• 제목/요약/키워드: lack of behavioral control

검색결과 29건 처리시간 0.027초

Acupuncture on ST36 Increases c-Fos Expression in vlPAG of Visceral Pain-induced Mice

  • Choo, Jin-Suk;Song, Yun-Kyung;Lim, Hyung-Ho
    • 대한한의학회지
    • /
    • 제29권1호
    • /
    • pp.39-46
    • /
    • 2008
  • Background : Acupuncture has been used as a clinical treatment in Oriental medicine for various diseases including pain relief. The descending pain control system of periaqueductal gray (PAG) is a powerful pain control system in mammalians. Expression of c-Fos is used as a marker for stimuli-induced metabolic changes of neurons. Objective : In the present study, the effects of acupuncture on analgesic effect in visceral pain were investigated through the writhing reflex and c-Fos expression in ventrolateral PAG (vlPAG) area using immunohistochemistry in mice. Method : For the writhing test, mice were divided into five groups. Immediately after finishing the behavioral test, the animals were weighed and overdosed with Zoletil. After a complete lack of response was observed, the brains of the mice were dissected into serial coronal sections, and c-Fos immunohistochemistry was performed. Statistical analysis of all data was performed using one-way ANOVA. Result : The present results showed that acupuncture affected the writhing reflex and that Choksamni (zusnali) acupoint and aspirin significantlysuppressed acetic acid treatment-induced increased writhing reflex, and the expression of c-Fos in vlPAG was significantly increased in the acupunctured group. Conclusion : The present study suggests that acupuncture has an antinociceptive effect on acetic acid-induced visceral pain by increase of c-Fos expression in mice. Aspirin also showed analgesic effect, however the mechanism is different from the acupuncture.

  • PDF

섬망 환자에서 항정신병약물 처방 유형에 따른 임상 경과의 차이 (Clinical Course according to Antipsychotics Prescription Pattern in Delirium)

  • 박재섭;김재진;박성종;김성민;박진영
    • 정신신체의학
    • /
    • 제25권2호
    • /
    • pp.120-128
    • /
    • 2017
  • 연구목적 섬망의 증상을 조절하기위해 일반적으로 항정신병약물이 사용되지만, 투약 기간 및 용법과 같은 처방 양상과 환자의 임상 경과 사이의 연관성에 대한 연구는 아직 부족한 상태이다. 이 연구를 통해 섬망을 경험한 환자에서 항정신병약물의 처방 양상에 따라 임상 경과에 차이가 있는지 확인하고자 하였다. 방 법 서울의 일 종합병원에서 섬망으로 자문조정이 의뢰된 입원 환자 중 2016년 7월부터 2017년 2월까지 퇴원한 212명을 대상으로 하였다. 환자의 전자의무기록을 후향적으로 검토하여 입원 기간, 사망, 인구통계학적 자료 및 임상적 요인을 조사하였고, CAM-ICU를 통해 섬망 지속 기간을 측정하였다. 항정신병약물의 처방 유형에 따라 지속투약군, 최적투약군, 필요투약군으로 나누어 임상 경과를 비교하였다. 결 과 항정신병약물을 섬망 회복 후에도 지속적으로 투약 받은 지속투약군은 섬망 증상이 있는 기간에만 투약 받은 최적투약에 비하여 입원 기간 및 섬망 이환기간에 유의한 차이가 없었으며, 퇴원시 불필요한 항정신병약물 처방을 받은 비율이 높았다. 섬망 이환기간에 비해 짧은 기간 항정신병약물을 사용한 필요투약군은 다른 두 군에 비해 섬망 이환기간이 길고 사망률이 높았다. 결 론 이 연구의 결과는 섬망 이환기간에만 항정신병약물을 투여하는 것이 적절함을 시사한다. 또한 섬망이 회복된 후에 불필요하게 항정신병약물이 처방되는 것을 최소화하기위한 정신건강의학과 자문의의 적극적인 개입이 필요하겠다.

지하공간의 환경디자인적 가치와 평가모델에 의한 디자인요소 추출 (Environmenal Design Value of Underground Space & Design Factor by Evaluation Model)

