving collaaterals there was one case(1.1%). 6. According to the classification of Cheng Zhongling, 43 cases(46.7%) were classed heart meridian, 25 cases(27.2%) were classed Spleen meridian, and 24 cases(26. 1%) were classed Kidney meridian. 7. According to the classification of Sun Simiao, 49 cases(52.7%) were classed Pyungo, two cases(2.2%) were classed Pungeui, ,seven cases(7.5%) were classed Pungbi( I ), and two cases(2.2%) were classed Pungbi( II ).