• Medical Lasers
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• 제10권4호
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• pp.220-228
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• 2021

Background and Objectives In designing a resistance exercise program, intensity, rest, and exercise volume are important. Many studies have been conducted to find the most suitable resistance exercise program incorporating the above, and in particular, many prior studies have been conducted on intensity. This study attempted to determine the effective volume of exercise by analyzing the number of repetitions performed at intensities of 65% one-repetition maximum (1RM) and 75% 1RM during the bench press exercise, and the electromyography (EMG) response of the agonist muscle. Materials and Methods Eight males in their 20s were selected as study subjects and they performed five sets of bench presses at two levels of intensity (65% 1RM, 75% 1RM). The following results were obtained by measuring the number of repetitions and the EMG response according to the exercise intensity and sets during the workout. Results First, the number of repetitions showed a sharp drop from the first set to the third set at 65% 1RM intensity and showed no change in the fourth and fifth sets. At 75% 1RM intensity, the intensity of hypertrophy showed a gradual decrease from the first set to the fifth set. Second, at 75% 1RM exercise intensity, the pectoralis major, anterior deltoid and triceps brachii showed high muscle activity, and the activity of the anterior deltoid continued to increase from the first set to the fourth set at 65% 1RM intensity, and from the first set to the fifth set at 75% 1RM. Conclusion It was found that during the bench press exercise, three minutes of rest at 75% 1RM intensity, five sets of five sets, one minute rest at 65% 1RM intensity, and three sets of the exercise were effective.

• Medical Lasers
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• 제10권1호
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• pp.22-30
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• 2021

Background and Objectives Ocular alkali burns cause severe damage to the ocular tissues and vision loss. Solcoseryl is a standardized calf blood extract that normalizes the metabolic disturbance and aids in maintaining the chemical and hormonal balance and has been used to treat burns in various tissues. This study examined the effects of Solcoseryl on a rat corneal alkali burn model. Materials and Methods Twenty rats were assigned randomly to four equal groups, including alkali burn, hyaluronic acid, Solcoseryl eyedrop, and Solcoseryl gel. A corneal alkali burn was induced by a NaOH-soaked paper disc. The treatments were given twice a day, every day. The wound area was measured after 24 and 48 hours, and the degree of neovascularization and corneal opacity were scored every week. The rats were sacrificed after three weeks for immunohistochemistry (IHC) to compare the level of inflammatory cytokines, IL-1β, IL-6, and TNF-α. The thickness of the retinal layers was compared to observe any changes in the retina. Results The use of Solcoseryl on corneal alkali burn accelerated wound healing with less neovascularization, greater opacity, and less cataract. IHC showed that the inflammation of the cornea was controlled by both the hyaluronic acid and Solcoseryl treatments. On the other hand, the inflammation had spread to the retina. When the dosage forms were compared, eyedrops were more effective on corneal inflammation, while the gel-type had a greater effect on retinal inflammation. Conclusion Solcoseryl was effective in accelerating the wound healing rate on a corneal alkali burn but could not prevent the spread of inflammation from the cornea to the retina. Eyedrops were more effective on inflammation in the cornea, and the gel was more effective in the retina.

• Medical Lasers
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• 제8권2호
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• pp.64-73
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• 2019

Background and Objectives The effectiveness of many physiotherapy modalities in reducing subcutaneous fat has been investigated in numerous previous studies. However, to the best of our knowledge, there have been no attempts to determine the effectiveness of physiotherapy modalities in body contouring. The present report determined the effect of 448-kHz capacitive resistive monopolar radiofrequency (CRMRF) in a porcine model. Materials and Methods This study investigated the effect of selective destruction of the subcutaneous fat layer in abdominal fat tissue using CRMRF. The effects of two types of CRMRF (capacitive electric transfer (CET) and resistive electric transfer (RET)) treatment were evaluated using regular digital photography in addition to thermal imaging evaluation, ultrasound measurement, hematological evaluation, and histologic analyses (H&E (hematoxylin and eosin), Oil red O, and immunohistochemistry staining). Results Preclinical evaluation was performed to obtain the data for comparison of the safety and efficacy of the subcutaneous fat reduction after applying CRMRF using CET and RET. After treatment, the thermal transmission was effective, and a 42-47℃ temperature change was observed in the fat layer while an approximately temperature of 42℃ was confirmed on the skin surface. Moreover, after the application of both types of CRMRF treatment, fibrotic septa were observed in the adipose tissue induced by heat at the treatment sites. TUNEL staining was also performed to confirm the process of apoptosis in the adipocytes. Conclusion These results suggest that both CET and RET for CRMRF treatment are safe and effective for subcutaneous fat reduction in a porcine model.