  • 최병오;채완석
    • 디자인학연구
    • /
    • 제11권2호
    • /
    • pp.117-126
    • /
    • 1998
  • 도시공간 활용의 효율화를 통한 도시문제의 해결과 지상개발 억제를 통한 도시경관 및 환경보존의 측면에서 새롭게 부각되고 있는 지하공간은 수요증가가 예상되는 지상 부 도시기능을 지하에 배치함으로써 도시의 서비스, 어메니티, 안정성 등을 증진시킬 수 있으며, 효율적인 도시공간 구조의 구축을 통하여 교통, 도심 복잡화, 토지부족 등의 문제를 해결하는데 효과적인 대응방안이 될 수 있다. 그러나 소극적이고 단편적인 개발에 국한되어 있는 현시점에서는 극히 부정적인 공간으로 인식되고 있으며, 이를 극복하여 쾌적한 환경을 조성해야 하는 필요성에 당면하게 되었다. 이에 지상공간의 공급한계와 이에 따른 지가상승의 문제와 함께 지상환경의 보존이라는 측면에서 지하공간의 개발은 도시변화의 예측을 수반하여 입체적 구성을 위한 장기적인 계힉을 수반하여 입체적 구성을 위한 장기적인 계획이 되어야 한다. 따라서 본 논문에서는 지하공간의 환경디자인 가치를 지하공간에 대한 총체적인 접근을 통해 검증하고, 환경설계 평가에서 다루어지는 기능적 인자, 기술적 인자, 행태 적 인자를 통해 평가모델을 설정함으로써 지하공간 개발 시 고려되어야 할 디자인요소를 추출하고자 한다.

  • PDF

비쥬얼 프로그래밍 환경을 이용한 Escherichia coli의 동적 거동 예측 (Dynamic Behavioral Prediction of Escherichia coli Using a Visual Programming Environment)

  • Lee, Sung-Gun;Hwang, Kyu-Suk;Kim, Cheol-Min
    • 한국생물정보학회:학술대회논문집
    • /
    • 한국생물정보시스템생물학회 2004년도 The 3rd Annual Conference for The Korean Society for Bioinformatics Association of Asian Societies for Bioinformatics 2004 Symposium
    • /
    • pp.39-49
    • /
    • 2004
  • When there is a lack of detailed kinetic information, dFBA(dynamic flux balance analysis) has correctly predicted cellular behavior under given environmental conditions with FBA and different ial equations. However, until now, dFBA has centered on substrate concentration, cell growth, and gene on/off, but a detailed hierarchical structure of a regulatory network has not been taken into account. For this reason, the dFBA has limited the represen tation of interactions between specific regulatory proteins and genes and the whole transcriptional regulation mechanism with environmental change. Moreover, to calculate optimal metabolic flux distribution which maximizes the growth flux and predict the b ehavior of cell system, linear programming package(LINDO) and spreadsheet package(EXCEL) have been used simultaneously. thses two software package have limited in the visual representation of simulation results and it can be difficult for a user to look at the effects of changing inputs to the models. Here, we descirbes the construction of hierarchical regulatory network with defined symbolsand the development of an integrated system that can predict the total control mechanism of regulatory elements (opero ns, genes, effectors, etc.), substrate concentration, growth rate, and optimal flux distribution with time. All programming procedures were accoplished in a visual programming environment (LabVIEW).

  • PDF

프라더윌리증후군 환자에서의 치과 치료 : 증례보고 (DENTAL TREATMENT IN A PRADER-WILLI SYNDROME PATIENT : A CASE REPORT)

  • 이수정;백광우
    • 대한장애인치과학회지
    • /
    • 제11권2호
    • /
    • pp.67-71
    • /
    • 2015
  • 본 논문에서 소개된 환자는 전형적인 PWS 증상인 섭식 장애, 타액분비감소, 지적장애, 비만과 같은 특성이 관찰되었다. 전신마취 하에서 적극적인 치과 치료를 시행하였고 보호자에게 비만 및 치아 우식을 예방하기 위해 탄수화물과 당분 섭취를 제한하는 식습관에 대한 교육을 시행하였다. 환자의 내원 횟수를 늘려 치과 치료를 위한 전신마취까지 발전하지 않도록 정기적인 관리가 필요하다.

ICNP의 후향적 개발방법에 의한 한국의 학교간호현상 (Development of School Health Nursing Phenomena in Korea by Retrospective Method of ICNP)

