• Asian Pacific Journal of Cancer Prevention
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• 제15권12호
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• pp.4893-4896
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• 2014

Background: Recent reports have shown that C-X-C chemokine receptor 4 (CXCR4) plays an important role in metastasis. Despite a clear understanding of the protein's structure and properties, its functional role remains elusive. We conducted the present study to evaluate the expressions of CXCR4 in pancreatic cancer, and to investigate its relationship with clinicopathological parameters, especially perineural invasion(PNI). Materials and Methods: The association between CXCR4 expression and perineural invasion was determined by immunohistochemistry in pancreatic cancer patients (n=51). Results: CXCR4 expression was correlated with the existence of PNI and the type of PNI (p=0.042, p=0.040). TIMP-2 expression was also correlated with the existence, the pathway and degree of PNI (p=0.000, p=0.006, p=0.000). Conclusions: Our results suggest an association between PNI and expression of CXCR4 and TIMP-2 in pancreatic cancer. CXCR4 may promote the occurrence of PNI in pancreatic cancer cells by decreasing the inhibition of TIMPs on MMP.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제12권10호
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• pp.4835-4855
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• 2018

In this paper, we study the sparse signal recovery that uses information of both support and amplitude of the sparse signal. A convergent iterative algorithm for sparse signal recovery is developed using Majorization-Minimization-based Non-convex Optimization (MM-NcO). Furthermore, it is shown that, typically, the sparse signals that are recovered using the proposed iterative algorithm are not globally optimal and the performance of the iterative algorithm depends on the initial point. Therefore, a modified MM-NcO-based iterative algorithm is developed that uses prior information of both support and amplitude of the sparse signal to enhance recovery performance. Finally, the modified MM-NcO-based iterative algorithm is used to estimate the time-varying sparse wireless channels with temporal correlation. The numerical results show that the new algorithm performs better than related algorithms.

• Structural Engineering and Mechanics
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• 제64권2호
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• pp.213-223
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• 2017

Bridges are lifeline and integral components of transportation system that are susceptible to seismic actions, their vulnerability assessment is essential for seismic risk assessment and mitigation. The vulnerability assessment of bridges common in Pakistan is very important as it is seismically very active region and the available code for the seismic design of bridges is obsolete. This research presents seismic vulnerability assessment of three real case simply supported multi-span reinforced concrete bridges commonly found in northern Pakistan, having one, two and three bents with circular piers. The vulnerability assessment is carried through the non-linear dynamic time history analyses for the derivation of fragility curves. Finite element based numerical models of the bridges were developed in MIDAS CIVIL (2015) and analyzed through with non-linear dynamic and incremental dynamic analyses, using a suite of bridge-specific natural spectrum compatible ground motion records. Seismic responses of shear key, bearing pad, expansion joint and pier components of each bridges were recorded during analysis and retrieved for performance based analysis. Fragility curves were developed for the bearing pads, shear key, expansion joint and pier of the bridges that first reach ultimate limit state. Dynamic analysis and the derived fragility curves show that ultimate limit state of bearing pads, shear keys and expansion joints of the bridges exceed first, followed by the piers ultimate limit state for all the three bridges. Mean collapse capacities computed for all the components indicated that bearing pads, expansion joints, and shear keys exceed the ultimate limit state at lowest seismic intensities.

• Geomechanics and Engineering
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• 제21권6호
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• pp.551-564
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• 2020

High-stress and complex geological conditions impose great challenges to maintain excavation stability during deep underground mining. In this research, large anisotropic deformation and its management by support system at a deep underground mine in Western Australia were simulated through three-dimensional finite-difference model. The ubiquitous-joint model was used and calibrated in FLAC3D to reproduce the deformation and failure characteristics of the excavation based on the field monitoring results. After modeling verification, the roles of mining depth also the intercept angle between excavation axis and foliation orientation on the deformation and damage were studied. Based on the results, quantitative relationships between key factors and damage classifications were presented, which can be used as an engineering tool. Subsequently, the performance of support system installation sequences was simulated and compared at four different scenarios. The results show that, first surface support and then reinforcement installation can obtain a better controlling effect. Finally, the influence of bolt spacing and ring spacing were also discussed. The outcomes obtained in this research may play a meaningful reference for facing the challenges in thin-bedded or foliated ground conditions.

