• Journal of Biomedical Engineering Research
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• v.14 no.1
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• pp.89-96
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• 1993

During high frequency ventilation (HFV), mean alveolar pressure has been measured to increase with mean airway opening pressure controlled at a constant level in both humans and experimental animals. Since this phenomenon could potentiate barotrauma limiting advantages of HFV, the present study theoretically predicted the difference between menu alveolar and airway opening pressures ($MP_{alv}$). In a Weibel's trumpet airway model, approximated formula for $MP_{alv}$ was derived based on momentum conservation assuming a uniform velocity profile. The prediction, equation was a func pion of gas density($\rho$), mean flow rate(Q), and diameter of the airway opening where the pressure measurement was made($D_0$) : $MP_{alv}=4{\rho}(Q/D_0^{2})^2$. This was a result of the difference in crosssectional area between the alveoli and the airway opening. A simple aireway model experiment was performed and the results well fitted to the prediction, which demonstrated the validity of the present analysis. Previously reported $MP_{alv}$ data from anesthetized dogs in supine position were comparable to the predicted values, indicating that the observed dissociation between mean alveolar and airway opening pressures during HFV can be explained by this innate geometric (or cross-sectional area) asymmetry of the airways. In lateral position, however, the prediction substantially underestimated the measurements suggesting involvement of other important physiological mechanisms.

• The Korean Journal of Pharmacology
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• v.12 no.2 s.20
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• pp.43-49
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• 1976

The facts that $PGE_2$ produced diuresis in the rabbit when given into a lateral ventricle of the brain and that $PGF_{2{\alpha}}$ is abundantly found in the brain prompted us to investigate the effects of $PGF_{2{\alpha}}$ introduced directly into the ventricle on the renal function. $PGF_{2{\alpha}}$ given intraventriculary in doses of $10{\mu}g\;and\;100{\mu}g$ elicited prompt diuresis, 10-fold increase of sodium excretion and two-fold increment of potassium excretion. Free water reabsorption also increased along with the increased osmolar clearance. Neither renal plasma flow nor glomerular filtration rate did change significantly. This, along with the fact that the percentage of reabsorbed sodium filtered decreased from 99.5 to 93.9, indicates the tubular site of the diuretic and natriuretic action. Atropine pretreatment did not influence the renal effects of intraventricular $PGF_{2{\alpha}}$. Intravenously administered $PGF_{2{\alpha}}$ in doses of 30 to $100{\mu}g$ did not produce any significant change in renal function. Intraventricular $PGF_{2{\alpha}}$ had no effect on the systemic blood pressure, whereas intravenous administration brought about a transient hypotension. These observations suggest that $PGF_{2{\alpha}}$ induces diuresis and natriuresis via central mechanism, that the site of the action resides in renal tubules, and that the reabsorption of sodium is inhibited in the proximal tubule, possibly through mediation of certain humoral agent. Overall, it is suggested that $PGF_{2{\alpha}}$ might play a roll in regulating renal function through the center.

• Wind and Structures
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• v.20 no.2
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• pp.143-168
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• 2015

A numerical model for analyzing air-train-track interaction is proposed to investigate the dynamic behavior of a high-speed train running on a track in crosswinds. The model is composed of a train-track interaction model and a train-air interaction model. The train-track interaction model is built on the basis of the vehicle-track coupled dynamics theory. The train-air interaction model is developed based on the train aerodynamics, in which the Arbitrary Lagrangian-Eulerian (ALE) method is employed to deal with the dynamic boundary between the train and the air. Based on the air-train-track model, characteristics of flow structure around a high-speed train are described and the dynamic behavior of the high-speed train running on track in crosswinds is investigated. Results show that the dynamic indices of the head car are larger than those of other cars in crosswinds. From the viewpoint of dynamic safety evaluation, the running safety of the train in crosswinds is basically controlled by the head car. Compared with the generally used assessment indices of running safety such as the derailment coefficient and the wheel-load reduction ratio, the overturning coefficient will overestimate the running safety of a train on a track under crosswind condition. It is suggested to use the wheel-load reduction ratio and the lateral wheel-rail force as the dominant safety assessment indices when high-speed trains run in crosswinds.