  • 김영임;양순옥;왕명자;김정남;김현숙;박태남;정미자;현혜진
    • 지역사회간호학회지
    • /
    • 제13권4호
    • /
    • pp.595-607
    • /
    • 2002
  • The objectives of this study were to identify the phenomena of school health nursing at schools in Korea and to contribute to building a school health domain of International Classification for Nursing Practice. A retrospective method was used in this study to develop ICNP during the period from July to October 200l. The procedure of the study involved choosing nursing phenomena using preliminary terms from the reports on the field of school health nursing practice documented by nursing students in 10 different nursing colleges. The detail procedures of the study were as follows. 1) Choosing nursing phenomena by using preliminary terms 2) Choosing the characteristics of school health nursing practice from the selected nursing phenomena 3) In order to make a consensus regarding the appropriate characteristics of phenomena. 15 study group members re-categorized the nursing phenomena through 5 times of cyber meetings and 3 times of formal meetings. 4) To verify each characteristic, 5 community nursing faculties and 25 school health nurses participated in the procedure to give scores on nursing characteristics. 5) Classification of the definite nursing phenomena and characteristics. Following the 5 step procedures, school health nursing phenomena were categorized into human and environmental domains. Human domains were classified into human behavioral and functional domains. Environmental domains were classified into physical and psychosocial domains. The essential characteristics of each phenomena were selected when it obtains the mean score of 3.0 or over at the related characteristics. The human behavioral domain consisted of 7 phenomena including risk for spinal disorder, inadequate dietary habit, inadequate weight control, smoking and substance abuse, inadequate stress management, inadequate sex related coping strategies and inadequate accident management. The human functional domain consisted of 6 phenomena including inadequate eye care and visual management, risk for respiratory disorder, inadequate dental health care, inappropriate infectious disease control, risk for gastrointestinal disorder, and lack of sexual identity. The physical environmental domain consisted of 6 phenomena including risk for incident at inside classroom, risk for incident at outside classroom, risk for incident around school, risk for exposure to hazardous facilities around school. inadequate garbage and disposal management, and inadequate physical environment for learning. The psychosocial domain included impaired social interaction at school. Each phenomenon was composed of 2 to 8 characteristics and all phenomena will include a total number of 85 characteristics. The phenomena of school health nursing in Korea partially confirmed school health architecture of ICNP. Further study on verification of school health nursing phenomena in Korea needs to be done to support the findings of this study through review of literature on nursing classifications or field studies.

  • PDF

Intelligent Intrusion Detection and Prevention System using Smart Multi-instance Multi-label Learning Protocol for Tactical Mobile Adhoc Networks

  • Roopa, M.;Raja, S. Selvakumar
    • KSII Transactions on Internet and Information Systems (TIIS)
    • /
    • 제12권6호
    • /
    • pp.2895-2921
    • /
    • 2018
  • Security has become one of the major concerns in mobile adhoc networks (MANETs). Data and voice communication amongst roaming battlefield entities (such as platoon of soldiers, inter-battlefield tanks and military aircrafts) served by MANETs throw several challenges. It requires complex securing strategy to address threats such as unauthorized network access, man in the middle attacks, denial of service etc., to provide highly reliable communication amongst the nodes. Intrusion Detection and Prevention System (IDPS) undoubtedly is a crucial ingredient to address these threats. IDPS in MANET is managed by Command Control Communication and Intelligence (C3I) system. It consists of networked computers in the tactical battle area that facilitates comprehensive situation awareness by the commanders for timely and optimum decision-making. Key issue in such IDPS mechanism is lack of Smart Learning Engine. We propose a novel behavioral based "Smart Multi-Instance Multi-Label Intrusion Detection and Prevention System (MIML-IDPS)" that follows a distributed and centralized architecture to support a Robust C3I System. This protocol is deployed in a virtually clustered non-uniform network topology with dynamic election of several virtual head nodes acting as a client Intrusion Detection agent connected to a centralized server IDPS located at Command and Control Center. Distributed virtual client nodes serve as the intelligent decision processing unit and centralized IDPS server act as a Smart MIML decision making unit. Simulation and experimental analysis shows the proposed protocol exhibits computational intelligence with counter attacks, efficient memory utilization, classification accuracy and decision convergence in securing C3I System in a Tactical Battlefield environment.

소아(小兒) stress에 관한 문헌적(文獻的) 고찰(考察) (A study on stress in Children)

  • 김기봉;김장현
    • 대한한방소아과학회지
    • /
    • 제16권1호
    • /
    • pp.105-124
    • /
    • 2002
  • With the progress of civilization, the disorders due to the stress, which derived from the social-structural complexity and diversity, are on an increasing trend in our times. Accordingly, the accurate diagnosis and appropriate treatment for them are required. Especially in the current years, children's disorders delivered by the emotional problems keep increasing. In this research, the researcher tried to figure out the cause of the children's stress and its treatment, studied the theories of the stress in the modem medicine and the sever emotions in oriental medicine, and came to the conclusion as follows: 1. The stress can be defined as the combination of the reaction to noxious stimuli and its defense mechanism of the body, In oriental medicine, it is considered as pathological notions which includes seven emotions as the internal factor, six evils as the external factor and other foods, expectoration, ecchymoma as the non-internal/external factors. 2. Children usually get stressed by various reasons in a growth process such as schooling, relationship with friends, the opposite sex of family, or change of surroundings, and these can cause the various disorders. 3. In the study of the children's stress symptoms, it is found that the silent reaction is uncommon. It usually appeared in both reactions: firs, physical reactions such as stomachache, vomiting, headache, neural frequent urination, bronchial asthma or excessive respiration and/or, second, behavioral reactions such as a decline of performance, alimentary disorder, e.g. anorexia nervosa or bulimia, sleep disorder, e.g. nightmare or panic in sleep, anthrophobia, refusal to a school attendance or hyperactiveness. Besides, the peculiar mental disorder such as paroxysm of anger, tic, autism, nocturnal enuresis, lack of attentiveness, impediment in linguistic development, learning difficulty, intellectual decline, etc. can be appeared, and the heavy stress during the babyhood can cause the regression of behavior or the immaturity of formation of character. 4. The appropriate treatments for the children's stress are Osteopathy, Manpulation, Aroma Therapy, Alexander Technique, Autonomic Never Control Treatment, Biofeedback, Chiropractic, Dance Therapy, Feldenkrasis Technique, Gravity Therapy, Homepathy, Aquatherapy, Hypnotherapy, Naturopathy and Meditation.

