• Earthquakes and Structures
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• 제16권4호
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• pp.469-485
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• 2019

A numerical investigation regarding local (${\mu}_L$) and story (${\mu}_S$) ductility demand evaluation of steel buildings with perimeter moment resisting frames (PMRF) and interior gravity frames (IGF), is conducted in this study. The interior connections are modeled, firstly as perfectly pinned (PP), and then as semi-rigid (SR). Three models used in the SAC steel project, representing steel buildings of low-, mid-, and high-rise, are considered. The story ductility reduction factor ($R_{{\mu}S}$) as well as the ratio ($Q_{GL}$) of $R_{{\mu}S}$ to ${\mu}_L$ are calculated. ${\mu}_L$ and ${\mu}_S$, and consequently structural damage, at the PMRF are significant reduced when the usually neglected effect of SR connections is considered; average reductions larger than 40% are observed implying that the behavior of the models with SR connections is superior and that the ductility detailing of the PMRF doesn't need to be so stringent when SR connections are considered. $R_{{\mu}S}$ is approximately constant through height for low-rise buildings, but for the others it tends to increase with the story number contradicting the same proportion reduction assumed in the Equivalent Static Lateral Method (ESLM). It is implicitly assumed in IBC Code that the overall ductility reduction factor for ductile moment resisting frames is about 4; the results of this study show that this value is non-conservative for low-rise buildings but conservative for mid- and high-rise buildings implying that the ESLM fails evaluating the inelastic interstory demands. If local ductility capacity is stated as the basis for design, a value of 0.4 for $Q_{GL}$ seems to be reasonable for low- and medium-rise buildings.

• Molecules and Cells
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• 제44권11호
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• pp.830-842
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• 2021

When perceiving microbe-associated molecular patterns (MAMPs) or plant-derived damage-associated molecular patterns (DAMPs), plants alter their root growth and development by displaying a reduction in the root length and the formation of root hairs and lateral roots. The exogenous application of a MAMP peptide, flg22, was shown to affect root growth by suppressing meristem activity. In addition to MAMPs, the DAMP peptide PEP1 suppresses root growth while also promoting root hair formation. However, the question of whether and how these elicitor peptides affect the development of the vascular system in the root has not been explored. The cellular receptors of PEP1, PEPR1 and PEPR2 are highly expressed in the root vascular system, while the receptors of flg22 (FLS2) and elf18 (EFR) are not. Consistent with the expression patterns of PEP1 receptors, we found that exogenously applied PEP1 has a strong impact on the division of stele cells, leading to a reduction of these cells. We also observed the alteration in the number and organization of cells that differentiate into xylem vessels. These PEP1-mediated developmental changes appear to be linked to the blockage of symplastic connections triggered by PEP1. PEP1 dramatically disrupts the symplastic movement of free green fluorescence protein (GFP) from phloem sieve elements to neighboring cells in the root meristem, leading to the deposition of a high level of callose between cells. Taken together, our first survey of PEP1-mediated vascular tissue development provides new insights into the PEP1 function as a regulator of cellular reprogramming in the Arabidopsis root vascular system.

• 대한통합의학회지
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• 제11권1호
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• pp.21-29
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• 2023

Purpose : Using a smartphone while walking districts attention and increases the risk of losing balance or falling. Ankle instability is caused by decreased muscle strength and decreased neuromuscular ability leading to postural control problems. Dual tasks increases the risk of falls by reducing postural control in adults with ankle instability. This study aimed to investigate the effect of performing a dual task on balance and muscle activity in adults with ankle instability using a smartphone. Methods : Forty-nine individuals with ankle instability participated in this study. A game of finding the wrong picture was performed using a smartphone in the dual task, and only looking at the blank screen of a smartphone was evaluated in the single task. The participants randomly performed single and dual task to evalutate balance and muscle atcitivy. Balance was evaluated using the Biodex balance system (BBS), and muscle activity was evaluated using surface EMG. Muscle activity of the gastrocnemius and tibialis anterior was measured at the same time as balance. Results : The results of this study showed that overall, anteior/posterior, and medial/lateral balance indices all showed significant differences when performing the dual task compared with those during the single task (p<.05). The muscle activity results showed a significant difference compared with that of the gastronemius muscle on the nondominant side during the dual task (p>.05). Conclusion : The results of this study showed that maintaining balance is more difficult when performing the dual task than during the single task, and only the muscle activity of the nondominant gastrocnemius muscle decreased. The dual task causes a decrease in concentration for postural control, which negatively affects postural stability. Individuals with ankle ankle instability should refrain from performing dual tasks, such as using smartphones, to prevent ankle damage.

