• Title/Summary/Keyword: international co-production

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Okadaic Acid Group Toxins: Toxicity, Exposure Routes, and Global Safety Management (오카다익산 군 독소: 독성, 분석법 및 관리 동향)

  • Kyoungah Lee;Namhyun Kim;Jang Kyun Kim;Youn-Jung Kim;Jung Suk Lee;Young-Seok Han
    • Journal of Food Hygiene and Safety
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    • v.38 no.6
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    • pp.409-419
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    • 2023
  • Okadaic acid (OA) group toxins, including OA and its analogs, such as dinophysis toxins (DTXs), have been reported to cause diarrheal shellfish poisoning (DSP). These toxins are primarily produced by dinoflagellates and are accumulated in bivalves. Recently, the presence of Dinophysis sp., a causative alga of DSP, has been reported along the coasts of Korea, posing a potential risk of contamination to domestic seafood and exerting an impact on both the production and consumption of marine products. Accordingly, the European Food Safety Authority (EFSA) and the World Health Organization (WHO) have established standards for the permissible levels of OA group toxins in marine products for safety management. Additionally, in line with international initiatives, the domestic inclusion and regulation of DTX2 among the substances falling under the purview of management outlined by the 2022 diarrheal shellfish toxin standard have been implemented. In this study, we reviewed the physicochemical properties of OA group toxins, their various exposure routes (such as acute toxicity, genotoxicity, reproductive and developmental toxicity), and the relative toxicity factors associated with these toxins. We also performed a comparative assessment of the methods employed for toxin analysis across different countries. Furthermore, we aimed to conduct a broad review of human exposure cases and assess the international guideline for risk management of OA group toxins.

Production of Lactulose by Biological Methods and Its Application (생물학적 방법을 통한 기능성 이당 lactulose의 생산과 응용 연구)

  • Kim, Yeong-Su;Kim, Do-Yeon;Park, Chang-Su
    • Journal of Life Science
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    • v.26 no.12
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    • pp.1477-1486
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    • 2016
  • Lactulose (4-O-β-D-galactopyranosyl-D-fructose) is a non-digestible synthetic ketose disaccharide which can used in food and pharmaceutical fields due to its useful functions for encephalopathy, chronic constipation, hyperammonemia, etc. Therefore, the lactulose is regarded as one of the most important disaccharides and have been concentrated much interesting as an attractive functional material in the current industry. From this reason, the research related on the production of lactulose has been carried out various academic and industrial research groups. To produce lactulose, two main methods, chemical production and enzymatic production have been used. Commercially lactulose produced by alkaline isomerization of lactose as chemical production method but it has many disadvantages such as rapid lactulose degradation, purification, and waste management. From these reasons, lactulose produced by enzymatic method which solves these problems has been suggested as a proper method for lactulose production. Two different enzymatic methods have been reported as methods for lactulose production. Lactulose can be obtained through hydrolysis and transfer reaction catalyzed by a β-galactosidase which requires fructose as co-substrate and exhibits a low conversion. Alternatively, lactulose can be produced by direct isomerization of lactose to lactulose catalyzed by cellobiose 2-epimerase which requires lactose as a single substrate and achieves a high lactulose yield. This review summarizes the current state of lactulose production by chemical and biological methods.

Activation of peroxisome proliferator-activated receptor gamma induces anti-inflammatory properties in the chicken free avian respiratory macrophages