  • PDF

유아의 리더십과 자기조절능력이 또래 놀이행동에 미치는 영향 (The Effect of Children's Leadership and Self-regulation Upon Peer Play Behaviors)

  • 장윤희;문혁준
    • 가정과삶의질연구
    • /
    • 제29권2호
    • /
    • pp.73-87
    • /
    • 2011
  • The purpose of this study is to investigate the influence of children's socia-demographic variables(i.e., gender, birth order, and the amount of time staying in kindergarten) on, leadership, self-regulation and children's peer play behaviors. The participants of this study are 336 children aged between five and seven in four classes in a private kindergarten and eight classes in a private preschool located in the capital region. The results revealed that, girls showed more leadership, self-regulation, and play interaction section than boys: whereas, boys showed higher response in play disruption and the lack of play disconnection. However, birth order, did not have a significant effect on the sub-domain of leadership, self-regulation competence, and peer play behaviors. As for the duration children stay in preschool or in preschool or kindergarten, children who spend half-day showed higher reaction in behavioral self-control and emotional taking abilities than children who stay in the preschool or kindergarten full day. On the other hand, self-esteem of full-time children was higher than half-time children. Children who were emotionally sensitive, knew how to lead their peer group, and those who were sociable and self-regulated presented to be more active in peer-interaction than others. Second, as the result of the correlation analysis reveals, children's leadership, self-regulation competence, peer play behaviors, and play interaction had a meaningful effect on the sub-variations of children's leadership and self-regulation and they showed significant influence upon play disruption and play disconnection. In addition, girls who were not able to manage or to inspect their behavior and had insensitive emotion demonstrated higher tendency to play disconnected. Children, who participated in full-day program with having difficulties in self-regulation or inspecting their behavior properly but had a strong leadership and insensitive showed play disruption highly.

한국농촌(韓國農村)의 기생충성인축공통질환(寄生蟲性人畜共通疾患)의 현황(現況)과 문제점(問題點) (Current Problems of Parasitic Zoonoses in Rural Korea)

  • 임한종
    • 농촌의학ㆍ지역보건
    • /
    • 제15권1호
    • /
    • pp.49-55
    • /
    • 1990
  • Zoonoses are those diseases and infections that are naturally transmitted between vertebrate animals and man. At present, approximately 175 diseases caused by virus, rickettsia, bacteria, protozoa and helminthes as well as some of arthropods and the number is continually increasing. Although zoonoses are generally recognized as significant health problems, the actual prevalence and incidence of zoonotic infections is difficult to determine. Medical services in a rural area are scarce and ill persons may have little chance to see a physician. Furthermore, a lack of physician awareness and of appropriate diagnostic support is made often misdiagnosis. In rural Korea, parasitic disease is still important subject in the field of zoonotic infections considering its number and morbidity. Recently there was conspicuous reduction of soil-transmitted parasitic diseases (i.e. ascariasis. hookworms, trichuriasis), but clonorchiasis. intestinal trematodiases and taeniasis are a considerable problem. This is often significantly related to human behavioral patterns based on socio-economic and cultural conditions and linked with the local biologic and physical environment. The most of all parasitic zoonoses to man and animals are the food-transmitted parasitic diseases, and domestic animals such as dog, cat, pig, as well as fat and some mammals, ruminants and birds are act as reservoir hosts. In the present topics, current problems of parasitic zoonoses caused by protozoan infections (i. e. toxoplasmosis, pneumocystosis and cryptosporidiosis) which are the most common opportunistic in AIDS or immunocompromised persons, trematode infections (i.e. clonorchiasis, paragonimiasis and some intestinal tremadodiases). cestode infections such as cysticercosis and sparganosis, and some nematode infections of anisakiasis, thelaziasis and strongyloidiasis, are discussed here those on the occurrence in man and animals and the source of transmission as well as prevention and control measures in Korea.

  • PDF