• Korean Journal of Acupuncture
• /
• 제33권4호
• /
• pp.183-193
• /
• 2016

Objectives : The purpose of this study is to find out the effect of Postural Yinyang Correction of TMJ(Functional Cerebrospinal Therapy; FCST) on Bell's palsy. Methods : We reviewed the medical records of 41 patients who were treated for Bell's palsy at the Dept. of Acupuncture and Moxibustion, Dong-Eui University from January $1^{st}$, 2016 to August $31^{st}$, 2016. The patients were divided into 2 groups: Group A(n=21), and Group B(n=20). Patients in Group A were treated by Korean Medical Treatments with FCST using ABA(Accurate Balancing Appliance), a standard intra-oral appliance. Patients in Group B were treated by Korean Medical Treatments without FCST. To estimate the efficacy in recovering palsy, we analyzed the House-Brackmann Grading Scale and Yanagihara's Unweighted Grading System. Results : In both groups, H-B grades were improved significantly during each period except the period from the first visit to one week later(P01). The improvement of H-B grade during each period in Group A is higher than Group B except the period from one week later to two weeks later, but statistically insignificant. In Group A, Y-score was significantly improved during each period except during P01. In group B, Y-score was significantly improved during each period except during P01 and the period from the first visit to two weeks later. The improvement of Y-score during each period in Group A is higher than Group B, but statistically insignificant. Conclusions : FCST using Standard Intraoral Appliance may be helpful in treating Bell's Palsy, but the further researches are needed.

• Biomolecules & Therapeutics
• /
• 제9권4호
• /
• pp.291-297
• /
• 2001

The bioequivalence of two triflusal products was evaluated with 20 healthy volunteers following single oral dose according to the guidelines of Korea Food and Drug Administration (KFDA). Trisa $l^{R}$ capsule (Whanin Pharm. Corp., Korea) and Disgre $n^{R}$ capsule (Myung-In Pharm. Corp., Korea) were used as test product and reference product, respectively. Both products contain 300 mg of trifusal. One capsule of test product or reference product was orally administered to the volunteers, respectively, by randomized two period crossover study (2$\times$2 Latin square method). Blood samples were taken at predetermined time intervals for 4 hours and the determination of trifusal was accomplished using semi-microbore HPLC equipped with automated column switching system. The analytical method with HPLC was validated according to the Bioanalytic Method Validation guideline by F7A prior to determining the plasma samples. The pharmacokinetic parameters (AU $C_{0-4h}$ $C_{max}$ and $T_{max}$) were calculated and ANOVA test was utilized for statistical analysis of parameters. As a result of the assay validation, the limit of quantification of trifusal in human plasma by current assay procedure was 50 ng/ml using 500 $\mu$l of plasma. The accuracy of the assay was from 97.76% to 116.51% while the intra-day and inter-day coefficient of variation of the same concentration range was less than 15%. Average drug concentration at the designated time intervals and pharmacokinetic parameters calculated were not significantly different between two products (p>0.05). The difference of mean AU $C_{olongrightarrow4hr}$, $C_{max}$, and $T_{max}$ between the two products (2.92, 4.39, and -2.44%, respectively) were less than 20%. The power (1-$\beta$) and treatment difference ($\Delta$) for AU $C_{olongrightarrow4hr}$ and $C_{max}$ were more than 0.8 and less than 0.2, respectively. Although the power for $T_{max}$ was under 0.8, $T_{max}$ of the two products was not significantly different from each other (p>0.05). These results satisfied the criteria of KFDA guideline for bioequivalence, indicating the two products of triflusal were bioequivalent.quivalent.ent.ent.

