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Isolation and Structure Determination of Streptochlorin, an Antiproliferative Agent from a Marine-derived Streptomyces sp. 04DH110  

Shin, Hee-Jae (Marine Natural Products Laboratory, Korea Ocean Research & Development Institute)
Jeong, Hyun-Sun (Marine Natural Products Laboratory, Korea Ocean Research & Development Institute)
Lee, Hyi-Seung (Marine Natural Products Laboratory, Korea Ocean Research & Development Institute)
Park, Song-Kyu (Bio-evaluation Center, Korea Research Institute of Bioscience and Biotechnology)
Kim, Hwan-Mook (Bio-evaluation Center, Korea Research Institute of Bioscience and Biotechnology)
Kwon, Ho-Jeong (Chemical Genomics Laboratory, Department of Biotechnology, College of Engineering, Yonsei University)
Publication Information
Journal of Microbiology and Biotechnology / v.17, no.8, 2007 , pp. 1403-1406 More about this Journal
Abstract
An antiproliferative agent, streptochlorin, was isolated from the fermentation broth of a marine actinomycete isolated from marine sediment. Phylogenetic analysis of the 16S rRNA gene sequence indicated that the strain belongs to the genus Streptomyces. Bioactivity guided fractionation of the culture extract by solvent partitioning, ODS open flash chromatography, and reversed-phase HPLC gave a pure compound, streptochlorin. Its structure was elucidated by extensive 2D NMR and mass spectral analyses. Streptochlorin exhibited significant antiproliferative activity against human cultured cell lines.
Keywords
Streptomyces sp. 04DH110; antiproliferative agent; streptochlorin;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By Web Of Science : 9  (Related Records In Web of Science)
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