• 응용통계연구
• /
• 제22권3호
• /
• pp.607-616
• /
• 2009

In many epidemiological studies, the occurrence times of the event of interest are right-censored or interval censored. In certain situations such as the AIDS data, however, the incubation period which is the time between HIV infection and the diagnosis of AIDS is usually doubly censored. In this paper, we impute the interval censored HIV infection time using three imputation methods. Mid imputation, conditional mean imputation and approximate Bayesian bootstrap are implemented to obtain right censored data, and then Gibbs sampler is used to estimate the coefficient factor of the incubation period. By using Bayesian approach, flexible modeling and the use of prior information is available. We applied both parametric and semi-parametric methods for estimating the effect of the covariate and compared the imputation results incorporating prior information for the covariate effects.

• Journal of the Korean Data and Information Science Society
• /
• 제19권4호
• /
• pp.1247-1253
• /
• 2008

In this paper, we propose a interval censored regression spline model with a variance function (non-constant variance that depends on a predictor). Simulation studies show our estimates from MCECM algorithm are consistent, but biased when the sample size is small because of boundary effects. Also, we examined how the distribution of $x_i$ affects the converging speed of these consistent estimates.

• Communications for Statistical Applications and Methods
• /
• 제21권1호
• /
• pp.93-103
• /
• 2014

This paper deals with the problem of predicting censored data in a half triangle distribution with an unknown parameter based on progressively Type-II censored samples. We derive maximum likelihood predictors and some approximate maximum likelihood predictors of censored failure times in a progressively Type-II censoring scheme. In addition, we construct the shortest-length predictive intervals for censored failure times. Finally, Monte Carlo simulations are used to assess the validity of the proposed methods.

• Communications for Statistical Applications and Methods
• /
• 제7권1호
• /
• pp.245-256
• /
• 2000

Large sample properties of Life-Table estimator are discussed for interval censored bivariate survival data. We restrict out attention to the situation where response times within pairs are not distinguishable and the univariate survival distribution is the same for any individual within any pair.

• Communications for Statistical Applications and Methods
• /
• 제17권5호
• /
• pp.689-696
• /
• 2010

구간중도 절단자료는 감염 자료, 종양 발생 자료등 그 발생 시간을 정확하게 관측할 수 없는 경우에 흔히 발생되는 자료로 정확한 사건 발생 시간대신에 발생 전 마지막 관측시점과 발생 후 첫 번째 관측시점으로 구성된다. 이러한 종류의 자료는 Sun (2006)에 의해 자세하게 논의되었으며 관측 개체간의 독립성 가정 하에서 여러 가지 방법들에 의해 분석되어져 왔다. 본 논문에서는 관측 개체들이 군집으로부터 발생하여 더 이상독립성 가정이 적절하지 못한 경우를 고려한다. 특히 반응변수인 사건 발생 시간이 군집의 크기와 연관되어 있을 때, 이를 고려하기 위한 결합 모형을 제시한다. 제안된 모형은 림프계 필라리아병의 실제 자료에 적용한다.

• Communications for Statistical Applications and Methods
• /
• 제22권6호
• /
• pp.599-604
• /
• 2015

Kendall's tau statistic has been applied to test an association of bivariate random variables. However, incomplete bivariate data with a truncation and a censoring results in incomparable or unorderable pairs. With such a partial information, Tsai (1990) suggested a conditional tau statistic and a test procedure for a quasi independence that was extended to more diverse cases such as double truncation and a semi-competing risk data. In this paper, we also employed a conditional tau statistic to estimate an association of bivariate interval censored data. The suggested method shows a better result in simulation studies than Betensky and Finkelstein's multiple imputation method except a case in cases with strong associations. The association of incubation time and infection time from an AIDS cohort study is estimated as a real data example.

• 응용통계연구
• /
• 제25권3호
• /
• pp.423-434
• /
• 2012

A two-sample test for equality of survival distribution is one of the important issues in survival analysis, especially for clinical and epidemiological research. With interval censored data, some testing methods have been developed. This study introduces some testing methods and compares them under various situations through simulation study. Based on simulation result, it provides some useful information on choosing the most appropriate testing method in a given situation.

• Communications for Statistical Applications and Methods
• /
• 제29권4호
• /
• pp.403-411
• /
• 2022

This article presents an independence test between pairs of interval censored failure times. The Mantel-Haenszel test is commonly applied to test the independence between two categorical variables accompanied with a strata variable. Hsu and Prentice (1996) applied a Mantel-Haenszel test to the sequence of 2 × 2 tables formed at the grids which are composed of failure times. In this article, due to unknown failure times, the suitable grid points should be determined and the status of failure and at risk are estimated at those grid points. We also consider a weighted test statistic to bring a more powerful test. Simulation studies are performed to evaluate the power of test statistics under finite samples. The method is applied to analyze two real data sets, mastitis data from milk cows and an age-related eye disease study.

• 응용통계연구
• /
• 제23권3호
• /
• pp.521-531
• /
• 2010

구간중도절단은 중도절단의 가장 일반적인 개념으로 구간중도절단자료는 의학 및 역학분야의 연구에서 흔히 관찰된다. 본 연구에서는 구간중도절단의 상황에서 생존함수와 중간생존시간을 추정하는 방법으로 평균대치법과 자기일치법을 비교 연구하고, 실제 자료로 혈우병환자에서 선천성면역결핍바이러스 감염시점을 추정하였다. 또한 구간중도절단자료를 생성하는 새로운 방법을 제시하였으며, 생성된 구간중도절단자료를 이용한 모의실험을 통하여 두 추정치에 대한 다양한 비교연구를 시행하였다. 구간중도절단자료에서 생존함수와 중간생존시간을 추정할 경우 중도절단율이 크지 않다면 평균대치법이 자기일치법보다 더 우수한 추정치로 판명되었다.

• Journal of the Korean Data and Information Science Society
• /
• 제21권5호
• /
• pp.927-934
• /
• 2010

본 논문은 점진 제1종 구간 중도절단표본과 점진 제2종 중도절단표본에서 모수를 추정하는 방법을 소개하고, 점진 제2종 중도절단표본에서 모수를 추정하는 방법을 활용하고자 점진 제1종 구간 중도절단표본에서 얻은 자료를 변환하여 모수를 추정하는 새로운 방법을 제안하였다. 척도모수가 미지인 지수 분포를 따르는 점진 제1종 구간 중도절단표본을 이용하여 점진 제2종 중도절단표본의 최대우도추정량을 사용하여 모수를 추정하였고, 모의실험을 통하여 두 방법에서 구한 추정량을 비교한 결과 본 논문에서 새로 제시한 방법을 이용하여 구한 모수의 추정량이 평균제곱오차 측면에서 더 우수한 추정량임이 나타났다.