• 제목/요약/키워드: layer by layer

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나프록센이 각인된 생분해성 고분자 기반 다층 바이오소재의 제조 및 약물 방출 특성 (Preparation and Drug Release Properties of Naproxen Imprinted Biodegradable Polymers Based Multi-Layer Biomaterials)

  • 조은비;김한성;황민진;윤순도
    • 공업화학
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    • 제34권2호
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    • pp.161-169
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    • 2023
  • 본 연구는 allbanggae starch (ABS), polyvinyl alcohol (PVA), alginic acid (SA)를 이용하여 naproxen (NP) 각인 starch 기반 다층 바이오소재를 제조하고, 물리화학적 특성과 약물 방출 제어 효과를 조사하였다. 또한, FE-SEM과 FT-IR 분석에 의해 제조한 다층 바이오소재의 특성을 조사하였다. 약물 방출 제어 효과와 경피 약물 전달 시스템의 적용 가능성을 확인하기 위해 NP 각인 다층 바이오소재로부터 NP 방출 특성을 사람의 체온인 36.5 ℃에서 다양한 pH buffer solution과 인공 피부를 이용하여 확인하였다. NP는 낮은 pH보다 높은 pH에서 1.3배 더 빠른 방출을 나타냈고, single-layer 바이오소재에서보다 multi-layer 바이오소재에서 약 4.0배 느린 방출이 일어남을 확인하였다. 인공 피부 방출에서도 동일하게 single-layer 바이오소재보다 multi-layer 바이오소재에서 약 4.0배 더 느린 약물 방출 결과를 나타내었다. 또한, double-layer와 triple-layer 바이오소재 모두 12시간 동안 지속적으로 NP가 방출되었음을 확인 하였다. NP 방출 mechanism을 규명하기 위해 수학적 모델링에 적용하여 비교했을 때, pH buffer solution에서의 방출은 Fickian diffusion mechanism, 인공 피부 방출은 empirical mechanism에 적합한 것을 확인하였다.

다양한 물성을 혼용하여 제작된 구강보호장치가 치아 및 악골에 미치는 영향 (Finite element analysis of the effects of mouthguard produced by combination of layers of different materials on teeth and jaw)

  • 소웅섭;이현종;최우진;홍성진;류경희;최대균
    • 대한치과보철학회지
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    • 제49권4호
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    • pp.324-332
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    • 2011
  • 연구 목적: 다양한 물성의 층으로 제작된 마우스가드를 장착하였을 때 치아와 악골에 가해지는 힘의 유한요소 분석을 시행하기 위함이다. 연구 재료 및 방법: 연구대상의 모형을 교합기에 장착한 뒤 Signature Mouthguard System (Dreve dentamid GmbH., Unna, Germany)을 이용하여 맞춤형 구강보호장치를 제작하여 장착한 후 두정부에서 경추까지 1.0 mm로 컴퓨터 단층촬영을 시행하였다. 영상을 Cantibio BIONIX 프로그램을 이용하여 3차원 유한요소 모델을 생성한 뒤 HyperMesh 소프트웨어를 이용하여 데이터 분석을 시행하였다. 마우스가드는 층에 따라 다음과 같이 분류하였다. 1. 연질(Bioplast)(SG) 2. 경질(Duran)(HG) 3. 중질(Drufomat)(MG) 4. 연질+중질(SG + HG) 5. 경질 + 연질(HG + SG) 6. 연질 + 경질 + 연질(SG + HG + SG) 7. 경질 + 연질 + 경질(HG + SG + HG) 하중위치는 하악골의 전방 이부(F1), 하악 좌측 제1대구치 하방의 하악체 중앙(F2), 하악각의 전연(F3) 세점으로 하였고 FH Plane에 45도 방향으로 800N, 0.1초의 힘을 가하였다. 통계방법으로는 반복분산분석과 사후분석(다중비교분석(Multiple comparison test) DUNCAN test)을 이용하였다. SPSS 소프트웨어 (Ver.13, SPSS Inc., Chicago, IL, USA)를 사용하여 분석하였다. 결과: 치아와 상악골에서의 응력분포는 모든 하중위치에 대하여 연질층이 하악 치아에 접촉하는 구강보호장치가 적은 응력값을 나타냈으며, 과두에서의 응력분포는 모든 하중위치에 대하여 경질층이 하악 치아에 접촉하는 구강보호장치가 적은 응력값을 나타내었다. 두 연질층 사이에 경질층이 개재된 세층의 구강보호장치가 하중 시 상대적으로 고르게 응력이 분산되는 것으로 나타났다. 결론: 상하악 치아에는 연질층이 접촉하고 두 연질층 사이에 경질층을 삽입하는 형태의 구강보호장치가 악안면 외상 시 상대적으로 하중을 분산시키는데 가장 우수하다고 생각된다.

