• KSII Transactions on Internet and Information Systems (TIIS)
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• 제8권5호
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• pp.1654-1675
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• 2014

In practical wireless systems, the erroneous channel state information (CSI) sometimes deteriorates the performance drastically. This paper focuses on robust design of coordinated set planning of coordinated multi-point (CoMP) transmission, with respect to the feedback delay and link error. The non-ideal channel models involving various uncertainty conditions are given. After defining a penalty factor, the robust net ergodic capacity optimization problem is derived, whose variables to be optimized are the number of coordinated base stations (BSs) and the divided area's radius. By the maximum minimum criterion, upper and lower bounds of the robust capacity are investigated. A practical scheme is proposed to determine the optimal number of cooperative BSs. The simulation results indicate that the robust design based on maxmin principle is better than other precoding schemes. The gap between two bounds gets smaller as transmission power increases. Besides, as the large scale fading is higher or the channel is less reliable, the number of the cooperated BSs shall be greater.

• Computers and Concrete
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• 제33권6호
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• pp.671-688
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• 2024

The modeling efficiency of concrete meso-models close to real concrete is one of the important issues that limit the accuracy of mechanical simulation. In order to improve the modeling efficiency and the closeness of the numerical aggregate shape to the real aggregate, this paper proposes a method for generating a two-dimensional concrete meso-model based on pixel matrix and skeleton theory. First, initial concrete model (a container for placing aggregate) is generated using pixel matrix. Then, the skeleton curve of the residual space that is the model after excluding the existing aggregate is obtained using a thinning algorithm. Finally, the final model is obtained by placing the aggregate according to the curve branching points. Compared with the traditional Monte Carlo placement method, the proposed method greatly reduces the number of overlaps between aggregates by up to 95%, and the placement efficiency does not significantly decrease with increasing aggregate content. The model developed is close to the actual concrete experiments in terms of aggregate gradation, aspect ratio, asymmetry, concavity and convexity, and old-new mortar ratio, cracking form, and stress-strain curve. In addition, the cracking loss process of concrete under uniaxial compression was explained at the mesoscale.

• 문화기술의 융합
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• 제8권3호
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• pp.331-337
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• 2022

본 연구는 중국 대학 육상선수의 운동몰입과 경기력에 미치는 영향을 규명하는 데 있다. 국 하남대학, 정주대학, 하남사범대학 체육대학 육상선수를 대상 19세 이상 남·여 선수들을 모집단으로 설정하여 직접 방문을 통해 설문조사를 위한 동의 및 협조를 구한 후 편의표집방법(Convenience sampling method)을 이용하여 1400부의 설문지를 배포하였고, 불성실한 응답, 무응답, 이중응답 등과 같이 자료로 활용하기 어려운 38부를 제외한 102부를 최종 분석에 사용하였다. 자료처리를 실시하여 얻은 결과는 다음과 같다. 첫째, 운동몰입의 하위요인(인지몰입, 행동몰입)이 경기력에 미치는 영향에서 모든 요인이 통계적으로 유의한 영향을 미쳤다. 둘째, 운동몰입의 하위요인(인지몰입, 행동몰입)이 수행력에 미치는 영향에서 모든 요인이 통계적으로 유의한 영향을 미쳤다. 셋째, 운동몰입의 하위요인(인지몰입, 행동몰입)이 집중력에 미치는 영향에서 모든 요인이 통계적으로 유의한 영향을 미쳤다.

• 대한치과교정학회지
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• 제53권3호
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• pp.205-216
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• 2023

Objective: To investigate changes in the immature teeth of Sprague-Dawley rats during orthodontic treatment and to explore the changes in the peri-radicular alveolar bone through micro-computed tomography (CT). Methods: Twenty-five 26-day-old male Sprague-Dawley rats were included. The maxillary left first molar was moved mesially under a continuous force of 30 cN, and the right first molar served as the control. After orthodontic treatment for 7, 14, 21, 28, and 42 days, the root length, tooth volume, and alveolar bone mineral density (BMD) around the mesial root were measured through micro-CT. Results: The immature teeth continued to elongate after application of orthodontic force. The root length on the force side was significantly smaller than that on the control side, whereas the differences in the volume change between both sides were not statistically significant. Alveolar bone in the coronal part of the compression and tension sides showed no difference in BMD between the experimental and control groups. The BMD of the experimental group decreased from day 14 to day 42 in the apical part of the compression side and increased from day 7 to day 42 in the apical part of the tension side. The BMD of the experimental group decreased in the root apex part on day 7. Conclusions: The root length and volume of immature teeth showed continued development under orthodontic forces. Alveolar bone resorption was observed on the compression side, and bone formation was observed on the tension side.

