The korean journal of orthodontics (대한치과교정학회지)

The Korean Association Of Orthodontists (대한치과교정학회)
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Micro-computed tomography evaluation of the effects of orthodontic force on immature maxillary first molars and alveolar bone mineral density of Sprague-Dawley rats

  • Jingwei Wang (Department of Orthodontic, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University) ;
  • Ruofang Zhang (Department of Orthodontic, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University) ;
  • Zhuoying Zhang (Department of Orthodontic, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University) ;
  • Chao Geng (Department of Orthodontic, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University) ;
  • Yanpeng Zhang (Department of Orthodontic, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University)
  • Received : 2022.09.26
  • Accepted : 2023.04.28
  • Published : 2023.05.25
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Abstract

Objective: To investigate changes in the immature teeth of Sprague-Dawley rats during orthodontic treatment and to explore the changes in the peri-radicular alveolar bone through micro-computed tomography (CT). Methods: Twenty-five 26-day-old male Sprague-Dawley rats were included. The maxillary left first molar was moved mesially under a continuous force of 30 cN, and the right first molar served as the control. After orthodontic treatment for 7, 14, 21, 28, and 42 days, the root length, tooth volume, and alveolar bone mineral density (BMD) around the mesial root were measured through micro-CT. Results: The immature teeth continued to elongate after application of orthodontic force. The root length on the force side was significantly smaller than that on the control side, whereas the differences in the volume change between both sides were not statistically significant. Alveolar bone in the coronal part of the compression and tension sides showed no difference in BMD between the experimental and control groups. The BMD of the experimental group decreased from day 14 to day 42 in the apical part of the compression side and increased from day 7 to day 42 in the apical part of the tension side. The BMD of the experimental group decreased in the root apex part on day 7. Conclusions: The root length and volume of immature teeth showed continued development under orthodontic forces. Alveolar bone resorption was observed on the compression side, and bone formation was observed on the tension side.

Keywords

Acknowledgement

This work was supported by the National Natural Science Foundation of China (Grant No. 81300849), Beijing Natural Science Foundation (Grant No. 7132067), Beijing Municipal Administration of Hospitals Incubating Program (Code: PX2018054), and Scientific Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Education of China (2013).

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