Effect of centrifugation on the structure and properties of silk sericin

  • Park, Chun Jin;Um, In Chul
    • International Journal of Industrial Entomology and Biomaterials
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    • 제33권2호
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    • pp.144-148
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    • 2016
  • Recently, silk sericin has been studied extensively for biomedical and cosmetic applications because of its unique properties, including UV resistance and wound healing ability. For use in applications, sericin is fabricated in various forms including films and gels. However, the mechanical properties of sericin are too weak. In this basic study on improving the mechanical properties of sericin, a silk sericin aqueous solution was separated into two layers by centrifugation. The solution viscosity, molecular conformation, and mechanical properties of each separation layer of the sericin were examined. Sericin from the lower layer had a higher solution viscosity and film mechanical properties (strength and strain) than that from the upper layer, implying that sericin from the lower layer had a higher molecular weight than that from the upper layer. The molecular conformation of the sericin films varied depending on the casting solvent. In aqueous solution, the sericin film from the lower layer showed a ${\beta}$-sheet conformation, whereas that from the upper layer displayed a random coil conformation. All the sericin films showed a highly ${\beta}$-sheet-crystallized state when cast in formic acid, regardless of the separation layer.

수용액중의 진주층에 대한 염기성 염료의 흡착매개변수 및 흡착모델 선정 (Selection of Adsorption Model and Parameters for Basic Dyes from Aqueous Solution onto Pearl Layer)

  • 신춘환;송동익
    • 한국환경과학회지
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    • 제14권12호
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    • pp.1203-1209
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    • 2005
  • Basic dyes, Rhodamine 6G(R6G), Rhodamine B(RB), and Methylene Blue(MB), dissolved in water were used to investigate single-component adsorption affinity to the pearl layer fractionated according to the size. Unfractionated pearl layers were also used as adsorbents for the R6G and RB. The Langmuir and the Redlich-Peterson(RP) models were used to fit the adsorption data, and the goodness of fit was examined by using determination coefficient($R^2$) and standard deviation(SSE). The 3-parameter RP model was found to be better in describing the dye adsorption data than the 2 parameter Langmuir model, as can be expected from the number of parameters involved in the model. The adsorption affinity to the fractionated pearl layer was higher than that to the unfractionated layer The affinity order to the fractionated Conchiolin layer was found to be R6G > MB > RB. Furthermore, the dye adsorption capacity of the various types of pearl layer was found to be in the order, the fractionated pearl > powdered pearl > unfractionated pearl, exhibiting different adsorption isotherms according to the types of layer used in the study.