• 대한소아치과학회지
• /
• 제31권2호
• /
• pp.136-143
• /
• 2004

이중치는 유치열에서 흔히 나타나는 발육 이상으로 후속 영구치의 결손, 융합, 형태 이상 등을 일으킬 수 있다. 본 연구에서는 2003년 1월부터 9월까지 원광대학교 치과병원 소아치과에 내원한 유치열기 및 혼합치열기 어린이 1,803명을 대상으로 유치열에서 나타나는 다양한 유형의 이중치를 악궁에서의 위치에 따라 분류하고 그에 따른 영구치의 발육 이상을 평가하였으며 동시에 이중치의 치관 및 치근의 형태 및 융합 정도에 따라 이중치를 네 가지 유형으로 분류한 Tannenbaum과 Ailing의 기준에 따라 이중치를 분류하고 그에 따른 영향도 평가하여 다음과 같은 결과를 얻었다. 1. 이중치는 49명(2.7%)이었고, 이중 5명의 어린이에서 양측성 이중치를 보이고 있었으며, 세 개의 치관 및 치근을 보이는 삼중치를 갖는 경우도 1명에서 나타났다. 2. 이중치는 하악 치열에서 현저히 높은 빈도로 나타났으며, 하악 유중절치와 유측절치가 융합된 경우 및 하악 유측절치와 유견치가 융합된 경우에서 유사하게 높게 나타났다. 하지만 후속 영구치가 결손되는 빈도는 유중절치와 유측절치가 융합된 경우(23.8%)보다 유측절치와 유견치가 융합된 경우(73.9%)에서 훨씬 높게 나타났다. 3. 상악의 경우는 오직 유중절치와 유측절치 부위에서만 이중치가 발견되었는데, 이중 유중 절치와 유측절치가 융합된 경우(75%) 특히 후속 영구치의 결손 빈도가 높았다. 4 이중치의 유형별로는 융합된 두개의 치관 및 치근을 갖는Type IV의 발생율이 가장 높았고(51.9%) 이에 따라 후속 영구치도 높은 빈도로 결손되었다(60.7%). 하지만 영구치 결손 빈도만으로는 큰 치관과 큰 치근을 갖는 Type II에서 가장 높았다(75%).

• 사상체질의학회지
• /
• 제15권1호
• /
• pp.90-108
• /
• 2003

Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) has been developed as prescriptions for the Soyeumin constitution. The hepatoprotective effect of the water extract of Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) was investigated against carbon tetrachloride (CCl4)-induced hepatic damage. A single intra-peritoneal injection of CCl4 produced liver damage in rats as manifested by the significant rise of aspartate aminotransferase(AST), alanine aminotransferase(ALT), and alkaline phosphatase(ALP) in serum as compared to those of untreated normal group. Pretreatments of rats with Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) 500 mg/kg for 7 days) were significantly reduced AST, ALT, and ALP levels compared with CCl4-treated control group. Treatment of rats with CCl4 led to significantly increase in lipid peroxidation and significantly decrease in cytochrome P450 and P450 reductase. The oral administration of Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) water extract significantly inhibited the accumulation of microsomal thiobarbituric acid reactive substance (TBARS) and increased the cytochrome P450 and P450 reductase activity. All these biochemical alterations resulting from CCl4 administration were inhibited by the pretreatment with Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SG1) extract. These results suggest that Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) water extract can be useful as a hepatoprotective agent. And the effect of NO modulation by NO synthesis or precursors, and Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang (SGT) water extract was researched on chronic liver damage induced by CCl4 administration. It was observed that endogenous NO protected the liver from lipid peroxidation, fibrosis, and damage. Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) water extract showed the hepatoprotective effect on the chronic liver cirrhosis model and relationship with NO modulation.

• Journal of Pharmaceutical Investigation
• /
• 제36권5호
• /
• pp.331-338
• /
• 2006

A rapid, selective and sensitive reverse-phase HPLC methods for the determination of atenolol and chlorthalidone in human serum and whole blood were validated, and applied to the pharmacokinetic study of atenolol and chlorthalidone combination therapy. Atenolol and an internal standard, pindolol, were extracted from human serum by liquid-liquid extraction, and analyzed on a $\mu$-Bondapak C18 $10-{\mu}$ column in a mobile phase of methanol-0.01 M potassium dihydrogenphosphate(30:70, v/v, adjusted to pH 3.5) and fluorescence detection(emission: 300 nm, excitation: 224 nm). Chlorthalidone and an internal standard, probenecid, were extracted form human whole blood by liquid-liquid extraction, and analyzed on a Luna C18 $5-{\mu}$ column in a mobile phase of acetonitrile containing 77% 0.01 M sodium acetate and UV detection at 214 nm. These analysis were performed at three different laboratories using the same quality control(QC) samples. The chromatograms showed good resolution, sensitivity, and no interference by human serum and whole blood, respectively. The methods showed linear responses over a concentration range of 10-1,000 ng/mL for atenolol and 0.05-20 ${\mu}g/mL$ for chlorthalidone, with correlation coefficients of greater than 0.999 at all the three laboratories. Intra- and inter-day assay precision and accuracy fulfilled international requirements. Stability studies(freeze-thaw, short-, long-term, extracted sample and stock solution) showed that atenolol and chlorthalidone were stable. The lower limit of quantitation of atenolol and chlorthalidone were 10 ng/mL and 0.05 ${\mu}g/mL$, respectively, which was sensitive enough for pharmacokinetic studies. These methods were applied to the pharmacokinetic study of atenolol and chlorthalidone in human volunteers following a single oral administration of Hyundai $Tenoretic^{\circledR}$ tablet(atenolol 50 mg and chlorthalidone 12.5 mg) at three different laboratories.