• Journal of Ginseng Research
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• 제44권2호
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• pp.222-228
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• 2020

Background: 20(S)-ginsenoside-Rg3 (C₄₂H₇₂O₁₃), a natural triterpenoid saponin, is extracted from red ginseng. The increasing use of 20(S)-ginsenoside Rg3 has raised product safety concerns. Methods: In acute toxicity, 20(S)-ginsenoside Rg3 was singly and orally administrated to Kunming mice and Sprague-Dawley (SD) rats at the maximum doses of 1600 mg/kg and 800 mg/kg, respectively. In the 26-week toxicity study, we used repeated oral administration of 20(S)-ginsenoside Rg3 in SD rats over 26 weeks at doses of 0, 20, 60, or 180 mg/kg. Moreover, a 4-week recovery period was scheduled to observe the persistence, delayed occurrence, and reversibility of toxic effects. Results: The result of acute toxicity shows that oral administration of 20(S)-ginsenoside Rg3 to mice and rats did not induce mortality or toxicity up to 1600 and 800 mg/kg, respectively. During a 26-week administration period and a 4-week withdrawal period (recovery period), there were no significant differences in clinical signs, body weight, food consumption, urinalysis parameters, biochemical and hematological values, or histopathological findings. Conclusion: The mean oral lethal dose (LD₅₀) of 20(S)-ginsenoside Rg3, in acute toxicity, is above 1600 mg/kg and 800 mg/kg in mice and rats, respectively. In a repeated-dose 26-week oral toxicity study, the no-observed-adverse-effect level for female and male SD rats was 180 mg/kg.

• Animal Bioscience
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• 제36권6호
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• pp.899-907
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• 2023

Objective: The better understanding of laying pattern of birds is crucial for developing breed-specific proper breeding scheme and management. Methods: Daily egg production until 50 wk of age of six chicken breeds including one layer (White Leghorn, WL), three dual-purpose (Rhode Island Red, RIR; Columbian Plymouth Rock, CR; and Barred Plymouth Rock, BR), one synthetic dwarf (DY), and one indigenous (Beijing-You Chicken, BYC) were used to characterize their clutch traits and egg production. The age at first egg, egg number, average and maximum clutch length, pause length, and number of clutches and pauses were calculated accordingly. Results: The egg number and average clutch length in WL, RIR, CR, and BR were higher than those in DY and BYC (p<0.01). The numbers of clutches and pauses, and pause length in WL, RIR, CR, and BR were lower than those in DY and BYC (p<0.01). The coefficient variations of clutch length in WL, RIR, CR, and BR (57.66%, 66.49%, 64.22%, and 55.35%, respectively) were higher than DY (41.84%) and BYC (36.29%), while the coefficient variations of egg number in WL, RIR, CR, and BR (9.10%, 9.97%, 10.82%, and 9.92%) were lower than DY (15.84%) and BYC (16.85%). The clutch length was positively correlated with egg number (r = 0.51 to 0.66; p<0.01), but not correlated with age at first egg in all breeds. Conclusion: The six breeds showed significant different clutch and egg production traits. Due to the selection history, the high and median productive layer breeds had higher clutch length than those of the less productive indigenous BYC. The clutch length is a proper selection criterion for further progress in egg production. The age at first egg, which is independent of clutch traits, is especially encouraged to be improved by selection in the BYC breed.

• The Korean Journal of Physiology and Pharmacology
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• 제27권6호
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• pp.521-531
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• 2023

Transmembrane protein TMEM16A, which encodes calcium-activated chloride channel has been implicated in tumorigenesis. Overexpression of TMEM16A is associated with poor prognosis and low overall survival in multiple cancers including lung adenocarcinoma, making it a promising biomarker and therapeutic target. In this study, three structure-related sesquiterpene lactones (mecheliolide, costunolide and dehydrocostus lactone) were extracted from the traditional Chinese medicine Aucklandiae Radix and identified as novel TMEM16A inhibitors with comparable inhibitory effects. Their effects on the proliferation and migration of lung adenocarcinoma cells were examined. Whole-cell patch clamp experiments showed that these sesquiterpene lactones potently inhibited recombinant TMEM16A currents in a concentration-dependent manner. The half-maximal concentration (IC50) values for three tested sesquiterpene lactones were 29.9 ± 1.1 µM, 19.7 ± 0.4 µM, and 24.5 ± 2.1 µM, while the maximal effect (E_max) values were 100.0% ± 2.8%, 85.8% ± 0.9%, and 88.3% ± 4.6%, respectively. These sesquiterpene lactones also significantly inhibited the endogenous TMEM16A currents and proliferation, and migration of LA795 lung cancer cells. These results demonstrate that mecheliolide, costunolide and dehydrocostus lactone are novel TMEM16A inhibitors and potential candidates for lung adenocarcinoma therapy.

• Nuclear Engineering and Technology
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• 제56권1호
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• pp.106-113
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• 2024

Understanding the tritium release and retention behavior of candidate tritium breeder materials is crucial for breeder blanket design. Recently, a melt spraying process was developed to prepare Li₄SiO₄ pebbles, which were subsequently subjected to the in-pile tritium production and extraction platform in China Mianyang Research Reactor (CMRR) to investigate their in-situ tritium release behavior and irradiation performance. The results demonstrate that HT is the main tritium release form, and adding hydrogen to the purge gas reduces tritium retention while increasing the HT percent in the purge gas. Post-irradiation experiments reveal that the irradiated pebbles darken in color and their grains swell, but the mechanical properties remain largely unchanged. It is concluded that the tritium residence time of Li₄SiO₄ made by melt spraying method at 467 ℃ is approximately 23.34 h. High-density Li₄SiO₄ pebbles exhibit tritium release at relatively low temperatures (<600 ℃) that is mainly controlled by bulk diffusion. The diffusion coefficient at 525 ℃ and 550 ℃ is 1.19 × 10^-11 cm²/s and 5.34 × 10^-11 cm²/s, respectively, with corresponding tritium residence times of 21.3 hours and 4.7 hours.