QualNet 기반의 WAVE 물리계층 연동 시뮬레이션 방안 (QualNet based Linked Simulation Method for WAVE Physical Layer)

  • 곽재민;박경원
    • 한국항행학회논문지
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    • 제13권3호
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    • pp.351-357
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    • 2009
  • 본 논문에서는 QualNet에 Matlab으로 구현해 놓은 WAVE 채널 모델과 물리계층 시뮬레이션 모듈을 효과적으로 연동시킬 수 있는 방안을 연구하였다. 우선, QualNet 시뮬레이터에서 사용하는 간소화된 무선 물리계층 및 통신매체의 구현 방법에 대해 검토 후, QualNet 네트워크 시뮬레이터가 상세한 다중경로 페이딩 모델과 IEEE802.11p 통신 모뎀이 구현된 이종의 물리계층 시뮬레이션 모듈을 도입하기 위한 실질적인 방안을 제시하였다. 본 논문의 결과는 차세대 DSRC 규격인 WAVE를 위한 상위계층에서부터 하위 물리계층 링크를 통합시뮬레이션 하는 링크 시뮬레이션 기법으로 활용될 것이다.

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Rubrene과 DCM2가 첨가된 적색 유기전계발광소자의 발광특성 (Luminescent characteristics of OLED doped with DCM2 and rubrene)

  • 박용규;성현호;김인회;조황신;양해석
    • 한국전기전자재료학회:학술대회논문집
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    • 한국전기전자재료학회 2001년도 하계학술대회 논문집
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    • pp.939-942
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    • 2001
  • We fabricated Red Organic light-emitting devices(OLED). The Basic Device Structure is ITO/hole transfer layer, TPD(50nm)/red emitting layer, Alq3 doped with DCM2 or DCM2:rubrene(xnm)/electorn transfer layer, Alq3(50-xnm)/LiF(0.8nm)/Al(8nm) . The thickness of emitting layer(xnm) changed 5, 10, 20nm. we demonstrate red emitting OLED with dependent on the thickness and concentrators of Alq3 layer doped with DCM2 or co-doped with DCM2:ruberene. The Emission color and Brightness are changed with doping or co-doping condition, dopant concentarton. In the case of rubrene:DCM2 co-doped layer structure, the red color Purity and device efficiency is improved. The CIE index of rubrene co-doped OLED is x=0.67, y=0.31. By co-doping the Alq3 layer with DCM2, rubrene, EL efficiency improved from 0.38cd/A to 0.44cd/A in comparison whit DCM2 doped Alq3 layer.

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Effect of composition and structure on exchange anisotropy of IrxMn(100-x)/NiFe films

  • Suh, Su-jung;Park, Young-suk;Ro, Jae-chul;Yong-sung;Yoon, Dae-ho
    • 한국결정성장학회:학술대회논문집
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    • 한국결정성장학회 1998년도 PROCEEDINGS OF THE 14TH KACG TECHNICAL MEETING AND THE 5TH KOREA-JAPAN EMGS (ELECTRONIC MATERIALS GROWTH SYMPOSIUM)
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    • pp.91-95
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    • 1998
  • Exchange anisotropy between IrMn antiferromagnetic layer and NiFe ferromagnetic layer has been studied in IrxMn(100-x)/NiFe/Buffr/Si(100) films deposited by D. C. magnetron sputtering method. Among Zr, Ta, and Cu used as buffer layer, Zr and Ta enhanced the fcc(111) texture of NiFe and IeMn layer, but Cu did not affect microstructure of those layer. Strong fcc(111) texture of IrMn layer was confirmed to be the origin of exchange anisotropy of IrMn. Ir composition control in IrMn layer showed that {{{{ gamma -phase}}}} IrMn is stabilized between 10 and 30 at % Ir, an 21 at. % Ir in IrMn layer was optimum composition that showed maximum exchange anisotropy field. above 200 ${\AA}$ thickness of IrMn, antiferromagnetic property is stabilzed to show saturated exchange anisotropy field. Based pressure was confirmed to be critical requisite in IrMn-based spin-valve GMR system.