  • Mutua, Mbuvi P.;Steinaa, Lucilla;Shadrack, Muya M.;Muita, Gicheru M.
    • Journal of Animal Science and Technology
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    • v.57 no.11
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    • pp.40.1-40.7
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    • 2015
  • Background: Activation of peroxisome proliferator activated receptor gamma (PPARγ) in the alveolar macrophages (AM) by selective synthetic PPARγ ligands, improves the ability of the cells to resolve inflammation. In birds, respiratory macrophages are known as free avian respiratory macrophages (FARM) and show distinct functional differences from AM. The effects of treating FARM with PPARγ ligands are unclear. Methods: FARM were harvested by lavage of chicken respiratory tract and their morphology assessed at microscopic level. The effects of PPARγ agonists on the FARM in vitro viability, phagocytic capacity and proinflammatory cytokine (TNF-α) production were assessed. Results: FARM had eccentric nucleus and plasma membrane ruffled with filopodial extensions. Ultrastructurally, numerous vesicular bodies presumed to be lysosomes were present. FARM treated with troglitazone, a selective PPARγ agonist, had similar in vitro viability with untreated FARM. However, treated FARM co-cultured with polystyrene particles, internalized more particles with a mean volume density of 41 % compared to that of untreated FARM of 21 %. Further, treated FARM significantly decreased LPS-induced TNF-α production in a dose dependent manner. Conclusion: Results from this study show that PPARγ synthetic ligands enhance phagocytic ability of FARM. Further the ligands attenuate production of proinflammatory cytokines in the FARM, suggesting potential therapeutic application of PPARγ ligands in the management of respiratory inflammatory disorders in the poultry industry.

Application for Uni-materialization and Life Cycle Assessment of the Vehicle Undercover (자동차 언더커버의 유니소재화 적용 및 전과정평가)

  • Yun, Hyeri;Park, Yoosung;Yu, MiJin;Bae, Hana;Lee, Hanwoong
    • Clean Technology
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    • v.23 no.3
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    • pp.256-269
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    • 2017
  • In response to national and international regulations for resource circulation and to reduce greenhouse gas emissions, the automotive industry has tried to reuse scrap parts and defective products produced in the disposal or production stages as recycled resources. Attempts have been made to reach the target recycling rate by reducing the number of material types required for each part. Moreover, in order to achieve greenhouse gas reduction targets while maintaining the performance of existing products, lighter components are being developed. Existing products were 100% incinerated at the disposal stage, but the uni-materialized products were improved to be possible that it could be recycled 90% through scraps and the defective product in the pre-production and production stage. It also appears that the fuel efficiency improves through 56% lightweight compared to the existing product. In this paper, a preliminary assessment is conducted on the applicability of uni-materialized product development of car parts. The environmental impact values of existing products and developed prototypes are compared and analyzed through life cycle assessment.

Study on the Optimization of Spent Sulfidic Caustic Applied for BNR Process (Spent Sulfidic Casutic의 BNR 공정 적용을 위한 최적화 연구)

  • Lee, Jae-Ho;Ju, Dong-Jin;Park, Jeung-Jin;Shin, Choon-Hwan
    • Journal of Environmental Science International
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    • v.20 no.12
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    • pp.1617-1624
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    • 2011
  • Caustic (NaOH) solution is used to remove H2S from hydrocarbon streams in petroleum refining industry, gradually being, so called, spent sulfidic caustic (SSC) which has high levels of H2S and alkalinity. Thus, SSC can be used as an electron donor and a buffering agent for autotrophic denitrification. As SSC, however, contains some non-biodegradable organics, air stripping was conducted to remove the non-biodegradable organics. As a result, over 93 % of the non-biodegradable organics was removed within 30 min of aeration. Then, Na2S2O35H2O, methanol and organic matters, which are produced from a biodiesel production plant, were added to reform the air-stripped SSC and their products being referred to new sulfidic caustics (NSCs) I, II and III, respectively. Thereafter, to investigate the effect of these products on the removal of COD and TN, these products were injected to a biological nitrogen removal (BNR) process, resulting in additional 44 % TN removal without noticeable increase in the effluent COD level. Therefore, it can be said that the BNR process is a promising option to treat NSC as demonstrated in this study whose results can be useful for developing resource recovery technologies.

