• The Korean Journal of Pharmacology
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• v.3 no.1
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• pp.43-49
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• 1967

Supplemental studies were made on the adrenotropic receptors of the rat uterus, using adrenergic activators such as phenylephrine, norepinephrine, epinephrine, and isoproterenol and adrenergic blocking agents such as phenoxybenzamine and inderal. The studies have revealed the following results : 1. Phenylephrine, norepinephrine, epinephrine, and isoproterenol inhibited the spontaneous motility of the isolated rat uterus in the following order : Isoproterenol>epinephrine>norepinephrine>phenylephrine. 2. The inhibitory responses of the isolated rat uterus to phenylephrine and epinephrine were abolished by the pretreatment with phenoxybenzamine. 3. The inhibitory responses of the isolated rat uterus to isoproterenol and epinephrine were not affected by phenoxybenzamine. 4. The motility of the isolated rat uterus pretreated with inderal was stimulated by phenylephrine, norepinephrine and epinephrine. 5. The inhibitory responses of the isolated rat uterus to isoproterenol were abolished by the pretreatment with inderal. 6. The motility of the isolated rat uterus pretreated with inderal and phenoxybenzamine was not affected by phenylephrine, norepinephrine and epinephrine. 7. It is, therefore, concluded that the rat uterus has both alpha excitatory and beta inhibitory receptors, with beta inhibitory receptors predominating.

• Korean Journal of Animal Reproduction
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• v.9 no.2
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• pp.148-152
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• 1985

When goat spermatozoa were preincubated for 4-6 h and 6 h in the uteri isolated from hamster and rat, and for 6 h in the hamster uterus in situ, they developed the ability to penetrate zona-free hamster eggs in vitro. Zona-free hamster eggs were not penetrated after insemination with goat spermatozoa preincubated in the isolated hamster uterus 4 h before and 2 h after expected time of ovulation, respectively. Zona-free hamster eggs were not penetrated after insemination with goat spermatozoa preincubated for 4 h in the isolated hamster uterus, but 10 and 18% of eggs were penetrated by spermatozoa preincubated for 5 and 6 h in the isolated uterus.

• The Korean Journal of Pharmacology
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• v.5 no.2
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• pp.129-133
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• 1969

The effect of the panaquilon (partial component of panax ginseng), on the isolated pregnant and nonpregnant uterus strip was observed. The movement of the strip of the rabbit uterus suspended in Locke's solution was refolded by the Magnus method. 1. The tonus of the pregnant uterus was slightly increased and returned the normal movement after a short period (approximately 60 seconds) in concentration of $10^{-6}$ of panaquilon. 2. The tonus and motility of panaquilon was slightly synergistic when pretreated with syntocinon and barium chloride.

• Korean Journal of Pharmacognosy
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• v.16 no.2
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• pp.73-80
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• 1985

Experimental studies were undertaken to investigate for the effect of Yijin-tang on the digestive system and isolated uterus of rats. Yijin-tang was composed of five crude drugs; Pinelliae Tuber, Aurantii nobilis Pericarpium, Hoelen, Glycyrrhizae Radix and Zingiberis Rhizoma. The results obtained from experiments with water soluble fraction extracted from Yijin-tang were as follows; Spontaneous motilities of isolated ileum of mice and rabbits were suppressed, and contraction of isolated ileum of mice and guinea-pigs induced acetylcholine, barium chloride and histamine were inhibited. The anticathartic action of mice induced by castor oil were significantly observed. The spontaneous motility of isolated uterus of rats was suppressed. Inhibitory effect of gastric juice secretion and antiulcerogenic action were significantly shown in Shay rats.

• Korean Journal of Pharmacognosy
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• v.15 no.2
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• pp.104-107
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• 1984

The essential oil fraction of Leonurus sibiricus was analyzed by TLC and gas chromatography. By utilizing silica gel column, a ketone compound, m.w. 167, was isolated from the essential oil. The essential oil showed considerably the diuretic action, but the water extract exhibited weak action. This diuretic action of the water extract was potentiated by combined administration of essential oil. On the isolated rabbit's uterus the essential oil decreased spontanous movement and showed relaxation.

• Korean Journal of Pharmacognosy
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• v.22 no.4
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• pp.246-248
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• 1991

The methanolic extracts of forty-two medicinal plants were screened for direct effects on the isolated ileum and uterus and for anticholinergic and oxytocic effects on the respective organ preparation.

• Korean Journal of Pharmacognosy
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• v.10 no.1
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• pp.27-30
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• 1979

The methanolic extracts of fifty medicinal plants were screened for anticholinergic and oxytocic activity in rat's ileum or uterus. In addition, their effect on the ileum and antagonism against oxytocin in the uterus were tested.

• Korean Journal of Pharmacognosy
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• v.13 no.3
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• pp.99-101
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• 1982

The methanolic extracts of thirty-one medicinal plants were screened for anticholinergic and oxytocic activity in rat's ileum and uterus, respectively. In addition, their effects on the ileum and antagonism against oxytocin in the uterus were observed.

• The Korean Journal of Pharmacology
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• v.2 no.1 s.2
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• pp.41-48
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• 1966

The author studied the adrenotropic receptors of the non-pregnant uteri of the rabbit and rat, using epinephrine (alpha and beta activator), phenoxybenzamine(alpha blocking agent) and nethalide (beta blockade), and obtained the following results: 1. The spontaneous motility of isolated non-pregnant uteri from rabbits were stimulated by epinephrine, whereas that of isolated non-pregnant rat uterus was inhibited by epinephrine. 2. Both alpha and beta adrenergic receptors were present in the uterine muscle of both animals. 3. In the non-pregnant rabbit uterus, alpha receptors were predominant, whereas in the non -pregnant rat uterus, beta receptors preponderated over alpha receptors.

• The Korean Journal of Pharmacology
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• v.9 no.1
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• pp.65-73
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• 1973

Zea mays Linne belonging to Graminae family has been ordinarily made use of foods and fodder. Maydis Stigma, the stigma of maize, has been discarded without any special application with the exception of being applied as diuretic in the sphere of Chinese medicine, moreover, the pharmacological research toward Maydis Stigma as a medical herb has not been regretfully undertaken at all. The authors hereby paid attention to this point of view and made experiment to find out whether the water extract of Maydis Stigma might possess some pharmacological effect on the motility of the isolated rabbit uterus. The experiment was performed making the use of several agents related to the uterine motility such as acetylcholine, pilocarpine, epinephrine, atropine, barium chloride, quinine sulfate and oxytocin. The motility of the isolated rabbit uterus in Tyrode' solution was recorded with the electric kymograph according to Magnus method. The results of the experiment are as follows. 1. The motility of the isolated pregnant and nonpregnant rabbit uterus represents the tendency of gradual contractility in proportion to the concentration of ZW $10^{-4}$, $5{\times}10^{-4}$ and $10^{-3}$. 2. The uterine contractile effect of ZW $10^{-3}$ probably seems to antagonize the effect of epinephrine $10^{-6}$. 3. ZW $10^{-3}$ does not seem to have the significance with barium chloride, quinine sulfate and oxytocin respectively.