• Archives of Pharmacal Research
• /
• v.10 no.4
• /
• pp.250-257
• /
• 1987

The development of physiologically based pharmacokinetic model for drug distribution and excretion is described. The physiological modeling procedure is useful in animal and clinical applications to obtain fundamental knowledge of the transport and metabolism of a substance in vivo. In this paper a review of physiologically based pharmacokinetics is presented in the hope of understanding and increasing the use of this modelling technique. The method of model development and the composition of equations based on the different models are explained. For the better understanding a physiological pharmacokinetic model of tenoxicam disposition in the rat is presented as an example of flow limited model.

• Proceedings of the Korea Database Society Conference
• /
• 1998.09a
• /
• pp.329-346
• /
• 1998

ㆍKM의 구조적 특징 - WWW의 Site 구성 특징과 유사 ㆍContributor와 Consumer의 철저한 선택적 관계 ㆍ기존 OLTP 구축 개념 적용 시는 효용성이 제한적 ㆍContributor의 경우 consumer(Customer)의 관심을 유도할 수 있는 다양한 방법의 동원이 필요 ㆍDynamic 변경, Multimedia Content 관리가 필수 ㆍ직접적인 업무 처리 시스템은 아님 ㆍ업무처리에 필요한 정보뿐만 아니라 확신을 얻는데 도움을 줌 ㆍ최소한 정보 검색의 One Point Contact 역할 수행ㆍKM의 방법론 - 일괄 처리 방식 : EDMS + E-Mail + Search Engine + Work Flow - 요소기술 결합 방식(중략)

• Proceedings of the Korean Society of Coastal and Ocean Engineers Conference
• /
• 1993.07a
• /
• pp.98-100
• /
• 1993

When we want to reproduce transport of sediment in the fields in a laboratory, we have to establish a similitude law. A similitude law is necessary when sediment transport of field is reproduced in a laboratory. When we apply our knowledge about sediment transport obtained in the laboratory to predict sediment transport in the field, we can apply Froudian law to a fluid motion that becomes agitation agency and transporting flow of sediment movement. (omitted)

• 한국신재생에너지학회:학술대회논문집
• /
• 2010.11a
• /
• pp.122.2-122.2
• /
• 2010

Knowledge of ground thermal properties is most important for the proper design of BHE(borehole heat exchanger) systems. The configure type, pipe size and thermal performance of the BHE is highly dependent on the ground source heatpump system-efficiency and instruction cost. Thermal response tests with mobile measurement devices were developed primarily for in-situ determination of design data for Standing Column Well apply. The main purpose has been to determine in-situ values of effective ground thermal conductivity and thermal resistance, including the effect of ground-water flow and natural convection in the boreholes. The test rig is set up on a some trailer, and contains a sub-circulation pump, a boiler, temperature sensors, flow meter and a data logger for recording the temperature and circulation fluid flow data. A constant heating power is injected into the SCW through the test rig and the resulting temperature change in the SCW is recorded. The recorded temperature data are analysed with a line-source model, which gives the effective in-situ values of rock thermal conductivity and thermal resistance of SCW.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.10 no.6
• /
• pp.2781-2800
• /
• 2016

Emerging attacks aim to access proprietary assets and steal data for business or political motives, such as Operation Aurora and Operation Shady RAT. Skilled Intruders would likely remove their traces on targeted hosts, but their network movements, which are continuously recorded by network devices, cannot be easily eliminated by themselves. However, without complete knowledge about both inbound/outbound and internal traffic, it is difficult for security team to unveil hidden traces of intruders. In this paper, we propose an autonomous anomaly detection system based on behavior profiling and relation mining. The single-hop access profiling model employ a novel linear grouping algorithm PSOLGA to create behavior profiles for each individual server application discovered automatically in historical flow analysis. Besides that, the double-hop access relation model utilizes in-memory graph to mine time-sequenced access relations between different server applications. Using the behavior profiles and relation rules, this approach is able to detect possible anomalies and violations in real-time detection. Finally, the experimental results demonstrate that the designed models are promising in terms of accuracy and computational efficiency.