Knowledge Domain and Emerging Trends of Intelligent Green Building and Smart City - A Visual Analysis Using CiteSpace

  • Li, Hongyang;Dai, Mingjie
    • International conference on construction engineering and project management
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    • 2017.10a
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    • pp.24-31
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    • 2017
  • As the concept of sustainability becomes more and more popular, a large amount of literature have been recorded recently on intelligent green building and smart city (IGB&SC). It is therefore needed to systematically analyse the existing knowledge structure as well as the future new development of this domain through the identification of the thematic trends, landmark articles, typical keywords together with co-operative researchers. In this paper, Citespace software package is applied to analyse the citation networks and other relevant data of the past eleven years (from 2006 to 2016) collected from Web of Science (WOS). Through this, a series of professional document analysis are conducted, including the production of core authors, the influence made by the most cited authors, keywords extraction and timezone analysis, hot topics of research, highly cited papers and trends with regard to co-citation analysis, etc. As a result, the development track of the IGB&SC domains is revealed and visualized and the following results reached: (i) in the research area of IGB&SC, the most productive researcher is Winters JV and Caragliu A is most influential on the other hand; (ii) different focuses of IGB&SC research have been emerged continually from 2006 to 2016 e.g. smart growth, sustainability, smart city, big data, etc.; (iii) Hollands's work is identified with the most citations and the emerging trends, as revealed from the bursts analysis in document co-citations, can be concluded as smart growth, the assessment of intelligent green building and smart city.

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AMPKα, C/EBPβ, CPT1β, GPR43, PPARγ, and SCD Gene Expression in Single- and Co-cultured Bovine Satellite Cells and Intramuscular Preadipocytes Treated with Palmitic, Stearic, Oleic, and Linoleic Acid

  • Choi, S.H.;Park, S.K.;Johnson, B.J.;Chung, K.Y.;Choi, C.W.;Kim, K. H.;Kim, W.Y.;Smith, S.B.
    • Asian-Australasian Journal of Animal Sciences
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    • v.28 no.3
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    • pp.411-419
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    • 2015
  • We previously demonstrated that bovine subcutaneous preadipocytes promote adipogenic gene expression in muscle satellite cells in a co-culture system. Herein we hypothesize that saturated fatty acids would promote adipogenic/lipogenic gene expression, whereas mono- and polyunsaturated fatty acids would have the opposite effect. Bovine semimembranosus satellite cells (BSC) and intramuscular preadipocytes (IPA) were isolated from crossbred steers and cultured with 10% fetal bovine serum (FBS)/Dulbecco's Modified Eagle Medium (DMEM) and 1% antibiotics during the 3-d proliferation period. After proliferation, cells were treated for 3 d with 3% horse serum/DMEM (BSC) or 5% FBS/DMEM (IPA) with antibiotics. Media also contained 10μg/mL insulin and 10μg/mL pioglitazone. Subsequently, differentiating BSC and IPA were cultured in their respective media with 40μM palmitic, stearic, oleic, or linoleic acid for 4 d. Finally, BSC and IPA were single- or co-cultured for an additional 2 h. All fatty acid treatments increased (p = 0.001) carnitine palmitoyltransferase-1 beta (CPT1β) gene expression, but the increase in CPT1β gene expression was especially pronounced in IPA incubated with palmitic and stearic acid (6- to 17-fold increases). Oleic and linoleic acid decreased (p = 0.001) stearoyl-CoA desaturase (SCD) gene expression over 80% in both BSC and IPA. Conversely, palmitic and stearic acid increased SCD gene expression three fold in co-cultured in IPA, and stearic acid increased AMPKα gene expression in single- and co-cultured BSC and IPA. Consistent with our hypothesis, saturated fatty acids, especially stearic acid, promoted adipogenic and lipogenic gene expression, whereas unsaturated fatty acids decreased expression of those genes associated with fatty acid metabolism.

