• Archives of Pharmacal Research
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• 제27권2호
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• pp.127-135
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• 2004

Multiple drug administration is common in elderly, HIV, and cancer patients. Such treatments may result in drug-drug interactions due to interference at the metabolic enzyme level, and due to modulation of transporter protein functions. Both kinds of interference may result in altered drug distribution and toxicity in the human body. In this review, we have dealt with drug-drug interactions related to the most studied human transporter, P-glycoprotein. This transporter is constitutively expressed in several sites in the human body. Its function can be studied in vitro with different cell lines expressing P-glycoprotein in experiments using methods and equipment such as flow cytometry, cell proliferation, cell-free ATP as activity determination and Transwell culture equipment. In vivo experiments can be carried out by mdr1a(-/-) animals and by noninvasive methods such as NMR spectrometry. Some examples are also given for determination of possible drug-drug interactions using the above-mentioned cell lines and methods. Such preclinical studies may influence decisions concerning the fate of new drug candidates and their possible dosages. Some examples of toxicities obtained in clinics and summarized in this review indicate careful consideration in cases of polypharmacy and the requirement of preclinical studies in drug development activities.

• Structural Monitoring and Maintenance
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• 제9권3호
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• pp.259-270
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• 2022

This study explores the use of the recently developed "strain-sensing smart skin" (S⁴) method for noncontact strain measurements on cement-based samples. S⁴ sensors are single-wall carbon nanotubes dilutely embedded in thin polymer films. Strains transmitted to the nanotubes cause systematic shifts in their near-infrared fluorescence spectra, which are analyzed to deduce local strain values. It is found that with cement-based materials, this method is hampered by spectral interference from structured near-infrared cement luminescence. However, application of an opaque blocking layer between the specimen surface and the nanotube sensing film enables interference-free strain measurements. Tests were performed on cement, mortar, and concrete specimens with such modified S⁴ coatings. When specimens were subjected to uniaxial compressive stress, the spectral peak separations varied linearly and predictably with induced strain. These results demonstrate that S⁴ is a promising emerging technology for measuring strains down to ca. 30 𝜇𝜀 in concrete structures.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2022년도 추계학술대회
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• pp.37-39
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• 2022

코로나19가 전 세계를 강타하면서 2021년 무관중 도쿄올림픽을 개최했다. 일부 방송사는 TV로 현장의 생생함을 전하고자 영상처리 기반 비접촉식 측정을 활용하여 실시간으로 선수들의 심박수를 보여주었다. 그러나 비접촉식 모델은 혈액순환에 따른 선수들의 얼굴 피부색 변화를 파라미터로 이용하기 때문에 자연광이나 안경 등과 같은 방해 요소로 인해 부정확할 가능성이 있다. 따라서 본 논문에서는 비접촉식 심박수 측정 모델과 접촉식 심박수 측정 모델을 방해 요소 유무에 따른 환경에서 실험하고 그에 따른 정확도를 분석한다.

• 비파괴검사학회지
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• 제13권2호
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• pp.20-30
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• 1993

CW레이저, 비디오장치, 화상처리장치를 이용한 ESPI를 고온에서 자유 열팽창하는 열팽창계수 측정에 적용하였다. ESPI는 이미 선정된 방향의 면내 변위분포를 나타내 준다. ESPI는 간섭 줄무늬를 실시간으로 나타내 주며 면에 비접촉이고 표면의 준비가 필요 없다는 장점이 있다. ESPI를 고온에 적용함에 있어서 줄무늬의 가시도를 저하시키는 여러 가지 문제점에 당면하게 된다. 고온 물체 주위의 뜨거운 공기로 인한 요란의 문제는 진공용기를 사용함으로 해결될 수 있을 것이다. 물체의 배경방사는 간섭 필터에 의해 매우 감소되었다. 물체의 표면 산화의 문제는 해결될 수 없었다. Human-Error를 방지하기 위해 FFT에 의해 계산된 간섭 줄무늬 간격은 $800^{\circ}C$까지 관찰되었다. ESPI에 의해 측정된 결과는 $800^{\circ}C$까지 이미 발표된 데이타와 거의 일치했다.

• Asian-Australasian Journal of Animal Sciences
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• 제23권4호
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• pp.456-464
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• 2010

RNA interference (RNAi) is an acknowledged useful and effective tool to study gene function in various cells. Here, we suppressed the Connexin 43 (Cx 43) gene expression during in vitro development of ovine pre-implantation embryos using the RNAi method. The 353 bp Cx 43 double-stranded RNA was microinjected into in vitro fertilized ovine zygotes, and the levels of target mRNA and protein were investigated. Control groups included uninjected zygotes or those injected with RNase-free water. The dsRNA injection resulted in the specific reduction of Cx 43 transcripts as analyzed by quantitative real-time RT-PCR and decreased protein levels as shown by Western blot analysis at the blastocyst stage. Microinjection of Cx 43 dsRNA led to 20.3%, 21.7% and 34.5% blastocyst rates and 19.2%, 37.5% and 41.3% hatched blastocyst rates in Cx 43 dsRNA-injected, water-injected and uninjected groups, respectively. Then the RNAi could not significantly affect cell number and cell death rates of blastocysts. Therefore, suppression of Cx 43 dsRNA and proteins did not apparently affect the development potential of ovine pre-implantation embryos but may play a role in embryo quality. RNAi technology is a promising approach to study gene function in early ovine embryogenesis.

