• Korean Journal of Oriental Medicine
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• v.2 no.1
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• pp.269-288
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• 1996

Coicis Semen is one of the oriental medicine that has been used for the treatment of the diseases such as pulmonary abscess, periappendicular abscess and wart since ancient times. However, the mechanism of the action of the drug is not well studied. This study was done to investigate the effects of Coicis Semen on the host defence mechanism. Effects of Coicis Semen on the immune responses were analysed by measuring the contact hypersensitivity, hemagglutinin, hemolysin and rosette formation, cytotoxicity, and reactive oxygen intermidiates production. As the results, water extract of Coicis Semen administration enhanced the antibodies (hemagglutinin and hemolysin) formation and the appearance of rosette forming cells of the spleen. Also Coicis Semen increased the allogeneic immune response in the mouse, showed cytotoxic activity against human leukemia cell line(K562) and decreased the contact hypersensitivity against dinitroflurobenzene. Also administration of Coicis Senlen slightly increased NK cell activity and enhanced the production of such reactive oxygen intermediates as superoxide and hydrogen peroxide from the macrophages in vivo and in vitro. The above results demonstrate that Coicis Semen has enhancing effects on cellular and humoral immune responses against disease.

• Journal of the Korea Safety Management & Science
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• v.13 no.4
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• pp.171-177
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• 2011

This paper reviewed the relationship between internal marketing and incremental innovation, and the moderating effect of firm size. The results of hierarchical multiple regression analysis, based on the responses from 322 employees in small business, showed that almost internal marketing factors effects positively on incremental innovation. All internal marketing factors(CEO support, compensation system, education & training, internal communication, authority delegation) appeared to be related positively with process innovation and service innovation. And all other factors(compensation system, education & training, internal communication, authority delegation) except CEO support showed to have positive relationship with operation innovation. In the moderating effects, internal communication effects more positively on incremental innovation in large firm-size than in small firm-size. But delegation effects more positively on incremental innovation in small firm-size than in large firm-size.

• Journal of KSNVE
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• v.8 no.6
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• pp.1144-1149
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• 1998

A two degree-of-freedom model of suspended cables is studied for forced resonant response. The method of averaging is used to obtain first-order approximations to the response of the system. A bifurcation analysis of the averaged system is performed in the case of 2-to-1 internal resonance. Nonlinear coupled-mode motions are found to bifurcate from single-mode responses and further bifurcate to limit cycle motions via Hopf bifurcations. The limit cycle solutions undergo period doubling bifurcations to chaos.

• Tuberculosis and Respiratory Diseases
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• v.70 no.4
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• pp.301-306
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• 2011

Background: It is well-known that cell-free nucleic acids rise in patients with many types of malignancies. Several recent experimental studies using cancer cell lines have shown that changes in cell-free RNA are predictive of the response to chemotherapy. The objective of this study was to determine whether quantification of free RNA can be used as a biomarker for clinical responses to chemotherapy in patients with lung cancer. Methods: Thirty-two patients with lung cancer (non-small cell lung cancer, n=24; small cell lung cancer, n=8) were divided into 2 groups according to their responses to chemotherapy (response group, n=19; non-response group, n=13). Blood samples were collected before and after two cycles of chemotherapy. Real-time quantitative RT-PCR was used for transcript quantification of the glyceraldehyde-3-phosphate dehydrogenase gene. Results: The pre chemotherapy values (Response group $41.36{\pm}1.72$ vs. Non-response group $41.33{\pm}1.54$, p=0.78) and post chemotherapy values (Response group $39.92{\pm}1.81$ vs. Non-response group $40.41{\pm}1.47$, p=0.40) for cell free RNA concentrations, expressed as Ct GAPDH (threshold cycle glyceraldehyde-3-phosphate dehydrogenase gene) levels, was not different between the two groups. There was no significant relationship between changes in the cell free RNA level clinical responses after chemotherapy (p=0.43). Conclusion: We did not find a correlation between quantification of serum cell free RNA levels and clinical responses to chemotherapy in patients with lung cancer. Further investigations are needed to determine whether the cell free RNA level is a useful predictor of responses to chemotherapy in patients with lung cancer.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.1
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• pp.271-283
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• 2021

This article provides empirical evidence on factors of internal audit (IA) characteristics affecting the internal audit effectiveness in steel enterprises in Vietnam. The study uses data from survey obtained from 114 responses representing owners, managers, and internal auditors from 38 steel enterprises in Vietnam for period from 2018 to 2019. Data collected is firstly checked with Cronbach's Alpha, then the EFA test, and the model linear regression is used to test the relationship between internal audit characteristics and internal audit effectiveness. Results reveal that internal audit effectiveness in steel enterprises in Vietnam is influenced by various internal factors, including the size of internal audit, the scope of internal audit, the capacity of internal auditors, the independence of internal auditor, and the operational bases and methods of internal audit. Based on the research results, the paper makes six recommendations: strengthening operational basis of IA; increasing the independence of IA; increasing the size and capacity of IA staff; expanding and not underestimate the scope of IA; and reforming the internal governance structure. These proposed recommendations could be applied, not only for steel companies in Vietnam, but also for other companies in Vietnam or other companies in jurisdictions that have similar conditions.