Using automated container type culture system Hericium erinaceum mushroom production technology (컨테이너형 버섯식물공장시스템설계 및 노루궁뎅이버섯 생산)

  • Jo, Woo-Sik;Lee, Sung-Hak;Ryu, Song-Yi;Kang, Min-Gu;Kim, Woo-Hyun;Park, Chang-Min;Park, Who-Won
    • Journal of Mushroom
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    • v.14 no.4
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    • pp.249-252
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    • 2016
  • Timing, place, and the high-tech industry to overcome barriers to the introduct of the so-called "smart agriculture". The core factors of precision agriculture, including temperature, humidity, location information, and real summary information, are all significant for ICT controlling technique. The system is a four-season container allowing mushroom product, humidity, illumination, and factors such as carbon dioxide were regulated to create the optimal environment for mushroom cultivation. Hericium erinaceum (also called Lion's Mane Mushroom, Bearded Tooth Mushroom, or Bearded Tooth Fungus) is an edible and medicinal mushroom in the tooth fungus group. During approximately 40 days of incubation, 1.4 kg of oak sawdust was used as the test medium. The humidity, temperature, and CO2 density were maintained at >85-95%, 1820C, and 700-1,000 ppm, respectively, in the container type culture system. The time for primordium formation was observed to be 4-7 days. The amount of fruitbody production was 74-95 g per bag. This technique will be used to establish a new community support program, in conjunction with international movement, domestic sales and exports are also planned.

Domestic and Overseas TBM Production Specification and Professional Training Program (국내외 TBM 제작 사양 및 전문인력 양성 프로그램 분석)

  • Kim, Ki-Hwan;Kim, Seong-Cheol;Kang, Si-On;Mun, Cheol-Hwa;Jeong, Yun-Young;Kim, Hyouk
    • Tunnel and Underground Space
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    • v.29 no.5
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    • pp.281-291
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    • 2019
  • In Overseas case, most tunnels in under are or through the river are constructed with shield TBM and the manufacturer orders of related equipment suitable for the project are mode. Accordingly, the client provides the specifications required for the equipment manufacture. In addition, TBM equipment has been operated by those who have completed the expert training program, which for minimizing the risk of equipment operation in construction field corresponding to the mechanized construction. However, in Korea, such a system related to above the program and specifications has not yet been built, which is causing a lot of difficulties in construction field. Therefore, this study investigated the differences in bidding guides provided by mechanized construction in domestic and abroad, and the professional education programs for expert training being conducted from overseas. Futhermore, we will propose the guidelines of essential equipment specification contained in domestic bidding and provide the necessary manual for the professional education program for TBM as the mechanized construction method.

Proinflammatory Cytokine and Nitric Oxide Production by Human Macrophages Stimulated with Trichomonas vaginalis

  • Han, Ik-Hwan;Goo, Sung-Young;Park, Soon-Jung;Hwang, Se-Jin;Kim, Yong-Seok;Yang, Michael Sungwoo;Ahn, Myoung-Hee;Ryu, Jae-Sook
    • Parasites, Hosts and Diseases
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    • v.47 no.3
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    • pp.205-212
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    • 2009
  • Trichomonas vaginalis commonly causes vaginitis and perhaps cervicitis in women and urethritis in men and women. Macrophages are important immune cells in response to T. vaginalis infection. In this study, we investigated whether human macrophages could be involved in inflammation induced by T. vaginalis. Human monocyte-derived macrophages (HMDM) were co-cultured with T. vaginalis. Live, opsonized-live trichomonads, and T. vaginalis Iysates increased proinflammatory cytokines, such as TNF-α, IL-1β, and IL-6 by HMDM. The involvement of nuclear factor (NF)-κB signaling pathway in cytokine production induced by T. vaginalis was confirmed by phosphorylation and nuclear translocation of p65 NF-κB. In addition, stimulation with live T. vaginalis induced marked augmentation of nitric oxide (NO) production and expression of inducible NO synthase (iNOS) levels in HMDM. However, trichomonad-induced NF-κB activation and TNF-α production in macrophages were significantly inhibited by inhibition of iNOS levels with L-NMMA (NO synthase inhibitor). Moreover, pretreatment with NF-κB inhibitors (PDTC or Bay11-7082) caused human macrophages to produce less TNF-α. These results suggest that T. vaginalis stimulates human macrophages to produce proinflammatory cytokines, such as IL-1, IL-6, and TNF-α, and NO. In particular, we showed that T. vaginalis induced TNF-α production in macrophages through NO-dependent activation of NF-κB, which might be closely involved in inflammation caused by T. vaginalis.