• Journal of the Korea Institute of Information and Communication Engineering
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• v.25 no.9
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• pp.1158-1165
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• 2021

This paper proposes a CNN accelerator which is optimized Pooling layer operation incorporated in Multiplication And Accumulation(MAC) to reduce the memory size. For optimizing memory and data path circuit, the quantized 8bit integer weights are used instead of 32bit floating-point weights for pre-training of MNIST data set. To reduce chip area, the proposed CNN model is reduced by a convolutional layer, a 4*4 Max Pooling, and two fully connected layers. And all the operations use specific MAC with approximation adders and multipliers. 94% of internal memory size reduction is achieved by simultaneously performing the convolution and the pooling operation in the proposed architecture. The proposed accelerator chip is designed by using TSMC65nmGP CMOS process. That has about half size of our previous paper, 0.8*0.9 = 0.72mm². The presented CNN accelerator chip achieves 94% accuracy and 77us inference time per an MNIST image.

• Journal of Lipid and Atherosclerosis
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• v.7 no.2
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• pp.77-87
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• 2018

Lowering serum low-density lipoprotein cholesterol (LDL-C) is the mainstay for reduction of risk of cardiovascular disease (CVD), the second most common cause of death in Korea. The 2015 Korean guidelines for management of dyslipidemia strongly recommend the use of statins in patients at risk of CVD. Statin therapy, which is the gold standard for CVD, reduces LDL-C level by 40% to 60% and is generally well tolerated. However, many patients are intolerant to statins and discontinue therapy or become nonadherent to therapy because of actual/perceived side effects. The most common of these side effects is the statin-associated muscle symptom (SAMS). Discontinuation and repetitive re-challenge with statins can help identify SAMS. If serum creatinine kinase level is more than 10 times the upper limit of normal, statin therapy must be stopped immediately, and the physician should identify possible causes including rhabdomyolysis and treat appropriately. In other patients, it might help to switch to a less potent statin or to use statins at intermittent non-daily dosing. To achieve target LDL-C level, non-statin lipid-lowering therapies such as dietary modifications, ezetimibe, and bile acid sequestrants may be added. Several new drugs have recently been approved for lowering LDL-C level. Alirocumab and evolocumab are monoclonal antibodies that inhibit proprotein convertase subtilisin/kexin type 9, and both drugs cause large reductions in LDL-C, similar to statins. Lomitapide and mipomersen are orphan drugs used as adjuncts to other lipid-lowering therapies in patients with homozygous familial hypercholesterolemia.

• Biomolecules & Therapeutics
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• v.27 no.3
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• pp.290-301
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• 2019

Paeonol has neuroprotective function, which could be useful for improving central nervous system disorder. The purpose of this study was to characterize the functional mechanism involved in brain transport of paeonol through blood-brain barrier (BBB). Brain transport of paeonol was characterized by internal carotid artery perfusion (ICAP), carotid artery single injection technique (brain uptake index, BUI) and intravenous (IV) injection technique in vivo. The transport mechanism of paeonol was examined using conditionally immortalized rat brain capillary endothelial cell line (TR-BBB) as an in vitro model of BBB. Brain volume of distribution (VD) of [$^3H$]paeonol in rat brain was about 6-fold higher than that of [$^{14}C$]sucrose, the vascular space marker of BBB. The uptake of [$^3H$]paeonol was concentration-dependent. Brain volume of distribution of paeonol and BUI as in vivo and inhibition of analog as in vitro studies presented significant reduction effect in the presence of unlabeled lipophilic compounds such as paeonol, imperatorin, diphenhydramine, pyrilamine, tramadol and ALC during the uptake of [$^3H$]paeonol. In addition, the uptake significantly decreased and increased at the acidic and alkaline pH in both extracellular and intracellular study, respectively. In the presence of metabolic inhibitor, the uptake reduced significantly but not affected by sodium free or membrane potential disruption. Similarly, paeonol uptake was not affected on OCTN2 or rPMAT siRNA transfection BBB cells. Interestingly. Paeonol is actively transported from the blood to brain across the BBB by a carrier mediated transporter system.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.44 no.6
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• pp.275-281
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• 2018