• 대한치과교정학회지
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• 제36권1호
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• pp.14-29
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• 2006

치과교정영역에서 컴퓨터기술의 발달로 안면 경조직 및 연조직의 3차원적인 분석이 가능해졌으며 이에 따라 교정환자의 진단과 치료계획 및 치료 후에 연조직의 3차원적인 평가가 가능하게 되었다. 그러나 안면 연조직의 3차원적 분석을 위한 표준화된 기준이 없고 임상적용이 가능한 진단 프로그램은 아직 없는 실정이다. 이에 본 연구에서는 3차원 진단 시 유용한 안면 연조직 계측점들의 3차원 계측치(X, Y, Z)를 제시하고, 이를 이용하여 설정된 길이, 각도 및 비율의 정상치를 제시하고자 한다. 3차원 촬영 기구로 비접촉식 3차원 레이저 스캐너를 이용하였으며, 한국 성인 정상교합 자 남녀 각각 30명(남자평균 20.1세, 여자평균 21.7세)을 연구대상으로 하였다. Rapidform 2004 프로그램(Inus Technology Inc., Seoul, Korea)으로 3차원 영상을 만든 후 3차원 입체영상에 soft tissue nasion을 원점으로 하는 좌표계(X축-좌우, Y축-상하, Z축-전후)를 설정하고, 29개의 계측점을 지정한 후 거리계측 45개 항목, 각도 8개 항목, 거리비율 29개 항목을 분석하였다. 각각의 계측점의 3차원 좌표(X, Y, Z)를 구하였으며 이를 바탕으로 각각의 계측항목을 계산하여 표준화하였다. 특히, 각도항목에서 transverse upper lip prominence (Ch(Rt)-ULPm-Ch(Lt))는 남자 $107^{\circ}$, 여자 $106^{\circ}$였고, transverse mandibular prominence (Go'(Rt)-Pog'-Go'(Lt))는 남녀 모두 $76^{\circ}$였다. Naso frontal angle (G-N'-Pn)은 남자 $142^{\circ}$, 여자 $147^{\circ}$, transverse nasal prominence (Zy(Rt)-Pn-Zy(Lt))는 남자 $112^{\circ}$, 여자 $116^{\circ}$로 남녀 간에 통계학적으로 유의차가 있었다 (p<0.05). 하안면고경 하방 2/3 (Li-Me')와 하악체길이(Go'-Me'), 입술고경(ULPm-Li)과 폭경(Ch(Rt)-Ch(Lt))의 비율은 각각 2/5로 나타났다. 관상기준평면에서 안면의 윤곽을 나타내는 계측점인 FT, Zy, Pn, ULPm, Li, Me'까지의 거리의 비는 -1/-1/1/0.5/0.5/-0.6였다. 또한 얻어진 자료를 이용하여 한국 성인 정상교합자의 3차원 안면 모델을 제작하였으며 이는 교정진단 또는 치료결과 비교 시 template로 활용될 수 있으리라 사료된다.

• Journal of Oral Medicine and Pain
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• 제35권4호
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• pp.245-258
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• 2010

