• KIEE International Transactions on Electrophysics and Applications
• /
• v.3C no.1
• /
• pp.28-32
• /
• 2003

In this paper, we have studied the in-situ end point detection (EPD) for direct chemical mechanical polishing (CMP) of shallow trench isolation (STI) structures without the reverse moat etch process. In this case, we applied a high selectivity $1n (HSS) that improves the silicon oxide removal rate and maximizes oxide to nitride selectivity Quite reproducible EPD results were obtained, and the wafer-to-wafer thickness variation was significantly reduced compared with the conventional predetermined polishing time method without EPD. Therefore, it is possible to achieve a global planarization without the complicated reverse moat etch process. As a result, the STI-CMP process can be simplified and improved using the new EPD method.

• Applied Biological Chemistry
• /
• v.4
• /
• pp.23-28
• /
• 1963

Various species of the genus Capsicum contain in their fruits an intensively sharp and pungent substance, Capsaicin, which was first isolated in an almost pure state by Thresh. Containing the pungent principle, Capsicums are used extensively in food as a spice and in medicine as a rubefacient and carminative. Numerous methods have been proposed for the isolation, the chemical structure and the quantitative determination of Capsaicin. Modifying the several methods described before, the Capsaicin contents in various species of the genus Capsicum were determined as follows. (1) The isolation of pure Capsaicin was the essential first step for the determination of Capsaicin contents. Powdered cayenne pepper was extracted with acetone. By the method of ether alkali partition extraction slightly modified at this laboratory and by the recrystallization with light petroleum ether that was repeated ten times, the pure crystalline Capsaicin was obtained. Using this Capsaicin, the standard absorption curve was drawn with Beckman spectrophotometer model DU for the quantitative determination of Capsaicin. 92) The powdered sample was extracted in a Soxhlet extractor with ether-acetone solvent system(3:1) for 25 hours. Capsaicin in this ether-acetone extracts was efficiently separated in a pure state by paper partition chromatography using 58% methanol solution as developing agent. It was found that 58% methanol was one of the most valuable solvent to separate Capsaicin from impurities such as sterols, fatty acids, waxes and carotenoid pigments. (3) The colorimetric method modifying the Schulte-Kruger's method which consists of measuring the red color produced with diazobenzenesulphonic acid was used. Capsaicin in various species of the genus Capsicum was determined quantitatively with use of Beckman spectrophotometer model DU at $480\;m{\mu}$.

• Journal of the Korean Chemical Society
• /
• v.57 no.4
• /
• pp.520-524
• /
• 2013

• Bulletin of the Korean Chemical Society
• /
• v.32 no.spc8
• /
• pp.3175-3178
• /
• 2011

• Archives of Pharmacal Research
• /
• v.18 no.3
• /
• pp.203-205
• /
• 1995

A new $4,5,8-trihydroxy-{\alpha}-tetralone-5-O-{\beta}-D-glucoside$ along with 1,4,8-trihydroxynaphthalene1-O-{\beta}-D-glucoside$ and gallic acid were isolated from the roots of Juglans mandshurica. Their structures were elucidated on the basis of spectroscopic studies.

• Natural Product Sciences
• /
• v.21 no.1
• /
• pp.25-29
• /
• 2015

In a continuation of our studies to discover bioactive secondary metabolites from marine sources, we further investigated samples from a tryptamine and phenyl-alkane producing sponge, which resulted in the isolation of four uncommon small molecules and five nucleosides. Their structures were determined to be 7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one (1), 5-chlorocavernicolin (2), maleimide-5-oxime (3), 3-methylmaleimide-5-oxime (4), uridine (5), 2'-deoxyuridine (6), thymidine (7), adenine (8), and adenosine (9) by spectroscopic analyses. The isolated compounds were evaluated for inhibitory activity against soluble epoxide hydrolase (sEH) as well as the Wnt/${\beta}$-catenine signaling pathway.