Objectives: Isolated mandibular fractures contribute to approximately 45% of maxillofacial traumas. Improper management of mandibular fractures can cause myriad potential complications and can lead to serious functional and aesthetic sequelae. The objective of the study is to design a stepwise approach for managing isolated mandibular fractures using open reduction and internal fixation (ORIF) with regional anesthesia on outpatient basis. Materials and Methods: Patients with isolated mandibular fractures presenting to the department of maxillofacial surgery were selected for ORIF under regional anesthesia based on occlusion, age, socioeconomic status, general condition, habits, and allied medical ailments. Standard preoperative, intraoperative, and postoperative protocols were followed. All patients were followed up for a minimum of 4 weeks up to a maximum of 1 year. Results: Of 23 patients who received regional anesthesia, all but one had good postoperative functional occlusion. One patient was hypersensitive and had difficulty tolerating the procedure. Two patients developed an extraoral draining sinus, one of whom was managed with local curettage, while the other required hardware removal. One patient, who was a chronic alcoholic, returned 1 week after treatment with deranged fracture segments after he fell while intoxicated. Conclusion: With proper case selection following a stepwise protocol, the majority of mandibular fractures requiring ORIF can be managed with regional anesthesia and yield minimal to no complications.

• Journal of The Korea Institute of Healthcare Architecture
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• v.24 no.4
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• pp.69-87
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• 2018

Purpose: This study has been started with the awareness that light and color are the main visual sensors of the multi-sensory stimulation environment to achieve the therapeutic environment for demented elderly. The purpose of this study therefore is for clarifying the application characteristics of therapeutic light and color for dementia care facilities. Methods: Internal and external literature reviews have been conducted for the investigation into a)disorders and visual system in demented elderly, b)therapeutic effects of light and color, c)heliotherapy, light therapy and color therapy to deduce the therapeutic characteristics of light and color for demented elderly, and finally into d)the application characteristics of it for dementia care facilities. Results: The application characteristics of the therapeutic light and color for dementia care facilities are classified into both qualitative and quantitative characteristics. Qualitative application characteristics of light represented using of daylight, using of lighting approximate to daylight, expansion of iluminance level, equality in iluminance Level, reduction of shadow, and as well as exclusion of blare. Quantitative application characteristics of it represented iluminance level, color temperature and color rendering index prescribed in international lighting standards. Qualitative application characteristics of color represented non-monochromatic color, color contrast, long wavelength of yellow-red colors, exclusion of short wavelength of blue colors and patterns, and as well as different colors for idenfication. Quantitative application characteristics of it represented kontrast(K) prescribed in DIN32975:2009 and light reflectance value(LRV) prescribed in BS8300:2009. Implications: To form dementia care facilities as therapeutic environment both qualitative and quantitative application characteristics of therapeutic light and color in dementia care facilities are needed.

• Journal of Convergence for Information Technology
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• v.8 no.6
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• pp.389-397
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• 2018

Recently, Global Shale gas development has expanded, increasing shale gas production has transformed the energy market.As a result of the reduction of energy facilities, in order to overcome the management deterioration of domestic casting valve industry and enter the enlarged shale gas plant, tried to confirm the SWOT factor through the second questionnaire based on the questionnaire survey of related industry experts and previous studies. As a strength-strategy, presented three factors besides collaboration with domestic companies, suggested four factors including product development specialized in shale gas plant as a weakness complement. Thesis offer to scholarly-Practical implications, Internal-external environmental factors, strategization for entering New energy market. thesis offer to scholarly, Practical implications, environmental factors, strategization for entering New energy market. After, analyze a important of research strategy, would like to study the impact on the company according to the ranking of importance.