• 대한통합의학회지
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• 제11권1호
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• pp.63-70
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• 2023

Purpose : Excessive alcohol causes damage to skeletal muscles, leading to the development of a specific disease entity called alcoholic myopathy. Chronic inflammation is related as an underlying mechanism for the loss of muscle mass induced by alcohol. Pro-inflammatory cytokines such as TNF-α (tumor necrosis factor-α) and IL-6 (interleukin-6) play a role in this process. The acupuncture point Feng Shi (GB 31) is located on the midline of the lateral aspect of the thigh, above the transverse popliteal crease. This acupoint is used for the treatment of weakness, atrophy, numbness, and post-stroke symptoms of lower limbs. The purpose of this study was to investigate the effect of Feng Shi stimulation on muscle atrophy caused by chronic alcohol administration. Method : Young male Sprague-Dawley rats were randomly divided into three groups of eight each: Normal, Control, and GB31. The rats in the Control and GB31 groups were orally given 25 % ethanol (5 ㎖/kg, body weight) daily for 4 weeks. The Normal group was similarly administered saline. The acupressure at Feng Shi was treated to rats in the GB31 group. After 4 weeks, the body weight, muscle weight and cross-sectional area of gastrocnemius were assessed and the histological changes in gastrocnemius muscle fiber were observed by hematoxylin and eosin staining. Moreover, TNF-α and IL-6 expressions were immunohistochemistrically evaluated. Results : Acupressure stimulation at Feng Shi had a protective effect on the weight reduction of the gastrocnemius muscle caused by alcohol intake, and had an effect of suppressing anatomical change in muscle fiber and decreasing the average cross-sectional area. Also, the immunoreactivities of TNF-α and IL-6 in the GB31 group were decreased. Conclusion : These results suggest that acupressure at Feng Shi has protective effects on chronic alcohol-induced muscle atrophy by inhibiting pre-inflammatory proteins such as TNF-α and IL-6.

• Structural Engineering and Mechanics
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• 제86권3호
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• pp.399-415
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• 2023

This paper presents the experimental and numerical evaluations on the circular SFRC columns reinforced GFRP rebars under the axial compressive loading. The test programs were designed to inquire and compare the effects of different parameters on the columns' structural behavior by performing experiments and finite element modeling. The research variables were conventional concrete (CC), fiber concrete (FC), types of longitudinal steel/GFRP rebars, and different configurations of lateral rebars. A total of 16 specimens were manufactured and categorized into four groups based on different rebar-concrete arrangements including GRCC, GRFC, SRCC, and SRFC. Adding steel fibers (SFs) into the concrete, it was essential to modify the concrete damage plastic (CDP) model for FC columns presented in the finite element method (FEM) using ABAQUS 6.14 software. Failure modes of the columns were similar and results of peak loads and corresponding deflections of compression columns showed a suitable agreement in tests and numerical analysis. The behavior of GFRP-RC and steel-RC columns was relatively linear in the pre-peak branch, up to 80-85% of their ultimate axial compressive loads. The axial compressive loads of GRCC and GRFC columns were averagely 80.5% and 83.6% of axial compressive loads of SRCC and SRFC columns. Also, DIs of GRCC and GRFC columns were 7.4% and 12.9% higher than those of SRCC and SRFC columns. Partially, using SFs compensated up to 3.1%, the reduction of the compressive strength of the GFRP-RC columns as compared with the steel-RC columns. The effective parameters on increasing the DIs of columns were higher volumetric ratios (up to 12%), using SFs into concrete (up to 6.6%), and spiral (up to 5.5%). The results depicted that GFRP-RC columns had higher DIs and lower peak loads compared with steel-RC columns.

• 한국공간구조학회논문집
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• 제23권2호
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• pp.37-44
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• 2023

In the case of a school building, even though it is a regular structure in terms of plan shape, if the masonry infill wall acts as a lateral load resisting element, it can be determined as a torsionally irregular building. As a result, the strength and ductility of the structure are reduced, which may cause additional earthquake damage to the structure. Therefore, in this study, a structure similar to a school building with torsional irregularity was selected as an example structure and the damping performance of the PC-BRB was analyzed by adjusting the eccentricity according to the amount of masonry infilled wall. As a result of nonlinear dynamic analysis after seismic reinforcement, the torsional irregularity of each floor was reduced compared to before reinforcement, and the beams and column members of the collapse level satisfied the performance level due to the reduction of shear force and the reinforcement of stiffness. The energy dissipation of PC-BRB was similar in the REC-10 ~ REC-20 analytical models with an eccentricity of 20% or less. REC-25 with an eccentricity of 25% was the largest, and it is judged that it is effective to combine and apply PC-BRB when it has an eccentricity of 25% or more to control the torsional behavior.