• 대한건축학회논문집:구조계
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• 제35권9호
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• pp.151-158
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• 2019

A concrete core is used widely as lateral stability systems in high-rise modular buildings. As an alternative to traditional cast in-situ core, the precast concrete(PC) method can accelerate the construction of reinforced concrete cores. A core composed of precast elements differs from a in-situ core in having connections between the precast elements. The typical vertical connection between PC panels is consisted of shear keys, loop bars, lacer bars and grout. In this study, the effect of vertical connection components on shear strength is investigated experimentally. The test results show that the contribution to the shear strength is greater in order of grout strength, shear keys, lacer bars and loop bars. In addition, the numerical models to estimate the shear strength according to two crack patterns in the vertical joint of the PC panels are derived. The feasibility of the numerical models is evaluated by comparing the estimated shear strength and the test results.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제15권7호
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• pp.2650-2667
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• 2021

In this paper, we derive the expression of the cache hitting probability with random caching policy and propose the joint optimization algorithm based on difference of convex algorithm (DCA) in the three-tier caching heterogeneous cellular network assisted by macro base stations, helpers and users. Under the constraint of the caching capacity of caching devices, we establish the optimization problem to maximize the cache hitting probability of the network. In order to solve this problem, a convex function is introduced to convert the nonconvex problem to a difference of convex (DC) problem and then we utilize DCA to obtain the optimal caching probability of macro base stations, helpers and users for each content respectively. Simulation results show that when the density of caching devices is relatively low, popular contents should be cached to achieve a good performance. However, when the density of caching devices is relatively high, each content ought to be cached evenly. The algorithm proposed in this paper can achieve the higher cache hitting probability with the same density.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제8권7호
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• pp.2350-2364
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• 2014

This paper addresses the problem of resource allocation in amplify-and-forward (AF) relayed OFDM based cognitive radio networks (CRNs). The purpose of resource allocation is to maximize the overall throughput, while satisfying the constraints on the individual power and the interference induced to the primary users (PUs). Additionally, different from the conventional resource allocation problem, the rate-guarantee constraints of the subcarriers are considered. We formulate the problem as a mixed integer programming task and adopt the dual decomposition technique to obtain an asymptotically optimal power allocation, subcarrier pairing and relay selection. Moreover, we further design a suboptimal algorithm that sacrifices little on performance but could significantly reduce computational complexity. Numerical simulation results confirm the optimality of the proposed algorithms and demonstrate the impact of the different constraints.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2005년도 추계학술발표대회 및 정기총회
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• pp.151-154
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• 2005

본 논문에서는 스케일러블 멀티미디어 콘텐츠에 대한 조건적 접근제어가 가능한 암호화 방법을 제안한다. 현재 표준화가 진행중인 스케일러블 비디오 코딩방법인 JSVM(Joint Scalable Video Model)은 부호화한 동영상에 대해 공간, 시간, 품질의 스케일러빌리티(Scalability)를 지원하는데, 각 스케일러 빌리티를 고려한 조건적인 접근제어기술은 스케일러빌리티에 따라 사용자를 제한해야 하는 경우를 위해 필수적인 기술이다. 제안하는 방법은 공간, 시간, 품질의 세가지 스케일러빌리티를 지원하도록 부호화(Encoding)후 구성되는 NAL(Network Abstract Layer)을 지원하는 스케일러빌리티에 따라 구분하고, 구분된 NAL 의 종류에 따라 암호화 key 를 다르게 제공하는 방법을 통해 사용자의 접근제어 수준에 맞게 암호화 key 를 조합하는 방법을 적용하였다. 실험 결과 제안한 방법은 JSVM 에서 공간, 시간, 품질의 스케일러빌리티가 보장되고, 이때 생성되는 Key 의 조합으로 조건적 접근제어(Conditional access control)가 가능함을 확인하였다.

• Structural Engineering and Mechanics
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• 제44권4호
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• pp.417-429
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• 2012

Taking the superficial temperature increment as the major fatigue damage indicator, the infrared thermography was used to predict fatigue parameters (fatigue strength and S-N curve) of welded joints subjected to fatigue loading with a high mean stress, showing good predictions. The fatigue damage status, related to safety evaluation, was tightly correlated with the temperature field evolution of the hot-spot zone on the specimen surface. An energetic damage model, based on the energy accumulation, was developed to evaluate the residual fatigue life of the welded specimens undergoing cyclic loading, and a good agreement was presented. It is concluded that the infrared thermography can not only well predict the fatigue behavior of welded joints, but also can play an important role in health detection of structures subjected to mechanical loading.

• ETRI Journal
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• 제29권5호
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• pp.596-606
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• 2007

It is well known that an OFDM receiver is vulnerable to synchronization errors. Despite fine estimations used in the initial acquisition, there are still residual synchronization errors. Though these errors are very small, they severely degrade the bit error rate (BER) performance. In this paper, we propose a residual error elimination scheme for the digital OFDM baseband receiver aiming to improve the overall BER performance. Three improvements on existing schemes are made: a pilot-aided recursive algorithm for joint estimation of the residual carrier frequency and sampling time offsets; a delay-based timing error correction technique, which smoothly adjusts the incoming data stream without resampling disturbance; and a decision-directed channel gain update algorithm based on recursive least-squares criterion, which offers faster convergence and smaller error than the least-mean-squares algorithms. Simulation results show that the proposed scheme works well in the multipath channel, and its performance is close to that of an OFDM system with perfect synchronization parameters.