• YAKHAK HOEJI
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• v.59 no.4
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• pp.151-157
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• 2015

The purpose of this study is to demonstrate how lead compounds are best optimized with the application of in silico QSAR and PBPK modeling at the early drug discovery stage. Several predictive QSAR models such as $IC_{50}$ potency model, intrinsic clearance model and brain penetration model were built and applied to a set of virtually synthesized library of the BACE1 inhibitors. Selected candidate compounds were also applied to the PBPK modeling for comparison between the predicted animal pharmacokinetic parameters and the observed ones in vivo. This novel lead optimization strategy using QSAR and PBPK modelings could be helpful to expedite the drug discovery process.

• Proceedings of the IEEK Conference
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• 2000.06e
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• pp.124-126
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• 2000

The Minimum-Norm Least-Square(MNLS) approach based on lead field theory is an useful method to find an unique inverse solution for the measured magnetic field. The lead field depends on head geometry and location of sources and sensors. So, optimization of sensor array location is important issue for MNLS estimation. In this paper, we present an investigation for the optimization of sensor array location in computer simulation.

• Progress in Superconductivity and Cryogenics
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• v.10 no.3
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• pp.43-46
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• 2008

Design of current lead for 21T superconducting magnets is presented. The current lead is composed of a normal metal element, conducting the current from room temperature to intermediate temperature, and an HTS element, conducting the current down to liquid helium temperature. The metal element is disengaged from the HTS element without breaking vacuum after excitation. The optimization of the lead is performed to minimize the thermal heat load when carrying operational current with some margin. In order to confirm the feasibility of our new design, the intermediate joint between a normal metal and HTS element is fabricated and the reliability is tested during engage and disengage performance. The effects of vacuum level and performance cycle on the electrical contact resistance are also investigated.

• The Korean Journal of Pesticide Science
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• v.8 no.3
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• pp.168-174
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• 2004

In a course of the process for a lead optimization of 2-imino-l,3-thiazolines 1 which show a selective in vivo antifungal activity against rice blast, new compounds 2 in which C-5 was substituted by methyl group of the lead compound were synthesized and tested for the biological activity. Bromination of $\beta$-keto ester 7 followed by the reaction with thiourea and hydrolysis gave 2-imino-5-methyl-l,3-thiazoline carboxylic acid 3. Coupling reactions of 3 with aniline derivatives afforded 17 kinds of the corresponding 2-imino-5-methyl-l,3-thiazoline carboxanilides 2. Their in vivo antifungal activity against rice blast was weaker than that of 1, indicating that the in vivo antifungal activity of 2-imino-l,3-thiazolines was affected by the substituent at C-5. These results would be an important data for the molecular design in the lead optimization process of this series.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.17 no.8
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• pp.764-771
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• 2005

A theoretical investigation for optimization of conduction-cooled Peltier current leads is undertaken. A Pottier current lead (PCL) is composed of a thermoelectric element (TE), a metallic lead and a high Tc superconductor (HTS) lead in the order of decreasing thermoelectric tempera ture. Mathematical expression for the minimum heat flow per unit current crossing the TE metal interface and that flowing from the metal lead to the joint of the metal and the HTS leads are obtained. It is shown that the temperature at the TE-metal interface possesses a unique optimal value that minimizes the heat flow to the joint and that this optimal value depends on the material properties of the 73 and the metallic lead but not the joint temperature nor electric current. It is also shown that there exists a unique optimal value for the joint temperature between the metal and the HTS leads that minimizes the sum of the power dissipated by ohmic heating in current leads and the refrigerator power consumed to cool the lead, for a given length of the HTS.

• Nuclear Engineering and Technology
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• v.55 no.6
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• pp.2047-2052
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• 2023

Risk-informed approach has been widely applied in the safety design, regulation, and operation of nuclear reactors. It has been commonly accepted that risk-informed design optimization should be used in the innovative reactor designs to make nuclear system highly safe and reliable. In spite of the risk-informed approach has been used in some advanced nuclear reactors designs, such as Westinghouse IRIS, Gen-IV sodium fast reactors and lead-based fast reactors, the process of risk-informed design of nuclear reactors is hardly to carry out when passive system reliability should be integrated in the framework. A practical method for new passive safety reactors based on probabilistic safety assessment (PSA) and passive system reliability analyze linking is proposed in this paper. New three-dimension frequency-consequence curve based on risk concept with three variables is used in this method. The proposed method has been applied to the determination optimization of design options selection in a 10 MWth lead-based research reactor(LR) to obtain one optimized system design in conceptual design stage, using the integrated reliability and probabilistic safety assessment program RiskA, and the computation resources and time consumption in this process was demonstrated reasonable and acceptable.

• Journal of the Semiconductor & Display Technology
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• v.22 no.2
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• pp.104-111
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• 2023

The semiconductor industry, which relies on global supply chains, has recently been facing longer lead time for material procurement due to supply chain uncertainties. Moreover, since increasing customer satisfaction and reducing inventory costs are in a trade-off relationship, it is challenging to determine the appropriate safety stock level under demand and lead time uncertainties. In this paper, we propose a framework for determining safety stock levels by utilizing the optimization method to determine the optimal safety stock level. Additionally, we employ a linear regression method to analyze customer satisfaction scores and inventory costs based on variations in lead time and demand. To verify the effectiveness of the proposed framework, we compared safety stock levels obtained by the regression equations with those of the conventional method. The numerical experiments demonstrated that the proposed method successfully reduces inventory costs while maintaining the same level of customer satisfaction when lead time increases.

• Management Science and Financial Engineering
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• v.8 no.2
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• pp.1-20
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• 2002

This paper presents a model that analyzes the impact of uncertainties in demand and processing times on the production lead time of a Kanban system. We consider the waste associated with under-production as well as over-production when we measure the production lead time. We set up an optimization model to minimize the production lead time. A simple heuristic procedure is developed to determine solutions in terms of the size of containers and the number of Kanban cards. In addition, we numerically examine the behavior of the optimal Kanban system.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.346.1-346.1
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• 2002

FXR (farnesoid X-activated receptor) is a member of nuclear steroid hormone receptor superfamily and especially a orphan receptor, which are able to control mevalonate pathway upon activation by binding of the specific ligands. We. have launched our study for development of FXR specific ligands getting on in lead discovery. A promising lead stilbene analog was obtained through the screening of a set of library compounds which was previously targeted for other nuclear receptors. And then synthetic modilication of the lead was perfoumde. In addition. fishing a new pharmacophore was fried by UNITT aearch. which brought new structural features.

• Proceedings of the KSME Conference
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• 2007.05a
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• pp.1149-1154
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• 2007

Fluctuation of control rod was experienced when plant was operating in normal operation mode in WH type NPPs. In order to cope with increased control rod fluctuation, the lead-lag controller setpoint for rod control system was optimized and resulted in increasing the margin of operation and minimizing unnecessary control rod movement. By optimization of the time constant, the margin of operation was increased by $1.5^{\circ}F$ and the control rod movement was not occurred due to mitigation of temperature fluctuation in loop. According to the mitigation of time constant, the margin of operation was increased but safety margin can be affected badly, so that the influences to FSAR design reference was evaluated. As the result of this evaluation, it satisfied the design reference of the existing safety analysis and was applied to NPP after obtaining the approval.