• 한국균학회소식:학술대회논문집
• /
• 2018.05a
• /
• pp.49-49
• /
• 2018

A variety of bioactive secondary metabolites have been reported from plant-associated microorganisms. Halophytes, plants that can only grow in hypersaline area, were reported to host beneficial microorganisms such as plant growth-promoting endophytes. The microorganisms have been reported to show notable mutualistic symbiosis with halophytes to help them survive in high saline condition. Finding out bioactive secondary metabolites as well as elucidation of relationship(s) between microbes and the host halophyte has been paid attention, because of their functional diversity. Novel microbes often have associated with novel natural products. In an effort to investigate natural compounds with interesting structures from fungi, we selected plants from a distinct environmental setting which could be a promising source. Several fungi were isolated from halophyte or medicinal plants. Some strains of the fungi were cultivated on a large scale and extracted with ethyl acetate, which were subjected to a series of chromatographic methods, leading to the isolation of tens of compounds. The isolated compounds were identified by analysis of spectroscopic methods such as 1D-, 2D-NMR, and MS. Details of isolation, structure determination, and biological activities will be discussed.

• Journal of Mechanical Science and Technology
• /
• v.19 no.8
• /
• pp.1529-1543
• /
• 2005

Recently an unmanned aerial vehicle (UAV) has been widely used for military and civil applications. The role of a navigation system in the UAV is to provide navigation data to the flight control computer (FCC) for guidance and control. Since performance of the FCC is highly reliant on the navigation data, a fault in the navigation system may lead to a disastrous failure of the whole UAV. Therefore, the navigation system should possess a fault detection and isolation (FDI) algorithm. This paper proposes an attitude determination GPS/INS integrated navigation system with an FDI algorithm for a UAV. Hardware for the proposed navigation system has been developed. The developed hardware comprises a commercial inertial measurement unit (IMU) and the integrated navigation package (INP) which includes an attitude determination GPS (ADGPS) receiver and a navigation computer unit (NCU). The navigation algorithm was implemented in a real-time operating system with a multi-tasking structure. To evaluate performance of the proposed navigation system, a flight test has been performed using a small aircraft. The test results show that the proposed navigation system can give accurate navigation results even in a high dynamic environment.

• Earthquakes and Structures
• /
• v.5 no.5
• /
• pp.499-526
• /
• 2013

Seismic isolation is an effective method for the protection of buildings and their contents during strong earthquakes. This research work aims to assess the appropriateness of the linear and nonlinear models that can be used in the analysis of typical low-rise base isolated steel buildings, taking into account the inherent nonlinearities of the isolation system as well as the potential nonlinearities of the superstructure in case of strong ground motions. The accuracy of the linearization of the isolator properties according to Eurocode 8 is evaluated comparatively with the corresponding response that can be obtained through the nonlinear hysteretic Bouc-Wen constitutive model. The suitability of the linearized model in the determination of the size of the required seismic gap is assessed, under various earthquake intensities, considering relevant methods that are provided by building codes. Furthermore, the validity of the common assumption of elastic behavior for the superstructure is explored and the alteration of the structural response due to the inelastic deformations of the superstructure as a consequence of potential collision to the restraining moat wall is studied. The usage of a nonlinear model for the isolation system is found to be necessary in order to achieve a sufficiently accurate assessment of the structural response and a reliable estimation of the required width of the provided seismic gap. Moreover, the simulations reveal that the superstructure's inelasticity should be taken into account, especially if the response of the structure under high magnitude earthquakes is investigated. The consideration of the inelasticity of the superstructure is also recommended in studies of structural collision of seismically isolated structures to the surrounding moat wall, since it affects the response.

• Journal of Microbiology and Biotechnology
• /
• v.17 no.8
• /
• pp.1403-1406
• /
• 2007

An antiproliferative agent, streptochlorin, was isolated from the fermentation broth of a marine actinomycete isolated from marine sediment. Phylogenetic analysis of the 16S rRNA gene sequence indicated that the strain belongs to the genus Streptomyces. Bioactivity guided fractionation of the culture extract by solvent partitioning, ODS open flash chromatography, and reversed-phase HPLC gave a pure compound, streptochlorin. Its structure was elucidated by extensive 2D NMR and mass spectral analyses. Streptochlorin exhibited significant antiproliferative activity against human cultured cell lines.