• 구강회복응용과학지
• /
• 제29권4호
• /
• pp.366-376
• /
• 2013

구강내 스캔(Group 1), 모델 광학 스캔(Group 2)과 모델 접촉식 스캔(Group 3)방식으로 각각 zirconia 코핑을 제작하여 광학 현미경으로 적합성을 관찰하였다. 측정항목은 변연오차(absolute marginal discrepancy;AMD), 변연간극(marginal gap; MG), 측방간격(gap of axial wall; GA), 선각간격(gap of line angle; GL)와 교합간격(gap of occusal surface; GO)이었으며, 결과는 아래와 같았다. 1. Group 1, Group 2, Group 3의 평균 AMD는 각 각 $141.21{\pm}42.94{\mu}m$, $140.63{\pm}31.64{\mu}m$, $109.37{\pm}28.42{\mu}m$이고, Group1, Group 2, Group 3의 MG는 각 각 $82.52{\pm}43.99{\mu}m$, $90.28{\pm}27.93{\mu}m$, $66.55{\pm}28.77{\mu}m$였다. AMD와 MG는 각 그룹에서 통계학적으로 유의한 차이를 보여주지 않았다(Anova test, P>0.05). 2. Group 2의 GA가 Group 1과 Group 3에 비해 통계학적으로 유의하게 적은 수치를 나타내었다(Anova test, P<0.05). 3. Group 1의 GL과 GO가 다른 그룹에 비해 통계학적으로 높은 수치를 나타내었다(Mann-whitney test(P<0.05). 세 가지 스캔 방식으로 제작된 zirconia 코핑은 세라믹 보철의 가장 중요한 평가 요소인 AMD와 MG에서 서로 통계학적 차이를 보이지 않았다.

• 한국의학물리학회지:의학물리
• /
• 제25권4호
• /
• pp.248-254
• /
• 2014

본 연구에서는 미국 Xoft 사에서 근접치료 장치(elecronic brachytherapy)를 목적으로 개발된 소형 X-선 튜브를 치과용 영상장비로 사용함에 있어서 고전압 발생장치의 제어용 장치를 개발하고 영상용 제어 방식으로 최적화하고자 한다. 연구에서 사용된 X-선 튜브와 고전압 발생 장치는 각각 Axxent S700과 XF060NZZ485를 사용하였고, AT90CAN128 MCU를 사용하여 제어보드를 제작하였다. 관전압을 50 kV로 고정한 후에 제어 방식에 따라서 필라멘트 전류 제어 방식과 관전류제어 방식으로 나누었다. 필라멘트 제어 방식은 다시 필라멘트 가열 시간에 따라서 5초와 10초의 두 가지로 나누어 실험하였다. 필라멘트 전류 제어 방식에서는 필라멘트 예열 시간이 10초 이상이 되지 않으면 설정된 관전류 값에 도달하기 어려웠고, 관전류가 발생하는 필라멘트 전류도 1,300~1,350 mA로 가변적이었으며, 관전류가 발생된 이후에도 설정된 목표 값에 도달하기 위해서는 약 5초 이상의 시간이 소요되었다. 하지만 관전류 제어 방식에서는 관전류가 설정된 목표 값에 시간 지연 없이 즉각적으로 도달하였으며 그 때의 필라멘트 전류 값은 1,500 mA였다. 본 연구에서는 소형의 X-선 튜브에 고전압을 안정적으로 공급하는 제어 장치를 개발하였고, 방사선 영상장비로 사용함에 있어서는 관전류 제어 방식이 적합함을 보였다.