흡연은 전신뿐 아니라 구강에서 발생하는 다양한 질병의 중요한 위험 인자이며, 치과의사가 금연 치료에 참여하는 것은 개인의 전신 건강과 치주치료와 임플란트 치료 같은 치과 치료의 예후에도 큰 차이를 보여주는 것으로 알려져 있다. 흡연이 구강암과 같은 생명을 위협하는 비교적 흔치 않은 질병으로부터 경미한 구강 내 증상에 이르기까지 구강 환경에 다양한 영향성과 관련한 많은 근거가 있음에도 불구하고, 흡연과 구강건강의 관련성에 대한 환자들의 인식 수준을 조사한 연구는 적고, 금연진료에 대한 국내 치의학계의 관심과 참여는 더욱 부족하다. 그러므로 본 연구는 국내 치과 외래 환자의 흡연 양상과 치과계의 금연 진료 현황을 파악하여 금연 진료 방향을 모색해 보고자 하였다. 대한치과의사협회 문화복지부의 후원으로 전국 11개 치과대학병원의 구강내과, 구강외과 및 치주과 환자 중 825명이 니코틴 패치를 이용한 4주 금연 프로그램 및 설문에 참여하였고, 297명이 금연 설문에 참여하였다. 각 설문지 분석을 통해 각 치과대학병원의 조사 현황, 치과 외래 환자의 흡연 양상을 분석하였고, 치과에서 시행된 4주간의 금연 치료의 참여목적과 성공률을 조사하였다. 본 연구의 결과에 따르면, 흡연자는 주로 30-50대 중 장년층이 많았고, 흡연기간은 연령 증가에 비례하며, 하루 흡연량은 30대에서 가장 많았다. 금연시도는 30,40대에서 금연시도 비율이 높았고 그 기간은 대부분 1-3개월이었다. 흡연의 이유로는 스트레스 해소와 습관이 가장 높은 빈도를 보였으며 Heavy Smoking Index (HSI)는 20대가 가장 낮고 (71.4%) 60대가 가장 높았다(93.7%). 흡연 경고 문구에 대해 참가자의 68%는 금연을 떠올렸다. 구강질환(구강점막질환, 치주질환, 치아우식증)과 흡연의 관련성에 대한 실험참가자들의 인식도는 비교적 높았지만(50~68%) 금연 성공률은 일반 의과진료실에 비해 아주 낮은 결과를 보였다(22.7%). 흡연관련 질환 예방 업무에서의 치과의사의 중요성을 고려할 때, 금연치료에 치과의사들이 보다 적극적으로 참여할 수 있는 인식의 변화가 필요하다. 낮은 치료 성공율이 체계화되지 못한 진료내용 때문임을 고려할 때, 5As' 방법 등과 같은 금연관련 상담에 대한 지속적인 치과의사 교육과 환자 교육을 위한 다양한 자료의 개발을 통해 금연 성공률을 높일 수 있도록 해야 한다.

• Korean Journal of Acupuncture
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• 제22권2호
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• pp.9-24
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• 2005

Objective: We have studied the effects of acupuncture and low level He-Ne laser therapy(LLLT) at $SI_3$, $BL_{40}$ on the tibial, sural nerve injury due to sports-damage or traffic accident and L5 spinal nerve ligature model like general herniation of nucleus pulposus(HNP) in a rat of neuopathic pain. Methods: A model of neuropathic pain was made by injuring tibial nerve and sural nerve while common peroneal nerve was maintained. Also, it was made by isolating left 5th lumbar spinal nerve. Three weeks after the neuropathic surgery, acupuncture and LLLT was injected at $SI_3$,$BL_{40}$ one time a day for one week. LLLT was divided three groups, that is LLLT-1(5mW), LLLT-2(10mW) and LLLT-3(30mW). After that, we examined the withdrawal response of neuropathic rats' legs by Von frey filament and acetone stimulation. And also we examined c-Fos, Nocieptin and KOR-3 in the midbrain central gray of neuropathic rats. Results: As we have observed the effect of mechanical allodynia, LLLT-3 group were diminished on 4 day, 5 day, 6 day and 7 day in the resection model compared with control model, LLLT-1 group were diminished on 5 day, LLLT-2 group were diminished on 3 day and 6 day, LLLT-3 group were diminished on 3 day, 4 day, 5 day, 6 day and 7 day in connected model compared with control group. As we have observed the effect of cold allodynia, LLLT-3 group were diminished on 7 day in the resection model compared with control model, LLLT-1 group were diminished on 6 day, 7 day, LLLT-3 group were diminished on 7 day in connected model compared with control group. As we have observed the effect of activity of c-Fos in the central gray part, LLLT-3 were diminished in resection model compared with control group, LLLT-1 group were diminished in connected model compared with control group. As we have observed the effect of activity of Nociceptin in the central gray part, resection model were not increased compared with control group, LLLT-1 group and LLLT-3 group were increased in connected model compared with control model. As we have observed the effect of activity of KOR-3 in the central gray part, resection model were not increased compared with control group, LLLT-3 group were increased in connected model compared with control model. Conclusions: We have noticed that LLLT-1 and LLLT-3 group have more controllable effect than acupuncture group. This study can be used in clinical therapy for neuropathic pain. But it is not reliability that Nociceptin and KOR-3 have effectively to control pain. Therefore We have to follow up about that.

