Purpose : In this descriptive, correlational study, the relationship between nursing students' adaptation to college life, self-directed learning ability, and learning flow was examined. Additionally, factors influencing nursing students' learning flow were identified. Methods : Data were collected from 101 third-year nursing students at University A in B city between July 10 and August 23, 2024. The evaluation was conducted using frequencies, percentages, independent t-tests, ANOVA, post-hoc analysis with Scheffé's test, Pearson correlation coefficients, and multiple regression analysis for factors influencing learning flow. Results : The scores for the participants' adaptation to college life, self-directed learning ability, and learning flow were 3.27±0.59, 3.68±0.57, and 2.93±0.67, respectively. Additionally, the score for department satisfaction was 6.60±2.06, and that for expectations for future roles was 6.97±2.16. Significant differences in learning flow were observed based on academic performance (F= 11.98, p<.001), school life (F= 5.98, p= .001), department satisfaction (F= 23.35, p<.001), and expectations for future roles (F= 7.93, p<.001). Learning flow was positively correlated with adaptation to college life (r= 0.41, p<.001) and self-directed learning ability (r= 0.71, p<.001). The results of the stepwise multiple regression analysis showed that the factors influencing learning flow were self-directed learning ability (𝛽= 0.648, p<.001), department satisfaction (𝛽= 0.329, p=.001), and school life (𝛽= 0.212, p=.025), with an explanatory power of 54.8 % (F= 41.39, p<.001). Conclusion : This study's results demonstrated that enjoyment of school life, department satisfaction, and self-directed learning ability as significant predictors of learning flow among nursing students, with self-directed learning ability emerging as the most crucial factor. Therefore, to enhance nursing students' learning flow, developing programs that improve self-directed learning ability, promote department satisfaction, and enhance enjoyment of school life is essential.