• 센서학회지
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• 제32권5호
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• pp.328-333
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• 2023

This study experimentally verified the etch rate of the SiO₂ sacrificial layer etching process with a single etch hole using vapor-phase hydrogen fluoride (VHF) etching. To fabricate small-sized polysilicon etch holes, both circular and triangular pattern masks were employed. Etch holes were fabricated in the polysilicon thin film on the SiO₂ sacrificial layer, and VHF etching was performed to release the polysilicon thin film. The lateral etch rate was measured for varying etch hole sizes and sacrificial layer thicknesses. Based on the measured results, we obtained an approximate equation for the etch rate as a function of the etch hole size and sacrificial layer thickness. The etch rates obtained in this study can be utilized to minimize structural damage caused by incomplete or excessive etching in sacrificial layer processes. In addition, the results of this study provide insights for optimizing sacrificial layer etching and properly designing the size and spacing of the etch holes. In the future, further research will be conducted to explore the formation of structures using chemical vapor deposition (CVD) processes to simultaneously seal etch hole and prevent adhesion owing to polysilicon film vibration.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2011년도 학술발표회
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• pp.8-9
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• 2011

On 4 September 2010 an earthquake of magnitude 7.1 on the Richter scale occurred on the Canterbury Plains in the South Island of New Zealand. The Canterbury Plains are an area of extensive groundwater and spring fed surface water systems. Since the September earthquake there have been several thousand aftershocks (Fig. 1), the largest being a 6.3 magnitude quake which occurred close to the centre of Christchurch on 22February 2011. This second quake caused extensive damage to the city of Christchurch including the deaths of 189 people. Both of these quakes had marked hydrological impacts. Water is a vital natural resource for Canterburywith groundwater being extracted for potable supply and both ground and surface water being used extensively for agricultural and horticultural irrigation.The groundwater is of very high quality so that the city of Christchurch (population approx. 400,000) supplies untreated artesian water to the majority of households and businesses. Both earthquakes caused immediate hydrological effects, the most dramatic of which was the liquefaction of sediments and the release of shallow groundwater containing a fine grey silt-sand material. The liquefaction that occurred fitted within the empirical relationship between distance from epicentre and magnitude of quake described by Montgomery et al. (2003). . It appears that liquefaction resulted in development of discontinuities in confining layers. In some cases these appear to have been maintained by artesian pressure and continuing flow, and the springs are continuing to flow even now. In spring-fed streams there was an increase in flow that lasted for several days and in some cases flows remained high for several months afterwards although this could be linked to a very wet winter prior to the September earthquake. Analysis of the slope of baseflow recession for a spring-fed stream before and after the September earthquake shows no change, indicating no substantial change in the aquifer structure that feeds this stream.A complicating factor for consideration of river flows was that in some places the liquefaction of shallow sediments led to lateral spreading of river banks. The lateral spread lessened the channel cross section so water levels rose although the flow might not have risen accordingly. Groundwater level peaks moved both up and down, depending on the location of wells. Groundwater level changes for the two earthquakes were strongly related to the proximity to the epicentre. The February 2011 earthquake resulted in significantly larger groundwater level changes in eastern Christchurch than occurred in September 2010. In a well of similar distance from both epicentres the two events resulted in a similar sized increase in water level but the slightly slower rate of increase and the markedly slower recession recorded in the February event suggests that the well may have been partially blocked by sediment flowing into the well at depth. The effects of the February earthquake were more localised and in the area to the west of Christchurch it was the earlier earthquake that had greater impact. Many of the recorded responses have been compromised, or complicated, by damage or clogging and further inspections will need to be carried out to allow a more definitive interpretation. Nevertheless, it is reasonable to provisionally conclude that there is no clear evidence of significant change in aquifer pressures or properties. The different response of groundwater to earthquakes across the Canterbury Plains is the subject of a new research project about to start that uses the information to improve groundwater characterisation for the region. Montgomery D.R., Greenberg H.M., Smith D.T. (2003) Stream flow response to the Nisqually earthquake. Earth & Planetary Science Letters 209 19-28.