• 대한전자공학회논문지SD
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• 제44권2호
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• pp.46-54
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• 2007

본 연구에서는 WDM 시스템의 집적화를 위해서 InP 기반의 신개념의 마이크로 링 공진기 필터를 제안하고, 제작을 통해서 그 특성을 측정 분석하였다. 전반사 미러가 삽입된 구조는 자동 정렬 (Self-Aligned) 공정을 통해서 구현 하였고, 측정된 전반사 미러의 손실은 한 개의 미러당 0.71 dB를 얻을 수 있었다. 마이크로 링 공진기의 결합기로는 다중모드 간섭기를 이용하여 빛이 광도파로를 따라 진행할 때 링으로 결합되는 파워를 높였다. 다중모드 간섭기의 주변을 깊게 에칭을 하여 간섭기의 길이와 폭을 $119{\mu}m$와 $9{\mu}m$로 하였다. 링 공진기 내부의 광도파로와 전반사 미러에서의 손실을 보상하기 위해서 링 공진기 내부에 길이가 $190{\mu}m$인 반도체 광 증폭기를 집적하였다. 이때 얻어진 FSR는 대략 1.333 nm (162 GHz)이고 소광비는 13 dB이다.

• 센서학회지
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• 제22권2호
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• pp.144-149
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• 2013

In this research, we developed a biosensor to detect lung cancer-specific biomarker using Anodic Aluminum Oxide (AAO) chip based on interference and nano surface plasmon resonance (nanoSPR). The nano-porous AAO chip was fabricated $2{\mu}m$ of pore-depth by two-step anodizing method for surface uniformity. NanoSPR has sensitivity to the refractive index (RI) of the surrounding medium and also provides simple and label-free detection when specific antibodies are immobilized to the Au-deposited surface of nano-porous AAO chip. To detect the lung cancer-specific biomarker, antibodies were immobilized on the surface of the chip by Self Assembled Monolayer (SAM) method. Since then lung cancer-specific biomarker was applied atop the antibodies immobilized layer. The specific reaction of the antigen-antibody contributed to the change in the refractive index that cause shift of resonance spectrum in the interference pattern. The Limit of Detection (LOD) was 1 fg/ml by using our nano-porous AAO biosensor chip.

• 대한조선학회논문집
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• 제44권2호
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• pp.198-209
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• 2007

In this paper, we present the gouging and collision-free tool-path generation for manufacturing model propellers using the 5-axis NC machine. Because it takes much time to generate tool-paths when we use general purpose CAD/CAM systems, a specific system would be necessary for marine propellers. Overall manufacturing process is composed of two steps: roughcut and finishcut steps. The roughcut is conducted using only 3-axis for efficient machining and the finishcut is done using 5-axis for avoiding collision. The tool-path that might happen to gouging is searched and the tool position is also decided for avoiding interference between the tool and the propeller blades. The present algorithm is applied extensively to the surface piercing propellers. Some results are demonstrated for its validation.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제19권1호
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• pp.28-37
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• 2008

Objectives : This study was conducted in order to examine the reliability and validity of the Children's Color Trails Test (CCTT). The objective of the study was also to provide the Korean normative data for the CCTT. Methods : Normative samples consisted of 766 children and adolescents living in Seoul and aged from 5 to 15 years. Eighty children who were diagnosed with ADHD, based on the DSM-IV criterion, were recruited from Seoul National University Children's Hospital. Among them, 46 ADHD children were receiving medication, while 34 children were drug-free. Results : The scores of the CCTT were significantly correlated with those of the Stroop test. Three factors were extracted through factor analysis-visual tracking and cognitive flexibility, distractibility and susceptibility to interference, and simple attention and impulsivity. The completion time of the CCTT for all children tended to decrease as age increased. There were significant differences in the CCTT scores between the ADHD group receiving medication, the ADHD-drug free group and the normal groups. The CCTT also showed sound test-retest reliability. These results confirmed the reliability and validity of the CCTT. Finally, we provided the Korean normative data for the CCTT. Conclusion : These results suggest that the CCTT is a reliable and valid test, which can be used to assess frontal function related to child psychiatric disorders in Korean children.

• 한국통신학회논문지
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• 제37권8C호
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• pp.655-662
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• 2012

본 연구에서는 다수 레이다신호의 간섭으로 인해 항공기가 데이터통신이 두절될 것을 대비하여 새로운 주파수(채널)을 탐색하기 위해 Cognitive Radio 기술을 활용한 항공인지무선시스템을 제안한다. 항공기의 데이터통신 채널을 확보하기 위해 비행환경하에 레이다의 주파수를 인지하여 지형정보를 통한 유효주파수를 산출하여 빠르게 스펙트럼을 센싱하는 방법을 제안하였다. 기지국은 항공기와 레이더의 위치를 기반으로 자유공간의 경로손실을 이용한 방식으로 유효 주파수를 계산하였고 이동체에 대한 변수를 병행하여 적용하였다. 분석 결과 기존 최대 주파수 탐색시간이 제안된 방법을 활용시 절반으로 단축됨을 입증하였다.