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막표면의 케이크층 세정 방법에 따른 여과 저항값 비교 (Comparison of Filtration Resistances according to Membrane Cleaning Methods)

  • 한송희;장인성
    • 한국환경과학회지
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    • 제25권6호
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    • pp.817-827
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    • 2016
  • The resistance in series model has been frequently used for determination of various filtration resistance to correctly understand the membrane fouling behaviour in MBR (membrane bio-reactor) for wastewater treatment. The cake layer resistance ($R_c$) which is commonly determined by calculation of flux dataset that are obtained empirically before and after removing the cake layer on membrane surface. However, the calculated Rc values are very dependent on the cleaning methods adapted for removal of cake layer. This study investigated how the various cleaning options affect $R_c$. Seven different cleaning methods were employed: i) ultrasonication (100 W, 10 min), ii) ultrasonication (200 W, 60 min), iii) ultrasonication (400 W, 120 min), iv) water rinsing in a shaker (100 rpm, 10 min), v) water rinsing in a shaker (300 rpm, 60 min), vi) water rinsing, vii) sponge scrubbing. For the hydrophilic PES membrane, the cake layer removal efficiencies ranged from 64% to 10%, indicating that the removal of cake layer was highly dependent on the cleaning options. For the hydrophobic PVDF membrane, the cake layer removal efficiencies ranged from 79% to 97%. Consequently, a standardized method for cake layer removal to determine cake resistance ($R_c$) is needed for correct interpretation of the fouling phenomena.

적색 유기발광소자의 휘도향상을 위한 Dielectric layer 설계 및 제작에 관한 연구 (The Study on Dielectric layer Design and Manufactor for Luminance Improvement of Red Organic Light Emitting Device)

  • 기현철;김선훈;김두근;김상기;정행윤;최용성;홍경진
    • 전기학회논문지
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    • 제59권5호
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    • pp.918-921
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    • 2010
  • We have proposed an dielectric layer to improve the luminance of red organic light emitting device. Here, we have calculated refractive index of dielectric layer material that was revised refractive index of organic material, ITO and glass. Refractive index of dielectric layer material was 1.711. The structure of dielectric layer was designed in organic material/ITO/dielectric layer/glass. Dielectric material changed thickness that deposited by ion-assisted deposition system. Transmittances of ITO were 95.66-98.85 [%]. Red OLED was fabricated with the structure of TPD($400[{\AA}]$)/DCMII($20[{\AA}]$), Rubrene($20[{\AA}]$)/Alq3($500[{\AA}]$)/LiF($15[{\AA}]$)/Al($1,000[{\AA}]$). Turn-on voltage and Luminance of Red OLED were 10 [V] and 5,857 cd/m2.

H.264/SVC의 계층간 화면내 예측에서 보간법에 따른 부호화 성능 분석 (Performance Analysis of Coding According to the Interpolation filter in Inter layer Intra Prediction of H.264/SVC)

  • 길대남;정차근
    • 대한전자공학회:학술대회논문집
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    • 대한전자공학회 2009년도 정보 및 제어 심포지움 논문집
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    • pp.225-227
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    • 2009
  • International standard specification, H.264/SVC improved from H.264/AVC, is set up so as to promote free use of huge multimedia data in various channel environments.;H.264/AVC is a international standard speicification for video compression, adopted and commercialized as standard for DMB broadcasting by JVT of ISO/IEC MPEG and ITU-T VCEG. SVC standard uses 'intra/inter prediction' in AVC as well as 'inter-layer intra prediction', 'inter-layer motion prediction' and 'inter-layer residual prediction' to improve efficiency of encoding. Among prediction technologies, 'inter-layer intra prediction' is to use co-located block of up sampled sublevels as a prediction signal. At this time, application of interpolation is one of the most important factors to determine encoding efficiency. SVC's currently using poly-phase FIR filter of 4-tap and 2-tap respectively to luma components. This paper is written for the purpose of analyzing encoding performance according to the interpolation. For this purpose, we applied poly-phase FIR filter of '2-tap', '4-tap' and '6-tap' respectively to luma components and then measured bit-rate, PNSR and running time of interpolation filter. We're expecting that the analysis results of this paper will be utilized for effective application of interpolation filter. SVC standard uses 'intra/inter prediction' in AVC as well as 'inter-layer intra prediction', 'inter-layer motion prediction' and 'inter-layer residual prediction' to improve efficiency of encoding.

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