• Journal of Ginseng Research
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• v.44 no.4
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• pp.664-671
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• 2020

Background: Ginsenoside compound-Mc1 (Mc1) is a member of the deglycosylated ginsenosides obtained from ginseng extract. Although several ginsenosides have a cardioprotective effect, this has not been demonstrated in ginsenoside Mc1. Methods: We treated H9c2 cells with hydrogen peroxide (H₂O₂) and ginsenoside Mc1 to evaluate the antioxidant effects of Mc1. The levels of antioxidant molecules, catalase, and superoxide dismutase 2 (SOD2) were measured, and cell viability was determined using the Bcl2-associated X protein (Bax):B-cell lymphoma-extra large ratio, a cytotoxicity assay, and flow cytometry. We generated mice with high-fat diet (HFD)-induced obesity using ginsenoside Mc1 and assessed their heart tissues to evaluate the antioxidant effect and the fibrosis-reducing capability of ginsenoside Mc1. Results: Ginsenoside Mc1 significantly increased the level of phosphorylated AMP-activated protein kinase (AMPK) in the H9c2 cells. The expression levels of catalase and SOD2 increased significantly after treatment with ginsenoside Mc1, resulting in a decrease in the production of H₂O₂-mediated reactive oxygen species. Treatment with ginsenoside Mc1 also significantly reduced the H₂O₂-mediated elevation of the Bax:Bcl2 ratio and the number of DNA-damaged cells, which was significantly attenuated by treatment with an AMPK inhibitor. Consistent with the in vitro data, ginsenoside Mc1 upregulated the levels of catalase and SOD2 and decreased the Bax:B-cell lymphoma-extra large ratio and caspase-3 activity in the heart tissues of HFD-induced obese mice, resulting in reduced collagen deposition. Conclusion: Ginsenoside Mc1 decreases oxidative stress and increases cell viability in H9c2 cells and the heart tissue isolated from HFD-fed mice via an AMPK-dependent mechanism, suggesting its potential as a novel therapeutic agent for oxidative stress-related cardiac diseases.

• Information Systems Review
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• v.15 no.3
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• pp.39-69
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• 2013

Business value of information technology has been the biggest interest of all such as practitioners and scholars for decades. Information technology is considered as the driving force or success factor of firm agility. The general assumption is that organizations making considerable efforts in IT investment are more agile than the organizations that are not. However, IT that should help the strategies of the firm that can hinder business or impede agility of the firm occasionally. In other words, it is still unknown if IT helps the agility of the firm or bothers it. Therefore, we note that contrary aspects of IT such as promotion and hindrance of firm agility have been observed frequently and theorize the relationships between them. In other words, we propose a rationale that firms should need to develop superior firm-wide IT capability to manage IT resources successfully in order to realize agility. Thus, this paper theorizes two IT capabilities, including technical IT capability and managerial IT capability as key factors impacting firm agility and firm performance. Further, we operationalize firm agility into two sub-types, including operational adjustment agility and market capitalizing agility. The data from 171 firms was analyzed using PLS approach. The results showed that technical IT capability has positive impact on firm agility and managerial IT capability had positive moderating effects between technical IT capability and firm agility. In addition, it was identified that top management championship positively moderates between agility and firm performance. Finally, it was indicated that firm agility was a very important causal variable of firm performance. Our study provides more exquisite and practical empirical evidences in the relationship between IT capability and firm agility by proposing applicable solution although IT has some contradicting effects on firm agility. Our findings suggest many useful implications to agility related researches in relatively primitive stage and working level officers in organizations.

• International Commerce and Information Review
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• v.15 no.2
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• pp.129-162
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• 2013

The purpose of this work is to explore the role of international entrepreneurship(IE) in explaining internationalization process of Korean ventures and to structure the model of IE with the logics of effectuation. The internationalization of entrepreneurial company is regarded as the realization of entrepreneurship which find out and use opportunities across borders in this point of view, and the realization process gets more realistic and applicable to the internationalization of ventures by effectuation. So we constructed the new concepts of the generating-internationalization-outcome capability(GIOC), which is the effectual capability allowing ventures to go international despite their lack of internal resources and experiences. Its sub-capabilities of GIOC are extemporaneous coping capability, perform-resource-in-hand capability and network-use capability. The empirical analyses of the relations among the capabilities and the performances of internationalization are performed in order to prove the rationale of the model, which provides finally significant evidences of the relationships. The key contribution of this study is that it highlights the important role of IE in internationalization of ventures and shows the possible role of effectuation in explaining the realization process of IE.

• Information Systems Review
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• v.20 no.2
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• pp.87-110
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• 2018

This study reviews previous studies about the effects of RFID capabilities on strategic supply chain competence and business performance in the Chinese context. This study introduces a new perspective that measures the degree to which RFID capability levels contribute to business performance. Such an assumption is based on the fact that companies build their own capabilities through RFID capabilities and that these capabilities provide a competitive advantage for enterprises. Data on all sorts of logistics, distribution, and manufacturing companies that introduced RFID system in China were collected for data analysis. This study analyzes the structural equation modeling using Smart-PLS 2.0 program. This study confirms that internal reliability, convergent validity, and discriminant validity are satisfied. The hypothesis test result on the relationship between RFID capacity and strategic supply chain competence and strategic supply chain competence and company results is partially adopted. This study aids in establishing a RFID system construction strategy to enhance supply chain competence by suggesting guidelines for the successful introduction of RFID system through identifying the causal relationship between RFID capacity and strategic supply chain competence. This study also suggests the influence of RFID competency on visibility, agility, flexibility, and collaborations.