• Biomedical Science Letters
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• v.13 no.4
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• pp.325-332
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• 2007

Cell-mediated immune response (CMI) is a major immune protective mechanism against tuberculosis (TB) infection. Among several components involved in CMI, recent studies suggest that CD8+ T cells are important in controlling TB infection. In our previous report, we defined four Mycobacterium tuberculosis (MTB) derived epiotpe peptides specific for HLA-A*0201-restricted CD8+ T cells. These four peptides are $PstAl_{75-83}$, $ThyA_{30-38}$, $RpoB_{127-135}$ and $85B_{15-23}$. In this study, these epitope peptides specific CD8+ T cell responses in tuberculous pleurisy were investigated using ex vivo $IFN-\gamma$ elispot assay and intracellular $IFN-\gamma$ staining method. As a result, we observed these epitope peptide specific CD8+ T cell responses are induced in all three patients with tuberculous pleurisy suggesting that CD8+ T cells are involved in protective immune mechanism against MTB infection in tuberculous pleurisy. However, the CMI to mitogens and MTB antigens from pleural fluids of patients with tuberculous pleurisy does not seem to correlate with that from peripheral blood, although the sample size is too small to make any conclusion. In sum, the MHC I restricted CD8+ T cell responses seem to be induced efficiently in the pleural fluids, at the site of TB infection, in which the CMI is actively induced. In addition, these experiments suggest that MHC I restricted CD8+ T cell mediated immune responses are also involved in protective mechanism against MTB infection in extra-pulmonary TB.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 1994.10a
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• pp.35-39
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• 1994

One of the important characteristics of the response of nonlinear systems is the existence of subharmonic resonances. When some conditions in parameter space are satisfied. It is possible even in the presence of damping for a periodically excited nonlinear system to possess a response which is the combination of a contribution at the excitation frequency and a component at the system natural frequency. The system natural frequency being a submultiple of the excitation frequency implies that the resulting response is a subharmonic oscillation. In general, there also co-exists, for the system, a response at the excitation frequency, and initial conditions determine which of the steady-state responses is achieved in an experiment or a numerical simulation. In single-degree-of-freedom systems with harmonic excitation, depending on the type of the nonlinearity, e.g., cubic or quadratic the frequency of subharmonic response is respectively, one-third or one-half of that of the excitation frequency. Although subharmonic resonance is one of the principal characteristics of a nonlinear system the subharmonic responses of structures in the presence of internal resonances have been studied very rarely. In this work, we consider subharmonic responses in the two-mode approximation of the plate equations. It is assumed that the two modes are in one-to-one internal resonance. Constant and periodic steady-state solutions of the averaged equations are studied. Finally, the results of direct time integration of the original equations of motion are presented and compared with those obtained from the averaged equations.

• Journal of the Korean Home Economics Association
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• v.38 no.6
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• pp.101-116
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• 2000

This study integrated mother's control behavior of child's misbehavior within social domain analysis and the framework of attributional models of social cognition. The purpose of this study was to identify, compare and contrast maternal attributions and control responses according to child's age and domains of social behavior, and to investigate that mother's social cognition factors(authoritarian attitude and self competence perception) influence material inference and responses for their child's acts. Then this study was to find out whether mother's attribution would mediate their socialization techniques. For empirical research, 654 mothers with 5.6 year old and 8.9 year old children as subjects answered the structured questionnaire. The data were analyzed by frequencies, t-test, oneway ANOVA, and multiple regression. The major findings were as follows: First, according to child's two domains of misbehavior, there were differences in mothers'attribution and control behavior. Also mothers regarded older child's behavior as more dispositional cause and as more deserving of punishment than younger child's. Second, mother's authoritarian altitude of parenting, self-competence perception, and educational level were significantly related to mother's judgment. Third, the more authoritarian attitude mothers had, the more dispositional factor of children they attributed. And the lower self-competence mothers perceived. the more internal factor of child they attributed. Finally, maternal attributions and control responses are interrelated. When they attributed their children's misdeeds to internal dispositions, they respond with more stronger control behavior. The results suggested maternal social cognition mediate socialization behavior.

• Korean Journal of Child Studies
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• v.35 no.5
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• pp.113-134
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• 2014

This study sought to develop a 'Meaning of Parenting Scale for Mothers(MPS-M)' in order to measure how Korean mothers perceive the meaning of parenting. To this end, in Study I, a preliminary scale was designed, based firstly on socio-cultural and evolutionary psychological perspectives and secondly on the responses from 118 mothers concerning meaning of parenting. This was followed up by the collection of 887 mothers' responses to the preliminary scale, which then underwent exploratory factor analysis for scale revision. In Study 2, confirmatory factor analysis was conducted on a collection of responses from 548 mothers using the revised scale. Concurrent validity was tested using a parenting stress scale, and reliability was then checked by conducting calculations for internal consistency. As a result, the MPS-M was finally developed, consisting of 25 items under six factors: 'Internal Maturity', 'Restoration of Naturality', 'Familial Union', 'Physical Burden', 'Affective Disorientation', and 'Comprehensive Loss'. Accordingly, the meaning of parenting was statistically confirmed as a hierarchical two-sided concept possessing six factors under positive and negative meaning categories.

• The Journal of Internal Korean Medicine
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• v.41 no.3
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• pp.424-433
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• 2020

Qingfei Paidu decoction is recommended for treatment and prevention of COVID-19. It is a prescription that combines Mahaenggamseok-tang, Oryeong-san, Soshiho-tang, Saganmahwang-tang, and Kwakhyangjeonggi-san. According to several clinical reviews, symptoms of COVID-19 were improved, laboratory test indicators were improved, and the cure rate was increased. Pharmacologically, the Qingfei Paidu decoction and its composition have been reported to inhibit viral replication, alleviate immune responses, and have anti-inflammatory and antiviral effects. Severe side effects were not revealed, and this treatment is considered relatively safe. However, to validate and better understand these findings, well-designed clinical studies are needed.