• 한국의학물리학회지:의학물리
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• 제20권4호
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• pp.298-307
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• 2009

본 연구는 MR T2 map기법을 이용하여 슬관절염이 없는 건강한 사람과 관절염이 있는 환자의 연골의 T2값 변화를 측정하여 슬관절 연골의 형태 및 손상 정도를 평가하고 아울러 T2 map기법의 유용성에 대하여 고찰해 보고자 한다. 과거 병력 및 현재 임상적으로 슬관절염이 없는 건강한 사람 30명과 2007년 11월부터 2008년 12월까지 무릎 통증으로 내원한 환자 중 단순 방사선 촬영에서 슬관절염 소견이 보이는 환자 30명을 대상으로 multi-echo 방식(TR: 1,000 ms, TE values (6.5, 13, 19.5, 26, 32.5. 40, 45.5, 52))인 T2 SE (spin echo) sequence를 이용하여 슬관절 연골 T2 SE 영상을 획득 하였다. 획득한 영상을 바탕으로 슬관절 연골 내 구역별 신호강도(S.I)의 변화를 측정하고 이를 Origin 7.0 Professional (northampton, MA 01060 USA)을 이용하여 평균 T2값을 산출하였다. 산출된 T2값은 독립표본검정(Independent samples T-test, SPSS win 12.0)을 이용하여 건강한 그룹과 슬관절염 그룹에 대한 정량적 분석을 시행, 통계적 유의성을 검증하였다. 건강한 그룹과 슬관절염 그룹의 시상면과 관상면의 내, 외측 관절연골에 대한 각각의 T2 값은 시상면에서는 대퇴연골의 경우 슬관절염 그룹의 평균 T2값($42.22{\pm}2.91$)이 건강한 그룹의 평균 T2값($36.26{\pm}5.01$)보다 크게 나타났고 경골 연골의 경우도 슬관절염 그룹의 평균 T2값($43.83{\pm}1.43$)이 건강한 그룹의 평균 T2값($36.45{\pm}3.15$)보다 크게 나타났다. 관상면에서는 내측 대퇴연골의 경우 슬관절염 그룹의 평균 T2값($45.65{\pm}7.10$)이 건강한 그룹의 평균 T2값($36.49{\pm}8.41$)보다 크게 나타났고 내측 경골 연골의 경우도 슬관절염 그룹의 평균 T2값($44.46{\pm}3.44$)이 건강한 그룹의 평균 T2값($37.61{\pm}1.97$)보다 크게 나타났다. 외측 대퇴연골의 경우 슬관절염 그룹의 평균 T2값($43.41{\pm}4.99$)이 건강한 그룹의 평균 T2값($37.64{\pm}4.02$)보다 크게 나타났고 외측 경골 연골의 경우도 슬관절염 그룹의 평균 T2값($43.78{\pm}8.08$)이 건강한 그룹의 평균 T2값($36.62{\pm}7.81$) 보다 크게 나타났다. 슬관절염이 있는 환자인 경우 T2 map기법을 이용하여 지금까지 사용되었던 형태학적 MR 영상화 방법과 더불어 연골의 구조적, 기능적 변화를 정량적으로 분석함으로써 연골질환의 조기 진단에 큰 도움을 줄 수 있을 것이라 사료된다.

• 대한한의학회지
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• 제35권4호
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• pp.10-23
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• 2014

Objectives: This study evaluated the effects of Guibi-tang (GBT) on neuronal apoptosis and cognitive impairment induced by beta amyloid ($A{\beta}$), (1-42) injection in the hippocampus of ICR mice. Methods: $A{\beta}$ (1-42) was injected unilaterally into the lateral ventricle using a Hamilton syringe and micropump ($2{\mu}g/3{\mu}{\ell}$, $0.6{\mu}{\ell}/min$). Water extract of GBT was administered orally once a day (500 mg/kg) for 3 weeks after the $A{\beta}$ (1-42) injection. Acquisition of learning and retention of memory were tested using the Morris water maze. Neuronal damage and $A{\beta}$ accumulation in the hippocampus was observed using cresyl violet and Congo red staining. The anti-apoptotic effect of GBT was evaluated using TUNEL labeling in the hippocampus. Results: GBT significantly shortened the escape latencies during acquisition training trials. GBT significantly increased the number of target headings to the platform site, the swimming time spent in the target quadrant, and significantly shortened the time for the 1st target heading during the retention test trial. GBT significantly attenuated the reduction in thickness and number of CA1 neurons, and $A{\beta}$ accumulation in the hippocampus produced by $A{\beta}$ (1-42) injection. GBT significantly reduced the number of TUNEL-labeled neurons in the hippocampus. Conclusion: These results suggest that GBT improved cognitive impairment by reducing neuronal apoptosis and $A{\beta}$ accumulation in the hippocampus. GBT may be a beneficial herbal formulation in treating cognitive impairment including Alzheimer's disease.