• The Korean Journal of Physiology and Pharmacology
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• v.23 no.2
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• pp.103-111
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• 2019

The study is to investigate effects of andrographolide on experimental autoimmune myocarditis (EAM). Lewis rats were immunized on day 0 with porcine cardiac myosin to establish EAM. The EAM rats were treated with either andrographolide (25, 50, 100 mg/kg/day) or vehicle for 21 days. An antigen-specific splenocytes proliferation assay was performed by using the cells from control rats immunized with cardiac myosin. Survival rates, myocardial pathology and myocardial functional parameters (left ventricle end-diastolic pressure, ${\pm}dP/dt$ and left ventricular internal dimension) of EAM rats received andrographolide were significantly improved. Andrographolide treatment caused an decrease in the infiltration of $CD3^+$ and $CD14^+$ positive cells in myocardial tissue. Moreover, andrographolide treatment caused a reduction in the plasma levels of tumor necrosis factor-alpha, interleukin-17 (IL-17) and myosin-antibody, and an increase in the level of IL-10 in EAM rats. Oral administration of andrographolide resulted in the decreased expression of p-PI3K, p-Akt without any change of PI3K and Akt. Further results indicate andrographolide significantly inhibited myosin-induced proliferation in splenocytes, and this effect was inhibited by co-treatment of SC79 (Akt activator). Our data indicate andrographolide inhibits development of EAM, and this beneficial effect may be due to powerful anti-inflammatory activity and inhibitory effect on PI3K/Akt pathway.

• Anxiety and mood
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• v.15 no.1
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• pp.20-28
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• 2019

Objective : The purpose of this study was to compare and analyze effectiveness of various psychotherapies of depressive symptoms in patients with anxiety disorders by means of a systemic review. Methods : A systematic search using key words was conducted using EMBASE, MEDLINE and CENTRAL. Results : Five studies were included in this systematic review. The Scottish Intercollegiate Guidelines Network (SIGN) was used for quality assessment. Diagnostic-specific cognitive behavioral therapies for various anxiety disorders (ds CBT) were also effective in reducing comorbid depression. Transdiagnostic cognitive behavioral therapies targeting anxiety and depression (tCBT-AD) were not superior than ds CBT for anxiety disorders. Mindfulness-based stress reduction (MBSR) was more effective than traditional cognitive behavioral therapy. Conclusion : ds CBT relieves anxiety symptoms as well as depressive symptoms comorbid with anxiety disorders effectively. In addition, MBSR is more successful for anxiety disorders with co-occurring depression by focusing broadly on the shifting relationship to internal experience rather than focusing narrowly on specific symptoms.

• Journal of Korean Institute of Architectural Sustainable Environment and Building Systems
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• v.12 no.6
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• pp.531-542
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• 2018

Building energy demands have highly risen in modern society; thus, It is necessary to reduce building energy demands especially commercial buildings adopting a curtain wall architecture. Curtain wall architectures have a high ratio of windows which is a vulnerable in heat insulations as cladding. In order to complement insulation performance of windows in these buildings, there are various methods adopted often such as installing blinds, wing wall and films. There are two suggestions of this paper. 1) WWR (Window-to-Wall Ratio) makes a impaction of energy demands in buildings. 2) Another one is an efficiency of blind systems which are installed in buildings in order to reduce cooling demands. It is also critical to make fundamental model for low-energy building construction by processing a lot of simulation As a result by this study, 1) an external blind system is more useful for reducing cooling energy demands rather than an internal blind system. 2) Buildings which have a large window require more amount of cooling demands. In case of WWR 45%, it needs more cooling energy rather than WWR 15% model's 3) Adopting blind system would reduce energy demands. WWR 45% model with external blind systems reduces about 4% of cooling energy demands compared to same model without any blind systems.4) it is necessary to study an efficiency of blind systems combined with renewable energy and it will be possible to reduce more energy demand in building significantly.

• Explosives and Blasting
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• v.37 no.1
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• pp.34-47
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• 2019

This case study is concerned with the project of the explosive demolition for the DCRE Incheon plant located in Hakik district in Incheon city. The building was severely aging due to the high temperature and sea winds of hundreds of degrees emitted by chimney-shaped steel structures inside the building. Due to this, the concrete of the column and the beam fell off and rusted rebar were exposed, and some of the slabs were severely damaged, making it difficult for workers to access the structure. Therefore, it is not possible to apply a mechanical demolition method in which heavy equipment enters the interior of the building, and an explosive demolition method was applied to allow the building to be demolished without dismantling the internal facilities of the building. The order of blasting proceeded in the order of (1) building ${\rightarrow}$ (2) chimney 2 ${\rightarrow}$ (3) chimney 1. A total of 406 electronic detonators (Unitronic 600) was used to sequentially initiate the explosives installed at appropriate in building and chimneys.