• Journal of Hydrogen and New Energy
• /
• v.25 no.3
• /
• pp.319-335
• /
• 2014

This study attempts to suggest an economic analysis model for SNG projects, which can reflect the future uncertainty objectively and applies the real option valuation incorporating the flexible investment decision. Based on this analysis model, net present value and internal rate of return were estimated by using preliminary feasibility study report of SNG project. And economic evaluation of SNG project was performed with real option valuation using binomial option model. Through this, the difference of analysis results between the real option valuation model and the discounted cash flow model were compared and the usefulness of the real option valuation model was confirmed. From the actual proof analysis, it is confirmed that the real option valuation model showed higher SNG project value than the discounted cash flow model did. It was confirmed that by applying the real option valuation model, economic analysis can be performed on not only the current straightforward SNG project, but also various future portfolios having options such as expansion, modification, or decommission.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.33 no.6
• /
• pp.461-467
• /
• 2009

Knowledge of airflow characteristics in nasal cavities is essential to understand the physiological and pathological aspects of nasal breathing. Several studies have utilized physical models of the healthy nasal cavity to investigate the relationship between nasal anatomy and airflow. In our laboratory, there have been a series of experimental investigations on the nasal airflow in normal, abnormal, and deformed nasal cavity models by PIV under both constant and periodic flow conditions. In this time normal and several deformed nasal cavity models, which simulate surgical operation, Turbinectomy, are investigated numerically by the FVM general purpose code and PIV analysis. The comparisons of these results are appreciated. Dense CT data and careful treatment of model surface under the ENT doctor's advice provide more sophisticated cavity models. The Davis (LaVision Co.) code is used for PIV flow analysis. Average and RMS distributions have been obtained for inspirational and expirational nasal airflows in the normal and deformed nasal cavities.

• International Journal of Fuzzy Logic and Intelligent Systems
• /
• v.12 no.1
• /
• pp.60-65
• /
• 2012

This paper presents a method for occluded object based motion estimation and tracking system in dynamic image sequences using particle filter with 3D reconstruction. A unique characteristic of this study is its ability to cope with partial occlusion based continuous motion estimation using particle filter inspired from the mirror neuron system in human brain. To update a prior knowledge about the shape or motion of objects, firstly, fundamental 3D reconstruction based occlusion tracing method is applied and object landmarks are determined. And optical flow based motion vector is estimated from the movement of the landmarks. When arbitrary partial occlusions are occurred, the continuous motion of the hidden parts of object can be estimated by particle filter with optical flow. The resistance of the resulting estimation to partial occlusions enables the more accurate detection and handling of more severe occlusions.

• Nuclear Engineering and Technology
• /
• v.50 no.4
• /
• pp.553-561
• /
• 2018

To easily understand and systematically express the behaviors of the industrial systems, various system modeling techniques have been developed. Particularly, the importance of system modeling has been greatly emphasized in recent years since modern industrial systems have become larger and more complex. Multilevel flow modeling (MFM) is one of the qualitative modeling techniques, applied for the representation and reasoning of target system characteristics and phenomena. MFM can be applied to industrial systems without additional domain-specific assumptions or detailed knowledge, and qualitative reasoning regarding event causes and consequences can be conducted with high speed and fidelity. However, current MFM techniques have a limitation, i.e., the dynamic features of a target system are not considered because time-related concepts are not involved. The applicability of MFM has been restricted since time-related information is essential for the modeling of dynamic systems. Specifically, the results from the reasoning processes include relatively less information because they did not utilize time-related data. In this article, the concepts of time-to-detect and time-to-effect were adopted from the system failure model to incorporate time-related issues into MFM, and a methodology for enhancing MFM-based reasoning with time-series data was suggested.

• 한국신재생에너지학회:학술대회논문집
• /
• 2009.11a
• /
• pp.581-586
• /
• 2009

Knowledge of ground thermal properties is most important for the proper design of large scale BHE(borehole heat exchanger) systems. The type, pipe size and thermal performance of the BHE is highly dependent on the ground source heatpump system-efficiency and instruction cost. Thermal response tests with mobile measurement devices were developed primarily for insitu determination of design data for large diameter BHE for triple-U spacer apply. The main purpose has been to determine insitu values of effective ground thermal conductivity and thermal resistance, including the effect of ground-water flow and natural convection in the boreholes. The test rig is set up on a some trailer, and contains a circulation pump, a inline heater, temperature sensors, flow meter, power analysis meter and a data logger for recording the temperature, fluid flow data. A constant heat power is injected into the borehole through the tripl-U pipes system of test rig and the resulting temperature change in the borehole is recorded. The recorded temperature data are analysed with a line-source model, which gives the effective insitu values of rock thermal conductivity and borehole thermal resistance of large diameter BHE for spacer apply.