• Applied Microscopy
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• 제34권4호
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• pp.231-239
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• 2004

뇌에서 혈액뇌장벽을 형성하는 내피세포는 치밀이음부를 통해 뇌의 항상성을 유지하고 있다. 치밀이음부의 단백질 중의 하나인 occludin은 뇌혈관장벽(BBB)의 기능을 유지하는 중요한 단백질로 인식되고 있다. 본 실험에서는 소의 뇌에서 배양된 BBB 내피세포에서 활성산소종의 하나인 $H_2O_2$에 의해 일어나는 occludin 단백질의 변화를 관찰하였다. $H_2O_2$에 의해 TEER가 감소하는 것은 occludin의 재분포에 의한 것이었다. 세포독성은 4시간내에서는 1mM $H_2O_2$ 이하에서는 나타나지 않았다. Confocal laser microscope으로 관찰한 결과, $H_2O_2$에 의해 occludin은 치밀이음부에서 중간중간이 사라져 감소해 있었고, 이러한 양상은 $H_2O_2$의 용량과 노출시간에 비례하였다. 그러나 Western blot 결과, occludin의 총량은 증가하였다. 투과전자현미경 관찰을 통해 $H_2O_2$가 세포사이의 결합의 구조에 뚜렷한 변화를 미치지 않는 것을 알 수 있었다. 이를 통해 $H_2O_2$에 의한 BBB 기능소실은 occludin이 치밀이음부에서 부분적으로 사라지는 것에 의하지만, 세포는 기능손상을 복구하기위한 방편으로 이 단백질의 생산을 더욱 증가시키는 것으로 생각된다.

• 한국안광학회지
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• 제19권3호
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• pp.353-362
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• 2014

목적: 나이의 증가에 따른 고위수차의 변화를 분석하고, 근시도가 나이와 고위수차 변화와의 상관관계에 미치는 영향을 알아보고자 하였다. 방법: Hartmann-Shack 방식의 LADARWave 장비를 이용하여 20세에서 60세 931안의 고위수차를 분석하였고, 현성굴절검사를 통해 측정된 근시도가 고위수차에 미치는 영향을 분석하였다. 결과: 코마수차, 수직코마수차는 나이가 증가함에 따라 통계적으로 유의하게 감소하였으며, 수직난시수차는 통계적으로 유의하게 증가하였다. 코마수차, 수직코마수차, 구면수차, 수직트레포일수차, 수평트레포일수차, 수직난시수차, 수평난시수차, 수직테트라포일수차와 나이와의 상관관계는 근시도에 의해 영향을 받았으며 수평코마수차와 수평테트라포일수차는 영향을 받지 않았다. 결론: 본 연구에서는 근시도수가 나이에 따라 유발되는 고위수차의 변화에 영향을 줄 수 있음을 밝혔으며 시력교정술이나 시력교정용구 사용 시 시력의 질을 위하여 이의 고려를 제안하고자 한다.

• Journal of Korean Neurosurgical Society
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• 제29권1호
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• pp.35-43
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• 2000

Objective : Percutaneous lumbar approaches such as arthroscopic discectomy, laser discectomy, and nucleotome remain controversial and have technical limitations to free fragment disc, bony pathology and access to L5-S1, The purpose of this study was to determine efficacy of this new endoscopic system and to report techniques and tactics. Methods : From July 1997 to May 1998, we treated 40 consecutive patients(43 levels) with the MED system. Mean age was 32 years(range ; 18 to 62). There were 30 males and 10 females. All patients had sciatica with SLRT limitation. There were 23 patients with disc herniation at L4-5 and 14 patients at L5-S1. Three patients had 2 level disc herniations. There was one far lateral disc herniation at L4-5. Results : Using modified MacNab criteria, there were 37 excellent results and 3 good result. Most patients were discharged within 3-4 days except 2 patients with dural tearing. There were no other complications. Mean operation time was 1.5 hours(range : 40 minutes to 2.5 hours). Conclusion : The MED system is a reliable approach to lumbar disc herniations. This system combines the advantages of conventional open surgery and a minimally invasive technique. As tactics for the doctors who wish to attempt, "palpate" the lamina by first dilator, identification of interlaminar space by removal of overlying soft tissue and confirmation of the shoulder portion of nerve root before discectomy are important to this procedure. We conclude that lumbar disc herniations can be successfully treated with MED approach.

• Tuberculosis and Respiratory Diseases
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• 제70권6호
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• pp.521-525
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• 2011

Bronchial carcinoid tumors are relatively uncommon neoplasms that are considered to be malignant tumors of low to intermediate grade. They are classified by pathologic features as typical or atypical carcinoids and have distinctly different prognoses and therapeutic options. Surgery is the treatment of choice in typical and atypical carcinoid tumors but the approach has been changing. Recently, several studies have described experiences using other technologies as adjuncts to bronchoscopic resection, technologies such as laser and cryotherapy with curative intent in endoluminal typical carcinoids. Here we present a case of atypical bronchial carcinoid that was treated with bronchoscopic cryotherapy.