• Journal of Korean Neurosurgical Society
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• v.49 no.1
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• pp.1-7
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• 2011

Objective: Glutamate is a key excitatory neurotransmitter in the brain, and its excessive release plays a key role in the development of neuronal injury. In order to define the effect of nimodipine on glutamate release, we monitored extracellular glutamate release in real-time in a global ischemia rat model with eleven vessel occlusion. Methods: Twelve rats were randomly divided into two groups: the ischemia group and the nimodipine treatment group. The changes of extracellular glutamate level were measured using microdialysis amperometric biosensor, in coincident with cerebral blood flow (CBF) and electroencephalogram. Nimodipine (0.025 ${\mu}g$/100 gm/min) was infused into lateral to the CBF probe, during the ischemic period. Also, we performed Nissl staining method to assess the neuroprotective effect of nimodipine. Results: During the ischemic period, the mean maximum change in glutamate concentration was $133.22{\pm}2.57\;{\mu}M$ in the ischemia group and $75.42{\pm}4.22\;{\mu}M$ (p<0.001) in the group treated with nimodipine. The total amount of glutamate released was significantly different (P<0.001) between groups during the ischemic period. The %cell viability in hippocampus was $47.50{\pm}5.64$ (p<0.005) in ischemia group, compared with sham group. But, the %cell viability in nimodipine treatment group was $95.46{\pm}6.60$ in hippocampus (p<0.005). Conclusion: From the real-time monitoring and Nissl staining results, we suggest that the nimodipine treatment is responsible for the protection of the neuronal cell death through the suppression of extracellular glutamate release in the 11-VO global ischemia model of rat.

• Journal of The Korean Society of Agricultural Engineers
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• v.53 no.6
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• pp.75-84
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• 2011

The objective of this study is to evaluate the hydrologic impacts of climate and land use changes in a rural small watershed. HadCM3 (Hadley Centre Coupled Model, ver.3) A2 scenario and LARS-WG (Long Ashton Research Station - Weather Generator) were used to generate future climatic data. Future land use data were also generated by the CA-Markov (Cellular Automata-Markov) method. The Soil and Water Assessment Tool (SWAT) model was used to evaluate hydrologic impacts. The SWAT model was calibrated and validated with stream flow measured at the Baran watershed in Korea. The SWAT model simulation results agreed well with observed values during the calibration and validation periods. In this study, hydrologic impacts were analyzed according to three scenarios: future climate change (Scenario I), future land use change (Scenario II), and both future climate and land use changes (Scenario III). For Scenario I, the comparison results between a 30-year baseline period (1997~2004) and a future 30-year period (2011~2040) indicated that the total runoff, surface runoff, lateral subsurface runoff, groundwater discharge, and evapotranspiration increased as precipitation and temperature for the future 30-year period increased. The monthly variation analysis results showed that the monthly runoff for all months except September increased compared to the baseline period. For Scenario II, both the total and surface runoff increased as the built-up area, including the impervious surface, increased, while the groundwater discharge and evapotranspiration decreased. The monthly variation analysis results indicated that the total runoff increased in the summer season, when the precipitation was concentrated. In Scenario III, the results showed a similar trend to that of Scenario II. The monthly runoff for all months except October increased compared to the baseline period.

• The Korean Journal of Physiology and Pharmacology
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• v.2 no.5
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• pp.555-563
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• 1998

The renal function is under regulatory influence of central nervous system (CNS), in which various neurotransmitter and neuromodulator systems take part. However, a possible role of central GABA-benzodiazepine system on the central regulation of renal function has not been explored. This study was undertaken to delineate the renal effects of diazepam. Diazepam, a benzodiazepine agonist, administered into a lateral ventricle (icv) of the rabbit brain in doses ranging from 10 to 100 ${\mu}g/kg,$ elicited dose-related diuresis and natriuresis along with improved renal hemodynamics. However, when given intravenously, 100 ${\mu}g/kg$ diazepam did not produce any significant changes in all parameters of renal function and systemic blood pressure. Diazepam, 100 ${\mu}g/kg$ icv, transiently decreased the renal nerve activity (RNA), which recovered after 3 min. The plasma level of atrial natriuretic peptide (ANP) increased 7-fold, the peak coinciding with the natriuresis and diuresis. Muscimol, a GABAergic agonist, 1.0 ${\mu}g/kg$ given icv, elicited marked antidiuresis and antinatriuresis, accompanied by decreases in systemic blood pressure and renal hemodynamics. When icv 0.3 ${\mu}g/kg$ muscimol was given 3 min prior to 30 ${\mu}g/kg$ of diazepam icv, urinary flow and Na excretion rates did not change significantly, while systemic hypotension was produced. These results indicate that icv diazepam may bring about natriuresis and diuresis by influencing the central regulation of renal function, and that the renal effects are related to the increased plasma ANP levels, not to the decreased renal nerve activity, and suggest that the effects may not be mediated by the activation of central GABAergic system.