• Proceedings of the Korean Geotechical Society Conference
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• 2009.03a
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• pp.729-736
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• 2009

Several well resistance effects induced by bending, confining stress, temperature, bubbles, and apparent opening size have been considered and researched for the reasonable PBD design. The effect of apparent opening size(AOS), however, was not extensively studied and the clogging effect by AOS was not clearly researched. In this paper, the slurry consolidation test which 4 types of PBD are installed in large slurry consolidometer($H{\times}D$, $2.0m{\times}1.2m$) is performed to investigate the clogging effect by filter's AOS. The results show that the internal clogging is observed all types of PBD, and a quantity of inflowed soil particles are increased at the lower part of PBD and the kink zone. In addition, the internal clogging phenomenon does not relate with the shape and size of PBD. In filter's AOS test, it was easily observed that soil particles bigger than AOS of tested filter passed PBD filter by SEM. This paper demonstrates that the reduction of discharge capability may be accelerated by internal clogging at the kink zone.

• The Journal of the Korea Contents Association
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• v.18 no.6
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• pp.434-442
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• 2018

Recently, the threat to the security and damage of important data leaked by devices of intranet infected by malicious code through the Internet have been increasing. Therefore, the partitioned intranet model that blocks access to the server for business use by implementing authentication of devices connected to the intranet is required. For this, logical net partition with the VDI(Virtual Desktop Infrastructure) method is no information exchange between physical devices connected to the intranet and the virtual device so that it could prevent data leakage and improve security but it is vulnerable to the attack to expose internal data, which has access to the server for business connecting a nonregistered device into the intranet. In order to protect the server for business, we suggest a blockchain based network partition model applying blockchain technology to VDI. It contributes to decrease in threat to expose internal data by improving not only capability to verify forgery of devices, which is the vulnerability of the VDI based logical net partition, but also the integrity of the devices.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.19 no.5
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• pp.454-461
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• 2009

Internal aeroacoustics of an axial fan used for circulating cold air in refrigerators are computed by using the hybrid method where CFD, acoustic analogy and BEM techniques are utilized. The unsteady flow field around the axial fan is predicted by solving the incompressible RANS equations with the conventional CFD techniques. Then, main noise sources are extracted from this unsteady flow field predictions using Acoustic Analogy. Lastly, BPF noise generated from an axial fan are predicted using these modeled sources combined with the tailed Green function techniques, which are numerically solved by the BEM technique. This hybrid model is validated by comparing the prediction with the experiment. Then, parameter studies are carried out, which suggest a capability of the current method as a design tool for the low-noise of the current axial fan system in a refrigerator.

• International Journal of Automotive Technology
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• v.8 no.6
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• pp.723-730
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• 2007

The typical design of automotive driveshafts generally utilizes Constant Velocity(CV) joints as a solution to NVH. CV joints are an integral part of vehicles and significantly affect steering, suspension, and vehicle vibration comfort levels. Thus, CV joints have been favored over universal joints due to the constant velocity torque transfer and plunging capability. Although CV joints are common in vehicle applications, current research works on modeling CV joint friction and assumes constant empirical friction coefficient values. However, such models are long known to be inaccurate, especially under dynamic conditions, which is the case for CV joints. In this paper, an instrumented advanced CV joint friction apparatus was developed to measure the internal friction behavior of CV joints using actual tripod-type joint assemblies. The setup is capable of measuring key performance of friction under different realistic operating conditions of oscillatory speeds, torque and joint installation angles. The apparatus incorporates a custom-installed triaxial force sensor inside of the joint to measure the internal CV joint forces(including friction). Using the designed test setup, the intrinsic interfacial parameters of CV joints were investigated in order to understand their contact and friction mechanisms. The results provide a better understanding of CV joint friction characteristics in developing improved automotive driveshafts.

• Smart Structures and Systems
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• v.13 no.1
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• pp.1-24
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• 2014

The present study deals with two dimensional electro-elastic analysis of a functionally graded piezoelectric (FGP) cylinder under internal pressure. Energy method and first order shear deformation theory (FSDT) are employed for this purpose. All mechanical and electrical properties except Poisson ratio are considered as a power function along the radial direction. The cylinder is subjected to uniform internal pressure. By supposing two dimensional displacement and electric potential fields along the radial and axial direction, the governing differential equations can be derived in terms of unknown electrical and mechanical functions. Homogeneous solution can be obtained by imposing the appropriate mechanical and electrical boundary conditions. This proposed solution has capability to solve the cylinder structure with arbitrary boundary conditions. The previous solutions have been proposed for the problem with simple boundary conditions (simply supported cylinder) by using the routine functions such as trigonometric functions. The axial distribution of the axial displacement, radial displacement and electric potential of the cylinder can be presented as the important results of this paper for various non homogeneous indexes. This paper evaluates the effect of a local support on the distribution of mechanical and electrical components. This investigation indicates that a support has important influence on the distribution of mechanical and electrical components rather than a cylinder with ignoring the effect of the supports. Obtained results using present method at regions that are adequate far from two ends of the cylinder can be compared with previous results (plane elasticity and one dimensional first order shear deformation theories).

• Proceedings of the SAREK Conference
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• 2009.06a
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• pp.39-44
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• 2009

Geothermal energy is the heat contained in the earth and its internal fluids. Geothermal energy is stored as sensible or latent heat. Supplied by both internal and external sources, it represents a vast supply which is only started to be tapped for generation of electric power. In general, this is natural dry or wet medium to high enthalpy steam at temperatures above $150^{\circ}C$. For some time, binary systems employing substances with a lower boiling point than water in a secondary circuit have been used to generate vapor for driving turbines at a lower temperature level. The utilization of binary plants and the possibility of production from enhanced geothermal systems can expand its availability on a worldwide basis. The geothermal electricity installed capacity is approaching the 10,000GW threshold. Geothermal energy is not present everywhere, but its baseload capability is a very important factor for its success.