• 대한치과보철학회지
• /
• 제41권6호
• /
• pp.732-746
• /
• 2003

Statement of problem. Soft lining materials, also referred to as tissue conditioning materials, tissue heating materials, relining materials, soft liners or tissue conditioners, were first introduced to dentistry by a plastic manufacturer in 1959. Since the introduction of the materials to the dental field, their material properties have been continually improved through the effort of many researchers. Soft lining materials have become widely accepted, particularly by prosthodontists, because of their numerous clinical advantages and ease of manipulation. Unfortunately, few reports have been issued upon the topic of increasing the bond strength between the base metal alloy used in cast denture bases and PMMA soft liner modified with 4-META, nor upon the pattern of debonding and material change in wet environment like a intra oral situation. Purpose. The purposes of this study were comparing the bond strength between base metal alloy used for the cast denture bases and PMMA soft liner modified with 4-META, and describing the pattern of debonding and material property change in wet environment like the intraoral situation. Material and Methods. This study consisted of four experiments: 1. The in vitro measurement of shear bond strength of the adhesive soft liner. 2. The in vitro measurement of shear bond strength of the adhesive soft liner after 2 weeks of aging. 3. A comparison of debonding patterns. 4. An evaluation the Relation time of modified soft liner. The soft liner used in this study was commercially available as Coe-soft (GC America.IL.,USA), which is provided in forms of powder and liquid. This is a PMMA soft liner commonly used in dental clinics. The metal primer used in this study was 4-META containing primer packed in Meta fast denture base resin (Sun Medical Co., Osaka, Japan). The specimens were formed in a single lap joint desist which is useful for evaluating the apparent shear bond strength of adhesively bonded metal plate by tensile loading. Using the $20{\times}20mm$ transparent grid, percent area of adhesive soft liner remaining on the shear area was calculated to classify the debonding patterns. To evaluate the change of the initial flow of the modified adhesive soft liner, the gelation time was measured with an oscillating rheometer (Haake RS150W/ TC50, Haake Co., Germany). It was a stress control and parallel plate type with the diameter of 35mm. Conclusion. Within the conditions and limitations of this study, the following conclusions were drawn as follows. 1. There was significant increase of bond strength in the 5% 4-META, 10% 4-META containing groups and in the primer coated groups versus the control group(P<0.05). 2. After 2 weeks of aging, no significant increase in bond strength was found except for the group containing 10% 4-META (P<0.05). 3. The gelation times of the modified soft liner were 9.3 minutes for the 5% 4-META containing liner and 11.5 minutes for the 10% 4-META liner. 4. The debonding patterns of the 4-META containing group after 2 weeks of aging were similar to those of immediaely after preparation, but the debonding pattern of the primer group showed more adhesive failure after 2 weeks of aging.

• 대한치과보철학회지
• /
• 제58권3호
• /
• pp.228-238
• /
• 2020

환자의 교합에 맞춰 적절한 고정성 보철물을 성공적으로 제작 및 수복하기 위해서 필요한 다양한 고려사항이 있다. 그 중 환자가 갖고 있는 교합의 형태를 파악하여 고정성 보철물에 부여하는 것은 필수적이라 할 수 있다. 견치 유도 교합, 군 기능 교합 등 여러가지 교합 형태를 파악하는데 있어서 하악의 운동을 기록하는 것이 중요한데, 1933년 Meyers에 의해 소개된 Functionally generated path (FGP) technique은 구내에서 왁스 등의 재료를 이용하여 교두가 지나가는 하악 운동로를 기록한 후 보철물 제작에 적용하는 치료 술식이다. 본 증례에서는 두 명의 환자에 있어서 상악 구치부에 이차 우식 혹은 치주염으로부터 기원한 치수 유래 병소가 있어, 근관 치료 및 치주 치료 완료 후 고정성 보철물 수복이 필요하였다. 장기적인 예후가 좋지 않은 치아이기에 측방 간섭을 최소화하기 위해 FGP technique을 이용하여 하악 운동을 기록하였다. 통상적인 석고 인상 방법이 아닌 구내 디지털 스캔을 시행함으로써 더 효율적으로 보철물을 제작하였다. 치료 후 환자와 술자 모두 기능적으로 만족할 만한 결과를 얻었기에 이를 보고하는 바이다.

• 구강회복응용과학지
• /
• 제34권1호
• /
• pp.17-31
• /
• 2018

목적: 이 연구의 목적은 다양한 구강 스캐너를 사용하여 협측 악간관계 스캔에 따른 상하악 악궁 관계의 정확성을 비교 평가하는 것이다. 연구 재료 및 방법: 정상 교합을 보이는 상하악 전악 모델을 5종(Cerec Omnicam, CS3500, iTero, Trios, TruDef)의 구강 스캐너로 제조사의 지시대로 스캔하였다. 폴리비닐실록산 교합 재료로 고정시킨 금속 지그를 이용하여 우측 구치부를 1, 2, 3, 4 mm 단계적으로 올린 후 좌측 협측 악간관계 스캔을 채득하였다. 두 데이터를 중첩하여 전체적인 삼차원 변이를 평가하였고, 교합 평면에 수직인 단면을 분석하여 교두간 거리의 양과 방향을 평가하였다. 결과: 중첩연구에서 Cerec Omnicam ($165.5{\mu}m$)이 가장 적은 변이를 보였고, CS3500 ($369.0{\mu}m$)이 가장 큰 변이를 보였으며(P < 0.01), 1 mm 보다 3, 4, 2 mm 이개 그룹에서 변이가 유의미하게 컸다(P < 0.01). 단면 연구에서는 Cerec Omnicam이 교두끼리의 거리가 가장 먼 변이를 보였고($-242.8{\mu}m$), CS3500이 가장 가까워지는 변이를 보였으며($312.5{\mu}m$), 다른 거상 높이 보다 3 mm 이개 그룹에서 유의하게 변이가 컸다(P < 0.01). 결론: 구강 스캐너 마다 협측 악간관계 스캔을 이용해 상하악 교합 관계를 재현하는 정확성이 달랐다.