• Journal of Ginseng Research
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• v.33 no.1
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• pp.65-71
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• 2009

This experiment was done to determine the optimum conditions for the induction of tetraploidy in Panax ginseng C. A. Meyer using bud length, temperature and plant growth regulator pretreatments. Highest callus formation was obtained when the medium was inoculated with flower bud in the size of 2-3 mm in length. The optimum temperature for the callus formation was high when treated at $4^{\circ}C$ for 4-5 days. Among the treatments of growth regulators and different concentration, highest callus formation was observed in combination of 5 mg/L 2,4-D and 1 mg/L kinetin for P. ginseng. As a result of flow cytometer analysis, all 7 adventitious roots were confirmed as tetraploidys. Cytological analysis revealed that the chromosome number of tetraploid roots was 96, while that of diploid roots was 48. Tetraploid ginseng roots were inoculated to flower bud size of 2-3 mm in length. The callus formation was optimum when treated with 1 mg/L 2,4-D at $4^{\circ}C$ for 5 days. Compared with control roots, tetraploid roots were thicker and longer and had few lateral branches. Fresh weight of tetraploid roots was relatively higher than the control roots.

• Korea-Australia Rheology Journal
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• v.21 no.4
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• pp.203-211
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• 2009

In flows with deformation rates larger than the inverse Rouse time of the polymer chain, chains are stretched and their confining tubes become increasingly anisotropic. The pressures exerted by a polymer chain on the walls of an anisotropic confinement are anisotropic and limit chain stretch. In the Molecular Stress Function (MSF) model, chain stretch is balanced by an interchain pressure term, which is inverse proportional to the $3^{rd}$ power of the tube diameter and is characterized by a tube diameter relaxation time. We show that the tube diameter relaxation time is equal to 3 times the Rouse time in the limit of small chain stretch. At larger deformations, we argue that chain stretch is balanced by two restoring tensions with weights of 1/3 in the longitudinal direction of the tube (due to a linear spring force) and 2/3 in the lateral direction (due to the nonlinear interchain pressure), both of which are characterized by the Rouse time. This approach is shown to be in quantitative agreement with transient and steady-state elongational viscosity data of two monodisperse polystyrene melts without using any nonlinear parameter, i.e. solely based on the linear-viscoelastic characterization of the melts. The same approach is extended to model experimental data of four styrene-butadiene random copolymer melts in shear flow. Thus for monodisperse linear polymer melts, for the first time a constitutive equation is presented which allows quantitative modeling of nonlinear extension and shear rheology on the basis of linear-viscoelastic data alone.

• Journal of the Korean GEO-environmental Society
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• v.9 no.7
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• pp.13-23
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• 2008

In this study, the centrifuge tests and numerical analyses were performed to investigate the lateral flow behavior and stability of abutment when high filling was applied on the soft ground improved by SCP. The centrifuge model tests and numerical analyses were fulfilled in the case of the back of abutment filled by EPS (case 1) and soil (case 2), and the potentiometer was installed on the abutment and fill to measure the vertical and horizontal displacement at the top of abutment. As a result of the centrifugal tests, the horizontal displacement of abutment in the case 1 was 1.4cm that is almost coincide with the results of numerical and satisfy the allowable standard. On the other hand, the horizontal displacement of abutment in the case 2 was 12 cm that is 18% greater than that of numerical analysis and exceed the allowable standard. As a result of analysis, the maximum horizontal displacement of pile was 1.26 cm in case 1 that satisfies the criterion of allowable horizontal displacement (1.5 cm). In contrast, the maximum horizontal displacement of pile was 1.005 m in case 2 that greatly exceeds the allowable horizontal displacement.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.48 no.3
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• pp.187-194
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• 2020

In this study, computational analyses are carried out to investigate the interference flows and the aerodynamic characteristics of a hit-to-kill intercepter due to lateral jets at medium altitude. In addition, the analyses are performed for air and multi-species gas used in the side jet. The results indicate that the position of the barrel shock are shifted upstream and the structure of the shock wave are changed for the multi-species jet when compared to the air jet. As a result, the high pressure region with multi-species jet moves forward and the pitching moment is higher under the same flow condition. Moreover, the inclusion of high temperature effects makes drastic changes in pressure distribution. The jet width is much bigger, and the jet diffuses over wider range in medium altitude than in low altitude, because of the low density of the freestream.